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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lichen metabolite
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Accession:CHEBI:78361 term browser browse the term
Definition:Any metabolite that is produced during a metabolite reaction in lichens (composite organisms consisting of a fungus and a photosynthetic partner co-existing in a symbiotic relationship).
Synonyms:related_synonym: lichen metabolites


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cannabidiolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhlhe41 basic helix-loop-helix family, member e41 increases expression ISO cannabidiolic acid results in increased expression of BHLHE41 mRNA CTD PMID:25242400 NCBI chr 4:178,833,085...178,838,685
Ensembl chr 4:178,834,271...178,838,468
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO cannabidiolic acid results in decreased expression of FOS mRNA CTD PMID:27530354 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression ISO cannabidiolic acid results in increased expression of HTR1A mRNA CTD PMID:27530354 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression ISO cannabidiolic acid results in decreased expression of ID1 mRNA CTD PMID:25242400 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO cannabidiolic acid results in increased expression of PPARG mRNA
cannabidiolic acid results in decreased expression of PPARG protein
CTD PMID:28853159 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
ISO cannabidiolic acid results in decreased expression of PTGS2 mRNA
cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA]; cannabidiolic acid promotes the reaction [GSK0660 results in decreased expression of PTGS2 mRNA]
CTD PMID:25242400 PMID:27530354 PMID:32238697 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO cannabidiolic acid results in increased activity of TRPA1 protein CTD PMID:31096838 NCBI chr 5:4,379,999...4,433,243
Ensembl chr 5:4,379,999...4,433,570
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 decreases expression ISO cannabidiolic acid results in decreased expression of TRPM8 mRNA CTD PMID:27530354 NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity
multiple interactions
ISO cannabidiolic acid results in increased activity of TRPV1 protein
[cannabidiolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium
CTD PMID:31096838 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 multiple interactions
increases expression
ISO [cannabidiolic acid results in increased activity of TRPV2 protein] which results in increased uptake of Calcium
cannabidiolic acid results in increased expression of TRPV2 mRNA
CTD PMID:27530354 PMID:31096838 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link
cannabigerolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator-activated receptor gamma increases expression
decreases expression
ISO cannabigerolic acid results in increased expression of PPARG mRNA
cannabigerolic acid results in decreased expression of PPARG protein
CTD PMID:28853159 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases activity
ISO [cannabigerolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
olivetol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO olivetol results in decreased activity of CYP1A1 protein CTD PMID:24667653 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
usnic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO usnic acid results in decreased phosphorylation of and results in decreased expression of AKT1 protein CTD PMID:25078063 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO 2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ATF4 protein] CTD PMID:25870318 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation
multiple interactions
ISO usnic acid results in increased phosphorylation of ATM protein
Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein]
CTD PMID:31715134 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
ISO usnic acid results in decreased expression of BAX protein
usnic acid results in increased expression of BAX protein
CTD PMID:22285236 PMID:31715134 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO usnic acid results in decreased expression of BCL2 protein CTD PMID:22285236 PMID:25078063 PMID:31715134 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein] CTD PMID:22285236 PMID:25078063 PMID:25870318 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 increases cleavage ISO usnic acid results in increased cleavage of CASP4 protein CTD PMID:25870318 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP7 protein] CTD PMID:25078063 PMID:25870318 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Cat catalase multiple interactions EXP usnic acid inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:16169175 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL21 mRNA
usnic acid results in increased expression of CCL21 mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA CTD PMID:22777745 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccnc cyclin C multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CCNC mRNA
usnic acid results in increased expression of CCNC mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO usnic acid results in decreased expression of CCND1 protein CTD PMID:27369375 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO usnic acid results in decreased expression of CCND3 protein CTD PMID:27369375 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO usnic acid results in decreased expression of CDK2 protein CTD PMID:27369375 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO usnic acid results in decreased expression of CDK4 protein CTD PMID:27369375 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO usnic acid results in decreased expression of CDK6 protein CTD PMID:27369375 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO usnic acid results in increased expression of CHEK1 protein modified form CTD PMID:27369375 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions
ISO usnic acid results in increased expression of CHEK2 protein; usnic acid results in increased expression of CHEK2 protein modified form
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of CHEK2 protein]
CTD PMID:27369375 PMID:31715134 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Cryab crystallin, alpha B multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CRYAB mRNA CTD PMID:22777745 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CSF2 mRNA
usnic acid results in decreased expression of CSF2 mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CXCL10 mRNA CTD PMID:22777745 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO usnic acid results in decreased expression of CYP1A1 mRNA CTD PMID:21953288 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP2E1 mRNA
usnic acid results in decreased expression of CYP2E1 mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 mRNA CTD PMID:22777745 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of DDB1 mRNA CTD PMID:22777745 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO 2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of DDIT3 protein]
usnic acid results in increased expression of DDIT3 mRNA; usnic acid results in increased expression of DDIT3 protein
CTD PMID:25870318 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:25078063 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of ERCC1 mRNA CTD PMID:22777745 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963
JBrowse link
G Faslg Fas ligand multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FASLG mRNA CTD PMID:22777745 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FMO1 mRNA CTD PMID:22777745 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]
usnic acid results in increased expression of GCLC mRNA; usnic acid results in increased expression of GCLC protein
CTD PMID:27369375 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GPX1 mRNA CTD PMID:22777745 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of GSR mRNA
usnic acid results in increased expression of GSR protein
CTD PMID:22777745 PMID:27369375 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression ISO usnic acid results in increased expression of GSTA1 protein CTD PMID:27369375 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO usnic acid results in increased expression of H2AX protein modified form
NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]
CTD PMID:27369375 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSP90AB1 mRNA CTD PMID:22777745 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPA1A mRNA CTD PMID:22777745
G Hspa2 heat shock protein family A (Hsp70) member 2 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA CTD PMID:22777745 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA5 mRNA CTD PMID:22777745 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPH1 mRNA CTD PMID:22777745 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Il18 interleukin 18 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA CTD PMID:22777745 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA CTD PMID:22777745 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1B mRNA CTD PMID:22777745 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL6 mRNA CTD PMID:22777745 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of LTA mRNA CTD PMID:22777745 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO usnic acid results in increased phosphorylation of MAPK1 protein CTD PMID:25078063 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO usnic acid results in increased phosphorylation of MAPK3 protein CTD PMID:25078063 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
ISO 3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:25078063 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP usnic acid inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:16169175 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO usnic acid results in decreased phosphorylation of and results in decreased expression of MTOR protein CTD PMID:25078063 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]; NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]; usnic acid results in increased expression of and affects the localization of NFE2L2 protein CTD PMID:27369375 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of NOS2 mRNA
usnic acid inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
CTD PMID:16169175 PMID:22777745 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO usnic acid results in increased expression of NQO1 protein CTD PMID:27369375 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 increases expression
multiple interactions
ISO
EXP
usnic acid results in increased expression of ORAI1 protein
2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ORAI1 protein]
CTD PMID:25870318 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO usnic acid results in increased cleavage of PARP1 protein CTD PMID:31715134 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of PDK1 protein CTD PMID:25078063 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of POR mRNA CTD PMID:22777745 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression
multiple interactions
ISO usnic acid results in increased expression of PRKDC protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of PRKDC protein]
CTD PMID:31715134 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA CTD PMID:22777745 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Rad50 RAD50 double strand break repair protein multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of RAD50 mRNA CTD PMID:22777745 NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO usnic acid results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25078063 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of SERPINE1 mRNA CTD PMID:22777745 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sqstm1 sequestosome 1 increases degradation ISO usnic acid results in increased degradation of SQSTM1 protein CTD PMID:25078063 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Stim1 stromal interaction molecule 1 increases expression ISO
EXP
usnic acid results in increased expression of STIM1 protein CTD PMID:25870318 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of TNF mRNA CTD PMID:22777745 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression
multiple interactions
increases expression
ISO usnic acid results in decreased expression of TP53 protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of TP53 protein]
CTD PMID:22285236 PMID:31715134 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases expression
ISO [usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA
usnic acid results in increased expression of UGT1A4 mRNA
CTD PMID:21953288 PMID:22777745 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO usnic acid results in increased splicing of XBP1 mRNA CTD PMID:25870318 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 multiple interactions ISO [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of XRCC1 mRNA CTD PMID:22777745 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            lichen metabolite 80
              arthothelin 0
              divarinol 0
              lichenin 0
              litmus 0
              lobarin 0
              olivetol + 11
              pannarin 0
              usnic acid + 70
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