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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dibenziodolium
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Accession:CHEBI:77986 term browser browse the term
Definition:An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.
Synonyms:exact_synonym: dibenzo[b,d]iodolium
 related_synonym: (1,1'-Biphenyl)-2,2'-diyliodonium;   2,2'-Biphenylyleneiodonium;   Diphenyleneiodonium;   Formula=C12H8I;   InChI=1S/C12H8I/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1-8H/q+1;   InChIKey=QFXKXRXFBRLLPQ-UHFFFAOYSA-N;   SMILES=[I+]1c2ccccc2-c2ccccc12
 xref: CAS:244-54-2;   LINCS:LSM-3467
 xref_mesh: MESH:C007517
 xref: PMID:24621828;   Reaxys:3905470


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dibenziodolium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; diphenyleneiodonium inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein] CTD PMID:18474546 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
ISO diphenyleneiodonium results in decreased expression of ACTA2 protein
diphenyleneiodonium promotes the reaction [gamma-mangostin results in decreased expression of ACTA2 protein]; gamma-mangostin promotes the reaction [diphenyleneiodonium results in decreased expression of ACTA2 protein]
CTD PMID:30502394 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of ADIPOQ protein]; diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of ADIPOQ protein]; diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of ADIPOQ protein]; diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein]
diphenyleneiodonium inhibits the reaction [Palmitates results in decreased expression of ADIPOQ mRNA]; diphenyleneiodonium inhibits the reaction [Palmitates results in decreased expression of ADIPOQ protein]
CTD PMID:17471172 PMID:17668557 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
diphenyleneiodonium inhibits the reaction [AGT protein affects the localization of RHOA protein]; diphenyleneiodonium inhibits the reaction [AGT protein results in increased phosphorylation of PPP1R12A protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased abundance of Superoxides]]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]]
CTD PMID:12606818 PMID:16569756 PMID:17391658 PMID:18250367 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]
diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]
CTD PMID:25199686 PMID:26514923 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin multiple interactions ISO diphenyleneiodonium inhibits the reaction [ALB protein results in increased abundance of Hydrogen Peroxide] CTD PMID:11961005 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite affects the localization of APEX1 protein] CTD PMID:12023366 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of ATF2 protein] CTD PMID:14687664 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO diphenyleneiodonium inhibits the reaction [Resveratrol affects the expression of BCL2 protein] CTD PMID:31151226 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bsg basigin (Ok blood group) multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL18 protein results in increased expression of BSG mRNA] CTD PMID:19561311 NCBI chr 7:12,875,536...12,882,753
Ensembl chr 7:12,875,537...12,882,753
JBrowse link
G Casp1 caspase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP1 protein] CTD PMID:23940760 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [AGT protein modified form results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Ethanol results in increased activity of CASP3 protein]
[diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
diphenyleneiodonium inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [docetaxel results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid analog results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T analog results in increased activity of CASP3 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T results in increased activity of CASP3 protein]
CTD PMID:12606818 PMID:12754411 PMID:14732287 PMID:15331178 PMID:15799720 PMID:20026259 PMID:25947082 PMID:26282491 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP [diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased activity of CASP8 protein] CTD PMID:15799720 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO diphenyleneiodonium inhibits the reaction [ganoderic acid analog results in increased activity of CASP9 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T analog results in increased activity of CASP9 protein]; diphenyleneiodonium inhibits the reaction [ganoderic acid T results in increased activity of CASP9 protein] CTD PMID:26282491 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; diphenyleneiodonium inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Indinavir results in increased expression of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Lopinavir results in increased expression of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Nelfinavir results in increased expression of CCL2 protein]; diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] CTD PMID:14576080 PMID:16600694 PMID:17668557 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA] CTD PMID:28321046 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd38 CD38 molecule multiple interactions ISO diphenyleneiodonium inhibits the reaction [VAV2 protein affects the localization of CD38 protein]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased expression of and results in increased activity of CD38 protein] CTD PMID:23940720 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with CD40LG protein binds to and co-treated with diphenyleneiodonium] inhibits the reaction [Oxygen deficiency results in increased abundance of Reactive Oxygen Species] CTD PMID:22295117 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CDKN1A protein] CTD PMID:15978937 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of CEBPB protein] CTD PMID:25199686 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cldn4 claudin 4 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of CREB1 protein] CTD PMID:25199686 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; diphenyleneiodonium inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 1:199,162,319...199,168,296
Ensembl chr 1:199,163,086...199,168,296
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA mRNA]; diphenyleneiodonium inhibits the reaction [Methanol results in increased expression of CYBA protein] CTD PMID:25726414 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX2 mRNA]; diphenyleneiodonium inhibits the reaction [S100B protein results in increased expression of NOX2 mRNA]
diphenyleneiodonium inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of NOX2 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NOX2 protein]
diphenyleneiodonium inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 mRNA]; diphenyleneiodonium inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOX2 protein]
CTD PMID:17327432 PMID:23272707 PMID:29183754 PMID:30797899 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [sodium arsenite promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]
diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]
CTD PMID:26535918 PMID:26880746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
EXP diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A2 protein]
diphenyleneiodonium results in decreased activity of CYP1A2 protein
CTD PMID:26880746 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
EXP diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]
diphenyleneiodonium results in decreased activity of CYP2E1 protein
CTD PMID:26880746 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP3A2 protein] CTD PMID:26880746 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP3A23-3A1 protein]; diphenyleneiodonium inhibits the reaction [Dexamethasone results in increased activity of CYP3A23-3A1 protein]; diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP3A23-3A1 protein]; diphenyleneiodonium inhibits the reaction [Pregnenolone Carbonitrile results in increased activity of CYP3A23-3A1 protein] CTD PMID:26880746 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP diphenyleneiodonium results in decreased activity of CYP3A4 protein CTD PMID:26880746 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Des desmin multiple interactions ISO diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:20036696 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP diphenyleneiodonium inhibits the reaction [Paraquat affects the localization of DIABLO protein] CTD PMID:25947082 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased activity of DIO2 protein] CTD PMID:17615150 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA] CTD PMID:28321046 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [AGT protein results in increased expression of EDN1 mRNA]
diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]
diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased oxidation of PTPN11 protein]; diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]
CTD PMID:16391241 PMID:17391658 PMID:20691780 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP
ISO
diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased phosphorylation of and results in increased activity of EGFR protein]
diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of EGFR protein]
CTD PMID:16391241 PMID:26514923 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]] CTD PMID:19281832 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO diphenyleneiodonium inhibits the reaction [Air Pollutants results in increased expression of F3 mRNA]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of F3 mRNA] CTD PMID:24752501 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Faslg Fas ligand multiple interactions EXP [diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin results in increased expression of FASL protein] CTD PMID:15799720 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO
diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of FN1 mRNA]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of FN1 mRNA]
diphenyleneiodonium inhibits the reaction [Glucose results in increased secretion of FN1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]
CTD PMID:15086456 PMID:16632126 PMID:17635749 PMID:31838053 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of FOS protein] CTD PMID:25199686 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [VEGFA protein results in increased phosphorylation of FOXO1 protein] CTD PMID:15308628 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions EXP diphenyleneiodonium affects the reaction [Glucose results in decreased expression of GNAI2 protein]; diphenyleneiodonium inhibits the reaction [Streptozocin results in decreased expression of GNAI2 protein] CTD PMID:18441196 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions EXP diphenyleneiodonium affects the reaction [Glucose results in decreased expression of GNAI3 protein]; diphenyleneiodonium inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein] CTD PMID:18441196 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gypa glycophorin A multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein] CTD PMID:20523355 NCBI chr19:31,115,545...31,131,079 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression
increases expression
ISO
EXP
diphenyleneiodonium inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HIF1A protein]
diphenyleneiodonium results in decreased expression of HIF1A protein
diphenyleneiodonium results in increased expression of HIF1A protein
CTD PMID:12595275 PMID:21687637 PMID:21984483 PMID:23144690 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 decreases secretion
multiple interactions
ISO diphenyleneiodonium results in decreased secretion of HMGB1 protein
diphenyleneiodonium promotes the reaction [gamma-mangostin results in decreased secretion of HMGB1 protein]; gamma-mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein]
CTD PMID:30502394 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]
diphenyleneiodonium inhibits the reaction [arsenic trioxide results in increased expression of HMOX1 protein]; diphenyleneiodonium inhibits the reaction [monomethylarsonous acid results in increased expression of HMOX1 protein]
CTD PMID:18336854 PMID:20934533 PMID:26945724 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions EXP diphenyleneiodonium inhibits the reaction [Paraquat affects the localization of HTR2A protein] CTD PMID:25947082 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of ICAM1 protein] CTD PMID:19632255 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions EXP diphenyleneiodonium results in decreased susceptibility to [IFNG protein co-treated with Lipopolysaccharides] CTD PMID:16307444 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il17a interleukin 17A multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein] CTD PMID:19940258 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL18 protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [IL18 protein results in increased expression of BSG mRNA]
diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL18 protein]; diphenyleneiodonium inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL18 protein]
CTD PMID:19561311 PMID:27311643 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO diphenyleneiodonium inhibits the reaction [Adenosine Triphosphate results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Silicon Dioxide analog promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; diphenyleneiodonium inhibits the reaction [Silicon Dioxide analog results in increased secretion of IL1B protein]
diphenyleneiodonium inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; diphenyleneiodonium inhibits the reaction [IL1B protein affects the localization of NCF1 protein]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased secretion of IL1B protein]; diphenyleneiodonium inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]
diphenyleneiodonium results in decreased susceptibility to IL1B protein
CTD PMID:18403674 PMID:19005069 PMID:19281832 PMID:21211511 PMID:23940760 PMID:24685903 PMID:27311643 PMID:27393034 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Indinavir results in increased expression of IL6 protein]; diphenyleneiodonium inhibits the reaction [Lopinavir results in increased expression of IL6 protein]; diphenyleneiodonium inhibits the reaction [Nelfinavir results in increased expression of IL6 protein]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased expression of IL6 mRNA]; diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein] CTD PMID:11950692 PMID:17668557 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ins2 insulin 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [INS protein results in increased expression of TRPC6 protein] CTD PMID:22031853 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Itga2b integrin subunit alpha 2b multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein] CTD PMID:20523355 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO diphenyleneiodonium inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA] CTD PMID:16357311 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein] CTD PMID:20523355 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of JUN protein]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of JUN protein] CTD PMID:14687664 PMID:25199686 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lep leptin multiple interactions ISO diphenyleneiodonium inhibits the reaction [Indinavir results in decreased expression of LEP protein]; diphenyleneiodonium inhibits the reaction [Lopinavir results in decreased expression of LEP protein]; diphenyleneiodonium inhibits the reaction [Nelfinavir results in decreased expression of LEP protein]; diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:12,918,352...12,922,509
Ensembl chr 7:12,918,710...12,922,112
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
diphenyleneiodonium inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]
diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
CTD PMID:11880281 PMID:15978937 PMID:16571865 PMID:16632126 PMID:17384286 PMID:19371610 PMID:19429262 PMID:19804834 PMID:21391979 PMID:21687637 PMID:21984483 PMID:22142850 PMID:23774252 PMID:25199686 PMID:26514923 PMID:30766661 PMID:31838053 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein] CTD PMID:19767766 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased phosphorylation of and results in increased activity of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
diphenyleneiodonium inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
diphenyleneiodonium inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:11880281 PMID:15978937 PMID:16571865 PMID:16632126 PMID:17384286 PMID:19371610 PMID:19429262 PMID:19804834 PMID:21391979 PMID:21687637 PMID:21984483 PMID:22142850 PMID:23774252 PMID:25199686 PMID:26514923 PMID:30766661 PMID:31838053 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK8 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK8 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK8 protein] CTD PMID:21391979 PMID:26514923 PMID:30766661 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; diphenyleneiodonium inhibits the reaction [Cadmium results in increased phosphorylation of MAPK9 protein]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased phosphorylation of MAPK9 protein] CTD PMID:21391979 PMID:26514923 PMID:30766661 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of MMP1 mRNA]; diphenyleneiodonium inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA] CTD PMID:17449795 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression
multiple interactions
ISO diphenyleneiodonium results in decreased expression of MMP12 mRNA
diphenyleneiodonium inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]
CTD PMID:23978445 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:21211511 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Doxorubicin results in increased expression of MMP2 mRNA] CTD PMID:16213474 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [Hydrogen Peroxide results in increased expression of MMP9 mRNA]; diphenyleneiodonium inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
diphenyleneiodonium inhibits the reaction [RELA protein binds to MMP9 promoter]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; diphenyleneiodonium promotes the reaction [Doxorubicin results in increased expression of MMP9 mRNA]
diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]
CTD PMID:15557194 PMID:16213474 PMID:19804834 PMID:23774252 PMID:26514923 PMID:30766661 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO diphenyleneiodonium inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]] CTD PMID:22906169 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO diphenyleneiodonium inhibits the reaction [Resveratrol affects the expression of MYC protein] CTD PMID:31151226 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL17A protein results in increased phosphorylation of MYL9 protein] CTD PMID:19940258 NCBI chr 3:152,857,573...152,863,961
Ensembl chr 3:152,857,592...152,863,960
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IL1B protein affects the localization of NCF1 protein] CTD PMID:19281832 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions EXP [diphenyleneiodonium co-treated with mitoquinol co-treated with mitoquinone] inhibits the reaction [Doxorubicin affects the localization of NFATC3 protein] CTD PMID:15799720 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [phenethyl isothiocyanate affects the localization of NFE2L2 protein] CTD PMID:26945724 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity
ISO diphenyleneiodonium inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]]
diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]]
diphenyleneiodonium results in decreased activity of NFKB1 protein
CTD PMID:11950692 PMID:12477282 PMID:18922898 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
affects activity
decreases activity
ISO diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
diphenyleneiodonium affects the activity of NOS2 protein
diphenyleneiodonium results in decreased activity of NOS2 protein
CTD PMID:19005069 PMID:26880746 PMID:31306686 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in decreased expression of NOS3 protein] CTD PMID:26906511 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 decreases activity
multiple interactions
ISO diphenyleneiodonium results in decreased activity of NOX1 protein
diphenyleneiodonium inhibits the reaction [NOX1 protein results in increased abundance of Superoxides]
[diphenyleneiodonium results in decreased activity of NOX1 protein] inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased abundance of Reactive Oxygen Species]; [diphenyleneiodonium results in decreased activity of NOX1 protein] which results in decreased susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]
CTD PMID:16393473 PMID:22307971 PMID:24912985 PMID:30797899 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein] CTD PMID:26906511 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions ISO diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS1 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS1 protein] CTD PMID:20036696 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:20036696 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO diphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of PARK7 protein] CTD PMID:11811539 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein]
diphenyleneiodonium inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein]
CTD PMID:14687664 PMID:25947082 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases activity
ISO
EXP
diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of Oxygen]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of NADP]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Paraquat] which results in increased metabolism of Oxygen]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased activity of POR protein]
diphenyleneiodonium results in decreased activity of POR protein
diphenyleneiodonium inhibits the reaction [POR protein affects the metabolism of Nitrofurantoin]
diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Hydroxyl Radical]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [[POR protein results in increased metabolism of Diquat] which results in increased metabolism of NADP]
CTD PMID:18206659 PMID:20934533 PMID:21215309 PMID:31356851 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A multiple interactions EXP diphenyleneiodonium inhibits the reaction [AGT protein results in increased phosphorylation of PPP1R12A protein] CTD PMID:16569756 NCBI chr 7:51,404,971...51,515,382
Ensembl chr 7:51,404,919...51,515,373
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP
diphenyleneiodonium inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of PRKCD protein]; diphenyleneiodonium inhibits the reaction [Ursodeoxycholic Acid results in increased localization of PRKCD protein]
diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of PRKCD protein]
CTD PMID:12821678 PMID:21362627 PMID:21420390 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon multiple interactions ISO diphenyleneiodonium inhibits the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) affects the localization of PRKCE protein] CTD PMID:21420390 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Glucose results in decreased expression of PRKG1 protein] CTD PMID:17320767 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]
diphenyleneiodonium inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of PTGS2 mRNA]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of PTGS2 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of PTGS2 protein]
CTD PMID:14687664 PMID:16024921 PMID:19804834 PMID:22288910 PMID:25199686 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions EXP diphenyleneiodonium inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein] CTD PMID:23774252 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions EXP diphenyleneiodonium inhibits the reaction [EDN1 protein results in increased oxidation of PTPN11 protein] CTD PMID:16391241 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Fungal Polysaccharides results in increased activity of RAC1 protein] CTD PMID:24447977 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
diphenyleneiodonium inhibits the reaction [RELA protein binds to MMP9 promoter]; diphenyleneiodonium inhibits the reaction [TNF protein affects the localization of RELA protein]
diphenyleneiodonium inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency promotes the reaction [RELA protein binds to NFKB1 protein]]; diphenyleneiodonium inhibits the reaction [VEGFA protein affects the localization of RELA protein]
diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]]; diphenyleneiodonium inhibits the reaction [Endosulfan results in increased expression of RELA protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
CTD PMID:11950692 PMID:12477282 PMID:15308628 PMID:19281832 PMID:19608869 PMID:23774252 PMID:25199686 PMID:27393034 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP diphenyleneiodonium inhibits the reaction [AGT protein affects the localization of RHOA protein]; diphenyleneiodonium inhibits the reaction [Brimonidine Tartrate promotes the reaction [AGT protein results in increased expression of RHOA protein]] CTD PMID:16569756 PMID:18250367 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein] CTD PMID:21984483 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO diphenyleneiodonium inhibits the reaction [S100B protein results in increased expression of NOX2 mRNA] CTD PMID:17327432 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of SCARB1 protein] CTD PMID:22442701 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [erastin results in increased expression of SESN2 protein] CTD PMID:31323261 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of SMAD2 protein] CTD PMID:31838053 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of SMAD4 protein] CTD PMID:31838053 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Snca synuclein alpha multiple interactions ISO [N-((3-(aminomethyl)phenyl)methyl)ethanimidamide co-treated with diphenyleneiodonium] inhibits the reaction [SNCA protein mutant form results in increased susceptibility to Lipopolysaccharides] CTD PMID:21245015 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SOD2 mRNA] CTD PMID:10601319 PMID:21705328 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein]; diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT3 protein]; diphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT3 protein] CTD PMID:19429262 PMID:20523355 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO diphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of STAT5A protein]; diphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT5A protein] CTD PMID:20523355 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Tert telomerase reverse transcriptase multiple interactions ISO diphenyleneiodonium inhibits the reaction [Arsenic Trioxide results in decreased activity of TERT protein]; diphenyleneiodonium inhibits the reaction [monomethylarsonous acid results in decreased activity of TERT protein] CTD PMID:18336854 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP
ISO
diphenyleneiodonium inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 mRNA]; diphenyleneiodonium inhibits the reaction [Pyruvaldehyde results in increased expression of TGFB1 protein]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [TGFB1 protein results in increased activity of CASP3 protein]
diphenyleneiodonium inhibits the reaction [4-cresol sulfate results in increased expression of and results in increased secretion of TGFB1 protein]
CTD PMID:14732287 PMID:17635749 PMID:23325087 PMID:31838053 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thpo thrombopoietin multiple interactions ISO diphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT3 protein]; diphenyleneiodonium inhibits the reaction [THPO protein results in increased phosphorylation of STAT5A protein] CTD PMID:20523355 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO
EXP
diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased secretion of IL1B protein]
diphenyleneiodonium inhibits the reaction [Palmitates results in increased expression of TNF mRNA]; diphenyleneiodonium inhibits the reaction [Palmitates results in increased expression of TNF protein]; diphenyleneiodonium inhibits the reaction [Particulate Matter results in increased expression of TNF protein]; diphenyleneiodonium inhibits the reaction [TNF protein affects the localization of RELA protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in decreased phosphorylation of PTK2B protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Vehicle Emissions results in increased expression of TNF protein]
diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein]; diphenyleneiodonium inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]
diphenyleneiodonium results in decreased susceptibility to TNF protein
CTD PMID:12388057 PMID:14576080 PMID:16632126 PMID:17471172 PMID:18474546 PMID:19608869 PMID:21211511 PMID:23774252 PMID:23940760 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions
decreases expression
ISO diphenyleneiodonium inhibits the reaction [INS protein results in increased expression of TRPC6 protein]
diphenyleneiodonium results in decreased expression of TRPC6 protein
CTD PMID:22031853 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO diphenyleneiodonium promotes the reaction [NCX 4040 results in increased oxidation of TXN1 protein] CTD PMID:18922898 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [Paraquat results in increased activity of TXNRD1 protein]; diphenyleneiodonium inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid] CTD PMID:17229725 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 multiple interactions ISO diphenyleneiodonium inhibits the reaction [VAV2 protein affects the localization of CD38 protein]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased abundance of Superoxides]; diphenyleneiodonium inhibits the reaction [VAV2 protein results in increased expression of and results in increased activity of CD38 protein] CTD PMID:23940720 NCBI chr 3:5,811,504...5,976,311
Ensembl chr 3:5,811,504...5,976,244
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO diphenyleneiodonium inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of VCAM1 protein]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of VCAM1 mRNA]; diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein] CTD PMID:19281832 PMID:19632255 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO diphenyleneiodonium inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; diphenyleneiodonium inhibits the reaction [VEGFA protein affects the localization of RELA protein]; diphenyleneiodonium inhibits the reaction [VEGFA protein results in increased phosphorylation of FOXO1 protein]
diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]
CTD PMID:15308628 PMID:20116427 PMID:21687637 PMID:23144690 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Zfp143 zinc finger protein 143 multiple interactions ISO diphenyleneiodonium inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein] CTD PMID:20733350 NCBI chr 1:174,702,310...174,738,133
Ensembl chr 1:174,702,373...174,738,126
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    chemical entity 19773
      molecular entity 19771
        ion 15935
          organic ion 8447
            organic cation 7303
              dibenziodolium 121
                dibenziodolium chloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    main group molecular entity 19665
                      p-block molecular entity 19665
                        carbon group molecular entity 19583
                          organic molecular entity 19573
                            organic ion 8447
                              organic cation 7303
                                dibenziodolium 121
                                  dibenziodolium chloride 0
paths to the root