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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:icariin
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Accession:CHEBI:78420 term browser browse the term
Definition:A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).
Synonyms:exact_synonym: 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
 related_synonym: Formula=C33H40O15;   InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1;   InChIKey=TZJALUIVHRYQQB-XLRXWWTNSA-N;   SMILES=COc1ccc(cc1)-c1oc2c(CC=C(C)C)c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc(O)c2c(=O)c1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O;   ieariline
 xref: CAS:489-32-7;   KEGG:C17555;   LINCS:LSM-3462;   LIPID_MAPS_instance:LMPK12112009
 xref_mesh: MESH:C056599
 xref: PMID:16380159;   PMID:16751992;   PMID:17120748;   PMID:17142971;   PMID:17169663;   PMID:17355822;   PMID:17419678;   PMID:17482445;   PMID:17499557;   PMID:17509675;   PMID:17557750;   PMID:17600559;   PMID:17613817;   PMID:17764702;   PMID:18053336;   PMID:18398927;   PMID:18501540;   PMID:18778098;   PMID:22216122;   PMID:23772748;   PMID:23824956;   PMID:23975599;   PMID:24265111;   PMID:24295650;   PMID:24311544;   PMID:24435883;   PMID:24462390;   PMID:24552978;   PMID:24590261;   PMID:24619236;   PMID:24710854;   PMID:24748177;   Reaxys:76280;   Wikipedia:Icariin


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icariin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 increases expression ISO icariin results in increased expression of ADRB1 mRNA CTD PMID:16490167 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]; icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA] CTD PMID:19782061 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bace1 beta-secretase 1 multiple interactions EXP icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA] CTD PMID:19782061 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361
JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions
EXP
ISO
icariin affects the expression of BCL2 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein]
CTD PMID:25472572 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l11 BCL2 like 11 affects expression
multiple interactions
EXP
ISO
icariin affects the expression of BCL2L11 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased expression of BCL2L11 protein]
CTD PMID:25472572 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression
ISO
EXP
NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA] CTD PMID:18236786, PMID:18295595 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
ISO
EXP
NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA] CTD PMID:15724410, PMID:16543677, PMID:17355822, PMID:19747809, PMID:20019778 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318
JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression EXP
ISO
icariin results in increased expression of BMP4 mRNA CTD PMID:18295595, PMID:20019778 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Cartpt CART prepropeptide increases expression ISO icariin results in increased expression of CARTPT mRNA; icariin results in increased expression of CARTPT protein CTD PMID:19858766 NCBI chr 2:30,125,249...30,127,408
Ensembl chr 2:30,125,249...30,127,269
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO icariin results in increased expression of CYP11A1 mRNA; icariin results in increased expression of CYP11A1 protein
[icariin co-treated with Diethylhexyl Phthalate] results in increased expression of CYP11A1 mRNA; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein]
CTD PMID:31175881 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO icariin results in increased expression of FOS mRNA; icariin results in increased expression of FOS protein
SB 203580 inhibits the reaction [icariin results in increased expression of FOS protein]; U 0126 inhibits the reaction [icariin results in increased expression of FOS protein]
CTD PMID:18423597 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization
ISO
EXP
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]]
icariin affects the localization of FOXO3 protein
CTD PMID:25472572 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gata4 GATA binding protein 4 increases expression ISO icariin results in increased expression of GATA4 mRNA CTD PMID:16490167 NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression
multiple interactions
ISO icariin results in increased expression of HSD3B1 mRNA; icariin results in increased expression of HSD3B1 protein
icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]
CTD PMID:31175881
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO icariin results in increased expression of ID1 mRNA CTD PMID:18295595 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP icariin results in increased expression of IGF1 mRNA CTD PMID:18236786 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 affects expression EXP icariin affects the expression of IL6 protein CTD PMID:25472572 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO icariin results in increased expression of JUN mRNA; icariin results in increased expression of JUN protein
SB 203580 inhibits the reaction [icariin results in increased expression of JUN protein]; U 0126 inhibits the reaction [icariin results in increased expression of JUN protein]
CTD PMID:18423597 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK1 protein] CTD PMID:18423597 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK3 protein] CTD PMID:18423597 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mef2c myocyte enhancer factor 2C affects localization
multiple interactions
increases expression
ISO icariin affects the localization of MEF2C protein
SB 203580 inhibits the reaction [icariin affects the localization of MEF2C protein]; SB 203580 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]; U 0126 inhibits the reaction [icariin affects the localization of MEF2C protein]; U 0126 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]
CTD PMID:18423597 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mir1224 microRNA 1224 decreases expression ISO icariin results in decreased expression of MIR1224 mRNA CTD PMID:30533443 NCBI chr11:83,992,628...83,992,712
Ensembl chr11:83,992,628...83,992,712
JBrowse link
G Mir139 microRNA 139 decreases expression ISO icariin results in decreased expression of MIR139 mRNA CTD PMID:30533443 NCBI chr 1:166,589,545...166,589,612
Ensembl chr 1:166,589,545...166,589,612
JBrowse link
G Mir140 microRNA 140 decreases expression ISO icariin results in decreased expression of MIR140 mRNA CTD PMID:30533443 NCBI chr19:39,608,951...39,609,049
Ensembl chr19:39,608,951...39,609,049
JBrowse link
G Mir146b microRNA 146b increases expression ISO icariin results in increased expression of MIR146B mRNA CTD PMID:30533443 NCBI chr 1:266,089,488...266,089,575
Ensembl chr 1:266,089,488...266,089,575
JBrowse link
G Mir150 microRNA 150 decreases expression ISO icariin results in decreased expression of MIR150 mRNA CTD PMID:30533443 NCBI chr 1:101,115,974...101,116,058
Ensembl chr 1:101,115,974...101,116,058
JBrowse link
G Mir183 microRNA 183 increases expression ISO icariin results in increased expression of MIR183 mRNA CTD PMID:30533443 NCBI chr 4:57,463,569...57,463,678
Ensembl chr 4:57,463,569...57,463,678
JBrowse link
G Mir200a microRNA 200a increases expression ISO icariin results in increased expression of MIR200A mRNA CTD PMID:30533443 NCBI chr 5:173,489,366...173,489,454 JBrowse link
G Mir200b microRNA 200b increases expression ISO icariin results in increased expression of MIR200B mRNA CTD PMID:30533443 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238
JBrowse link
G Mir205 microRNA 205 increases expression ISO icariin results in increased expression of MIR205 mRNA CTD PMID:30533443 NCBI chr13:112,233,283...112,233,390
Ensembl chr13:112,233,283...112,233,390
JBrowse link
G Mir21 microRNA 21 increases expression ISO icariin results in increased expression of MIR21A mRNA CTD PMID:30533443 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir30e microRNA 30e increases expression ISO icariin results in increased expression of MIR30E mRNA CTD PMID:30533443 NCBI chr 5:139,702,872...139,702,963
Ensembl chr 5:139,702,872...139,702,963
JBrowse link
G Mir3545 microRNA 3545 increases expression ISO icariin results in increased expression of MIR203 mRNA CTD PMID:30533443 NCBI chr 6:136,704,947...136,705,061
Ensembl chr 6:136,704,947...136,705,061
JBrowse link
G Mir429 microRNA 429 increases expression ISO icariin results in increased expression of MIR429 mRNA CTD PMID:30533443 NCBI chr 5:173,488,331...173,488,415
Ensembl chr 5:173,488,331...173,488,415
JBrowse link
G Mir455 microRNA 455 decreases expression ISO icariin results in decreased expression of MIR455 mRNA CTD PMID:30533443 NCBI chr 5:79,097,208...79,097,285
Ensembl chr 5:79,097,208...79,097,285
JBrowse link
G Myh6 myosin heavy chain 6 increases expression ISO icariin results in increased expression of MYH6 mRNA CTD PMID:15780198, PMID:16490167 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myl2 myosin light chain 2 increases expression ISO icariin results in increased expression of MYL2 mRNA CTD PMID:15780198, PMID:16490167 NCBI chr12:39,951,863...39,959,065
Ensembl chr12:39,951,987...39,958,239
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 increases expression ISO icariin results in increased expression of NFE2L1 mRNA; icariin results in increased expression of NFE2L1 protein CTD PMID:17883938 NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO icariin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein; SB 203580 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; U 0126 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18423597, PMID:20686223 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nkx2-5 NK2 homeobox 5 increases expression ISO icariin results in increased expression of NKX2-5 mRNA CTD PMID:16490167 NCBI chr10:16,635,989...16,638,758
Ensembl chr10:16,635,989...16,638,764
JBrowse link
G Nog noggin multiple interactions ISO NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA] CTD PMID:18295595, PMID:19747809 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP icariin results in increased expression of NOS1 mRNA CTD PMID:16281085 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
icariin results in increased expression of NOS2 mRNA; icariin results in increased expression of NOS2 protein
icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:15329286, PMID:16281085, PMID:20686223 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions
ISO
EXP
icariin results in increased expression of NOS3 mRNA
icariin results in increased expression of NOS3 mRNA; icariin results in increased expression of NOS3 protein
icariin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; icariin results in increased expression of and results in increased activity of NOS3 protein
CTD PMID:15329286, PMID:17499557 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions
increases expression
ISO icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 protein]
icariin results in increased expression of NR5A1 mRNA; icariin results in increased expression of NR5A1 protein
CTD PMID:31175881 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441
JBrowse link
G Pde5a phosphodiesterase 5A decreases activity
decreases expression
ISO
EXP
icariin analog results in decreased activity of PDE5A protein; icariin results in decreased activity of PDE5A protein
icariin results in decreased expression of PDE5A mRNA alternative form
CTD PMID:17120748, PMID:18778098 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO icariin results in increased expression of PGR mRNA
fulvestrant inhibits the reaction [icariin results in increased expression of PGR mRNA]
CTD PMID:15541416 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO icariin results in increased expression of PPARA mRNA; icariin results in increased expression of PPARA protein CTD PMID:17883938 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions
ISO
EXP
icariin results in increased expression of PPARGC1A mRNA; icariin results in increased expression of PPARGC1A protein
Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]
CTD PMID:17883938, PMID:31251943 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:20686223 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
ISO icariin results in increased activity of RELA protein
icariin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; icariin results in increased expression of and affects the localization of RELA protein; SB 203580 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]; U 0126 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]
CTD PMID:17499557, PMID:18423597, PMID:20686223 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
ISO
EXP
icariin results in increased expression of RUNX2 mRNA
NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]
CTD PMID:18295595, PMID:19747809, PMID:20019778 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
affects expression
increases expression
ISO
EXP
icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]; icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]]
icariin affects the expression of SIRT1 mRNA; icariin affects the expression of SIRT1 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]
icariin results in increased expression of SIRT1 mRNA; icariin results in increased expression of SIRT1 protein
CTD PMID:19303870, PMID:25472572 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein] CTD PMID:31251943 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity
multiple interactions
ISO icariin results in decreased activity of SLCO1B3 protein
[icariin results in decreased activity of SLCO1B3 protein] which results in decreased uptake of Sincalide
CTD PMID:24265111 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions
decreases activity
ISO [icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate CTD PMID:24265111 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Smad4 SMAD family member 4 increases expression
multiple interactions
ISO icariin results in increased expression of SMAD4 mRNA
NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]
CTD PMID:19747809 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smad6 SMAD family member 6 multiple interactions ISO SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA] CTD PMID:18295595 NCBI chr 8:68,897,746...68,967,221
Ensembl chr 8:68,898,296...68,966,108
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects expression
EXP
ISO
icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SOD2 protein]
icariin affects the expression of SOD2 protein
CTD PMID:19782061, PMID:25472572 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
ISO
EXP
NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA] CTD PMID:16696327, PMID:18236786, PMID:18295595 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [icariin results in increased expression of TFF1 mRNA] CTD PMID:15541416 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP icariin results in increased expression of TGFB1 mRNA CTD PMID:18236786 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP icariin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:31251943 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
ISO
EXP
icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
icariin affects the expression of TNF protein
CTD PMID:20686223, PMID:25472572 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions
ISO icariin results in increased expression of TNFRSF11B mRNA
NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA]
CTD PMID:19747809 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions
ISO icariin results in decreased expression of TNFSF11 mRNA
NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]
CTD PMID:19747809 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 increases expression ISO icariin results in increased expression of TRP53 mRNA; icariin results in increased expression of TRP53 protein CTD PMID:15878162 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      chemical role 19275
        antioxidant 14222
          icariin 67
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19483
                              organic cyclic compound 19252
                                organic heterocyclic compound 18422
                                  oxacycle 17197
                                    benzopyran 10139
                                      1-benzopyran 9853
                                        flavonoid 6363
                                          flavones 4167
                                            hydroxyflavone 4156
                                              flavonols 4073
                                                icariin 67
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.