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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ponatinib
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Accession:CHEBI:78543 term browser browse the term
Definition:A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline.
Synonyms:exact_synonym: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
 related_synonym: AP 24534;   AP24534;   Formula=C29H27F3N6O;   InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39);   InChIKey=PHXJVRSECIGDHY-UHFFFAOYSA-N;   SMILES=CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1;   ponatinibum
 xref: CAS:943319-70-8;   Drug_Central:4716;   KEGG:D09950;   LINCS:LSM-1151
 xref_mesh: MESH:C545373
 xref: PMID:24297701;   PMID:24402926;   PMID:24407160;   PMID:24408322;   PMID:24472312;   PMID:24481648;   PMID:24550512;   PMID:24552773;   PMID:24586514;   PMID:24596204;   PMID:24602068;   PMID:24695735;   PMID:24729118;   PMID:24756787;   PMID:24766374;   PMID:24768818;   PMID:24807266;   PMID:24934866;   Patent:US2014038920;   Reaxys:12923700;   Wikipedia:Ponatinib


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ponatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions
decreases phosphorylation
decreases activity
ISO ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of ABL1 protein mutant form]; ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]; ponatinib inhibits the reaction [ABL1 protein results in increased phosphorylation of ABL1 protein]
ponatinib results in decreased phosphorylation of ABL1 protein; ponatinib results in decreased phosphorylation of ABL1 protein mutant form
ponatinib analog results in decreased activity of ABL1 protein; ponatinib analog results in decreased activity of ABL1 protein mutant form; ponatinib results in decreased activity of ABL1 protein; ponatinib results in decreased activity of ABL1 protein mutant form
CTD PMID:19878872, PMID:20513156, PMID:21561767, PMID:22781593, PMID:25304212 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase decreases activity ISO ponatinib results in decreased activity of ABL2 protein CTD PMID:19878872 NCBI chr13:74,154,533...74,333,244
Ensembl chr13:74,154,835...74,333,244
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of AKT1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of AKT1 protein] CTD PMID:25053825, PMID:25304212 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of BCL2 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of BCL2 protein] CTD PMID:25053825 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions
increases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased expression of BCL2L11 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased expression of BCL2L11 protein] CTD PMID:25053825 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases phosphorylation ISO ponatinib results in decreased phosphorylation of BCR protein mutant form CTD PMID:19878872 NCBI chr20:14,421,250...14,546,406
Ensembl chr20:14,421,141...14,545,772
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of BLK protein CTD PMID:19878872 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653
JBrowse link
G Bmx BMX non-receptor tyrosine kinase decreases activity ISO ponatinib results in decreased activity of BMX protein CTD PMID:19878872 NCBI chr  X:31,976,231...32,046,326
Ensembl chr  X:31,984,612...32,045,448
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases activity ISO ponatinib analog results in decreased activity of BRAF protein; ponatinib analog results in decreased activity of BRAF protein mutant form CTD PMID:21561767 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Casp3 caspase 3 increases cleavage ISO ponatinib results in increased cleavage of CASP3 protein CTD PMID:29341879 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK4 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK4 protein] CTD PMID:25053825 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of CDK6 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of CDK6 protein] CTD PMID:25053825 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased expression of CDKN1A protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein] CTD PMID:25053825 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein multiple interactions
decreases phosphorylation
ISO ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of CRKL protein]
ponatinib results in decreased phosphorylation of CRKL protein
CTD PMID:19878872, PMID:25304212 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases activity ISO ponatinib analog results in decreased activity of CSF1R protein; ponatinib results in decreased activity of CSF1R protein CTD PMID:19878872, PMID:21561767 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csk C-terminal Src kinase decreases activity ISO ponatinib results in decreased activity of CSK protein CTD PMID:19878872 NCBI chr 8:62,405,714...62,424,707
Ensembl chr 8:62,405,715...62,424,303
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of DDR2 protein CTD PMID:19878872 NCBI chr13:88,311,639...88,436,561
Ensembl chr13:88,317,145...88,436,789
JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO ponatinib results in decreased activity of EGFR protein mutant form CTD PMID:19878872 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Epha1 Eph receptor A1 decreases activity ISO ponatinib results in decreased activity of EPHA1 protein CTD PMID:19878872 NCBI chr 4:71,749,100...71,763,681
Ensembl chr 4:71,749,242...71,763,679
JBrowse link
G Epha2 Eph receptor A2 decreases activity ISO ponatinib analog results in decreased activity of EPHA2 protein; ponatinib results in decreased activity of EPHA2 protein CTD PMID:19878872, PMID:21561767 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
G Epha3 Eph receptor A3 decreases activity ISO ponatinib analog results in decreased activity of EPHA3 protein; ponatinib results in decreased activity of EPHA3 protein CTD PMID:19878872, PMID:21561767 NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954
JBrowse link
G Epha4 Eph receptor A4 decreases activity ISO ponatinib results in decreased activity of EPHA4 protein CTD PMID:19878872 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Epha5 EPH receptor A5 decreases activity ISO ponatinib results in decreased activity of EPHA5 protein CTD PMID:19878872 NCBI chr14:25,589,312...25,958,258
Ensembl chr14:25,589,762...25,958,227
JBrowse link
G Epha7 Eph receptor A7 decreases activity ISO ponatinib analog results in decreased activity of EPHA7 protein; ponatinib results in decreased activity of EPHA7 protein CTD PMID:19878872, PMID:21561767 NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549
JBrowse link
G Epha8 Eph receptor A8 decreases activity ISO ponatinib results in decreased activity of EPHA8 protein CTD PMID:19878872 NCBI chr 5:155,293,731...155,321,016
Ensembl chr 5:155,295,314...155,316,495
JBrowse link
G Ephb1 Eph receptor B1 decreases activity ISO ponatinib results in decreased activity of EPHB1 protein CTD PMID:19878872 NCBI chr 8:110,376,954...110,813,193
Ensembl chr 8:110,376,954...110,813,000
JBrowse link
G Ephb2 Eph receptor B2 decreases activity ISO ponatinib results in decreased activity of EPHB2 protein CTD PMID:19878872 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456
JBrowse link
G Ephb3 Eph receptor B3 decreases activity ISO ponatinib results in decreased activity of EPHB3 protein CTD PMID:19878872 NCBI chr11:83,527,960...83,546,742
Ensembl chr11:83,527,962...83,546,674
JBrowse link
G Ephb4 EPH receptor B4 decreases activity ISO ponatinib results in decreased activity of EPHB4 protein CTD PMID:19878872 NCBI chr12:22,393,338...22,418,332
Ensembl chr12:22,393,330...22,417,980
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases activity ISO ponatinib results in decreased activity of ERBB4 protein CTD PMID:19878872 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases activity
decreases phosphorylation
ISO ponatinib analog results in decreased activity of FGFR1 protein; ponatinib results in decreased activity of FGFR1 protein; ponatinib results in decreased activity of FGFR1 protein mutant form
ponatinib results in decreased phosphorylation of FGFR1 protein mutant form
CTD PMID:19878872, PMID:21482694, PMID:21561767, PMID:22875613 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases activity ISO ponatinib analog results in decreased activity of FGFR2 protein; ponatinib results in decreased activity of FGFR2 protein; ponatinib results in decreased activity of FGFR2 protein mutant form CTD PMID:19878872, PMID:21561767 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO ponatinib analog results in decreased activity of FGFR3 protein; ponatinib results in decreased activity of FGFR3 protein CTD PMID:19878872, PMID:21561767 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases activity ISO ponatinib analog results in decreased activity of FGFR4 protein; ponatinib results in decreased activity of FGFR4 protein CTD PMID:19878872, PMID:21561767 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FGR protein CTD PMID:19878872 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases activity ISO ponatinib analog results in decreased activity of FLT1 protein; ponatinib results in decreased activity of FLT1 protein CTD PMID:19878872, PMID:21561767 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases activity
decreases phosphorylation
multiple interactions
ISO ponatinib analog results in decreased activity of FLT3 protein; ponatinib results in decreased activity of FLT3 protein; ponatinib results in decreased activity of FLT3 protein mutant form
ponatinib results in decreased phosphorylation of FLT3 protein mutant form
ponatinib inhibits the reaction [FLT3 protein mutant form results in increased phosphorylation of FLT3 protein mutant form]
CTD PMID:19878872, PMID:21482694, PMID:21561767, PMID:22409268 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases activity ISO ponatinib analog results in decreased activity of FLT4 protein; ponatinib results in decreased activity of FLT4 protein CTD PMID:19878872, PMID:21561767 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G Frk fyn-related Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FRK protein CTD PMID:19878872 NCBI chr20:41,266,408...41,383,731
Ensembl chr20:41,266,566...41,383,424
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of FYN protein CTD PMID:19878872 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO ponatinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of HCK protein CTD PMID:19878872 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033
JBrowse link
G Jak1 Janus kinase 1 decreases activity ISO ponatinib results in decreased activity of JAK1 protein CTD PMID:19878872 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Jak2 Janus kinase 2 decreases activity ISO ponatinib results in decreased activity of JAK2 protein CTD PMID:19878872 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jak3 Janus kinase 3 decreases activity ISO ponatinib results in decreased activity of JAK3 protein CTD PMID:19878872 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
G Kdr kinase insert domain receptor decreases activity ISO ponatinib analog results in decreased activity of KDR protein; ponatinib results in decreased activity of KDR protein CTD PMID:19878872, PMID:21561767 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases activity
decreases phosphorylation
ISO ponatinib results in decreased activity of KIT protein; ponatinib results in decreased activity of KIT protein mutant form
ponatinib results in decreased phosphorylation of KIT protein mutant form
CTD PMID:19878872, PMID:21482694 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of LCK protein CTD PMID:19878872 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lmna lamin A/C increases cleavage ISO ponatinib results in increased cleavage of LMNA protein CTD PMID:22875613 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of LYN protein CTD PMID:19878872 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases lipidation ISO ponatinib results in increased lipidation of MAP1LC3A protein CTD PMID:29341879 NCBI chr 3:150,801,289...150,802,935
Ensembl chr 3:150,801,289...150,802,935
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of MAPK1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK1 protein] CTD PMID:22409268, PMID:22875613, PMID:25053825, PMID:25304212 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased phosphorylation of MAPK3 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of MAPK3 protein] CTD PMID:22409268, PMID:22875613, PMID:25053825, PMID:25304212 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO ponatinib results in decreased expression of MCL1 protein CTD PMID:22409268 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in decreased expression of MYC protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in decreased expression of MYC protein] CTD PMID:25053825 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 decreases activity ISO ponatinib results in decreased activity of NTRK1 protein CTD PMID:19878872 NCBI chr 2:187,143,568...187,160,373
Ensembl chr 2:187,143,568...187,160,373
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of NTRK2 protein CTD PMID:19878872 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 decreases activity ISO ponatinib results in decreased activity of NTRK3 protein CTD PMID:19878872 NCBI chr 1:139,890,537...140,262,503
Ensembl chr 1:139,890,560...140,262,503
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO (+)-JQ1 compound promotes the reaction [ponatinib results in increased cleavage of PARP1 protein]; ponatinib promotes the reaction [(+)-JQ1 compound results in increased cleavage of PARP1 protein] CTD PMID:21482694, PMID:22875613, PMID:25053825 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha decreases activity
decreases phosphorylation
ISO ponatinib analog results in decreased activity of PDGFRA protein; ponatinib results in decreased activity of PDGFRA protein; ponatinib results in decreased activity of PDGFRA protein mutant form
ponatinib results in decreased phosphorylation of PDGFRA protein mutant form
CTD PMID:19878872, PMID:21482694, PMID:21561767 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases activity ISO ponatinib analog results in decreased activity of PDGFRB protein; ponatinib results in decreased activity of PDGFRB protein CTD PMID:19878872, PMID:21561767 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta decreases activity ISO ponatinib results in decreased activity of PTK2B protein CTD PMID:19878872 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptk6 protein tyrosine kinase 6 decreases activity ISO ponatinib results in decreased activity of PTK6 protein CTD PMID:19878872 NCBI chr 3:176,698,305...176,706,896
Ensembl chr 3:176,698,305...176,706,896
JBrowse link
G Ret ret proto-oncogene decreases activity ISO ponatinib analog results in decreased activity of RET protein; ponatinib results in decreased activity of RET protein; ponatinib results in decreased activity of RET protein mutant form CTD PMID:19878872, PMID:21561767 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases activity ISO ponatinib analog results in decreased activity of SRC protein; ponatinib results in decreased activity of SRC protein CTD PMID:19878872, PMID:21561767 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions
decreases phosphorylation
ISO ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5A protein]
ponatinib results in decreased phosphorylation of STAT5A protein
CTD PMID:22875613, PMID:25053825 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO ponatinib promotes the reaction [(+)-JQ1 compound results in decreased phosphorylation of STAT5B protein] CTD PMID:25053825 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Tek TEK receptor tyrosine kinase decreases activity ISO ponatinib analog results in decreased activity of TEK protein; ponatinib results in decreased activity of TEK protein CTD PMID:19878872, PMID:21561767 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion ISO ponatinib results in increased secretion of TNNI3 protein CTD PMID:25304212 NCBI chr 1:72,882,806...72,886,490
Ensembl chr 1:72,882,806...72,886,488
JBrowse link
G Tyk2 tyrosine kinase 2 decreases activity ISO ponatinib results in decreased activity of TYK2 protein CTD PMID:19878872 NCBI chr 8:22,118,224...22,149,807
Ensembl chr 8:22,124,560...22,150,005
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase decreases activity ISO ponatinib results in decreased activity of YES1 protein CTD PMID:19878872 NCBI chr 9:121,802,471...121,918,906
Ensembl chr 9:121,802,673...121,902,678
JBrowse link

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  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            antineoplastic agent 17001
              ponatinib 71
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  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
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            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
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                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                monocarboxylic acid amide 14569
                                                  arenecarboxamide 6511
                                                    benzamides 6511
                                                      ponatinib 71
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.