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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Wnt signalling inhibitor
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Accession:CHEBI:78031 term browser browse the term
Definition:A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
Synonyms:related_synonym: Wnt signalling inhibitors;   Wnt-signaling inhibitor;   Wnt-signaling inhibitors



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LGK974 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased expression of BAK1 protein] CTD PMID:30205152 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Casp3 caspase 3 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein] CTD PMID:30205152 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in decreased expression of CCND1 protein] CTD PMID:30205152 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat affects the localization of CTNNB1 protein]; LGK974 inhibits the reaction [Paraquat results in increased expression of and results in decreased phosphorylation of CTNNB1 protein] CTD PMID:30205152 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased transport of DIABLO protein] CTD PMID:30205152 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Htra2 HtrA serine peptidase 2 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased transport of HTRA2 protein] CTD PMID:30205152 NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO LGK974 inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein] CTD PMID:30205152 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        inhibitor 18590
          Wnt signalling inhibitor 7
            (3S)-3-\{[3',4'-difluoro-5-(\{4'-fluoro-6-[(3S)-pyrrolidinium-3-yloxy][biphenyl]-3-yl\}carbamoyl)[biphenyl]-2-yl]oxy\}pyrrolidinium dichloride 0
            3',4'-difluoro-N-\{4'-fluoro-6-[(3S)-pyrrolidin-3-yloxy][biphenyl]-3-yl\}-6-[(3S)-pyrrolidin-3-yloxy][biphenyl]-3-carboxamide 0
            CCT251545 0
            IWR-1-endo 0
            LGK974 7
            SKLB-677 0
            Trolox 0
            cardionogen-1 0
            toxoflavin 0
paths to the root