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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oseltamivir
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Accession:CHEBI:7798 term browser browse the term
Definition:A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.
Synonyms:exact_synonym: ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
 related_synonym: 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R-(3alpha,4beta,5alpha))-;   Agucort;   Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate;   Formula=C16H28N2O4;   GS-4104;   HSDB 7433;   InChI=1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1;   InChIKey=VSZGPKBBMSAYNT-RRFJBIMHSA-N;   SMILES=CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1;   Tamiflu;   oseltamivirum
 alt_id: CHEBI:42582
 xref: Beilstein:8003908;   CAS:196618-13-0;   DrugBank:DB00198;   Drug_Central:2001;   HMDB:HMDB0014343;   KEGG:C08092;   KEGG:D08306
 xref_mesh: MESH:D053139
 xref: PMID:11075941;   PMID:11270942;   PMID:11825310;   PMID:17912363;   PMID:18559644;   PMID:18936828;   PMID:19355841;   PMID:19439487;   PMID:19557131;   PMID:19884755;   Patent:US5763483;   Reaxys:8003908;   Wikipedia:Oseltamivir


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oseltamivir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Oseltamivir binds to and results in decreased activity of AR protein; Oseltamivir binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ces1d carboxylesterase 1D affects hydrolysis
multiple interactions
increases metabolic processing		 ISO CES1 protein affects the hydrolysis of Oseltamivir
7,8-dihydromethysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; [CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate; [hirsutine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [mitragynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [paynantheine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [Plant Extracts results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [speciogynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; desmethoxyyangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; dihydrokavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; kavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; methysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; yangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]		 CTD PMID:18983829 PMID:35278473 PMID:37716419 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Il6 interleukin 6 decreases response to substance ISO IL6 protein results in decreased susceptibility to Oseltamivir CTD PMID:17537833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO Oseltamivir binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Oseltamivir results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        xenobiotic 18732
          oseltamivir 5
            oseltamivir phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            heteroorganic entity 19541
                              organochalcogen compound 19301
                                organooxygen compound 19193
                                  carbon oxoacid 18681
                                    carboxylic acid 18678
                                      carboacyl group 17728
                                        univalent carboacyl group 17728
                                          carbamoyl group 17548
                                            carboxamide 17580
                                              acetamides 14651
                                                oseltamivir 5
                                                  oseltamivir phosphate 0
paths to the root