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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:huperzine A
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Accession:CHEBI:78330 term browser browse the term
Definition:A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity.
Synonyms:exact_synonym: (5R,9R,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
 related_synonym: (-)-huperazine A;   Formula=C15H18N2O;   InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1;   InChIKey=ZRJBHWIHUMBLCN-YQEJDHNASA-N;   SMILES=C\\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(C)=C2;   selagine
 xref: CAS:102518-79-6;   DrugBank:DB04864
 xref_mesh: MESH:C050426
 xref: PMID:12895686;   PMID:23306162;   PMID:24129696;   PMID:24190328;   PMID:24299147;   PMID:24332448;   PMID:24639880;   Reaxys:3592896;   Wikipedia:Huperzine_A


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huperzine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases transport
ISO ABCB1A gene mutant form affects the transport of and results in increased abundance of huperzine A
ABCB1 protein results in increased transport of huperzine A
Elacridar inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of huperzine A]
CTD PMID:28587984 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
huperzine A results in decreased activity of ACHE protein
huperzine A binds to and results in decreased activity of ACHE protein
ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein]; huperzine A inhibits the reaction [ACHE protein results in increased hydrolysis of Butyrylthiocholine]
[huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein
CTD PMID:15135892, PMID:15652380, PMID:17309523, PMID:18572153, PMID:18573242, PMID:19345205, PMID:20624417, PMID:22407886, PMID:26902639, PMID:27238725 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin multiple interactions ISO ALB protein affects the reaction [huperzine A results in decreased activity of ACHE protein] CTD PMID:26902639 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing EXP CYP1A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing EXP CYP3A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases metabolic processing EXP CYP3A23-3A1 protein results in increased metabolism of huperzine A CTD PMID:12586202 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of IL1B protein] CTD PMID:23810507 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of RELA protein] CTD PMID:23810507 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP huperzine A inhibits the reaction [Acetic Acid results in increased expression of TNF protein] CTD PMID:23810507 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        refrigerant 17418
          ammonia 16940
            organic amino compound 16939
              primary amino compound 7860
                huperzine A 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  terpene 9594
                                    terpenoid 9578
                                      sesquiterpenoid 2692
                                        sesquiterpene alkaloid 9
                                          huperzine A 9
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