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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:78538 term browser browse the term
Definition:A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.
Synonyms:exact_synonym: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
 related_synonym: 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid;   Formula=C14H7Cl2NO3;   Fx-1006;   InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19);   InChIKey=TXEIIPDJKFWEEC-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1;   tafamidisum
 xref: CAS:594839-88-0;   Drug_Central:4192;   KEGG:D09673
 xref_mesh: MESH:C547076
 xref: PDBeChem:3MI;   PMID:22378262;   PMID:22645360;   PMID:22645721;   PMID:22843282;   PMID:23569001;   PMID:23834402;   PMID:23974642;   PMID:24000164;   PMID:24101373;   PMID:24749898;   PMID:24998820;   PMID:24998822;   PMID:24998826;   PMID:25003808;   PMID:25022953;   Patent:WO2011131661;   Patent:WO2013060668;   Reaxys:9496624;   Wikipedia:Tafamidis
 cyclic_relationship: is_conjugate_acid_of CHEBI:79344

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tafamidis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttr transthyretin multiple interactions ISO tafamidis promotes the reaction [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]; tafamidis results in increased stability of [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein] CTD PMID:25595224 PMID:27093678 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
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  CHEBI ontology 19773
    role 19723
      application 19413
        pharmaceutical 19301
          drug 19301
            central nervous system drug 16477
              tafamidis 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic molecule 19505
                              organic cyclic compound 19332
                                carbocyclic compound 18303
                                  benzenoid aromatic compound 17405
                                    benzenes 17175
                                      chlorobenzenes 13588
                                        dichlorobenzene 10605
                                          tafamidis 1
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