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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxcarbazepine
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Accession:CHEBI:7824 term browser browse the term
Definition:A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy.
Synonyms:exact_synonym: 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
 related_synonym: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide;   Formula=C15H12N2O2;   InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19);   InChIKey=CTRLABGOLIVAIY-UHFFFAOYSA-N;   SMILES=NC(=O)N1c2ccccc2CC(=O)c2ccccc12;   oxcarbazepina;   oxcarbazepinum
 xref: CAS:28721-07-5;   Drug_Central:2017;   KEGG:C07492;   KEGG:D00533;   LINCS:LSM-5219
 xref_mesh: MESH:C036006
 xref: PMID:21924464



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oxcarbazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions EXP [BRL 44408 binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to oxcarbazepine CTD PMID:17959985 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions EXP [L 657743 binds to and results in decreased activity of ADRA2C protein] which results in decreased susceptibility to oxcarbazepine CTD PMID:17959985 NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases reduction ISO AKR1C4 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases reduction ISO AKR1C2 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases reduction ISO AKR1C3 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Cbr1 carbonyl reductase 1 increases reduction ISO CBR1 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr11:32,860,618...32,862,981
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cbr3 carbonyl reductase 3 increases reduction ISO CBR3 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO oxcarbazepine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of oxcarbazepine CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases activity EXP oxcarbazepine results in increased activity of GABRA1 protein CTD PMID:18717705 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases activity EXP oxcarbazepine results in increased activity of GABRA2 protein CTD PMID:18717705 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP oxcarbazepine results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Shbg sex hormone binding globulin increases expression ISO oxcarbazepine results in increased expression of SHBG protein CTD PMID:11148232 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Vim vimentin affects expression EXP oxcarbazepine affects the expression of VIM protein CTD PMID:22142741 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

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  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            drug allergen 10073
              oxcarbazepine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              oxcarbazepine 14
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