CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: oxcarbazepine
Accession: CHEBI:7824
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Definition: A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy.
Synonyms: exact_synonym: 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
related_synonym: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide; Formula=C15H12N2O2; InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19); InChIKey=CTRLABGOLIVAIY-UHFFFAOYSA-N; SMILES=NC(=O)N1c2ccccc2CC(=O)c2ccccc12; oxcarbazepina; oxcarbazepinum
xref: CAS:28721-07-5; Drug_Central:2017; KEGG:C07492; KEGG:D00533; LINCS:LSM-5219
xref_mesh: MESH:C036006
xref: PMID:21924464
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Adra2a
adrenoceptor alpha 2A
multiple interactions
EXP
[BRL 44408 binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to oxcarbazepine
CTD
PMID:17959985
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Adra2c
adrenoceptor alpha 2C
multiple interactions
EXP
[L 657743 binds to and results in decreased activity of ADRA2C protein] which results in decreased susceptibility to oxcarbazepine
CTD
PMID:17959985
NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846
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Akr1c1
aldo-keto reductase family 1, member C1
increases reduction
ISO
AKR1C1 protein results in increased reduction of Oxcarbazepine
CTD
PMID:25063510
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
increases reduction
ISO
AKR1C2 protein results in increased reduction of oxcarbazepine
CTD
PMID:25063510
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
increases reduction
ISO
AKR1C3 protein results in increased reduction of oxcarbazepine
CTD
PMID:25063510
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Bora
bora, aurora kinase A activator
increases expression
EXP
Oxcarbazepine results in increased expression of BORA mRNA
CTD
PMID:34333065
NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322
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Casp3
caspase 3
increases cleavage
EXP
Oxcarbazepine results in increased cleavage of CASP3 protein
CTD
PMID:34333065
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Cbr1
carbonyl reductase 1
increases reduction
ISO
CBR1 protein results in increased reduction of Oxcarbazepine
CTD
PMID:25063510
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cbr3
carbonyl reductase 3
increases reduction
ISO
CBR3 protein results in increased reduction of oxcarbazepine
CTD
PMID:25063510
NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
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Ccnb1
cyclin B1
increases expression multiple interactions
EXP
Oxcarbazepine results in increased expression of CCNB1 mRNA Oxcarbazepine results in increased expression of and results in increased phosphorylation of CCNB1 protein
CTD
PMID:34333065
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cdc20
cell division cycle 20
increases expression
EXP
Oxcarbazepine results in increased expression of CDC20 mRNA
CTD
PMID:34333065
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
ISO
oxcarbazepine results in decreased activity of CYP19A1 protein
CTD
PMID:17959350
NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
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Dhrs7
dehydrogenase/reductase 7
increases reduction
ISO
DHRS7 protein results in increased reduction of oxcarbazepine
CTD
PMID:24246760
NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
increases activity
EXP
oxcarbazepine results in increased activity of GABRA1 protein
CTD
PMID:18717705
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
increases activity
EXP
oxcarbazepine results in increased activity of GABRA2 protein
CTD
PMID:18717705
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
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Nos2
nitric oxide synthase 2
increases expression
EXP
oxcarbazepine results in increased expression of NOS2 protein
CTD
PMID:14511393
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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Plk1
polo-like kinase 1
decreases phosphorylation
EXP
Oxcarbazepine results in decreased phosphorylation of PLK1 protein
CTD
PMID:34333065
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
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Shbg
sex hormone binding globulin
increases expression
ISO
oxcarbazepine results in increased expression of SHBG protein
CTD
PMID:11148232
NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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Vim
vimentin
affects expression
EXP
oxcarbazepine affects the expression of VIM protein
CTD
PMID:22142741
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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