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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:78538 term browser browse the term
Definition:A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.
Synonyms:exact_synonym: 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
 related_synonym: 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid;   Formula=C14H7Cl2NO3;   Fx-1006;   InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19);   InChIKey=TXEIIPDJKFWEEC-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1;   tafamidisum
 xref: CAS:594839-88-0;   Drug_Central:4192;   KEGG:D09673
 xref_mesh: MESH:C547076
 xref: PDBeChem:3MI;   PMID:22378262;   PMID:22645360;   PMID:22645721;   PMID:22843282;   PMID:23569001;   PMID:23834402;   PMID:23974642;   PMID:24000164;   PMID:24101373;   PMID:24749898;   PMID:24998820;   PMID:24998822;   PMID:24998826;   PMID:25003808;   PMID:25022953;   Patent:WO2011131661;   Patent:WO2013060668;   Reaxys:9496624;   Wikipedia:Tafamidis
 cyclic_relationship: is_conjugate_acid_of CHEBI:79344

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tafamidis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttr transthyretin multiple interactions ISO tafamidis promotes the reaction [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein]; tafamidis results in increased stability of [TTR protein binds to TTR protein binds to TTR protein binds to TTR protein] CTD PMID:25595224 PMID:27093678 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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  CHEBI ontology 20050
    role 20001
      application 19737
        pharmaceutical 19610
          drug 19610
            central nervous system drug 16571
              tafamidis 1
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  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                carbocyclic compound 18516
                                  benzenoid aromatic compound 17764
                                    benzenes 17567
                                      chlorobenzenes 13889
                                        dichlorobenzene 10995
                                          tafamidis 1
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