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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tafamidis
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Accession:CHEBI:78538 term browser browse the term
Definition:A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.
Synonyms:exact_synonym: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
 related_synonym: 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid;   Formula=C14H7Cl2NO3;   Fx-1006;   InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19);   InChIKey=TXEIIPDJKFWEEC-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1;   tafamidisum
 xref: CAS:594839-88-0;   Drug_Central:4192;   KEGG:D09673
 xref_mesh: MESH:C547076
 xref: PDBeChem:3MI;   PMID:22378262;   PMID:22645360;   PMID:22645721;   PMID:22843282;   PMID:23569001;   PMID:23834402;   PMID:23974642;   PMID:24000164;   PMID:24101373;   PMID:24749898;   PMID:24998820;   PMID:24998822;   PMID:24998826;   PMID:25003808;   PMID:25022953;   Patent:WO2011131661;   Patent:WO2013060668;   Reaxys:9496624;   Wikipedia:Tafamidis
 cyclic_relationship: is_conjugate_acid_of CHEBI:79344

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              tafamidis 0
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