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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxazepam
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Accession:CHEBI:7823 term browser browse the term
Definition:A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
Synonyms:exact_synonym: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
 related_synonym: (RS)-Oxazepam;   Formula=C15H11ClN2O2;   InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19);   InChIKey=ADIMAYPTOBDMTL-UHFFFAOYSA-N;   SMILES=OC1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O;   Serax;   Tazepam
 xref: CAS:604-75-1;   DrugBank:DB00842;   Drug_Central:2015;   HMDB:HMDB0014980;   KEGG:C07359;   KEGG:D00464
 xref_mesh: MESH:D010076
 xref: PMID:17456431;   PMID:9811432;   Patent:CN1543961;   Reaxys:754065;   Wikipedia:Oxazepam


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oxazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf2 ADP-ribosylation factor 2 decreases expression ISO Oxazepam results in decreased expression of ARF2 mRNA CTD PMID:12727805 NCBI chr10:92,018,562...92,040,335
Ensembl chr10:92,018,562...92,040,333
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Oxazepam results in increased expression of CDKN1A mRNA CTD PMID:15618236 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Oxazepam results in increased expression of CES1D mRNA CTD PMID:12727805 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression ISO Oxazepam results in decreased expression of CIDEA mRNA CTD PMID:12727805 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression ISO Oxazepam results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis ISO Oxazepam results in increased mutagenesis of CTNNB1 gene CTD PMID:10467420 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP
ISO
Oxazepam results in increased expression of CYP2B1 protein
Oxazepam results in increased expression of CYP2B10 mRNA; Oxazepam results in increased expression of CYP2B10 protein
CTD PMID:12727805 PMID:15618236 PMID:16684660 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Oxazepam results in increased expression of CYP2B2 protein CTD PMID:16684660 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Oxazepam results in decreased expression of EGFR mRNA; Oxazepam results in decreased expression of EGFR protein CTD PMID:15618236 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egr1 early growth response 1 decreases expression ISO Oxazepam results in decreased expression of EGR1 mRNA CTD PMID:15618236 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Oxazepam results in increased expression of GADD45B mRNA; Oxazepam results in increased expression of GADD45B protein CTD PMID:12727805 PMID:15618236 PMID:17533171 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Oxazepam results in increased expression of IGFBP1 mRNA; Oxazepam results in increased expression of IGFBP1 protein CTD PMID:12727805 PMID:15618236 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Inhba inhibin subunit beta A decreases expression ISO Oxazepam results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr17:51,894,869...51,919,998
Ensembl chr17:51,898,217...51,912,496
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Oxazepam results in decreased expression of JUNB mRNA CTD PMID:15618236 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Lzts2 leucine zipper tumor suppressor 2 increases expression ISO Oxazepam results in increased expression of LZTS2 mRNA CTD PMID:12727805 PMID:15618236 NCBI chr 1:264,765,256...264,776,553
Ensembl chr 1:264,768,105...264,776,616
JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO Oxazepam results in increased expression of MAF mRNA CTD PMID:12727805 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Oxazepam results in increased expression of MAFF mRNA CTD PMID:15618236 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases expression ISO Oxazepam results in increased expression of MAP3K7 mRNA CTD PMID:12727805 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
Ensembl chr 9:47,186,558...47,244,416
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Oxazepam results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Oxazepam results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Oxazepam results in decreased expression of PPARA protein CTD PMID:12727805 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 increases expression ISO Oxazepam results in increased expression of ST6GAL1 mRNA CTD PMID:12727805 NCBI chr11:80,927,601...80,981,424
Ensembl chr11:80,927,601...80,981,422
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO Oxazepam results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:88,686,207...88,712,313
Ensembl chr10:88,686,207...88,754,829
JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO Oxazepam results in decreased expression of TFF1 mRNA CTD PMID:12727805 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 increases expression ISO Oxazepam results in increased expression of TNFAIP2 mRNA; Oxazepam results in increased expression of TNFAIP2 protein CTD PMID:12727805 NCBI chr 6:135,890,869...135,903,647
Ensembl chr 6:135,890,931...135,903,647
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO Oxazepam results in decreased expression of TSC22D1 mRNA; Oxazepam results in decreased expression of TSC22D1 protein CTD PMID:15618236 PMID:17533171 NCBI chr15:58,554,358...58,658,156
Ensembl chr15:58,554,374...58,658,153
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases metabolic processing ISO UGT1A9 protein results in increased metabolism of Oxazepam CTD PMID:12386133 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
increases metabolic processing
ISO UGT2B7 protein results in increased glucuronidation of Oxazepam
UGT2B7 protein results in increased metabolism of Oxazepam
CTD PMID:7773302 PMID:12386133 NCBI chr14:22,597,103...22,619,968 JBrowse link

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  CHEBI ontology 19761
    role 19711
      biological role 19711
        xenobiotic 18387
          oxazepam 28
Path 2
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  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic molecule 19493
                              organic cyclic compound 19318
                                organic heterocyclic compound 18510
                                  organonitrogen heterocyclic compound 17521
                                    benzodiazepine 548
                                      1,4-benzodiazepinone 123
                                        oxazepam 28
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