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ONTOLOGY REPORT - ANNOTATIONS


Term:dorsomorphin
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Accession:CHEBI:78510 term browser browse the term
Definition:A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine which is substituted at positions 3 and 6 by pyridin-4-yl and p-[2-(piperidin-1-yl)ethoxy]phenyl groups, respectively. It is a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase, EC 2.7.11.31) and a selective inhibitor of bone morphogenetic protein (BMP) signaling.
Synonyms:exact_synonym: 6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine
 related_synonym: Formula=C24H25N5O;   InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2;   InChIKey=XHBVYDAKJHETMP-UHFFFAOYSA-N;   SMILES=C(CN1CCCCC1)Oc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1;   compound C
 alt_id: MESH:C516138
 xref: CAS:866405-64-3;   DrugBank:DB08597;   LINCS:LSM-3207
 xref_mesh: MESH:C516138
 xref: PDBeChem:TAK;   PMID:18026094;   PMID:18682835;   PMID:19996563;   PMID:20691279;   PMID:21384475;   PMID:21543851;   PMID:21988724;   PMID:23526253;   PMID:23936500;   PMID:24280125;   PMID:24396733;   Reaxys:11725482


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19758
    role 19705
      biological role 19704
        pharmacological role 18809
          antagonist 16216
            bone morphogenetic protein receptor antagonist 5647
              dorsomorphin 5647
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    p-block element atom 19641
                      carbon group element atom 19532
                        carbon atom 19521
                          organic molecular entity 19521
                            organic molecule 19441
                              organic cyclic compound 19203
                                organic heterocyclic compound 18278
                                  organic heteropolycyclic compound 17585
                                    organic heterobicyclic compound 16255
                                      pyrazolopyrimidine 5685
                                        dorsomorphin 5647
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.