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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxazepam
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Accession:CHEBI:7823 term browser browse the term
Definition:A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.
Synonyms:exact_synonym: 7-chloro-3-hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
 related_synonym: (RS)-Oxazepam;   Formula=C15H11ClN2O2;   InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19);   InChIKey=ADIMAYPTOBDMTL-UHFFFAOYSA-N;   SMILES=OC1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O;   Serax;   Tazepam
 xref: CAS:604-75-1;   DrugBank:DB00842;   Drug_Central:2015;   HMDB:HMDB0014980;   KEGG:C07359;   KEGG:D00464
 xref_mesh: MESH:D010076
 xref: PMID:17456431;   PMID:9811432;   Patent:CN1543961;   Reaxys:754065;   Wikipedia:Oxazepam



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oxazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf2 ADP-ribosylation factor 2 decreases expression ISO Oxazepam results in decreased expression of ARF2 mRNA CTD PMID:12727805 NCBI chr10:88,867,844...88,889,654
Ensembl chr10:88,867,836...88,889,659
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Oxazepam results in increased expression of CDKN1A mRNA CTD PMID:15618236 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Oxazepam results in increased expression of CES1D mRNA CTD PMID:12727805 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Cidea cell death-inducing DFFA-like effector a decreases expression ISO Oxazepam results in decreased expression of CIDEA mRNA CTD PMID:12727805 NCBI chr18:60,894,917...60,920,485
Ensembl chr18:60,894,874...60,920,481
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression ISO Oxazepam results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis ISO Oxazepam results in increased mutagenesis of CTNNB1 gene CTD PMID:10467420 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP
ISO
Oxazepam results in increased expression of CYP2B1 protein
Oxazepam results in increased expression of CYP2B10 mRNA; Oxazepam results in increased expression of CYP2B10 protein
CTD PMID:12727805 PMID:15618236 PMID:16684660 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Oxazepam results in increased expression of CYP2B2 protein CTD PMID:16684660 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Oxazepam results in decreased expression of EGFR mRNA; Oxazepam results in decreased expression of EGFR protein CTD PMID:15618236 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 decreases expression ISO Oxazepam results in decreased expression of EGR1 mRNA CTD PMID:15618236 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Oxazepam results in increased expression of GADD45B mRNA; Oxazepam results in increased expression of GADD45B protein CTD PMID:12727805 PMID:15618236 PMID:17533171 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Oxazepam results in increased expression of IGFBP1 mRNA; Oxazepam results in increased expression of IGFBP1 protein CTD PMID:12727805 PMID:15618236 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Inhba inhibin subunit beta A decreases expression ISO Oxazepam results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Oxazepam results in decreased expression of JUNB mRNA CTD PMID:15618236 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Lzts2 leucine zipper tumor suppressor 2 increases expression ISO Oxazepam results in increased expression of LZTS2 mRNA CTD PMID:12727805 PMID:15618236 NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423
JBrowse link
G Maf MAF bZIP transcription factor increases expression ISO Oxazepam results in increased expression of MAF mRNA CTD PMID:12727805 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Oxazepam results in increased expression of MAFF mRNA CTD PMID:15618236 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases expression ISO Oxazepam results in increased expression of MAP3K7 mRNA CTD PMID:12727805 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Oxazepam results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Oxazepam results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Oxazepam results in decreased expression of PPARA protein CTD PMID:12727805 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 increases expression ISO Oxazepam results in increased expression of ST6GAL1 mRNA CTD PMID:12727805 NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO Oxazepam results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO Oxazepam results in decreased expression of TFF1 mRNA CTD PMID:12727805 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 increases expression ISO Oxazepam results in increased expression of TNFAIP2 mRNA; Oxazepam results in increased expression of TNFAIP2 protein CTD PMID:12727805 NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
JBrowse link
G Tsc22d1 TSC22 domain family, member 1 decreases expression ISO Oxazepam results in decreased expression of TSC22D1 mRNA; Oxazepam results in decreased expression of TSC22D1 protein CTD PMID:15618236 PMID:17533171 NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases metabolic processing ISO UGT1A9 protein results in increased metabolism of Oxazepam CTD PMID:12386133 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation
increases metabolic processing
ISO UGT2B7 protein results in increased glucuronidation of Oxazepam
UGT2B7 protein results in increased metabolism of Oxazepam
CTD PMID:7773302 PMID:12386133 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link

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  CHEBI ontology 20050
    role 20001
      biological role 20000
        xenobiotic 18623
          oxazepam 28
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  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                organic heterocyclic compound 18799
                                  organonitrogen heterocyclic compound 17736
                                    benzodiazepine 869
                                      1,4-benzodiazepinone 122
                                        oxazepam 28
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