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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxcarbazepine
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Accession:CHEBI:7824 term browser browse the term
Definition:A dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy.
Synonyms:exact_synonym: 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide
 related_synonym: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide;   Formula=C15H12N2O2;   InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19);   InChIKey=CTRLABGOLIVAIY-UHFFFAOYSA-N;   SMILES=NC(=O)N1c2ccccc2CC(=O)c2ccccc12;   oxcarbazepina;   oxcarbazepinum
 xref: CAS:28721-07-5;   Drug_Central:2017;   KEGG:C07492;   KEGG:D00533;   LINCS:LSM-5219
 xref_mesh: MESH:C036006
 xref: PMID:21924464


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oxcarbazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions EXP [BRL 44408 binds to and results in decreased activity of ADRA2A protein] which results in decreased susceptibility to oxcarbazepine CTD PMID:17959985 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2c adrenoceptor alpha 2C multiple interactions EXP [L 657743 binds to and results in decreased activity of ADRA2C protein] which results in decreased susceptibility to oxcarbazepine CTD PMID:17959985 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases reduction ISO AKR1C4 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases reduction ISO AKR1C2 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases reduction ISO AKR1C3 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Cbr1 carbonyl reductase 1 increases reduction ISO CBR1 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793
JBrowse link
G Cbr3 carbonyl reductase 3 increases reduction ISO CBR3 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO oxcarbazepine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of oxcarbazepine CTD PMID:24246760 NCBI chr 6:95,522,577...95,541,393
Ensembl chr 6:95,522,577...95,541,393
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases activity EXP oxcarbazepine results in increased activity of GABRA1 protein CTD PMID:18717705 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases activity EXP oxcarbazepine results in increased activity of GABRA2 protein CTD PMID:18717705 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP oxcarbazepine results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Shbg sex hormone binding globulin increases expression ISO oxcarbazepine results in increased expression of SHBG protein CTD PMID:11148232 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Vim vimentin affects expression EXP oxcarbazepine affects the expression of VIM protein CTD PMID:22142741 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link

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  CHEBI ontology 19816
    role 19764
      application 19426
        pharmaceutical 19301
          drug 19301
            drug allergen 9926
              oxcarbazepine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              oxcarbazepine 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.