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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxybutynin
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Accession:CHEBI:7856 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.
Synonyms:exact_synonym: rac-4-(diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate
 related_synonym: Formula=C22H31NO3;   InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;   InChIKey=XIQVNETUBQGFHX-UHFFFAOYSA-N;   SMILES=C1(CCCCC1)C(C2=CC=CC=C2)(C(OCC#CCN(CC)CC)=O)O;   ditropan;   kentera;   oxibutinina;   oxybutynine;   oxybutyninum
 xref: Beilstein:2707356;   CAS:5633-20-5;   DrugBank:DB01062;   Drug_Central:2028;   KEGG:C07360;   KEGG:D00465;   LINCS:LSM-5111
 xref_mesh: MESH:C005419
 xref: Patent:GB940540;   Wikipedia:Oxybutynin


show annotations for term's descendants           Sort by:
oxybutynin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO oxybutynin results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO oxybutynin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of oxybutynin CTD PMID:9300133 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO oxybutynin binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO oxybutynin binds to and results in decreased activity of CHRM3 protein CTD PMID:15140916 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO oxybutynin results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Drd2 dopamine receptor D2 affects binding ISO oxybutynin binds to DRD2 protein CTD PMID:10888308 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Il24 interleukin 24 decreases expression ISO oxybutynin results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP oxybutynin results in decreased expression of JUN mRNA CTD PMID:10458442 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO oxybutynin results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO oxybutynin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO oxybutynin results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    chemical entity 19919
      chemical substance 14418
        mixture 13731
          racemate 12103
            oxybutynin 12
              oxybutynin chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19867
                    main group molecular entity 19867
                      s-block molecular entity 19697
                        hydrogen molecular entity 19686
                          hydrides 19161
                            inorganic hydride 18132
                              pnictogen hydride 18121
                                nitrogen hydride 18027
                                  azane 17828
                                    ammonia 17827
                                      organic amino compound 17827
                                        tertiary amino compound 10140
                                          4-(diethylamino)but-2-yn-1-ol 12
                                            esoxybutynin 12
                                              oxybutynin 12
                                                oxybutynin chloride 0
paths to the root