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Accession:CHEBI:78420 term browser browse the term
Definition:A member of the class of flavonols that is kaempferol which is substituted at position 8 by a 3-methylbut-2-en-1-yl group and in which the hydroxy groups at positions 3, 4', and 7 have been converted to the corresponding 6-deoxy-alpha-L-mannopyranoside, methyl ether, and beta-D-glucopyranoside, respectively. A phoshphodiesterase-5 inhibitor, it is obtained from several species of plants in the genus Epimedium and is thought to be the main active ingredient of the Chinese herbal medicine Herba Epimedii (yinyanghuo).
Synonyms:exact_synonym: 3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
 related_synonym: Formula=C33H40O15;   InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1;   InChIKey=TZJALUIVHRYQQB-XLRXWWTNSA-N;   SMILES=COc1ccc(cc1)-c1oc2c(CC=C(C)C)c(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc(O)c2c(=O)c1O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O;   ieariline
 xref: CAS:489-32-7 "ChemIDplus";   CAS:489-32-7 "KEGG COMPOUND";   KEGG:C17555;   LINCS:LSM-3462;   LIPID_MAPS_instance:LMPK12112009 "LIPID MAPS"
 xref_mesh: MESH:C056599
 xref: PMID:16380159 "Europe PMC";   PMID:16751992 "Europe PMC";   PMID:17120748 "Europe PMC";   PMID:17142971 "Europe PMC";   PMID:17169663 "Europe PMC";   PMID:17355822 "Europe PMC";   PMID:17419678 "Europe PMC";   PMID:17482445 "Europe PMC";   PMID:17499557 "Europe PMC";   PMID:17509675 "Europe PMC";   PMID:17557750 "Europe PMC";   PMID:17600559 "Europe PMC";   PMID:17613817 "Europe PMC";   PMID:17764702 "Europe PMC";   PMID:18053336 "Europe PMC";   PMID:18398927 "Europe PMC";   PMID:18501540 "Europe PMC";   PMID:18778098 "Europe PMC";   PMID:22216122 "Europe PMC";   PMID:23772748 "Europe PMC";   PMID:23824956 "Europe PMC";   PMID:23975599 "Europe PMC";   PMID:24265111 "Europe PMC";   PMID:24295650 "Europe PMC";   PMID:24311544 "Europe PMC";   PMID:24435883 "Europe PMC";   PMID:24462390 "Europe PMC";   PMID:24552978 "Europe PMC";   PMID:24590261 "Europe PMC";   PMID:24619236 "Europe PMC";   PMID:24710854 "Europe PMC";   PMID:24748177 "Europe PMC";   Reaxys:76280 "Reaxys";   Wikipedia:Icariin

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icariin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NOS3 nitric oxide synthase 3 JBrowse link 16 15,054,196 15,072,454 RGD:6480464

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Path 1
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  CHEBI ontology 225
    role 225
      chemical role 162
        antioxidant 36
          icariin 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      carbon group element atom 206
                        carbon atom 205
                          organic molecular entity 205
                            organic molecule 200
                              organic cyclic compound 184
                                organic heterocyclic compound 144
                                  oxacycle 53
                                    benzopyran 12
                                      1-benzopyran 12
                                        flavonoid 5
                                          flavones 4
                                            hydroxyflavone 4
                                              flavonols 4
                                                icariin 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.