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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ponatinib
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Accession:CHEBI:78543 term browser browse the term
Definition:A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline.
Synonyms:exact_synonym: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
 related_synonym: AP 24534;   AP24534;   Formula=C29H27F3N6O;   InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39);   InChIKey=PHXJVRSECIGDHY-UHFFFAOYSA-N;   SMILES=CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1;   ponatinibum
 xref: CAS:943319-70-8;   Drug_Central:4716;   KEGG:D09950;   LINCS:LSM-1151
 xref_mesh: MESH:C545373
 xref: PMID:24297701;   PMID:24402926;   PMID:24407160;   PMID:24408322;   PMID:24472312;   PMID:24481648;   PMID:24550512;   PMID:24552773;   PMID:24586514;   PMID:24596204;   PMID:24602068;   PMID:24695735;   PMID:24729118;   PMID:24756787;   PMID:24766374;   PMID:24768818;   PMID:24807266;   PMID:24934866;   Patent:US2014038920;   Reaxys:12923700;   Wikipedia:Ponatinib


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ponatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
decreases phosphorylation
decreases activity
ISO ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of ABL1 protein mutant form]; ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]; ponatinib inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]
ponatinib results in decreased phosphorylation of ABL1 protein; ponatinib results in decreased phosphorylation of ABL1 protein mutant form
ponatinib analog results in decreased activity of ABL1 protein; ponatinib analog results in decreased activity of ABL1 protein mutant form; ponatinib results in decreased activity of ABL1 protein; ponatinib results in decreased activity of ABL1 protein mutant form
CTD PMID:19878872 PMID:20513156 PMID:21561767 PMID:22781593 PMID:25304212 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase decreases activity ISO ponatinib results in decreased activity of ABL2 protein CTD PMID:19878872 NCBI chr13:68,673,702...68,839,742
Ensembl chr13:68,673,722...68,839,742
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of AKT1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of AKT1 protein] CTD PMID:25053825 PMID:25304212 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of BCL2 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of BCL2 protein] CTD PMID:25053825 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased expression of BCL2L11 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased expression of BCL2L11 protein] CTD PMID:25053825 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases phosphorylation ISO ponatinib results in decreased phosphorylation of BCR protein mutant form CTD PMID:19878872 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of BLK protein CTD PMID:19878872 NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
JBrowse link
G Bmx BMX non-receptor tyrosine kinase decreases activity ISO ponatinib results in decreased activity of BMX protein CTD PMID:19878872 NCBI chr  X:30,227,251...30,290,015
Ensembl chr  X:30,227,251...30,289,993
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases activity ISO ponatinib analog results in decreased activity of BRAF protein; ponatinib analog results in decreased activity of BRAF protein mutant form CTD PMID:21561767 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Casp3 caspase 3 increases cleavage ISO ponatinib results in increased cleavage of CASP3 protein CTD PMID:29341879 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK4 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK4 protein] CTD PMID:25053825 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK6 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein] CTD PMID:25053825 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased expression of CDKN1A protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein] CTD PMID:25053825 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein multiple interactions
decreases phosphorylation
ISO ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]
ponatinib results in decreased phosphorylation of CRKL protein
CTD PMID:19878872 PMID:25304212 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases activity ISO ponatinib analog results in decreased activity of CSF1R protein; ponatinib results in decreased activity of CSF1R protein CTD PMID:19878872 PMID:21561767 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csk C-terminal Src kinase decreases activity ISO ponatinib results in decreased activity of CSK protein CTD PMID:19878872 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of DDR2 protein CTD PMID:19878872 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO ponatinib results in decreased activity of EGFR protein mutant form CTD PMID:19878872 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Epha1 Eph receptor A1 decreases activity ISO ponatinib results in decreased activity of EPHA1 protein CTD PMID:19878872 NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846
JBrowse link
G Epha2 Eph receptor A2 decreases activity ISO ponatinib analog results in decreased activity of EPHA2 protein; ponatinib results in decreased activity of EPHA2 protein CTD PMID:19878872 PMID:21561767 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
JBrowse link
G Epha3 Eph receptor A3 decreases activity ISO ponatinib analog results in decreased activity of EPHA3 protein; ponatinib results in decreased activity of EPHA3 protein CTD PMID:19878872 PMID:21561767 NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
JBrowse link
G Epha4 Eph receptor A4 decreases activity ISO ponatinib results in decreased activity of EPHA4 protein CTD PMID:19878872 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Epha5 EPH receptor A5 decreases activity ISO ponatinib results in decreased activity of EPHA5 protein CTD PMID:19878872 NCBI chr14:23,653,393...24,020,135
Ensembl chr14:23,653,393...24,017,317
JBrowse link
G Epha7 Eph receptor A7 decreases activity ISO ponatinib analog results in decreased activity of EPHA7 protein; ponatinib results in decreased activity of EPHA7 protein CTD PMID:19878872 PMID:21561767 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
JBrowse link
G Epha8 Eph receptor A8 decreases activity ISO ponatinib results in decreased activity of EPHA8 protein CTD PMID:19878872 NCBI chr 5:149,166,107...149,193,498
Ensembl chr 5:149,166,697...149,193,399
JBrowse link
G Ephb1 Eph receptor B1 decreases activity ISO ponatinib results in decreased activity of EPHB1 protein CTD PMID:19878872 NCBI chr 8:102,507,549...102,944,839
Ensembl chr 8:102,507,549...102,944,839
JBrowse link
G Ephb2 Eph receptor B2 decreases activity ISO ponatinib results in decreased activity of EPHB2 protein CTD PMID:19878872 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Ephb3 Eph receptor B3 decreases activity ISO ponatinib results in decreased activity of EPHB3 protein CTD PMID:19878872 NCBI chr11:79,840,668...79,859,467
Ensembl chr11:79,840,668...79,859,370
JBrowse link
G Ephb4 EPH receptor B4 decreases activity ISO ponatinib results in decreased activity of EPHB4 protein CTD PMID:19878872 NCBI chr12:19,326,411...19,351,667
Ensembl chr12:19,326,427...19,351,314
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases activity ISO ponatinib results in decreased activity of ERBB4 protein CTD PMID:19878872 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases activity
decreases phosphorylation
ISO ponatinib analog results in decreased activity of FGFR1 protein; ponatinib results in decreased activity of FGFR1 protein; ponatinib results in decreased activity of FGFR1 protein mutant form
ponatinib results in decreased phosphorylation of FGFR1 protein mutant form
CTD PMID:19878872 PMID:21482694 PMID:21561767 PMID:22875613 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases activity ISO ponatinib analog results in decreased activity of FGFR2 protein; ponatinib results in decreased activity of FGFR2 protein; ponatinib results in decreased activity of FGFR2 protein mutant form CTD PMID:19878872 PMID:21561767 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO ponatinib analog results in decreased activity of FGFR3 protein; ponatinib results in decreased activity of FGFR3 protein CTD PMID:19878872 PMID:21561767 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases activity ISO ponatinib analog results in decreased activity of FGFR4 protein; ponatinib results in decreased activity of FGFR4 protein CTD PMID:19878872 PMID:21561767 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FGR protein CTD PMID:19878872 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases activity ISO ponatinib analog results in decreased activity of FLT1 protein; ponatinib results in decreased activity of FLT1 protein CTD PMID:19878872 PMID:21561767 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases activity
decreases phosphorylation
multiple interactions
ISO ponatinib analog results in decreased activity of FLT3 protein; ponatinib results in decreased activity of FLT3 protein; ponatinib results in decreased activity of FLT3 protein mutant form
ponatinib results in decreased phosphorylation of FLT3 protein mutant form
ponatinib inhibits the reaction [FLT3 protein mutant form results in increased phosphorylation of FLT3 protein mutant form]
CTD PMID:19878872 PMID:21482694 PMID:21561767 PMID:22409268 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases activity ISO ponatinib analog results in decreased activity of FLT4 protein; ponatinib results in decreased activity of FLT4 protein CTD PMID:19878872 PMID:21561767 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
JBrowse link
G Frk fyn-related Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FRK protein CTD PMID:19878872 NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FYN protein CTD PMID:19878872 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO ponatinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of HCK protein CTD PMID:19878872 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Jak1 Janus kinase 1 decreases activity ISO ponatinib results in decreased activity of JAK1 protein CTD PMID:19878872 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Jak2 Janus kinase 2 decreases activity ISO ponatinib results in decreased activity of JAK2 protein CTD PMID:19878872 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jak3 Janus kinase 3 decreases activity ISO ponatinib results in decreased activity of JAK3 protein CTD PMID:19878872 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Kdr kinase insert domain receptor decreases activity ISO ponatinib analog results in decreased activity of KDR protein; ponatinib results in decreased activity of KDR protein CTD PMID:19878872 PMID:21561767 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases activity
decreases phosphorylation
ISO ponatinib results in decreased activity of KIT protein; ponatinib results in decreased activity of KIT protein mutant form
ponatinib results in decreased phosphorylation of KIT protein mutant form
CTD PMID:19878872 PMID:21482694 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of LCK protein CTD PMID:19878872 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Lmna lamin A/C increases cleavage ISO ponatinib results in increased cleavage of LMNA protein CTD PMID:22875613 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of LYN protein CTD PMID:19878872 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases lipidation ISO ponatinib results in increased lipidation of MAP1LC3A protein CTD PMID:29341879 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of MAPK1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK1 protein] CTD PMID:22409268 PMID:22875613 PMID:25053825 PMID:25304212 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of MAPK3 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK3 protein] CTD PMID:22409268 PMID:22875613 PMID:25053825 PMID:25304212 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO ponatinib results in decreased expression of MCL1 protein CTD PMID:22409268 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of MYC protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein] CTD PMID:25053825 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases activity ISO ponatinib results in decreased activity of NTRK1 protein CTD PMID:19878872 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of NTRK2 protein CTD PMID:19878872 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases activity ISO ponatinib results in decreased activity of NTRK3 protein CTD PMID:19878872 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased cleavage of PARP1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased cleavage of PARP1 protein] CTD PMID:21482694 PMID:22875613 PMID:25053825 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases activity
decreases phosphorylation
ISO ponatinib analog results in decreased activity of PDGFRA protein; ponatinib results in decreased activity of PDGFRA protein; ponatinib results in decreased activity of PDGFRA protein mutant form
ponatinib results in decreased phosphorylation of PDGFRA protein mutant form
CTD PMID:19878872 PMID:21482694 PMID:21561767 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases activity ISO ponatinib analog results in decreased activity of PDGFRB protein; ponatinib results in decreased activity of PDGFRB protein CTD PMID:19878872 PMID:21561767 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta decreases activity ISO ponatinib results in decreased activity of PTK2B protein CTD PMID:19878872 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Ptk6 protein tyrosine kinase 6 decreases activity ISO ponatinib results in decreased activity of PTK6 protein CTD PMID:19878872 NCBI chr 3:168,307,073...168,315,664
Ensembl chr 3:168,307,073...168,315,664
JBrowse link
G Ret ret proto-oncogene decreases activity ISO ponatinib analog results in decreased activity of RET protein; ponatinib results in decreased activity of RET protein; ponatinib results in decreased activity of RET protein mutant form CTD PMID:19878872 PMID:21561767 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity ISO ponatinib analog results in decreased activity of SRC protein; ponatinib results in decreased activity of SRC protein CTD PMID:19878872 PMID:21561767 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
decreases phosphorylation
ISO ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein]
ponatinib results in decreased phosphorylation of STAT5A protein
CTD PMID:22875613 PMID:25053825 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein] CTD PMID:25053825 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tek TEK receptor tyrosine kinase decreases activity ISO ponatinib analog results in decreased activity of TEK protein; ponatinib results in decreased activity of TEK protein CTD PMID:19878872 PMID:21561767 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion ISO ponatinib results in increased secretion of TNNI3 protein CTD PMID:25304212 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580
JBrowse link
G Tyk2 tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of TYK2 protein CTD PMID:19878872 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of YES1 protein CTD PMID:19878872 NCBI chr 9:113,200,256...113,275,942
Ensembl chr 9:113,200,256...113,299,837
JBrowse link

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  CHEBI ontology 19812
    role 19761
      application 19471
        pharmaceutical 19319
          drug 19319
            antineoplastic agent 17316
              ponatinib 71
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        carboacyl group 17482
                                          univalent carboacyl group 17482
                                            carbamoyl group 17298
                                              carboxamide 17298
                                                monocarboxylic acid amide 15014
                                                  arenecarboxamide 7265
                                                    benzamides 7265
                                                      ponatinib 71
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