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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxybutynin
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Accession:CHEBI:7856 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.
Synonyms:exact_synonym: rac-4-(diethylamino)but-2-yn-1-yl cyclohexyl(hydroxy)phenylacetate
 related_synonym: Formula=C22H31NO3;   InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;   InChIKey=XIQVNETUBQGFHX-UHFFFAOYSA-N;   SMILES=C1(CCCCC1)C(C2=CC=CC=C2)(C(OCC#CCN(CC)CC)=O)O;   ditropan;   kentera;   oxibutinina;   oxybutynine;   oxybutyninum
 xref: Beilstein:2707356;   CAS:5633-20-5;   DrugBank:DB01062;   Drug_Central:2028;   KEGG:C07360;   KEGG:D00465;   LINCS:LSM-5111
 xref_mesh: MESH:C005419
 xref: Patent:GB940540;   Wikipedia:Oxybutynin


show annotations for term's descendants           Sort by:
oxybutynin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO oxybutynin results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO oxybutynin results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:38009396 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of oxybutynin CTD PMID:9300133 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO oxybutynin binds to and results in decreased activity of CHRM2 protein CTD PMID:15140916 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 multiple interactions ISO oxybutynin binds to and results in decreased activity of CHRM3 protein CTD PMID:15140916 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO oxybutynin results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Drd2 dopamine receptor D2 affects binding ISO oxybutynin binds to DRD2 protein CTD PMID:10888308 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:38009396 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il24 interleukin 24 decreases expression ISO oxybutynin results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:38009396 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP oxybutynin results in decreased expression of JUN mRNA CTD PMID:10458442 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO oxybutynin results in decreased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein] CTD PMID:38009396 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein] CTD PMID:38009396 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:38009396 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:38009396 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO oxybutynin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO oxybutynin results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] CTD PMID:38009396 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; oxybutynin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:38009396 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      chemical substance 14419
        mixture 13738
          racemate 12115
            oxybutynin 21
              oxybutynin chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        tertiary amino compound 10155
                                          4-(diethylamino)but-2-yn-1-ol 21
                                            esoxybutynin 21
                                              oxybutynin 21
                                                oxybutynin chloride 0
paths to the root