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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:asarone
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Accession:CHEBI:78308 term browser browse the term
Definition:A phenylpropanoid that is benzene substituted by methoxy groups at positions 1, 2 and 4 and a propen-1-yl group at position 5. It has been isolated from Acorus.
Synonyms:exact_synonym: 1,2,4-trimethoxy-5-(prop-1-en-1-yl)benzene
 related_synonym: 2,4,5-trimethoxy-1-propenylbenzene;   Formula=C12H16O3;   InChI=1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3;   InChIKey=RKFAZBXYICVSKP-UHFFFAOYSA-N;   SMILES=COc1cc(OC)c(C=CC)cc1OC
 xref_mesh: MESH:C012195
 xref: Reaxys:2210026



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asarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein multiple interactions EXP asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC mRNA]; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of ARC protein] CTD PMID:27936013 NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO asarone results in increased expression of BAX mRNA CTD PMID:29174417 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO asarone results in decreased expression of BCL2 mRNA CTD PMID:29174417 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp8 caspase 8 increases activity ISO asarone results in increased activity of CASP8 protein CTD PMID:29174417 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GRIN2B protein] CTD PMID:27936013 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:25066769 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25066769 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:25066769 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; asarone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:25066769 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; asarone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:25066769 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:25066769 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO asarone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:25066769 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Wnt7a Wnt family member 7A multiple interactions EXP asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A mRNA]; asarone inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of WNT7A protein] CTD PMID:27936013 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biochemical role 19588
          metabolite 19574
            eukaryotic metabolite 19387
              plant metabolite 17985
                asarone 13
                  alpha-asarone 0
                  beta-asarone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                carbocyclic compound 18616
                                  benzenoid aromatic compound 17993
                                    benzenes 17844
                                      alkenylbenzene 1329
                                        asarone 13
                                          alpha-asarone 0
                                          beta-asarone 0
paths to the root