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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oseltamivir
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Accession:CHEBI:7798 term browser browse the term
Definition:A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.
Synonyms:exact_synonym: ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
 related_synonym: 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R-(3alpha,4beta,5alpha))-;   Agucort;   Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate;   Formula=C16H28N2O4;   GS-4104;   HSDB 7433;   InChI=1S/C16H28N2O4/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19/h9,12-15H,5-8,17H2,1-4H3,(H,18,19)/t13-,14+,15+/m0/s1;   InChIKey=VSZGPKBBMSAYNT-RRFJBIMHSA-N;   SMILES=CCOC(=O)C1=C[C@@H](OC(CC)CC)[C@H](NC(C)=O)[C@@H](N)C1;   Tamiflu;   oseltamivirum
 alt_id: CHEBI:42582
 xref: Beilstein:8003908;   CAS:196618-13-0;   DrugBank:DB00198;   Drug_Central:2001;   HMDB:HMDB0014343;   KEGG:C08092;   KEGG:D08306
 xref_mesh: MESH:D053139
 xref: PMID:11075941;   PMID:11270942;   PMID:11825310;   PMID:17912363;   PMID:18559644;   PMID:18936828;   PMID:19355841;   PMID:19439487;   PMID:19557131;   PMID:19884755;   Patent:US5763483;   Reaxys:8003908;   Wikipedia:Oseltamivir



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oseltamivir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Oseltamivir binds to and results in decreased activity of AR protein; Oseltamivir binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ces1d carboxylesterase 1D affects hydrolysis
multiple interactions
increases metabolic processing
ISO CES1 protein affects the hydrolysis of Oseltamivir
7,8-dihydromethysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; [CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate; [hirsutine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [mitragynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [paynantheine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [Plant Extracts results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; [speciogynine results in decreased activity of CES1 protein] which results in decreased metabolism of Oseltamivir; desmethoxyyangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; dihydrokavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; kavain inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; methysticin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]; yangonin inhibits the reaction [[CES1 protein results in increased metabolism of Oseltamivir] which results in increased abundance of oseltamivir carboxylate]
CTD PMID:18983829 PMID:35278473 PMID:37716419 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Il6 interleukin 6 decreases response to substance ISO IL6 protein results in decreased susceptibility to Oseltamivir CTD PMID:17537833 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Oseltamivir binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Oseltamivir results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        xenobiotic 18778
          oseltamivir 5
            oseltamivir phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                acetamides 14649
                                                  oseltamivir 5
                                                    oseltamivir phosphate 0
paths to the root