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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:icariin
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Accession:CHEBI:78420 term browser browse the term
Definition:A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).
Synonyms:exact_synonym: 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
 related_synonym: Formula=C33H40O15;   InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1;   InChIKey=TZJALUIVHRYQQB-XLRXWWTNSA-N;   SMILES=COc1ccc(cc1)-c1oc2c(CC=C(C)C)c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc(O)c2c(=O)c1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O;   ieariline
 xref: CAS:489-32-7;   KEGG:C17555;   LINCS:LSM-3462;   LIPID_MAPS_instance:LMPK12112009
 xref_mesh: MESH:C056599
 xref: PMID:16380159;   PMID:16751992;   PMID:17120748;   PMID:17142971;   PMID:17169663;   PMID:17355822;   PMID:17419678;   PMID:17482445;   PMID:17499557;   PMID:17509675;   PMID:17557750;   PMID:17600559;   PMID:17613817;   PMID:17764702;   PMID:18053336;   PMID:18398927;   PMID:18501540;   PMID:18778098;   PMID:22216122;   PMID:23772748;   PMID:23824956;   PMID:23975599;   PMID:24265111;   PMID:24295650;   PMID:24311544;   PMID:24435883;   PMID:24462390;   PMID:24552978;   PMID:24590261;   PMID:24619236;   PMID:24710854;   PMID:24748177;   Reaxys:76280;   Wikipedia:Icariin


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icariin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 increases expression ISO icariin results in increased expression of ADRB1 mRNA CTD PMID:16490167 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein
afimoxifene inhibits the reaction [icariin results in increased phosphorylation of AKT1 protein]; icariin affects the reaction [Diethylhexyl Phthalate affects the phosphorylation of AKT1 protein]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of AKT1 protein]; icariin inhibits the reaction [MK 2206 results in decreased phosphorylation of AKT1 protein]		 CTD PMID:32344236 PMID:35259346 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]; icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA] CTD PMID:19782061 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions EXP icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA] CTD PMID:19782061 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
multiple interactions		 EXP
ISO		 icariin affects the expression of BCL2 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein]		 CTD PMID:25472572 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l11 Bcl2-like 11 affects expression
multiple interactions		 EXP
ISO		 icariin affects the expression of BCL2L11 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased expression of BCL2L11 protein]		 CTD PMID:25472572 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
increases expression		 ISO
EXP		 NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA] CTD PMID:18236786 PMID:18295595 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression		 ISO
EXP		 NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA] CTD PMID:15724410 PMID:16543677 PMID:17355822 PMID:19747809 PMID:20019778 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression EXP
ISO		 icariin results in increased expression of BMP4 mRNA CTD PMID:18295595 PMID:20019778 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Cartpt CART prepropeptide increases expression ISO icariin results in increased expression of CARTPT mRNA; icariin results in increased expression of CARTPT protein CTD PMID:19858766 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Casp1 caspase 1 increases cleavage ISO icariin results in increased cleavage of CASP1 protein CTD PMID:35532261 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 ISO [naphthol AS-E phosphate co-treated with icariin] results in increased phosphorylation of CREB1 protein; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of CREB1 protein]; icariin inhibits the reaction [MK 2206 results in decreased phosphorylation of CREB1 protein]
icariin results in increased phosphorylation of CREB1 protein		 CTD PMID:35259346 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression
multiple interactions		 ISO icariin results in increased expression of CYP11A1 mRNA; icariin results in increased expression of CYP11A1 protein
[icariin co-treated with Diethylhexyl Phthalate] results in increased expression of CYP11A1 mRNA; [icariin co-treated with naphthol AS-E phosphate] results in decreased expression of CYP11A1 protein; [MK 2206 co-treated with icariin] results in increased expression of CYP11A1 mRNA; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein]; icariin inhibits the reaction [MK 2206 results in decreased expression of CYP11A1 protein]		 CTD PMID:31175881 PMID:35259346 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA CTD PMID:32344236 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO icariin results in increased expression of FOS mRNA; icariin results in increased expression of FOS protein
SB 203580 inhibits the reaction [icariin results in increased expression of FOS protein]; U 0126 inhibits the reaction [icariin results in increased expression of FOS protein]		 CTD PMID:18423597 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization		 ISO
EXP		 icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]]
icariin affects the localization of FOXO3 protein		 CTD PMID:25472572 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gata4 GATA binding protein 4 increases expression ISO icariin results in increased expression of GATA4 mRNA CTD PMID:16490167 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 increases expression
multiple interactions		 ISO icariin results in increased expression of HSD3B1 mRNA; icariin results in increased expression of HSD3B1 protein
icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]		 CTD PMID:31175881 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO icariin results in increased expression of ID1 mRNA CTD PMID:18295595 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP icariin results in increased expression of IGF1 mRNA CTD PMID:18236786 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP
ISO		 [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein
icariin results in increased expression of IL1B protein		 CTD PMID:32344236 PMID:35532261 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 affects expression
multiple interactions		 EXP icariin affects the expression of IL6 protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein		 CTD PMID:25472572 PMID:32344236 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 ISO icariin results in increased expression of JUN mRNA; icariin results in increased expression of JUN protein
SB 203580 inhibits the reaction [icariin results in increased expression of JUN protein]; U 0126 inhibits the reaction [icariin results in increased expression of JUN protein]		 CTD PMID:18423597 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK1 protein] CTD PMID:18423597 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK3 protein] CTD PMID:18423597 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mef2c myocyte enhancer factor 2C affects localization
multiple interactions
increases expression		 ISO icariin affects the localization of MEF2C protein
SB 203580 inhibits the reaction [icariin affects the localization of MEF2C protein]; SB 203580 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]; U 0126 inhibits the reaction [icariin affects the localization of MEF2C protein]; U 0126 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]		 CTD PMID:18423597 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mir1224 microRNA 1224 decreases expression ISO icariin results in decreased expression of MIR1224 mRNA CTD PMID:30533443 NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986 		JBrowse link
G Mir139 microRNA 139 decreases expression ISO icariin results in decreased expression of MIR139 mRNA CTD PMID:30533443 NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902 		JBrowse link
G Mir140 microRNA 140 decreases expression ISO icariin results in decreased expression of MIR140 mRNA CTD PMID:30533443 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir146b microRNA 146b increases expression ISO icariin results in increased expression of MIR146B mRNA CTD PMID:30533443 NCBI chr 1:245,203,438...245,203,525
Ensembl chr 1:245,203,438...245,203,525 		JBrowse link
G Mir150 microRNA 150 decreases expression ISO icariin results in decreased expression of MIR150 mRNA CTD PMID:30533443 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108 		JBrowse link
G Mir183 microRNA 183 increases expression ISO icariin results in increased expression of MIR183 mRNA CTD PMID:30533443 NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723 		JBrowse link
G Mir200a microRNA 200a increases expression ISO icariin results in increased expression of MIR200A mRNA CTD PMID:30533443 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir200b microRNA 200b increases expression ISO icariin results in increased expression of MIR200B mRNA CTD PMID:30533443 NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366 		JBrowse link
G Mir205 microRNA 205 increases expression ISO icariin results in increased expression of MIR205 mRNA CTD PMID:30533443 NCBI chr13:105,035,878...105,035,985
Ensembl chr13:105,035,878...105,035,985 		JBrowse link
G Mir21 microRNA 21 increases expression ISO icariin results in increased expression of MIR21A mRNA CTD PMID:30533443 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir223 microRNA 223 decreases expression ISO icariin results in decreased expression of MIR223 mRNA CTD PMID:35532261 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir30e microRNA 30e increases expression ISO icariin results in increased expression of MIR30E mRNA CTD PMID:30533443 NCBI chr 5:134,352,232...134,352,323
Ensembl chr 5:134,352,232...134,352,323 		JBrowse link
G Mir3545 microRNA 3545 increases expression ISO icariin results in increased expression of MIR203 mRNA CTD PMID:30533443 NCBI chr 6:131,199,542...131,199,656
Ensembl chr 6:131,199,542...131,199,656 		JBrowse link
G Mir429 microRNA 429 increases expression ISO icariin results in increased expression of MIR429 mRNA CTD PMID:30533443 NCBI chr 5:166,647,459...166,647,543
Ensembl chr 5:166,647,459...166,647,543 		JBrowse link
G Mir455 microRNA 455 decreases expression ISO icariin results in decreased expression of MIR455 mRNA CTD PMID:30533443 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein CTD PMID:32344236 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA CTD PMID:32344236 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein CTD PMID:32344236 NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475 		JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA CTD PMID:32344236 NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250 		JBrowse link
G Myh6 myosin heavy chain 6 increases expression ISO icariin results in increased expression of MYH6 mRNA CTD PMID:15780198 PMID:16490167 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myl2 myosin light chain 2 increases expression ISO icariin results in increased expression of MYL2 mRNA CTD PMID:15780198 PMID:16490167 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 increases expression ISO icariin results in increased expression of NFE2L1 mRNA; icariin results in increased expression of NFE2L1 protein CTD PMID:17883938 NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO icariin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein; SB 203580 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; U 0126 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18423597 PMID:20686223 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nkx2-5 NK2 homeobox 5 increases expression ISO icariin results in increased expression of NKX2-5 mRNA CTD PMID:16490167 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 increases expression ISO icariin results in increased expression of NLRP3 mRNA; icariin results in increased expression of NLRP3 protein CTD PMID:35532261 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nog noggin multiple interactions ISO NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA] CTD PMID:18295595 PMID:19747809 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP icariin results in increased expression of NOS1 mRNA CTD PMID:16281085 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 icariin results in increased expression of NOS2 mRNA; icariin results in increased expression of NOS2 protein
icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]		 CTD PMID:15329286 PMID:16281085 PMID:20686223 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions		 ISO
EXP		 icariin results in increased expression of NOS3 mRNA
icariin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; icariin results in increased expression of and results in increased activity of NOS3 protein
icariin results in increased expression of NOS3 mRNA; icariin results in increased expression of NOS3 protein		 CTD PMID:15329286 PMID:17499557 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions
increases expression		 ISO icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 protein]
icariin results in increased expression of NR5A1 mRNA; icariin results in increased expression of NR5A1 protein		 CTD PMID:31175881 PMID:35259346 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Pde5a phosphodiesterase 5A decreases activity
decreases expression		 ISO
EXP		 icariin analog results in decreased activity of PDE5A protein; icariin results in decreased activity of PDE5A protein
icariin results in decreased expression of PDE5A mRNA alternative form		 CTD PMID:17120748 PMID:18778098 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO icariin results in increased expression of PGR mRNA
fulvestrant inhibits the reaction [icariin results in increased expression of PGR mRNA]		 CTD PMID:15541416 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO icariin results in increased expression of PPARA mRNA; icariin results in increased expression of PPARA protein CTD PMID:17883938 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions		 ISO
EXP		 icariin results in increased expression of PPARGC1A mRNA; icariin results in increased expression of PPARGC1A protein
Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]		 CTD PMID:17883938 PMID:31251943 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:20686223 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions		 ISO icariin results in increased activity of RELA protein
icariin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; icariin results in increased expression of and affects the localization of RELA protein; SB 203580 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]; U 0126 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]		 CTD PMID:17499557 PMID:18423597 PMID:20686223 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions		 ISO
EXP		 icariin results in increased expression of RUNX2 mRNA
NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]		 CTD PMID:18295595 PMID:19747809 PMID:20019778 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
affects expression		 ISO
EXP		 icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]; icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]]
icariin results in increased expression of SIRT1 mRNA; icariin results in increased expression of SIRT1 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]
icariin affects the expression of SIRT1 mRNA; icariin affects the expression of SIRT1 protein		 CTD PMID:19303870 PMID:25472572 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt3 sirtuin 3 multiple interactions EXP Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein] CTD PMID:31251943 NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases activity
multiple interactions		 ISO icariin results in decreased activity of SLCO1B3 protein
[icariin results in decreased activity of SLCO1B3 protein] which results in decreased uptake of Sincalide		 CTD PMID:24265111 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions
decreases activity		 ISO [icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate CTD PMID:24265111 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Smad4 SMAD family member 4 increases expression
multiple interactions		 ISO icariin results in increased expression of SMAD4 mRNA
NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]		 CTD PMID:19747809 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Smad6 SMAD family member 6 multiple interactions ISO SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA] CTD PMID:18295595 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects expression		 EXP
ISO		 icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]
icariin affects the expression of SOD2 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SOD2 protein]		 CTD PMID:19782061 PMID:25472572 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression		 ISO
EXP		 NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA] CTD PMID:16696327 PMID:18236786 PMID:18295595 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation
multiple interactions		 ISO icariin results in increased phosphorylation of SRC protein
afimoxifene inhibits the reaction [icariin results in increased phosphorylation of SRC protein]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased phosphorylation of SRC protein]		 CTD PMID:35259346 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression		 ISO fulvestrant inhibits the reaction [icariin results in increased expression of TFF1 mRNA] CTD PMID:15541416 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP icariin results in increased expression of TGFB1 mRNA CTD PMID:18236786 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP icariin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:31251943 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein CTD PMID:32344236 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression		 ISO
EXP		 icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
icariin affects the expression of TNF protein
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein		 CTD PMID:20686223 PMID:25472572 PMID:32344236 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression
multiple interactions		 ISO icariin results in increased expression of TNFRSF11B mRNA
NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA]		 CTD PMID:19747809 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression
multiple interactions		 ISO icariin results in decreased expression of TNFSF11 mRNA
NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]		 CTD PMID:19747809 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO icariin results in increased expression of TRP53 mRNA; icariin results in increased expression of TRP53 protein CTD PMID:15878162 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      chemical role 19422
        antioxidant 16120
          icariin 80
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                organic heterocyclic compound 18862
                                  oxacycle 17819
                                    benzopyran 11950
                                      1-benzopyran 11702
                                        flavonoid 7190
                                          anthoxanthin 4536
                                            flavones 4536
                                              hydroxyflavone 4517
                                                flavonols 4408
                                                  icariin 80
paths to the root