CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: oxazepam
Accession: CHEBI:7823
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Definition: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
Synonyms: exact_synonym: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
related_synonym: (RS)-Oxazepam; Formula=C15H11ClN2O2; InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19); InChIKey=ADIMAYPTOBDMTL-UHFFFAOYSA-N; SMILES=OC1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O; Serax; Tazepam
xref: CAS:604-75-1; DrugBank:DB00842; Drug_Central:2015; HMDB:HMDB0014980; KEGG:C07359; KEGG:D00464
xref_mesh: MESH:D010076
xref: PMID:17456431; PMID:9811432; Patent:CN1543961; Reaxys:754065; Wikipedia:Oxazepam
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Arf2
ADP-ribosylation factor 2
decreases expression
ISO
Oxazepam results in decreased expression of ARF2 mRNA
CTD
PMID:12727805
NCBI chr10:88,867,836...88,889,654
Ensembl chr10:88,867,836...88,889,659
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Oxazepam results in increased expression of CDKN1A mRNA
CTD
PMID:15618236
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ces1d
carboxylesterase 1D
increases expression
ISO
Oxazepam results in increased expression of CES1D mRNA
CTD
PMID:12727805
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Cidea
cell death-inducing DFFA-like effector a
decreases expression
ISO
Oxazepam results in decreased expression of CIDEA mRNA
CTD
PMID:12727805
NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
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Cish
cytokine inducible SH2-containing protein
decreases expression
ISO
Oxazepam results in decreased expression of CISH mRNA
CTD
PMID:15618236
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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Ctnnb1
catenin beta 1
increases mutagenesis
ISO
Oxazepam results in increased mutagenesis of CTNNB1 gene
CTD
PMID:10467420
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Oxazepam results in increased expression of CYP2B1 protein
CTD
PMID:16684660
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
Oxazepam results in increased expression of CYP2B2 protein
CTD
PMID:16684660
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
Oxazepam results in increased expression of CYP2B10 mRNA; Oxazepam results in increased expression of CYP2B10 protein
CTD
PMID:12727805 PMID:15618236 PMID:16684660
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Egfr
epidermal growth factor receptor
decreases expression
ISO
Oxazepam results in decreased expression of EGFR mRNA; Oxazepam results in decreased expression of EGFR protein
CTD
PMID:15618236
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egr1
early growth response 1
decreases expression
ISO
Oxazepam results in decreased expression of EGR1 mRNA
CTD
PMID:15618236
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Gadd45b
growth arrest and DNA-damage-inducible, beta
increases expression
ISO
Oxazepam results in increased expression of GADD45B mRNA; Oxazepam results in increased expression of GADD45B protein
CTD
PMID:12727805 PMID:15618236 PMID:17533171
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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Igfbp1
insulin-like growth factor binding protein 1
increases expression
ISO
Oxazepam results in increased expression of IGFBP1 mRNA; Oxazepam results in increased expression of IGFBP1 protein
CTD
PMID:12727805 PMID:15618236
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Inhba
inhibin subunit beta A
decreases expression
ISO
Oxazepam results in decreased expression of INHBA mRNA
CTD
PMID:15618236
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
decreases expression
ISO
Oxazepam results in decreased expression of JUNB mRNA
CTD
PMID:15618236
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Lzts2
leucine zipper tumor suppressor 2
increases expression
ISO
Oxazepam results in increased expression of LZTS2 mRNA
CTD
PMID:12727805 PMID:15618236
NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423
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Maf
MAF bZIP transcription factor
increases expression
ISO
Oxazepam results in increased expression of MAF mRNA
CTD
PMID:12727805
NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
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Maff
MAF bZIP transcription factor F
increases expression
ISO
Oxazepam results in increased expression of MAFF mRNA
CTD
PMID:15618236
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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Map3k7
mitogen activated protein kinase kinase kinase 7
increases expression
ISO
Oxazepam results in increased expression of MAP3K7 mRNA
CTD
PMID:12727805
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
Oxazepam results in increased activity of NFE2L2 protein
CTD
PMID:30114225 PMID:30203046
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
Oxazepam results in increased activity of NR1I3 protein
CTD
PMID:30203046
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Ppara
peroxisome proliferator activated receptor alpha
decreases expression
ISO
Oxazepam results in decreased expression of PPARA protein
CTD
PMID:12727805
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Sprr2a2
small proline-rich protein 2A2
decreases expression
ISO
Oxazepam results in decreased expression of SPRR2A2 mRNA
CTD
PMID:12727805
NCBI chr 2:177,719,576...177,719,845
Ensembl chr 2:177,719,576...177,719,845
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St6gal1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
increases expression
ISO
Oxazepam results in increased expression of ST6GAL1 mRNA
CTD
PMID:12727805
NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310
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Stat5b
signal transducer and activator of transcription 5B
decreases activity
ISO
Oxazepam results in decreased activity of STAT5B protein
CTD
PMID:30114225
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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Tff1
trefoil factor 1
decreases expression
ISO
Oxazepam results in decreased expression of TFF1 mRNA
CTD
PMID:12727805
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Tnfaip2
TNF alpha induced protein 2
increases expression
ISO
Oxazepam results in increased expression of TNFAIP2 mRNA; Oxazepam results in increased expression of TNFAIP2 protein
CTD
PMID:12727805
NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
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Tsc22d1
TSC22 domain family, member 1
decreases expression
ISO
Oxazepam results in decreased expression of TSC22D1 mRNA; Oxazepam results in decreased expression of TSC22D1 protein
CTD
PMID:15618236 PMID:17533171
NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases metabolic processing
ISO
UGT1A9 protein results in increased metabolism of Oxazepam
CTD
PMID:12386133
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b7
UDP glucuronosyltransferase family 2 member B7
increases glucuronidation increases metabolic processing
ISO
UGT2B7 protein results in increased glucuronidation of Oxazepam UGT2B7 protein results in increased metabolism of Oxazepam
CTD
PMID:7773302 PMID:12386133
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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