Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:iron dextran
go back to main search page
Accession:CHEBI:78291 term browser browse the term
Definition:Please consider adding concept for iron dextran. CAS# 9004-66-4. Thank you.
Synonyms:related_synonym: Iron dextran complex
 xref: CAS:9004-66-4;   KEGG:C13774;   KEGG:D02141
 xref_mesh: MESH:D007505


show annotations for term's descendants           Sort by:
iron dextran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; GW 6471 inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]; tin protoporphyrin IX inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; tin protoporphyrin IX promotes the reaction [Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]] CTD PMID:20709802 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Iron-Dextran Complex affects the reaction [AHR affects the susceptibility to Tetrachlorodibenzodioxin] CTD PMID:9443932 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] CTD PMID:32828744 PMID:33580994 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:33285147 PMID:33393188 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein] CTD PMID:33285147 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression		 ISO [ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; [pirinixic acid results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; Bilirubin promotes the reaction [Iron-Dextran Complex results in increased expression of BCL2L1 protein] CTD PMID:20709802 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression EXP Iron-Dextran Complex results in decreased expression of BGLAP mRNA CTD PMID:29122540 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions
affects expression		 ISO Diltiazem inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]; Verapamil inhibits the reaction [Iron-Dextran Complex affects the expression of CACNA1C protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein]		 CTD PMID:27095094 PMID:33285147 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 ISO
EXP		 [ADIPOQ protein results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CASP3 protein; [pirinixic acid results in increased expression of BCL2L1 protein] inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; Bilirubin inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; GW 6471 inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]; tin protoporphyrin IX inhibits the reaction [ADIPOQ protein inhibits the reaction [Iron-Dextran Complex results in increased activity of CASP3 protein]]
Iron-Dextran Complex results in increased expression of CASP3 protein modified form
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein; Arginine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]; U 0126 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]		 CTD PMID:20709802 PMID:32135237 PMID:32828744 PMID:33285147 PMID:33393188 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
decreases activity
increases expression
increases activity		 ISO
EXP		 Iron-Dextran Complex promotes the reaction [Benzoyl Peroxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [mezerein results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein]
Iron-Dextran Complex results in decreased activity of CAT protein
Arginine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]; Cyclosporine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; Edaravone inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]
Iron-Dextran Complex results in increased expression of CAT protein
Iron-Dextran Complex results in increased activity of CAT protein		 CTD PMID:12065085 PMID:24120471 PMID:28700905 PMID:32135237 PMID:33580994 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein] CTD PMID:33285147 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 ISO Iron-Dextran Complex results in increased expression of COL1A1 protein
Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of COL1A1 protein]		 CTD PMID:27095094 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cyba cytochrome b-245 alpha chain increases expression EXP Iron-Dextran Complex results in increased expression of CYBA protein CTD PMID:15086920 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression EXP Iron-Dextran Complex results in increased expression of CYBB protein CTD PMID:28700905 PMID:29990562 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO Iron-Dextran Complex inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Iron-Dextran Complex results in decreased activity of CYP1A1 protein		 CTD PMID:9443932 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO Iron-Dextran Complex inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
Iron-Dextran Complex results in decreased activity of CYP1A2 protein		 CTD PMID:9443932 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 multiple interactions
decreases expression		 ISO [Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine; Arginine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; Arginine inhibits the reaction [Iron-Dextran Complex results in decreased expression of DDAH2 protein]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased abundance of Nitric Oxide]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Malondialdehyde]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of N,N-dimethylarginine]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Reactive Oxygen Species]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; tetramethylpyrazine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased expression of DDAH2 protein] CTD PMID:32135237 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation		 EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein; bergenin inhibits the reaction [Iron-Dextran Complex results in increased phosphorylation of FOS protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:32828744 PMID:33580994 PMID:36207002 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression		 ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 mRNA; Deferoxamine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Resveratrol inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of FTH1 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein]		 CTD PMID:27095094 PMID:33285147 PMID:33393188 PMID:34044072 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] CTD PMID:32828744 PMID:33580994 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GSR protein CTD PMID:33393188 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression		 ISO [Iron-Dextran Complex co-treated with Tetrachlorodibenzodioxin] results in increased expression of GSTM1 protein
Iron-Dextran Complex results in increased expression of GSTM1 protein		 CTD PMID:9443932 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
increases expression		 ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of HAMP mRNA; Diltiazem promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]; Nimodipine promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA]; Verapamil promotes the reaction [Iron-Dextran Complex results in increased expression of HAMP mRNA] CTD PMID:27095094 PMID:33393188 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]; tin protoporphyrin IX promotes the reaction [Iron-Dextran Complex inhibits the reaction [ADIPOQ protein results in increased expression of and results in increased activity of HMOX1 protein]]
Iron-Dextran Complex results in increased expression of HMOX1 mRNA; Iron-Dextran Complex results in increased expression of HMOX1 protein		 CTD PMID:20709802 PMID:23525258 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein; bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of IL1B protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein] CTD PMID:32828744 PMID:36207002 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 EXP
ISO		 Iron-Dextran Complex results in increased expression of IL6 mRNA
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]		 CTD PMID:29122540 PMID:32828744 PMID:33285147 PMID:33580994 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP
ISO		 Iron-Dextran Complex results in increased phosphorylation of MAPK1 protein
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein]		 CTD PMID:28700905 PMID:33285147 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP
ISO		 Iron-Dextran Complex results in increased phosphorylation of MAPK3 protein
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein]		 CTD PMID:28700905 PMID:33285147 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein] CTD PMID:33285147 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Iron-Dextran Complex results in increased expression of NOS2 protein CTD PMID:28700905 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases phosphorylation		 EXP
ISO		 Iron-Dextran Complex results in increased expression of and results in increased phosphorylation of NOS3 protein
Arginine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]		 CTD PMID:29990562 PMID:32135237 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity		 ISO Iron-Dextran Complex promotes the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [Hydrogen Peroxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [mezerein results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
Iron-Dextran Complex results in increased activity of ODC1 protein		 CTD PMID:12065085 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein CTD PMID:32828744 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions EXP [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein; [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein] CTD PMID:32828744 PMID:33580994 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression		 EXP bergenin inhibits the reaction [Iron-Dextran Complex results in decreased expression of PPARG protein] CTD PMID:36207002 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP Iron-Dextran Complex results in increased expression of PTGS2 protein
bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of PTGS2 protein]		 CTD PMID:36207002 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 [Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; SB 203580 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; U 0126 inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]
[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein; bergenin inhibits the reaction [Iron-Dextran Complex affects the localization of and results in increased expression of RELA protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]; Iron-Dextran Complex affects the localization of and results in increased expression of RELA protein		 CTD PMID:33285147 PMID:33580994 PMID:36207002 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rho rhodopsin multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA] CTD PMID:33285147 NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:148,980,611...148,985,773 		JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA] CTD PMID:33285147 NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions
increases expression		 ISO Diltiazem inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]; Nimodipine inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]; Verapamil inhibits the reaction [Iron-Dextran Complex results in increased expression of SLC11A2 protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein]		 CTD PMID:27095094 PMID:33285147 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA CTD PMID:33393188 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Iron-Dextran Complex results in increased expression of SOD1 protein CTD PMID:29990562 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Iron-Dextran Complex results in decreased expression of SOD2 protein CTD PMID:28700905 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tfr2 transferrin receptor 2 increases expression ISO Iron-Dextran Complex results in increased expression of TFR2 protein CTD PMID:27095094 NCBI chr12:19,107,673...19,124,622
Ensembl chr12:19,107,673...19,124,591 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein]; Deferiprone inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases secretion EXP Iron-Dextran Complex results in increased secretion of TGFB1 protein CTD PMID:23525258 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein; bergenin inhibits the reaction [Iron-Dextran Complex results in increased expression of TNF protein]; Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]
[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]		 CTD PMID:32828744 PMID:33285147 PMID:33580994 PMID:36207002 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression EXP Iron-Dextran Complex results in decreased expression of TNFRSF11B mRNA CTD PMID:29122540 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 increases expression EXP Iron-Dextran Complex results in increased expression of TNFSF11 mRNA CTD PMID:29122540 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Txnip thioredoxin interacting protein multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNIP mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNIP protein CTD PMID:33393188 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of TXNRD1 mRNA; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TXNRD1 protein CTD PMID:33393188 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Urod uroporphyrinogen decarboxylase multiple interactions ISO Iron-Dextran Complex promotes the reaction [Tetrachlorodibenzodioxin results in decreased activity of UROD protein] CTD PMID:9443932 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19818
    chemical entity 19816
      atom 19816
        nonmetal atom 19749
          carbon atom 19698
            organic molecular entity 19698
              iron dextran 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            iron dextran 52
paths to the root