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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxcarbazepine
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Accession:CHEBI:7824 term browser browse the term
Definition:A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy.
Synonyms:exact_synonym: 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
 related_synonym: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide;   Formula=C15H12N2O2;   InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19);   InChIKey=CTRLABGOLIVAIY-UHFFFAOYSA-N;   SMILES=NC(=O)N1c2ccccc2CC(=O)c2ccccc12;   oxcarbazepina;   oxcarbazepinum
 xref: CAS:28721-07-5;   Drug_Central:2017;   KEGG:C07492;   KEGG:D00533;   LINCS:LSM-5219
 xref_mesh: MESH:C036006
 xref: PMID:21924464



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oxcarbazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions EXP [BRL 44408 binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to oxcarbazepine CTD PMID:17959985 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions EXP [L 657743 binds to and results in decreased activity of ADRA2C protein] which results in decreased susceptibility to oxcarbazepine CTD PMID:17959985 NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases reduction ISO AKR1C1 protein results in increased reduction of Oxcarbazepine CTD PMID:25063510 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases reduction ISO AKR1C2 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases reduction ISO AKR1C3 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Bora bora, aurora kinase A activator increases expression EXP Oxcarbazepine results in increased expression of BORA mRNA CTD PMID:34333065 NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322
JBrowse link
G Casp3 caspase 3 increases cleavage EXP Oxcarbazepine results in increased cleavage of CASP3 protein CTD PMID:34333065 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cbr1 carbonyl reductase 1 increases reduction ISO CBR1 protein results in increased reduction of Oxcarbazepine CTD PMID:25063510 NCBI chr11:32,876,563...32,884,234 JBrowse link
G Cbr3 carbonyl reductase 3 increases reduction ISO CBR3 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875
JBrowse link
G Ccnb1 cyclin B1 increases expression
multiple interactions
EXP Oxcarbazepine results in increased expression of CCNB1 mRNA
Oxcarbazepine results in increased expression of and results in increased phosphorylation of CCNB1 protein
CTD PMID:34333065 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdc20 cell division cycle 20 increases expression EXP Oxcarbazepine results in increased expression of CDC20 mRNA CTD PMID:34333065 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO oxcarbazepine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of oxcarbazepine CTD PMID:24246760 NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases activity EXP oxcarbazepine results in increased activity of GABRA1 protein CTD PMID:18717705 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases activity EXP oxcarbazepine results in increased activity of GABRA2 protein CTD PMID:18717705 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP oxcarbazepine results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Plk1 polo-like kinase 1 decreases phosphorylation EXP Oxcarbazepine results in decreased phosphorylation of PLK1 protein CTD PMID:34333065 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Shbg sex hormone binding globulin increases expression ISO oxcarbazepine results in increased expression of SHBG protein CTD PMID:11148232 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Vim vimentin affects expression EXP oxcarbazepine affects the expression of VIM protein CTD PMID:22142741 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19747
    role 19720
      application 19552
        pharmaceutical 19430
          drug 19430
            drug allergen 10402
              oxcarbazepine 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19747
    subatomic particle 19745
      composite particle 19745
        hadron 19745
          baryon 19745
            nucleon 19745
              atomic nucleus 19745
                atom 19745
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19638
                        carbon atom 19634
                          organic molecular entity 19634
                            organic group 18850
                              organic divalent group 18836
                                organodiyl group 18836
                                  carbonyl group 18802
                                    carbonyl compound 18802
                                      carboxylic acid 18522
                                        carboacyl group 17658
                                          univalent carboacyl group 17658
                                            carbamoyl group 17499
                                              oxcarbazepine 19
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