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ONTOLOGY REPORT - ANNOTATIONS


Term:bleomycin A5
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Accession:CHEBI:78160 term browser browse the term
Definition:A member of the class of bleomycins that is used in sclerotherapy for cervicofacial lymphatic malformations.
Synonyms:related_synonym: BLM A5;   Bleomycetin;   Formula=C57H89N19O21S2;   InChI=1S/C57H89N19O21S2/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98-34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58/h16,19-21,23-27,31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60,80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H,75,90)(H2,61,73,76)/t23-,24+,25+,26-,27-,31-,32+,36-,37-,38-,39+,40+,41-,42-,43-,44-,45-,55+,56-/m0/s1;   InChIKey=QYOAUOAXCQAEMW-UTXKDXHTSA-N;   N1-(3-((4-Aminobutyl)amino)propyl)bleomycinamide;   Pingyangmycin;   SMILES=C[C@@H](O)[C@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]1O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](OC(N)=O)[C@@H]1O)c1c[nH]cn1)C(=O)NCCc1nc(cs1)-c1nc(cs1)C(=O)NCCCNCCCCN;   Zhengguangmycin A5
 xref: CAS:11116-32-8 "ChemIDplus"
 xref_mesh: MESH:C025703
 xref: PMID:14675139 "Europe PMC";   PMID:19740258 "Europe PMC";   PMID:20843632 "Europe PMC";   PMID:22378834 "Europe PMC";   PMID:22932480 "Europe PMC";   PMID:23073810 "Europe PMC";   PMID:23236562 "Europe PMC";   PMID:23257316 "Europe PMC";   PMID:23426884 "Europe PMC";   PMID:23508003 "Europe PMC";   PMID:23534516 "Europe PMC";   PMID:23603483 "Europe PMC";   PMID:23708035 "Europe PMC";   PMID:23708044 "Europe PMC";   PMID:23848975 "Europe PMC";   PMID:23898618 "Europe PMC";   PMID:23953485 "Europe PMC";   PMID:24396428 "Europe PMC";   PMID:24504597 "Europe PMC";   PMID:24604118 "Europe PMC";   Reaxys:8386869 "Reaxys"


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bleomycin A5 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd10 abhydrolase domain containing 10 JBrowse link 11 60,053,719 60,068,142 RGD:6480464
G Alg12 ALG12, alpha-1,6-mannosyltransferase JBrowse link 7 129,798,663 129,812,677 RGD:6480464
G Amacr alpha-methylacyl-CoA racemase JBrowse link 2 60,949,276 60,961,342 RGD:6480464
G Arf4 ADP-ribosylation factor 4 JBrowse link 16 2,338,333 2,354,909 RGD:6480464
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:6480464
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:6480464
G Ca9 carbonic anhydrase 9 JBrowse link 5 59,008,277 59,015,535 RGD:6480464
G Casd1 CAS1 domain containing 1 JBrowse link 4 29,638,280 29,693,151 RGD:6480464
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Cdhr5 cadherin-related family member 5 JBrowse link 1 214,255,118 214,263,848 RGD:6480464
G Cox7b cytochrome c oxidase subunit 7B JBrowse link X 77,065,427 77,071,676 RGD:6480464
G Cul4a cullin 4A JBrowse link 16 81,718,784 81,756,653 RGD:6480464
G Ddit4 DNA-damage-inducible transcript 4 JBrowse link 20 29,509,283 29,511,382 RGD:6480464
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 5 126,164,708 126,188,926 RGD:6480464
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:6480464
G Dpysl2 dihydropyrimidinase-like 2 JBrowse link 15 43,475,640 43,581,725 RGD:6480464
G Ehd4 EH-domain containing 4 JBrowse link 3 111,877,853 111,941,841 RGD:6480464
G Eif4g1 eukaryotic translation initiation factor 4 gamma, 1 JBrowse link 11 83,907,659 83,927,683 RGD:6480464
G Emc4 ER membrane protein complex subunit 4 JBrowse link 3 103,852,139 103,857,172 RGD:6480464
G Emc7 ER membrane protein complex subunit 7 JBrowse link 3 103,945,276 103,955,970 RGD:6480464
G Eno2 enolase 2 JBrowse link 4 157,285,192 157,294,090 RGD:6480464
G Fbn2 fibrillin 2 JBrowse link 18 53,068,495 53,272,254 RGD:6480464
G Fkbp1a FKBP prolyl isomerase 1A JBrowse link 3 147,042,944 147,062,725 RGD:6480464
G Fkbp9 FKBP prolyl isomerase 9 JBrowse link 4 87,167,514 87,234,198 RGD:6480464
G Frs3 fibroblast growth factor receptor substrate 3 JBrowse link 9 15,297,794 15,306,850 RGD:6480464
G Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 JBrowse link 10 43,067,316 43,208,992 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gng11 G protein subunit gamma 11 JBrowse link 4 28,989,170 28,994,610 RGD:6480464
G Gstk1 glutathione S-transferase kappa 1 JBrowse link 4 71,621,777 71,626,096 RGD:6480464
G H2bc12 H2B clustered histone 12 JBrowse link 17 44,527,421 44,527,801 RGD:6480464
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B JBrowse link 10 34,955,713 34,961,662 RGD:6480464
G Hoxb7 homeo box B7 JBrowse link 10 84,135,224 84,138,642 RGD:6480464
G Hsph1 heat shock protein family H (Hsp110) member 1 JBrowse link 12 6,322,685 6,341,898 RGD:6480464
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha JBrowse link 8 59,164,601 59,183,899 RGD:6480464
G Idi1 isopentenyl-diphosphate delta isomerase 1 JBrowse link 17 57,976,266 57,984,036 RGD:6480464
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:6480464
G Itgb5 integrin subunit beta 5 JBrowse link 11 70,056,500 70,172,164 RGD:6480464
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6480464
G Kat6b lysine acetyltransferase 6B JBrowse link 15 2,811,933 2,966,833 RGD:6480464
G Lypd3 Ly6/Plaur domain containing 3 JBrowse link 1 81,499,856 81,504,306 RGD:6480464
G Mageb2 MAGE family member B2 JBrowse link X 54,804,987 54,806,956 RGD:6480464
G Man1b1 mannosidase, alpha, class 1B, member 1 JBrowse link 3 2,547,259 2,569,051 RGD:6480464
G Mcm2 minichromosome maintenance complex component 2 JBrowse link 4 120,825,699 120,840,221 RGD:6480464
G Med11 mediator complex subunit 11 JBrowse link 10 57,057,272 57,059,415 RGD:6480464
G Metrn meteorin, glial cell differentiation regulator JBrowse link 10 15,164,439 15,166,457 RGD:6480464
G Mt2A metallothionein 2A JBrowse link 19 11,307,966 11,308,740 RGD:6480464
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:6480464
G Ncbp2 nuclear cap binding protein subunit 2 JBrowse link 11 72,071,838 72,103,087 RGD:6480464
G Ndrg1 N-myc downstream regulated 1 JBrowse link 7 107,734,326 107,775,701 RGD:6480464
G Nop10 NOP10 ribonucleoprotein JBrowse link 3 103,747,654 103,748,739 RGD:6480464
G Nop56 NOP56 ribonucleoprotein JBrowse link 3 122,803,726 122,808,564 RGD:6480464
G Nrdc nardilysin convertase JBrowse link 5 128,629,949 128,694,209 RGD:6480464
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 JBrowse link 20 28,920,616 28,972,576 RGD:6480464
G Parn poly(A)-specific ribonuclease JBrowse link 10 1,309,724 1,461,123 RGD:6480464
G Pdgfa platelet derived growth factor subunit A JBrowse link 12 17,734,141 17,756,186 RGD:6480464
G Pgd phosphogluconate dehydrogenase JBrowse link 5 165,966,128 165,982,327 RGD:6480464
G Pgrmc2 progesterone receptor membrane component 2 JBrowse link 2 127,986,106 128,002,005 RGD:6480464
G Pkn3 protein kinase N3 JBrowse link 3 8,628,033 8,656,464 RGD:6480464
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta JBrowse link 18 36,985,709 37,421,383 RGD:6480464
G Pqbp1 polyglutamine binding protein 1 JBrowse link X 15,448,570 15,453,130 RGD:6480464
G Ptges prostaglandin E synthase JBrowse link 3 9,727,408 9,738,752 RGD:6480464
G Rab31 RAB31, member RAS oncogene family JBrowse link 9 113,370,072 113,504,606 RGD:6480464
G Rbp4 retinol binding protein 4 JBrowse link 1 256,806,476 256,813,678 RGD:6480464
G Rps4x ribosomal protein S4, X-linked JBrowse link X 72,074,108 72,078,551 RGD:6480464
G Rsl1d1 ribosomal L1 domain containing 1 JBrowse link 10 4,375,329 4,387,195 RGD:6480464
G Ruvbl1 RuvB-like AAA ATPase 1 JBrowse link 4 120,411,917 120,447,458 RGD:6480464
G Scnn1a sodium channel epithelial 1 alpha subunit JBrowse link 4 157,834,339 157,860,472 RGD:6480464
G Sdc4 syndecan 4 JBrowse link 3 160,872,503 160,891,190 RGD:6480464
G Sfpq splicing factor proline and glutamine rich JBrowse link 5 145,079,803 145,088,517 RGD:6480464
G Sgk1 serum/glucocorticoid regulated kinase 1 JBrowse link 1 24,185,451 24,302,309 RGD:6480464
G Sltm SAFB-like, transcription modulator JBrowse link 8 76,977,698 77,022,847 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Srxn1 sulfiredoxin 1 JBrowse link 3 147,608,850 147,614,410 RGD:6480464
G Tcp1 t-complex 1 JBrowse link 1 48,025,664 48,033,343 RGD:6480464
G Tma7 translation machinery associated 7 homolog JBrowse link 8 117,815,725 117,820,422 RGD:6480464
G Tmem230 transmembrane protein 230 JBrowse link 3 124,870,867 124,879,274 RGD:6480464
G Tpm4 tropomyosin 4 JBrowse link 16 19,385,810 19,399,851 RGD:6480464
G Tsc22d1 TSC22 domain family, member 1 JBrowse link 15 58,554,358 58,658,156 RGD:6480464
G Upp1 uridine phosphorylase 1 JBrowse link 14 89,314,234 89,334,060 RGD:6480464
G Usp37 ubiquitin specific peptidase 37 JBrowse link 9 81,717,626 81,818,421 RGD:6480464
G Uxt ubiquitously-expressed, prefoldin-like chaperone JBrowse link X 1,275,402 1,287,781 RGD:6480464
G Zfp541 zinc finger protein 541 JBrowse link 1 77,957,188 77,993,816 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      biological role 19599
        antimicrobial agent 17148
          bleomycin 571
            bleomycin A5 83
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                peptide 9293
                                                  peptide antibiotic 1590
                                                    chelate-forming peptide 571
                                                      bleomycin 571
                                                        bleomycin A5 83
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.