Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tafamidis
go back to main search page
Accession:CHEBI:78538 term browser browse the term
Definition:A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.
Synonyms:exact_synonym: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
 related_synonym: 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid;   Formula=C14H7Cl2NO3;   Fx-1006;   InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19);   InChIKey=TXEIIPDJKFWEEC-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1;   tafamidisum
 xref: CAS:594839-88-0;   Drug_Central:4192;   KEGG:D09673
 xref_mesh: MESH:C547076
 xref: PDBeChem:3MI;   PMID:22378262;   PMID:22645360;   PMID:22645721;   PMID:22843282;   PMID:23569001;   PMID:23834402;   PMID:23974642;   PMID:24000164;   PMID:24101373;   PMID:24749898;   PMID:24998820;   PMID:24998822;   PMID:24998826;   PMID:25003808;   PMID:25022953;   Patent:WO2011131661;   Patent:WO2013060668;   Reaxys:9496624;   Wikipedia:Tafamidis
 cyclic_relationship: is_conjugate_acid_of CHEBI:79344



show annotations for term's descendants           Sort by:
tafamidis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttr transthyretin multiple interactions ISO tafamidis promotes the reaction [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]; tafamidis results in increased stability of [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein] CTD PMID:25595224 PMID:27093678 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      application 19679
        pharmaceutical 19495
          drug 19520
            central nervous system drug 16785
              tafamidis 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            organic molecule 19670
                              organic cyclic compound 19481
                                carbocyclic compound 18573
                                  benzenoid aromatic compound 17992
                                    benzenes 17858
                                      chlorobenzenes 15040
                                        dichlorobenzene 11548
                                          tafamidis 1
paths to the root