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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxaprozin
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Accession:CHEBI:7822 term browser browse the term
Definition:A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis.
Synonyms:exact_synonym: 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
 related_synonym: Danoprox;   Daypro;   Dayrun;   Deflam;   Duraprox;   Formula=C18H15NO3;   InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21);   InChIKey=OFPXSFXSNFPTHF-UHFFFAOYSA-N;   SMILES=OC(=O)CCc1nc(-c2ccccc2)c(o1)-c1ccccc1;   Walix;   oxaprozina;   oxaprozine;   oxaprozinum
 xref: CAS:21256-18-8;   DrugBank:DB00991;   Drug_Central:2013;   HMDB:HMDB0015126;   KEGG:C07356;   KEGG:D00463;   LINCS:LSM-2553
 xref_mesh: MESH:C008729
 xref: PMID:1603605;   PMID:1617910;   PMID:19338579;   PMID:19672323;   PMID:20206429;   PMID:23865335;   PMID:385873;   PMID:6432657;   PMID:6611288;   PMID:6863578;   PMID:9459947;   Patent:FR2001036;   Patent:GB1206403;   Patent:US3578671;   Patent:WO2007082542;   Reaxys:1083168;   Wikipedia:Oxaprozin


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oxaprozin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ngfr nerve growth factor receptor increases expression ISO oxaprozin results in increased expression of NGFR protein CTD PMID:17409433 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO oxaprozin results in increased activity of PPARG protein CTD PMID:12065695 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression ISO oxaprozin affects the expression of HLA-DQB1 mRNA CTD PMID:25811541 NCBI chr20:4,043,726...4,049,367
Ensembl chr20:4,039,413...4,049,711
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          analgesic 13063
            oxaprozin 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            saturated fatty acid 15812
                                              propionic acid 3666
                                                oxaprozin 3
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