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ONTOLOGY REPORT - ANNOTATIONS


Term:ceritinib
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Accession:CHEBI:78432 term browser browse the term
Definition:A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.
Synonyms:exact_synonym: 5-chloro-N(2)-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N(4)-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
 related_synonym: Formula=C28H36ClN5O3S;   InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34);   InChIKey=VERWOWGGCGHDQE-UHFFFAOYSA-N;   SMILES=N=1C(=NC(=C(C1)Cl)NC=2C(=CC=CC2)S(C(C)C)(=O)=O)NC=3C=C(C(=CC3OC(C)C)C4CCNCC4)C;   ZYKADIA;   ceritinibum
 xref: CAS:1032900-25-6;   Drug_Central:4866;   LINCS:LSM-36374
 xref_mesh: MESH:C586847
 xref: PMID:24670165;   PMID:24675041;   PMID:24789171;   PMID:24856155;   PMID:24891360;   PMID:24963575;   PMID:24963576;   PMID:24980964;   PMID:24984564;   PMID:24998601;   PMID:25002599;   Reaxys:18383989;   Wikipedia:Ceritinib


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ceritinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alk ALK receptor tyrosine kinase JBrowse link 6 22,696,415 23,203,791 RGD:6480464
G Gpt glutamic--pyruvic transaminase JBrowse link 7 117,759,083 117,761,932 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19758
    role 19705
      application 19359
        pharmaceutical 19228
          drug 19228
            antineoplastic agent 16905
              ceritinib 2
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Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    main group molecular entity 19641
                      s-block molecular entity 19403
                        hydrogen molecular entity 19392
                          hydrides 18362
                            inorganic hydride 17222
                              pnictogen hydride 17186
                                nitrogen hydride 17020
                                  azane 16711
                                    ammonia 16709
                                      organic amino compound 16708
                                        aromatic amine 13619
                                          aminopyrimidine 1063
                                            ceritinib 2
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