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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:asarone
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Accession:CHEBI:78308 term browser browse the term
Definition:A phenylpropanoid that is benzene substituted by methoxy groups at positions 1, 2 and 4 and a propen-1-yl group at position 5. It has been isolated from Acorus.
Synonyms:exact_synonym: 1,2,4-trimethoxy-5-(prop-1-en-1-yl)benzene
 related_synonym: 2,4,5-trimethoxy-1-propenylbenzene;   Formula=C12H16O3;   InChI=1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3;   InChIKey=RKFAZBXYICVSKP-UHFFFAOYSA-N;   SMILES=COc1cc(OC)c(C=CC)cc1OC
 xref_mesh: MESH:C012195
 xref: Reaxys:2210026



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asarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO asarone results in increased expression of BAX mRNA CTD PMID:29174417 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO asarone results in decreased expression of BCL2 mRNA CTD PMID:29174417 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp8 caspase 8 increases activity ISO asarone results in increased activity of CASP8 protein CTD PMID:29174417 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:25066769 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25066769 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:25066769 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; asarone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:25066769 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; asarone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:25066769 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:25066769 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:25066769 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        biochemical role 19640
          metabolite 19623
            eukaryotic metabolite 19326
              plant metabolite 17657
                asarone 10
                  alpha-asarone 0
                  beta-asarone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                carbocyclic compound 18521
                                  benzenoid aromatic compound 17760
                                    benzenes 17560
                                      methoxybenzenes 1908
                                        asarone 10
                                          alpha-asarone 0
                                          beta-asarone 0
paths to the root