enzyme mimic - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	enzyme mimic	go back to main search page
Accession:	CHEBI:78152	browse the term
Definition:	Any small molecule that mimics the action of an enzyme.
Synonyms:	related_synonym:	enzyme mimetic; enzyme mimetics; enzyme mimics

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Rat (58) Mouse (57) Human (58) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (2) Green Monkey (0) Naked Mole-rat (0) All
Genes (57)

ebselen

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle, aorta

multiple interactions

ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

ADAM metallopeptidase domain 9

multiple interactions

ebselen inhibits the reaction [Hydrogen Peroxide results in increased expression of ADAM9 protein]

NCBI chr 8:25,439,627...25,507,138
Ensembl chr 8:25,439,627...25,506,943

G

alpha fetoprotein

multiple interactions

ebselen inhibits the reaction [Aflatoxin B1 results in increased expression of AFP mRNA]

NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766

G

aminolevulinate, delta-, dehydratase

multiple interactions
decreases activity

Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]
ebselen inhibits the reaction [Cadmium Chloride results in decreased activity of ALAD protein]

PMID:14630126 PMID:17624921 PMID:23933410

NCBI chr 4:62,422,762...62,438,300
Ensembl chr 4:62,427,406...62,438,155

G

arachidonate 5-lipoxygenase

decreases activity

ebselen results in decreased activity of ALOX5 protein

NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139

G

BCL2-associated X protein

multiple interactions

ebselen inhibits the reaction [sodium arsenite results in increased expression of BAX protein]

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions

ebselen inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 3

multiple interactions
increases activity

ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP3 protein]
ebselen inhibits the reaction [Methylmercury Compounds results in increased activity of CASP3 protein]; ebselen inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
ebselen results in increased activity of CASP3 protein

PMID:21300091 PMID:23649643 PMID:25068500 PMID:30558456

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 9

multiple interactions

ebselen inhibits the reaction [Mechlorethamine results in increased activity of CASP9 protein]
ebselen inhibits the reaction [Cadmium Chloride results in increased activity of CASP9 protein]

PMID:18629305 PMID:23649643

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

increases activity
multiple interactions

ebselen results in increased activity of CAT protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]

PMID:27282967 PMID:30558456

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

cytochrome c oxidase subunit 4I1

increases expression

ebselen results in increased expression of COX4I1 protein

NCBI chr 8:121,394,964...121,400,948
Ensembl chr 8:121,394,961...121,400,946

G

citrate synthase

multiple interactions

ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]
ebselen inhibits the reaction [Cisplatin results in decreased activity of CS protein]

PMID:27385396 PMID:32860823

NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348

G

C-X-C motif chemokine ligand 15

multiple interactions

ebselen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; ebselen inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; ebselen inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 mRNA]; ebselen inhibits the reaction [Peroxynitrous Acid results in increased expression of CXCL8 protein]

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 mRNA]

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

eukaryotic translation initiation factor 2, subunit 1 alpha

increases phosphorylation

ebselen results in increased phosphorylation of EIF2S1 protein

NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784

G

epoxide hydrolase 2, cytoplasmic

multiple interactions

ebselen binds to and results in decreased activity of EPHX2 protein

NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949

G

fragile X messenger ribonucleoprotein 1

multiple interactions

ebselen inhibits the reaction [FMR1 5' UTR mutant form results in decreased activity of CS protein]

NCBI chr X:67,722,144...67,761,569
Ensembl chr X:67,722,147...67,761,569

G

FBJ osteosarcoma oncogene

multiple interactions

ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

ebselen inhibits the reaction [Cisplatin results in increased activity of G6PC1 protein]

NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729

G

glucokinase

multiple interactions

[ebselen co-treated with Glucose] results in increased activity of GCK protein

NCBI chr11:5,850,816...5,900,081
Ensembl chr11:5,850,820...5,900,081

G

glial fibrillary acidic protein

increases phosphorylation

ebselen results in increased phosphorylation of GFAP protein

NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738

G

gap junction protein, alpha 1

multiple interactions

ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 mRNA]; ebselen inhibits the reaction [Oxygen deficiency results in increased expression of GJA1 protein]

NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609

G

glutathione peroxidase 1

multiple interactions

ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]
ebselen inhibits the reaction [Methylmercury Compounds results in decreased activity of GPX1 protein]

PMID:23795780 PMID:28383113

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione reductase

increases activity
multiple interactions

ebselen results in increased activity of GSR protein
ebselen inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]

PMID:27282967 PMID:30558456

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

glutathione S-transferase, mu 1

multiple interactions

ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein]

NCBI chr 3:107,919,566...107,925,289
Ensembl chr 3:107,919,571...107,925,289

G

glutathione S-transferase, mu 2

multiple interactions

ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein]

NCBI chr 3:107,889,018...107,893,736
Ensembl chr 3:107,889,018...107,893,769

G

glutathione S-transferase, pi 1

multiple interactions

ebselen binds to and results in decreased activity of GSTP1 protein

NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985

G

hypoxia inducible factor 1, alpha subunit

multiple interactions

ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [Acetylcysteine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]]; ebselen inhibits the reaction [glutathione glycylethyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]]

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

multiple interactions

[ebselen affects the abundance of Reactive Oxygen Species] which results in decreased expression of HMOX1 protein; [ebselen affects the abundance of Reactive Oxygen Species] which results in increased activity of HMOX1 protein

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

hematopoietic prostaglandin D synthase

increases expression

ebselen results in increased expression of HPGDS mRNA

NCBI chr 6:65,094,019...65,121,960
Ensembl chr 6:65,094,277...65,121,892

G

heat shock factor 1

increases activity

ebselen results in increased activity of HSF1 protein

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

interferon gamma

multiple interactions

ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interleukin 6

multiple interactions

ebselen inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

insulin I

multiple interactions

ebselen inhibits the reaction [GPX1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; ebselen promotes the reaction [Glucose results in increased secretion of INS1 protein]

NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation
increases activity

ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen analog results in increased phosphorylation of MAPK1 protein; ebselen results in increased phosphorylation of MAPK1 protein
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK1 protein]
ebselen results in increased activity of MAPK1 protein

PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation
increases activity

ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
ebselen inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of MAPK3 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; ebselen inhibits the reaction [tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex results in increased phosphorylation of and results in increased activity of MAPK3 protein]
ebselen analog results in increased phosphorylation of MAPK3 protein; ebselen results in increased phosphorylation of MAPK3 protein
ebselen results in increased activity of MAPK3 protein

PMID:20495008 PMID:21300091 PMID:21960664 PMID:22001386 PMID:27282967

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 9

increases phosphorylation

ebselen results in increased phosphorylation of MAPK9 protein

NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248

G

matrix metallopeptidase 13

multiple interactions

ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]

NCBI chr 9:7,272,514...7,283,333
Ensembl chr 9:7,272,514...7,283,331

G

nerve growth factor

multiple interactions

ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [NGF protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329

G

nitric oxide synthase 2, inducible

multiple interactions
decreases activity

ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; ebselen inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
ebselen results in decreased activity of NOS2 protein

PMID:7590103 PMID:12794164

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NAD(P)H dehydrogenase, quinone 1

decreases activity

ebselen results in decreased activity of NQO1 protein

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

pancreatic and duodenal homeobox 1

multiple interactions

[ebselen co-treated with Glucose] results in increased expression of PDX1 protein

NCBI chr 5:147,206,907...147,212,658
Ensembl chr 5:147,206,769...147,212,658

G

phosphatase, orphan 1

decreases activity

ebselen results in decreased activity of PHOSPHO1 protein

NCBI chr11:95,715,326...95,722,966
Ensembl chr11:95,715,325...95,722,966

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

ebselen inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; ebselen inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

multiple interactions

ebselen inhibits the reaction [SLC11A2 protein results in increased uptake of Iron]

NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953

G

solute carrier family 2 (facilitated glucose transporter), member 2

multiple interactions

[ebselen co-treated with Glucose] results in increased expression of SLC2A2 protein
ebselen inhibits the reaction [Cisplatin results in increased expression of SLC2A2 protein]

PMID:23795780 PMID:32860823

NCBI chr 3:28,752,052...28,782,510
Ensembl chr 3:28,752,052...28,785,508

G

SMAD family member 3

multiple interactions

ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]

NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276

G

superoxide dismutase 1, soluble

decreases response to substance
multiple interactions

ebselen results in decreased susceptibility to SOD1 protein mutant form
ebselen inhibits the reaction [SOD1 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein]]

PMID:16702190 PMID:23795780

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

superoxide dismutase 2, mitochondrial

multiple interactions

ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; ebselen inhibits the reaction [SOD2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

tyrosine aminotransferase

multiple interactions

ebselen inhibits the reaction [Cisplatin results in increased activity of TAT protein]

NCBI chr 8:110,712,710...110,726,436
Ensembl chr 8:110,717,069...110,726,435

G

transforming growth factor, beta 1

multiple interactions

ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]
ebselen inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; ebselen inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]

PMID:11903743 PMID:16757516 PMID:21131394

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tissue inhibitor of metalloproteinase 1

multiple interactions

ebselen inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tumor necrosis factor

multiple interactions

ebselen inhibits the reaction [sodium arsenite results in increased expression of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

thioredoxin reductase 1

multiple interactions

ebselen results in increased expression of and results in increased activity of TXNRD1 protein

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

uncoupling protein 2 (mitochondrial, proton carrier)

multiple interactions

[ebselen co-treated with Glucose] results in decreased expression of UCP2 protein

NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227

G

X-box binding protein 1

increases phosphorylation

ebselen results in increased phosphorylation of XBP1 protein

NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893

G

xeroderma pigmentosum, complementation group A

multiple interactions

ebselen inhibits the reaction [Zinc binds to XPA protein]

NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22178
role	22194
application	21744
enzyme mimic	57
ebselen	57

paths to the root