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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apremilast
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Accession:CHEBI:78540 term browser browse the term
Definition:A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.
Synonyms:exact_synonym: N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
 related_synonym: CC-10004;   CC10004;   Formula=C22H24N2O7S;   InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1;   InChIKey=IMOZEMNVLZVGJZ-QGZVFWFLSA-N;   OTEZLA;   SMILES=CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O;   apremilastum
 xref: CAS:608141-41-9;   Drug_Central:4829;   KEGG:D08860
 xref_mesh: MESH:C505730
 xref: PMID:22910104;   PMID:22984171;   PMID:23030767;   PMID:23569359;   PMID:23588944;   PMID:23663752;   PMID:23986162;   PMID:24072562;   PMID:24592316;   PMID:24595547;   PMID:24702658;   PMID:24797159;   PMID:24846499;   PMID:24852768;   PMID:24869713;   PMID:24882690;   PMID:24962564;   PMID:24979544;   PMID:24997741;   PMID:24998661;   PMID:25027606;   PMID:25050054;   PMID:25054629;   Reaxys:12446985;   Wikipedia:Apremilast


show annotations for term's descendants           Sort by:
apremilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased activity of CASP3 protein] CTD PMID:27785949 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of CKM protein] CTD PMID:27785949 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of GOT1 protein] CTD PMID:27785949 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased secretion of LDHA protein] CTD PMID:27785949 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK1 mRNA] CTD PMID:27785949 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of MAPK8 mRNA] CTD PMID:27785949 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in decreased expression of NFKBIA protein] CTD PMID:27785949 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP apremilast inhibits the reaction [carfilzomib results in increased expression of RELA mRNA] CTD PMID:27785949 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20841
    role 20801
      application 20602
        anti-inflammatory agent 16819
          anti-inflammatory drug 15083
            non-steroidal anti-inflammatory drug 14389
              apremilast 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20841
    subatomic particle 20839
      composite particle 20839
        hadron 20839
          baryon 20839
            nucleon 20839
              atomic nucleus 20839
                atom 20839
                  main group element atom 20762
                    p-block element atom 20786
                      carbon group element atom 20695
                        carbon atom 20690
                          organic molecular entity 20690
                            heteroorganic entity 20202
                              organochalcogen compound 19889
                                organooxygen compound 19791
                                  carbon oxoacid 19142
                                    carboxylic acid 19139
                                      carboacyl group 18069
                                        univalent carboacyl group 18069
                                          carbamoyl group 17904
                                            carboxamide 17904
                                              acetamides 14852
                                                N-acetylarylamine 8
                                                  apremilast 8
paths to the root