Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:huperzine A
go back to main search page
Accession:CHEBI:78330 term browser browse the term
Definition:A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Synonyms:related_synonym: (-)-huperazine A;   (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one;   Formula=C15H18N2O;   Hup A;   HupA;   InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1;   InChIKey=ZRJBHWIHUMBLCN-YQEJDHNASA-N;   SMILES=C\\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(C)=C2;   hupzine A;   kimpukan A;   selagine
 xref: AGR:IND606941294;   CAS:102518-79-6;   Chemspider:16736021;   DrugBank:DB04864;   HMDB:HMDB0242654;   KNApSAcK:C00028361
 xref_mesh: MESH:C050426
 xref: PMID:12895686;   PMID:23306162;   PMID:24129696;   PMID:24190328;   PMID:24299147;   PMID:24332448;   PMID:24639880;   PMID:31305343;   PMID:31922239;   PMID:31990212;   PMID:32052235;   PMID:32576772;   PMID:32708929;   PMID:32729341;   PMID:32869005;   PMID:32970179;   PMID:32970952;   PMID:33252842;   PMID:33278032;   PMID:33504676;   PMID:33567664;   PMID:33675928;   PMID:33708959;   PMID:33851462;   PMID:33891962;   PMID:33930191;   PMID:34072855;   PMID:34198639;   PMID:34306441;   PMID:34363318;   PMID:34368579;   PMID:34419561;   Reaxys:3592896;   Wikipedia:Huperzine_A
 cyclic_relationship: is_conjugate_base_of CHEBI:178022



show annotations for term's descendants           Sort by:
 
huperzine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO ABCB1A gene mutant form affects the transport of and results in increased abundance of huperzine A
ABCB1 protein results in increased transport of huperzine A
Elacridar inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]
CTD PMID:28587984 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
huperzine A results in decreased activity of ACHE protein
huperzine A binds to and results in decreased activity of ACHE protein
ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein]; huperzine A inhibits the reaction [ACHE protein results in increased hydrolysis of Butyrylthiocholine]
[huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein
CTD PMID:15135892 PMID:15652380 PMID:17309523 PMID:18572153 PMID:18573242 More... NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing EXP CYP1A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing EXP CYP3A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of IL1B protein] CTD PMID:23810507 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of RELA protein] CTD PMID:23810507 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of TNF protein] CTD PMID:23810507 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        pharmaceutical 19618
          drug 19618
            nootropic agent 137
              huperzine A 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            organic hydride 18653
                              organic fundamental parent 18653
                                hydrocarbon 18389
                                  terpene 13624
                                    terpenoid 13273
                                      sesquiterpenoid 2771
                                        sesquiterpene alkaloid 9
                                          huperzine A 9
paths to the root