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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:icariin
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Accession:CHEBI:78420 term browser browse the term
Definition:A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).
Synonyms:exact_synonym: 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
 related_synonym: Formula=C33H40O15;   InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1;   InChIKey=TZJALUIVHRYQQB-XLRXWWTNSA-N;   SMILES=COc1ccc(cc1)-c1oc2c(CC=C(C)C)c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc(O)c2c(=O)c1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O;   ieariline
 xref: CAS:489-32-7;   KEGG:C17555;   LINCS:LSM-3462;   LIPID_MAPS_instance:LMPK12112009
 xref_mesh: MESH:C056599
 xref: PMID:16380159;   PMID:16751992;   PMID:17120748;   PMID:17142971;   PMID:17169663;   PMID:17355822;   PMID:17419678;   PMID:17482445;   PMID:17499557;   PMID:17509675;   PMID:17557750;   PMID:17600559;   PMID:17613817;   PMID:17764702;   PMID:18053336;   PMID:18398927;   PMID:18501540;   PMID:18778098;   PMID:22216122;   PMID:23772748;   PMID:23824956;   PMID:23975599;   PMID:24265111;   PMID:24295650;   PMID:24311544;   PMID:24435883;   PMID:24462390;   PMID:24552978;   PMID:24590261;   PMID:24619236;   PMID:24710854;   PMID:24748177;   Reaxys:76280;   Wikipedia:Icariin


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icariin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenergic receptor, beta 1 increases expression EXP icariin results in increased expression of ADRB1 mRNA CTD PMID:16490167 NCBI chr19:56,722,117...56,725,150
Ensembl chr19:56,722,199...56,733,113
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions ISO icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]; icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA] CTD PMID:19782061 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions ISO icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA] CTD PMID:19782061 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 affects expression
multiple interactions
ISO icariin affects the expression of BCL2 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of BCL2 protein]
CTD PMID:25472572 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) affects expression
multiple interactions
ISO icariin affects the expression of BCL2L11 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased expression of BCL2L11 protein]
CTD PMID:25472572 NCBI chr 2:128,126,038...128,162,547
Ensembl chr 2:128,126,038...128,162,547
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions
increases expression
EXP
ISO
NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA] CTD PMID:18236786, PMID:18295595 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions
increases expression
EXP
ISO
NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA] CTD PMID:15724410, PMID:16543677, PMID:17355822, PMID:19747809, PMID:20019778 NCBI chr 2:133,552,159...133,562,896
Ensembl chr 2:133,552,159...133,562,885
JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO
EXP
icariin results in increased expression of BMP4 mRNA CTD PMID:18295595, PMID:20019778 NCBI chr14:46,383,525...46,390,669
Ensembl chr14:46,383,520...46,390,669
JBrowse link
G Cartpt CART prepropeptide increases expression EXP icariin results in increased expression of CARTPT mRNA; icariin results in increased expression of CARTPT protein CTD PMID:19858766 NCBI chr13:99,898,483...99,910,179
Ensembl chr13:99,898,489...99,901,091
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP [icariin co-treated with Diethylhexyl Phthalate] results in increased expression of CYP11A1 mRNA; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein]
icariin results in increased expression of CYP11A1 mRNA; icariin results in increased expression of CYP11A1 protein
CTD PMID:31175881 NCBI chr 9:57,998,024...58,027,031
Ensembl chr 9:58,006,411...58,027,023
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression
multiple interactions
EXP icariin results in increased expression of FOS mRNA; icariin results in increased expression of FOS protein
SB 203580 inhibits the reaction [icariin results in increased expression of FOS protein]; U 0126 inhibits the reaction [icariin results in increased expression of FOS protein]
CTD PMID:18423597 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization
ISO icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in increased acetylation of and results in increased expression of FOXO3 protein]]
icariin affects the localization of FOXO3 protein
CTD PMID:25472572 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Gata4 GATA binding protein 4 increases expression EXP icariin results in increased expression of GATA4 mRNA CTD PMID:16490167 NCBI chr14:63,198,914...63,271,712
Ensembl chr14:63,198,922...63,271,692
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions
increases expression
EXP icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]
icariin results in increased expression of HSD3B1 mRNA; icariin results in increased expression of HSD3B1 protein
CTD PMID:31175881 NCBI chr 3:98,842,356...98,859,794
Ensembl chr 3:98,852,194...98,859,794
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression EXP icariin results in increased expression of ID1 mRNA CTD PMID:18295595 NCBI chr 2:152,736,251...152,737,410
Ensembl chr 2:152,736,251...152,737,410
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO icariin results in increased expression of IGF1 mRNA CTD PMID:18236786 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Il6 interleukin 6 affects expression ISO icariin affects the expression of IL6 protein CTD PMID:25472572 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Jun jun proto-oncogene increases expression
multiple interactions
EXP icariin results in increased expression of JUN mRNA; icariin results in increased expression of JUN protein
SB 203580 inhibits the reaction [icariin results in increased expression of JUN protein]; U 0126 inhibits the reaction [icariin results in increased expression of JUN protein]
CTD PMID:18423597 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK1 protein] CTD PMID:18423597 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP U 0126 inhibits the reaction [icariin results in increased phosphorylation of MAPK3 protein] CTD PMID:18423597 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mef2c myocyte enhancer factor 2C affects localization
increases expression
multiple interactions
EXP icariin affects the localization of MEF2C protein
icariin results in increased expression of MEF2C mRNA
SB 203580 inhibits the reaction [icariin affects the localization of MEF2C protein]; SB 203580 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]; U 0126 inhibits the reaction [icariin affects the localization of MEF2C protein]; U 0126 inhibits the reaction [icariin results in increased expression of MEF2C mRNA]
CTD PMID:18423597 NCBI chr13:83,504,017...83,667,079
Ensembl chr13:83,504,034...83,667,080
JBrowse link
G Mir1224 microRNA 1224 decreases expression EXP icariin results in decreased expression of MIR1224 mRNA CTD PMID:30533443 NCBI chr16:20,604,452...20,604,536
Ensembl chr16:20,604,452...20,604,536
JBrowse link
G Mir139 microRNA 139 decreases expression EXP icariin results in decreased expression of MIR139 mRNA CTD PMID:30533443 NCBI chr 7:101,475,376...101,475,443
Ensembl chr 7:101,475,376...101,475,443
JBrowse link
G Mir140 microRNA 140 decreases expression EXP icariin results in decreased expression of MIR140 mRNA CTD PMID:30533443 NCBI chr 8:107,551,244...107,551,313
Ensembl chr 8:107,551,244...107,551,313
JBrowse link
G Mir146b microRNA 146b increases expression EXP icariin results in increased expression of MIR146B mRNA CTD PMID:30533443 NCBI chr19:46,342,762...46,342,870
Ensembl chr19:46,342,762...46,342,870
JBrowse link
G Mir150 microRNA 150 decreases expression EXP icariin results in decreased expression of MIR150 mRNA CTD PMID:30533443 NCBI chr 7:45,121,757...45,121,821
Ensembl chr 7:45,121,757...45,121,821
JBrowse link
G Mir183 microRNA 183 increases expression EXP icariin results in increased expression of MIR183 mRNA CTD PMID:30533443 NCBI chr 6:30,169,668...30,169,737
Ensembl chr 6:30,169,668...30,169,737
JBrowse link
G Mir1931 microRNA 1931 decreases expression EXP icariin results in decreased expression of MIR1931 mRNA CTD PMID:30533443 NCBI chr10:93,162,785...93,162,903
Ensembl chr10:93,162,785...93,162,903
JBrowse link
G Mir1971 microRNA 1971 decreases expression EXP icariin results in decreased expression of MIR1971 mRNA CTD PMID:30533443 NCBI chr14:78,191,373...78,191,478
Ensembl chr14:78,191,373...78,191,478
JBrowse link
G Mir199b microRNA 199b increases expression EXP icariin results in increased expression of MIR199B mRNA CTD PMID:30533443 NCBI chr 2:32,318,460...32,318,569
Ensembl chr 2:32,318,460...32,318,569
JBrowse link
G Mir200a microRNA 200a increases expression EXP icariin results in increased expression of MIR200A mRNA CTD PMID:30533443 NCBI chr 4:156,054,896...156,054,985
Ensembl chr 4:156,054,896...156,054,985
JBrowse link
G Mir200b microRNA 200b increases expression EXP icariin results in increased expression of MIR200B mRNA CTD PMID:30533443 NCBI chr 4:156,055,681...156,055,750
Ensembl chr 4:156,055,681...156,055,750
JBrowse link
G Mir203 microRNA 203 increases expression EXP icariin results in increased expression of MIR203 mRNA CTD PMID:30533443 NCBI chr12:112,130,880...112,130,955
Ensembl chr12:112,130,880...112,130,955
JBrowse link
G Mir205 microRNA 205 increases expression EXP icariin results in increased expression of MIR205 mRNA CTD PMID:30533443 NCBI chr 1:193,507,463...193,507,530
Ensembl chr 1:193,507,463...193,507,530
JBrowse link
G Mir2137 microRNA 2137 decreases expression EXP icariin results in decreased expression of MIR2137 mRNA CTD PMID:30533443 NCBI chr  X:72,992,079...72,992,144
Ensembl chr  X:72,992,079...72,992,144
JBrowse link
G Mir21a microRNA 21a increases expression EXP icariin results in increased expression of MIR21A mRNA CTD PMID:30533443 NCBI chr11:86,584,067...86,584,158
Ensembl chr11:86,584,067...86,584,158
JBrowse link
G Mir2861 microRNA 2861 decreases expression EXP icariin results in decreased expression of MIR2861 mRNA CTD PMID:30533443 NCBI chr 2:32,712,807...32,712,888
Ensembl chr 2:32,712,807...32,712,888
JBrowse link
G Mir3072 microRNA 3072 decreases expression EXP icariin results in decreased expression of MIR3072 mRNA CTD PMID:30533443 NCBI chr12:109,747,878...109,747,960
Ensembl chr12:109,747,878...109,747,960
JBrowse link
G Mir3077 microRNA 3077 decreases expression EXP icariin results in decreased expression of MIR3077 mRNA CTD PMID:30533443 NCBI chr14:57,798,424...57,798,487
Ensembl chr14:57,798,424...57,798,487
JBrowse link
G Mir30e microRNA 30e increases expression EXP icariin results in increased expression of MIR30E mRNA CTD PMID:30533443 NCBI chr 4:120,772,606...120,772,697
Ensembl chr 4:120,772,606...120,772,697
JBrowse link
G Mir3547 microRNA 3547 decreases expression EXP icariin results in decreased expression of MIR3547 mRNA CTD PMID:30533443 NCBI chr17:25,245,551...25,245,638
Ensembl chr17:25,245,551...25,245,638
JBrowse link
G Mir429 microRNA 429 increases expression EXP icariin results in increased expression of MIR429 mRNA CTD PMID:30533443 NCBI chr 4:156,053,905...156,053,987
Ensembl chr 4:156,053,905...156,053,987
JBrowse link
G Mir455 microRNA 455 decreases expression EXP icariin results in decreased expression of MIR455 mRNA CTD PMID:30533443 NCBI chr 4:63,256,851...63,256,932
Ensembl chr 4:63,256,851...63,256,932
JBrowse link
G Mir5107 microRNA 5107 decreases expression EXP icariin results in decreased expression of MIR5107 mRNA CTD PMID:30533443 NCBI chr18:60,812,076...60,812,163
Ensembl chr18:60,812,076...60,812,163
JBrowse link
G Mir511 microRNA 511 increases expression EXP icariin results in increased expression of MIR511 mRNA CTD PMID:30533443 NCBI chr 2:14,261,003...14,261,081
Ensembl chr 2:14,261,003...14,261,081
JBrowse link
G Mir5126 microRNA 5126 decreases expression EXP icariin results in decreased expression of MIR5126 mRNA CTD PMID:30533443 NCBI chr 1:84,695,839...84,695,915
Ensembl chr 1:84,695,839...84,695,915
JBrowse link
G Mir5130 microRNA 5130 decreases expression EXP icariin results in decreased expression of MIR5130 mRNA CTD PMID:30533443 NCBI chr14:102,982,549...102,982,632
Ensembl chr14:102,982,549...102,982,632
JBrowse link
G Mir6366 microRNA 6366 decreases expression EXP icariin results in decreased expression of MIR6366 mRNA CTD PMID:30533443 NCBI chr16:18,165,089...18,165,170
Ensembl chr16:18,165,089...18,165,170
JBrowse link
G Mir6368 microRNA 6368 decreases expression EXP icariin results in decreased expression of MIR6368 mRNA CTD PMID:30533443 NCBI chr13:28,710,781...28,710,873
Ensembl chr13:28,710,781...28,710,873
JBrowse link
G Mir674 microRNA 674 increases expression EXP icariin results in increased expression of MIR674 mRNA CTD PMID:30533443 NCBI chr 2:117,185,127...117,185,226
Ensembl chr 2:117,185,127...117,185,226
JBrowse link
G Mir6906 microRNA 6906 decreases expression EXP icariin results in decreased expression of MIR6906 mRNA CTD PMID:30533443 NCBI chr10:60,126,776...60,126,833
Ensembl chr10:60,126,776...60,126,833
JBrowse link
G Mir6931 microRNA 6931 decreases expression EXP icariin results in decreased expression of MIR6931 mRNA CTD PMID:30533443 NCBI chr11:102,999,848...102,999,921
Ensembl chr11:102,999,848...102,999,921
JBrowse link
G Mir6968 microRNA 6968 decreases expression EXP icariin results in decreased expression of MIR6968 mRNA CTD PMID:30533443 NCBI chr17:26,935,472...26,935,539
Ensembl chr17:26,935,472...26,935,539
JBrowse link
G Mir7001 microRNA 7001 decreases expression EXP icariin results in decreased expression of MIR7001 mRNA CTD PMID:30533443 NCBI chr 2:93,421,929...93,422,007
Ensembl chr 2:93,421,929...93,422,007
JBrowse link
G Mir7030 microRNA 7030 increases expression EXP icariin results in increased expression of MIR7030 mRNA CTD PMID:30533443 NCBI chr 5:115,645,573...115,645,632
Ensembl chr 5:115,645,573...115,645,632
JBrowse link
G Mir7045 microRNA 7045 decreases expression EXP icariin results in decreased expression of MIR7045 mRNA CTD PMID:30533443 NCBI chr 6:125,097,024...125,097,086
Ensembl chr 6:125,097,024...125,097,086
JBrowse link
G Mir705 microRNA 705 decreases expression EXP icariin results in decreased expression of MIR705 mRNA CTD PMID:30533443 NCBI chr 6:85,336,292...85,336,373
Ensembl chr 6:85,336,292...85,336,373
JBrowse link
G Mir7070 microRNA 7070 decreases expression EXP icariin results in decreased expression of MIR7070 mRNA CTD PMID:30533443 NCBI chr 8:85,062,086...85,062,171
Ensembl chr 8:85,062,086...85,062,171
JBrowse link
G Mir7082 microRNA 7082 decreases expression EXP icariin results in decreased expression of MIR7082 mRNA CTD PMID:30533443 NCBI chr 9:21,075,497...21,075,588
Ensembl chr 9:21,075,497...21,075,588
JBrowse link
G Mir7118 microRNA 7118 decreases expression EXP icariin results in decreased expression of MIR7118 mRNA CTD PMID:30533443 NCBI chr15:89,162,848...89,162,908
Ensembl chr15:89,162,848...89,162,908
JBrowse link
G Mir7j microRNA 7j increases expression EXP icariin results in increased expression of MIR7J mRNA CTD PMID:30533443 NCBI chr 3:140,028,249...140,028,370
Ensembl chr 3:140,028,249...140,028,370
JBrowse link
G Mir8101 microRNA 8101 decreases expression EXP icariin results in decreased expression of MIR8101 mRNA CTD PMID:30533443 NCBI chr11:102,230,040...102,230,150
Ensembl chr11:102,230,040...102,230,150
JBrowse link
G Mir8110 microRNA 8110 decreases expression EXP icariin results in decreased expression of MIR8110 mRNA CTD PMID:30533443 NCBI chr 8:89,024,735...89,024,831
Ensembl chr 8:89,024,735...89,024,831
JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha increases expression EXP icariin results in increased expression of MYH6 mRNA CTD PMID:15780198, PMID:16490167 NCBI chr14:54,941,921...54,968,017
Ensembl chr14:54,941,921...54,966,927
JBrowse link
G Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow increases expression EXP icariin results in increased expression of MYL2 mRNA CTD PMID:15780198, PMID:16490167 NCBI chr 5:122,092,724...122,113,473
Ensembl chr 5:122,100,951...122,113,472
JBrowse link
G Nfe2l1 nuclear factor, erythroid derived 2,-like 1 increases expression EXP icariin results in increased expression of NFE2L1 mRNA; icariin results in increased expression of NFE2L1 protein CTD PMID:17883938 NCBI chr11:96,817,414...96,829,968
Ensembl chr11:96,817,414...96,829,968
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP icariin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein; SB 203580 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; U 0126 inhibits the reaction [icariin results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:18423597, PMID:20686223 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nkx2-5 NK2 homeobox 5 increases expression EXP icariin results in increased expression of NKX2-5 mRNA CTD PMID:16490167 NCBI chr17:26,838,664...26,844,988
Ensembl chr17:26,838,664...26,845,009
JBrowse link
G Nog noggin multiple interactions EXP NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA] CTD PMID:18295595, PMID:19747809 NCBI chr11:89,300,638...89,302,559
Ensembl chr11:89,300,638...89,302,332
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal increases expression ISO icariin results in increased expression of NOS1 mRNA CTD PMID:16281085 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions
increases expression
EXP
ISO
icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
icariin results in increased expression of NOS2 mRNA; icariin results in increased expression of NOS2 protein
CTD PMID:15329286, PMID:16281085, PMID:20686223 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression
multiple interactions
ISO icariin results in increased expression of NOS3 mRNA
icariin results in increased expression of NOS3 mRNA; icariin results in increased expression of NOS3 protein
icariin promotes the reaction [NOS3 protein results in increased chemical synthesis of Nitric Oxide]; icariin results in increased expression of and results in increased activity of NOS3 protein
CTD PMID:15329286, PMID:17499557 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions
increases expression
EXP icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 mRNA]; icariin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NR5A1 protein]
icariin results in increased expression of NR5A1 mRNA; icariin results in increased expression of NR5A1 protein
CTD PMID:31175881 NCBI chr 2:38,692,656...38,714,542
Ensembl chr 2:38,692,656...38,714,542
JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific decreases activity
decreases expression
ISO icariin analog results in decreased activity of PDE5A protein; icariin results in decreased activity of PDE5A protein
icariin results in decreased expression of PDE5A mRNA alternative form
CTD PMID:17120748, PMID:18778098 NCBI chr 3:122,729,158...122,859,374
Ensembl chr 3:122,728,947...122,859,374
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO icariin results in increased expression of PGR mRNA
fulvestrant inhibits the reaction [icariin results in increased expression of PGR mRNA]
CTD PMID:15541416 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression EXP icariin results in increased expression of PPARA mRNA; icariin results in increased expression of PPARA protein CTD PMID:17883938 NCBI chr15:85,734,910...85,806,851
Ensembl chr15:85,734,983...85,802,819
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression
multiple interactions
EXP
ISO
icariin results in increased expression of PPARGC1A mRNA; icariin results in increased expression of PPARGC1A protein
Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of PPARGC1A protein]
CTD PMID:17883938, PMID:31251943 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:20686223 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) increases activity
multiple interactions
ISO
EXP
icariin results in increased activity of RELA protein
icariin inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; icariin results in increased expression of and affects the localization of RELA protein; SB 203580 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]; U 0126 inhibits the reaction [icariin results in increased expression of and affects the localization of RELA protein]
CTD PMID:17499557, PMID:18423597, PMID:20686223 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Runx2 runt related transcription factor 2 increases expression
multiple interactions
EXP
ISO
icariin results in increased expression of RUNX2 mRNA
NOG protein inhibits the reaction [icariin results in increased expression of RUNX2 mRNA]
CTD PMID:18295595, PMID:19747809, PMID:20019778 NCBI chr17:44,495,987...44,814,797
Ensembl chr17:44,495,987...44,814,797
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
affects expression
increases expression
EXP
ISO
icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]; icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 mRNA]]; SB 203580 inhibits the reaction [icariin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT1 protein]]
icariin affects the expression of SIRT1 mRNA; icariin affects the expression of SIRT1 protein
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]; Niacinamide inhibits the reaction [icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SIRT1 protein]]
icariin results in increased expression of SIRT1 mRNA; icariin results in increased expression of SIRT1 protein
CTD PMID:19303870, PMID:25472572 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
G Sirt3 sirtuin 3 multiple interactions ISO Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein]]; icariin inhibits the reaction [Rotenone results in decreased expression of SIRT3 protein] CTD PMID:31251943 NCBI chr 7:140,863,663...140,882,309
Ensembl chr 7:140,863,666...140,882,309
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions
decreases activity
ISO [icariin results in decreased activity of SLCO1B3 protein] which results in decreased uptake of Sincalide CTD PMID:24265111 NCBI chr 6:141,629,452...141,686,646
Ensembl chr 6:141,629,518...141,686,646
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions
decreases activity
ISO [icariin results in decreased activity of SLCO2B1 protein] which results in decreased uptake of estrone sulfate CTD PMID:24265111 NCBI chr 7:99,657,804...99,711,340
Ensembl chr 7:99,657,804...99,711,340
JBrowse link
G Smad4 SMAD family member 4 increases expression
multiple interactions
EXP icariin results in increased expression of SMAD4 mRNA
NOG protein inhibits the reaction [icariin results in increased expression of SMAD4 mRNA]
CTD PMID:19747809 NCBI chr18:73,634,790...73,703,791
Ensembl chr18:73,639,009...73,703,780
JBrowse link
G Smad6 SMAD family member 6 multiple interactions EXP SMAD6 protein inhibits the reaction [icariin results in increased expression of BGLAP mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA] CTD PMID:18295595 NCBI chr 9:63,953,076...64,022,085
Ensembl chr 9:63,953,076...64,022,059
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions
affects expression
ISO icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]
icariin inhibits the reaction [[Oxygen co-treated with Oxygen deficiency] results in decreased expression of SOD2 protein]
icariin affects the expression of SOD2 protein
CTD PMID:19782061, PMID:25472572 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
EXP
ISO
NOG protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA]; SMAD6 protein inhibits the reaction [icariin results in increased expression of SPP1 mRNA] CTD PMID:16696327, PMID:18236786, PMID:18295595 NCBI chr 5:104,435,111...104,441,053
Ensembl chr 5:104,435,118...104,441,050
JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression
ISO fulvestrant inhibits the reaction [icariin results in increased expression of TFF1 mRNA] CTD PMID:15541416 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO icariin results in increased expression of TGFB1 mRNA CTD PMID:18236786 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO icariin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:31251943 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Tnf tumor necrosis factor multiple interactions
affects expression
EXP
ISO
icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; icariin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
icariin affects the expression of TNF protein
CTD PMID:20686223, PMID:25472572 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) increases expression
multiple interactions
EXP icariin results in increased expression of TNFRSF11B mRNA
NOG protein inhibits the reaction [icariin results in increased expression of TNFRSF11B mRNA]
CTD PMID:19747809 NCBI chr15:54,250,619...54,278,484
Ensembl chr15:54,250,619...54,278,484
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 decreases expression
multiple interactions
EXP icariin results in decreased expression of TNFSF11 mRNA
NOG protein inhibits the reaction [icariin results in decreased expression of TNFSF11 mRNA]
CTD PMID:19747809 NCBI chr14:78,277,446...78,308,043
Ensembl chr14:78,277,445...78,308,043
JBrowse link
G Trp53 transformation related protein 53 increases expression EXP icariin results in increased expression of TRP53 mRNA; icariin results in increased expression of TRP53 protein CTD PMID:15878162 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21475
    role 21452
      chemical role 20726
        antioxidant 14383
          icariin 95
Path 2
Term Annotations click to browse term
  CHEBI ontology 21475
    subatomic particle 21460
      composite particle 21460
        hadron 21460
          baryon 21460
            nucleon 21460
              atomic nucleus 21460
                atom 21460
                  main group element atom 21360
                    p-block element atom 21360
                      carbon group element atom 21147
                        carbon atom 21045
                          organic molecular entity 21045
                            organic molecule 20935
                              organic cyclic compound 20496
                                organic heterocyclic compound 19336
                                  oxacycle 17497
                                    benzopyran 10433
                                      1-benzopyran 10157
                                        flavonoid 6483
                                          flavones 4227
                                            hydroxyflavone 4215
                                              flavonols 4129
                                                icariin 95
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.