lichen metabolite - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	lichen metabolite	go back to main search page
Accession:	CHEBI:78361	browse the term
Definition:	Any metabolite that is produced during a metabolite reaction in lichens (composite organisms consisting of a fungus and a photosynthetic partner co-existing in a symbiotic relationship).
Synonyms:	related_synonym:	lichen metabolites

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Rat (89) Mouse (88) Human (90) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (89)

cannabidiolic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 1

increases expression

cannabidiolic acid results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

basic helix-loop-helix family, member e41

increases expression

cannabidiolic acid results in increased expression of BHLHE41 mRNA

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

CCAAT/enhancer binding protein alpha

multiple interactions
increases expression

cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]
cannabidiolic acid results in increased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

carnitine palmitoyltransferase 1A

increases expression

cannabidiolic acid results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

fatty acid binding protein 4

multiple interactions
increases expression

cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]
cannabidiolic acid results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

cannabidiolic acid results in decreased expression of FOS mRNA

PMID:27530354 PMID:30496661

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

5-hydroxytryptamine receptor 1A

increases expression

cannabidiolic acid results in increased expression of HTR1A mRNA

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

inhibitor of DNA binding 1

decreases expression

cannabidiolic acid results in decreased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

insulin-like growth factor 1

decreases expression

cannabidiolic acid results in decreased expression of IGF1 protein

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin 2

multiple interactions

cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of CEBPA mRNA]; cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

peroxisome proliferator activated receptor alpha

multiple interactions
increases expression

cannabidiolic acid binds to and results in increased activity of PPARA protein
cannabidiolic acid results in increased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions
decreases expression

cannabidiolic acid results in increased expression of PPARG mRNA
cannabidiolic acid binds to and results in increased activity of PPARG protein; cannabidiolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]
cannabidiolic acid results in decreased expression of PPARG protein

PMID:28853159 PMID:30611848

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

cannabidiolic acid results in decreased expression of PTGS2 mRNA
cannabidiolic acid inhibits the reaction [GW 501516 results in increased expression of PTGS2 mRNA]; cannabidiolic acid promotes the reaction [GSK0660 results in decreased expression of PTGS2 mRNA]

PMID:25242400 PMID:27530354 PMID:30496661 PMID:32238697

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

transient receptor potential cation channel, subfamily A, member 1

increases activity

cannabidiolic acid results in increased activity of TRPA1 protein

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily M, member 8

decreases expression

cannabidiolic acid results in decreased expression of TRPM8 mRNA

NCBI chr 9:88,897,039...88,990,167
Ensembl chr 9:88,903,880...88,988,552

G

transient receptor potential cation channel, subfamily V, member 1

increases activity
multiple interactions

cannabidiolic acid results in increased activity of TRPV1 protein
[cannabidiolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

transient receptor potential cation channel, subfamily V, member 2

multiple interactions
increases expression

[cannabidiolic acid results in increased activity of TRPV2 protein] which results in increased uptake of Calcium
cannabidiolic acid results in increased expression of TRPV2 mRNA

PMID:27530354 PMID:31096838

NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260

cannabigerolic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA oxidase 1

increases expression

cannabigerolic acid results in increased expression of ACOX1 mRNA

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

carnitine palmitoyltransferase 1A

increases expression

cannabigerolic acid results in increased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

fatty acid binding protein 4

multiple interactions
increases expression

cannabigerolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]
cannabigerolic acid results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

insulin 2

multiple interactions

cannabigerolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of FABP4 mRNA]; cannabigerolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

peroxisome proliferator activated receptor alpha

increases expression
multiple interactions

cannabigerolic acid results in increased expression of PPARA mRNA
cannabigerolic acid binds to and results in increased activity of PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

increases expression
decreases expression
multiple interactions

cannabigerolic acid results in increased expression of PPARG mRNA
cannabigerolic acid results in decreased expression of PPARG protein
cannabigerolic acid binds to and results in increased activity of PPARG protein; cannabigerolic acid promotes the reaction [[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG mRNA]

PMID:28853159 PMID:30611848

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

transient receptor potential cation channel, subfamily V, member 1

multiple interactions
increases activity

[cannabigerolic acid results in increased activity of TRPV1 protein] which results in increased uptake of Calcium

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

transient receptor potential cation channel, subfamily V, member 3

affects activity

cannabigerolic acid affects the activity of TRPV3 protein

NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296

olivetol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
increases expression

olivetol results in decreased activity of CYP1A1 protein
olivetol results in increased expression of CYP1A1 mRNA

PMID:24667653 PMID:26187180

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

olivetol results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

usnic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

usnic acid results in decreased phosphorylation of and results in decreased expression of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

activating transcription factor 4

multiple interactions
increases expression

2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ATF4 protein]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATM serine/threonine kinase

increases phosphorylation
multiple interactions

usnic acid results in increased phosphorylation of ATM protein
Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein]

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

G

BCL2 associated X, apoptosis regulator

decreases expression
increases expression

usnic acid results in decreased expression of BAX protein
usnic acid results in increased expression of BAX protein

PMID:22285236 PMID:31715134

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

usnic acid results in decreased expression of BCL2 protein

PMID:22285236 PMID:25078063 PMID:31715134

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions
increases activity

3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP3 protein]

PMID:22285236 PMID:25078063 PMID:25870318

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases cleavage

usnic acid results in increased cleavage of CASP4 protein

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

multiple interactions
increases activity

3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; 4-phenylbutyric acid inhibits the reaction [usnic acid results in increased activity of CASP7 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein]; pyrazolanthrone promotes the reaction [usnic acid results in increased activity of CASP7 protein]

PMID:25078063 PMID:25870318

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

catalase

multiple interactions

usnic acid inhibits the reaction [Indomethacin results in increased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 21

multiple interactions
increases expression

[usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL21 mRNA
usnic acid results in increased expression of CCL21 mRNA

PMID:21953288 PMID:22777745

NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686

G

C-C motif chemokine ligand 4

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in increased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

cyclin C

multiple interactions
increases expression

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CCNC mRNA
usnic acid results in increased expression of CCNC mRNA

PMID:21953288 PMID:22777745

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

decreases expression

usnic acid results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

decreases expression

usnic acid results in decreased expression of CCND3 protein

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin dependent kinase 2

decreases expression

usnic acid results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases expression

usnic acid results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

decreases expression

usnic acid results in decreased expression of CDK6 protein

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

checkpoint kinase 1

increases expression

usnic acid results in increased expression of CHEK1 protein modified form

NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

increases expression
multiple interactions

usnic acid results in increased expression of CHEK2 protein; usnic acid results in increased expression of CHEK2 protein modified form
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of CHEK2 protein]

PMID:27369375 PMID:31715134

NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286

G

crystallin, alpha B

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CRYAB mRNA

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

colony stimulating factor 2

multiple interactions
decreases expression

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CSF2 mRNA
usnic acid results in decreased expression of CSF2 mRNA

PMID:21953288 PMID:22777745

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

C-X-C motif chemokine ligand 10

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases expression

usnic acid results in decreased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases expression

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP2E1 mRNA
usnic acid results in decreased expression of CYP2E1 mRNA

PMID:21953288 PMID:22777745

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

damage-specific DNA binding protein 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of DDB1 mRNA

NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of DDIT3 protein]
usnic acid results in increased expression of DDIT3 mRNA; usnic acid results in increased expression of DDIT3 protein

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation

usnic acid results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

ERCC excision repair 1, endonuclease non-catalytic subunit

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of ERCC1 mRNA

NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963

G

Fas ligand

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

flavin containing dimethylaniline monoxygenase 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]
usnic acid results in increased expression of GCLC mRNA; usnic acid results in increased expression of GCLC protein

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutathione peroxidase 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in increased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions
increases expression

[usnic acid co-treated with Lipopolysaccharides] results in increased expression of GSR mRNA
usnic acid results in increased expression of GSR protein

PMID:22777745 PMID:27369375

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

increases expression

usnic acid results in increased expression of GSTA1 protein

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

H2A.X variant histone

increases expression
multiple interactions

usnic acid results in increased expression of H2AX protein; usnic acid results in increased expression of H2AX protein modified form
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of H2AX protein]; NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]

PMID:27369375 PMID:31715134

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

heat shock protein 90 alpha family class B member 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 2

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family H (Hsp110) member 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPH1 mRNA

NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224

G

interleukin 18

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in increased expression of IL18 mRNA

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1A mRNA

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

lymphotoxin alpha

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of LTA mRNA

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

mitogen activated protein kinase 1

increases phosphorylation

usnic acid results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

usnic acid results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]; pyrazolanthrone promotes the reaction [usnic acid results in decreased expression of MCL1 protein]

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

myeloperoxidase

multiple interactions

usnic acid inhibits the reaction [Indomethacin results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mechanistic target of rapamycin kinase

multiple interactions

usnic acid results in decreased phosphorylation of and results in decreased expression of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

NFE2 like bZIP transcription factor 2

multiple interactions

NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form]; NFE2L2 protein promotes the reaction [usnic acid results in increased expression of GCLC protein]; usnic acid results in increased expression of and affects the localization of NFE2L2 protein

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of NOS2 mRNA
usnic acid inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]

PMID:16169175 PMID:22777745

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

increases expression

usnic acid results in increased expression of NQO1 protein

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

ORAI calcium release-activated calcium modulator 1

increases expression
multiple interactions

usnic acid results in increased expression of ORAI1 protein
2-aminoethoxydiphenyl borate inhibits the reaction [usnic acid results in increased expression of ORAI1 protein]

NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405

G

poly (ADP-ribose) polymerase 1

increases cleavage

usnic acid results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pyruvate dehydrogenase kinase 1

decreases phosphorylation

usnic acid results in decreased phosphorylation of PDK1 protein

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

cytochrome p450 oxidoreductase

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

protein kinase, DNA-activated, catalytic subunit

increases expression
multiple interactions

usnic acid results in increased expression of PRKDC protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of PRKDC protein]

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of PTGS1 mRNA

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

RAD50 double strand break repair protein

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of RAD50 mRNA

NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396

G

ribosomal protein S6 kinase B1

decreases phosphorylation

usnic acid results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

serpin family E member 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

sequestosome 1

increases degradation

usnic acid results in increased degradation of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

stromal interaction molecule 1

increases expression

usnic acid results in increased expression of STIM1 protein

NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363

G

tumor necrosis factor

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

decreases expression
multiple interactions
increases expression

usnic acid results in decreased expression of TP53 protein
Acetylcysteine inhibits the reaction [usnic acid results in increased expression of TP53 protein]

PMID:22285236 PMID:31715134

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

UDP glucuronosyltransferase family 1 member A5

multiple interactions
increases expression

[usnic acid co-treated with Lipopolysaccharides] results in increased expression of UGT1A4 mRNA
usnic acid results in increased expression of UGT1A4 mRNA

PMID:21953288 PMID:22777745

NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

X-box binding protein 1

increases splicing

usnic acid results in increased splicing of XBP1 mRNA

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

X-ray repair cross complementing 1

multiple interactions

[usnic acid co-treated with Lipopolysaccharides] results in decreased expression of XRCC1 mRNA

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19911
role	19854
biological role	19852
biochemical role	19582
metabolite	19562
lichen metabolite	89
arthothelin	0
divarinol	0
lichenin	0
litmus	0
lobarin	0
olivetol +	20
pannarin	0
usnic acid +	70

paths to the root