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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:humectant
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Accession:CHEBI:77968 term browser browse the term
Definition:A compound that is used to keep a substance moist.
Synonyms:related_synonym: humectants
 xref: Wikipedia:humectant


show annotations for term's descendants           Sort by:
D-glucitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions
increases abundance		 ISO AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol]
AKR1B1 protein results in increased abundance of Sorbitol		 CTD PMID:25451566 PMID:25541468 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO [Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein CTD PMID:10779545 PMID:11698504 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions
increases uptake		 ISO
EXP		 Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite]
AQP9 protein results in increased uptake of Sorbitol		 CTD PMID:9733774 PMID:19341753 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Bola2 bolA family member 2 increases expression ISO Sorbitol results in increased expression of BOLA2 mRNA CTD PMID:35678645 NCBI chr 1:190,722,535...190,723,401
Ensembl chr 1:181,291,398...181,292,676 		JBrowse link
G Caprin1 cell cycle associated protein 1 multiple interactions ISO Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] CTD PMID:33939924 NCBI chr 3:110,606,489...110,685,408
Ensembl chr 3:90,153,620...90,230,502 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 EXP Sorbitol results in increased activity of CASP3 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]		 CTD PMID:20609311 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions		 EXP Sorbitol results in increased activity of CASP8 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]		 CTD PMID:20609311 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 EXP Sorbitol results in increased activity of CASP9 protein
Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]		 CTD PMID:20609311 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccna1 cyclin A1 decreases expression ISO Sorbitol results in decreased expression of CCNA1 mRNA CTD PMID:35678645 NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccnf cyclin F increases expression ISO Sorbitol results in increased expression of CCNF mRNA CTD PMID:35678645 NCBI chr10:13,757,884...13,783,669
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Sorbitol results in decreased expression of CDK1 mRNA CTD PMID:35678645 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Chkb choline kinase beta decreases expression ISO Sorbitol results in decreased expression of CHKB mRNA CTD PMID:35678645 NCBI chr 7:122,380,592...122,385,102
Ensembl chr 7:120,500,984...120,504,461 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein increases phosphorylation EXP Sorbitol results in increased phosphorylation of CRK protein CTD PMID:16187300 NCBI chr10:61,028,736...61,054,971
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression ISO Sorbitol results in increased expression of DDB1 mRNA CTD PMID:35678645 NCBI chr 1:216,677,810...216,703,605
Ensembl chr 1:207,252,890...207,278,676 		JBrowse link
G Eef1d eukaryotic translation elongation factor 1 delta increases expression ISO Sorbitol results in increased expression of EEF1D mRNA CTD PMID:35678645 NCBI chr 7:109,462,645...109,478,021
Ensembl chr 7:107,581,930...107,608,799 		JBrowse link
G Eif3h eukaryotic translation initiation factor 3, subunit H decreases expression ISO Sorbitol results in decreased expression of EIF3H mRNA CTD PMID:35678645 NCBI chr 7:84,980,891...85,064,284
Ensembl chr 7:83,091,039...83,174,451 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:9545260 NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] CTD PMID:9545260 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eny2 ENY2, transcription and export complex 2 subunit increases expression ISO Sorbitol results in increased expression of ENY2 mRNA CTD PMID:35678645 NCBI chr 7:77,465,885...77,489,637
Ensembl chr 7:75,581,240...75,605,897 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 increases abundance ISO FMR1 5' UTR mutant form results in increased abundance of Sorbitol CTD PMID:27385396 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Sorbitol promotes the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:10221768 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation		 ISO JNK-IN-8 inhibits the reaction [Sorbitol results in increased phosphorylation of JUN protein] CTD PMID:24184208 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
increases activity		 ISO Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK12 protein CTD PMID:15362974 NCBI chr 7:122,085,647...122,096,307
Ensembl chr 7:120,206,271...120,216,664 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK14 protein CTD PMID:15362974 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 increases activity ISO Sorbitol results in increased activity of MAPK7 protein CTD PMID:11163183 NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,170,167...46,176,267 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK8 protein CTD PMID:24184208 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO Sorbitol results in increased phosphorylation of MAPK9 protein CTD PMID:24184208 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases activity
increases phosphorylation
multiple interactions		 ISO Sorbitol results in increased activity of MAPKAPK2 protein
Sorbitol results in increased phosphorylation of MAPKAPK2 protein
SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein]		 CTD PMID:9545260 PMID:15362974 NCBI chr13:45,066,027...45,112,326
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 increases activity ISO Sorbitol results in increased activity of MKNK1 protein CTD PMID:9545260 NCBI chr 5:134,554,881...134,594,392
Ensembl chr 5:129,318,170...129,357,639 		JBrowse link
G Mrps16 mitochondrial ribosomal protein S16 decreases expression ISO Sorbitol results in decreased expression of MRPS16 mRNA CTD PMID:35678645 NCBI chr15:3,967,809...3,970,211
Ensembl chr15:3,918,615...3,921,656 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Sorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 increases expression ISO Sorbitol results in increased expression of PPT1 mRNA CTD PMID:35678645 NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Pten phosphatase and tensin homolog affects localization ISO
EXP		 Sorbitol affects the localization of PTEN protein CTD PMID:16807353 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rpl18 ribosomal protein L18 increases expression ISO Sorbitol results in increased expression of RPL18 mRNA CTD PMID:35678645 NCBI chr 1:105,325,269...105,327,911
Ensembl chr 1:96,188,112...96,191,452 		JBrowse link
G Snrnp200 small nuclear ribonucleoprotein U5 subunit 200 multiple interactions ISO Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] CTD PMID:33939924 NCBI chr 3:134,882,173...134,911,512
Ensembl chr 3:114,428,854...114,458,182 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions
increases abundance
increases metabolic processing		 ISO [SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose; epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]; ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] CTD PMID:32367058 NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Tardbp TAR DNA binding protein increases ubiquitination ISO Sorbitol results in increased ubiquitination of TARDBP protein CTD PMID:31780563 NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO Sorbitol results in increased expression of TK1 mRNA CTD PMID:35678645 NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C decreases expression ISO Sorbitol results in decreased expression of UBE2C mRNA CTD PMID:35678645 NCBI chr 3:173,925,975...173,928,375
Ensembl chr 3:153,506,636...153,513,339 		JBrowse link
G Ubxn1 UBX domain protein 1 increases phosphorylation ISO Sorbitol results in increased phosphorylation of UBXN1 protein CTD PMID:15362974 NCBI chr 1:215,194,418...215,198,343
Ensembl chr 1:205,745,120...205,816,520 		JBrowse link
D-mannitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1 mRNA]; Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1A mRNA] CTD PMID:15327746 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acacb acetyl-CoA carboxylase beta decreases expression ISO Mannitol results in decreased expression of ACACB mRNA CTD PMID:25270620 NCBI chr12:48,026,394...48,138,214
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Acly ATP citrate lyase increases expression ISO Mannitol results in increased expression of ACLY mRNA CTD PMID:25270620 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 increases expression ISO Mannitol results in increased expression of ADAMTS18 mRNA CTD PMID:25270620 NCBI chr19:58,596,095...58,749,239
Ensembl chr19:41,688,617...41,839,781 		JBrowse link
G Aida axin interactor, dorsalization associated decreases expression ISO Mannitol results in decreased expression of AIDA mRNA CTD PMID:25270620 NCBI chr13:97,471,931...97,499,531
Ensembl chr13:94,939,741...94,967,920 		JBrowse link
G Aire autoimmune regulator decreases expression ISO Mannitol results in decreased expression of AIRE mRNA CTD PMID:25270620 NCBI chr20:10,635,775...10,650,709
Ensembl chr20:10,636,123...10,651,060 		JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Mannitol CTD PMID:9733774 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression ISO Mannitol results in increased expression of ARHGAP1 mRNA CTD PMID:25270620 NCBI chr 3:98,077,064...98,099,163
Ensembl chr 3:77,620,655...77,643,396 		JBrowse link
G Arr3 arrestin 3 increases expression ISO Mannitol results in increased expression of ARR3 mRNA CTD PMID:25270620 NCBI chr  X:69,739,959...69,752,300
Ensembl chr  X:65,698,699...65,712,153 		JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation
multiple interactions		 EXP Mannitol results in increased phosphorylation of BAD protein
wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]		 CTD PMID:15786717 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO Mannitol results in decreased expression of BBOX1 mRNA CTD PMID:25270620 NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:96,822,655...96,871,458 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Mannitol results in increased expression of BCL2 protein CTD PMID:15786717 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cables2 Cdk5 and Abl enzyme substrate 2 decreases expression ISO Mannitol results in decreased expression of CABLES2 mRNA CTD PMID:25270620 NCBI chr 3:187,725,128...187,739,880
Ensembl chr 3:167,347,461...167,362,279 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein] CTD PMID:10567913 PMID:12011046 PMID:29803612 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO Mannitol results in increased activity of CASP9 protein CTD PMID:12011046 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cbx1 chromobox 1 increases expression ISO Mannitol results in increased expression of CBX1 mRNA CTD PMID:25270620 NCBI chr10:82,266,746...82,286,431
Ensembl chr10:81,770,342...81,791,096 		JBrowse link
G Ccdc127 coiled-coil domain containing 127 decreases expression ISO Mannitol results in decreased expression of CCDC127 mRNA CTD PMID:25270620 NCBI chr 1:30,757,010...30,764,473
Ensembl chr 1:28,928,325...28,935,893 		JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO Mannitol results in decreased expression of CCN3 mRNA CTD PMID:25270620 NCBI chr 7:87,983,788...87,990,810
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Ckap5 cytoskeleton associated protein 5 increases expression ISO Mannitol results in increased expression of CKAP5 mRNA CTD PMID:25270620 NCBI chr 3:97,946,966...98,049,050
Ensembl chr 3:77,491,276...77,593,264 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 affects response to substance ISO CLCN3 protein affects the susceptibility to Mannitol deficiency CTD PMID:22108225 NCBI chr16:34,138,004...34,210,984
Ensembl chr16:29,127,419...29,200,119 		JBrowse link
G Ctnna2 catenin alpha 2 decreases expression ISO Mannitol results in decreased expression of CTNNA2 mRNA CTD PMID:25270620 NCBI chr 4:110,852,265...112,001,351
Ensembl chr 4:109,293,978...110,443,522 		JBrowse link
G Dbh dopamine beta-hydroxylase increases expression ISO Mannitol results in increased expression of DBH mRNA CTD PMID:25270620 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Dctn2 dynactin subunit 2 increases expression ISO Mannitol results in increased expression of DCTN2 mRNA CTD PMID:25270620 NCBI chr 7:64,977,338...64,992,875
Ensembl chr 7:63,092,057...63,108,543 		JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO Mannitol results in increased expression of DGKA mRNA CTD PMID:25270620 NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,148,735...1,175,110 		JBrowse link
G Elf2 E74 like ETS transcription factor 2 increases expression ISO Mannitol results in increased expression of ELF2 mRNA CTD PMID:25270620 NCBI chr 2:137,445,787...137,536,512
Ensembl chr 2:135,294,906...135,385,947 		JBrowse link
G Fam185a family with sequence similarity 185, member A increases expression ISO Mannitol results in increased expression of FAM185A mRNA CTD PMID:25270620 NCBI chr 4:14,469,165...14,555,167
Ensembl chr 4:13,608,464...13,662,967 		JBrowse link
G Fam222a family with sequence similarity 222, member A decreases expression ISO Mannitol results in decreased expression of FAM222A mRNA CTD PMID:25270620 NCBI chr12:47,647,221...47,693,703
Ensembl chr12:41,986,780...42,033,682 		JBrowse link
G Fgf23 fibroblast growth factor 23 decreases export
decreases expression
multiple interactions		 EXP
ISO		 Mannitol results in decreased export of FGF23 protein
Mannitol results in decreased expression of FGF23 mRNA
Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 mRNA]; Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 protein]		 CTD PMID:37992803 NCBI chr 4:161,600,439...161,609,991
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mannitol results in increased expression of FOS mRNA CTD PMID:11557636 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gal3st2 galactose-3-O-sulfotransferase 2 decreases expression ISO Mannitol results in decreased expression of GAL3ST2 mRNA CTD PMID:25270620 NCBI chr 9:101,823,815...101,836,507
Ensembl chr 9:94,376,174...94,389,174 		JBrowse link
G Gas2l2 growth arrest-specific 2 like 2 decreases expression ISO Mannitol results in decreased expression of GAS2L2 mRNA CTD PMID:25270620 NCBI chr10:68,719,999...68,727,549
Ensembl chr10:68,222,475...68,229,881 		JBrowse link
G Gpc6 glypican 6 increases expression ISO Mannitol results in increased expression of GPC6 mRNA CTD PMID:25270620 NCBI chr15:100,437,415...101,435,038
Ensembl chr15:94,029,884...95,024,006 		JBrowse link
G Gpr19 G protein-coupled receptor 19 decreases expression ISO Mannitol results in decreased expression of GPR19 mRNA CTD PMID:25270620 NCBI chr 4:169,442,278...169,468,805
Ensembl chr 4:167,710,666...167,741,036 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Mannitol results in increased expression of HMOX1 mRNA CTD PMID:11592956 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO Mannitol results in increased expression of HPRT1 mRNA CTD PMID:25270620 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hrh2 histamine receptor H 2 increases expression ISO Mannitol results in increased expression of HRH2 mRNA CTD PMID:25270620 NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:16285992 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein] CTD PMID:10567913 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Rotenone inhibits the reaction [Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] CTD PMID:23867654 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mannitol results in increased expression of JUN mRNA CTD PMID:11557636 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member increases expression ISO Mannitol results in increased expression of KHDC3 mRNA CTD PMID:25270620 NCBI chr 8:82,722,980...82,724,884
Ensembl chr 8:73,842,344...73,844,248 		JBrowse link
G Krtap11-1 keratin associated protein 11-1 increases expression ISO Mannitol results in increased expression of KRTAP11-1 mRNA CTD PMID:25270620 NCBI chr11:42,296,147...42,297,151
Ensembl chr11:28,810,341...28,810,892 		JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Mannitol results in decreased expression of LSM6 mRNA CTD PMID:25270620 NCBI chr19:46,002,592...46,017,152
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein] CTD PMID:16510265 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein] CTD PMID:16510265 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK1 protein] CTD PMID:10910949 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK8 protein] CTD PMID:10910949 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mta2 metastasis associated 1 family, member 2 increases expression ISO Mannitol results in increased expression of MTA2 mRNA CTD PMID:25270620 NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:205,837,964...205,846,946 		JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP Mannitol results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:165,742,020...165,748,409
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Mylk3 myosin light chain kinase 3 increases expression ISO Mannitol results in increased expression of MYLK3 mRNA CTD PMID:25270620 NCBI chr19:37,858,298...37,916,805
Ensembl chr19:21,691,929...21,742,954 		JBrowse link
G Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 increases expression ISO Mannitol results in increased expression of NAALAD2 mRNA CTD PMID:25270620 NCBI chr 8:23,682,499...23,756,066
Ensembl chr 8:15,407,043...15,479,714 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 decreases expression ISO Mannitol results in decreased expression of NDUFA13 mRNA CTD PMID:25270620 NCBI chr16:19,560,526...19,567,500
Ensembl chr16:19,526,565...19,535,726
Ensembl chr 7:19,526,565...19,535,726 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression
multiple interactions		 ISO
EXP		 Mannitol results in increased expression of NFAT5 mRNA
Mannitol results in increased expression of NFAT5 mRNA; Mannitol results in increased expression of NFAT5 protein
Mannitol inhibits the reaction [Sodium Chloride deficiency results in decreased expression of NFAT5 mRNA]		 CTD PMID:23867654 PMID:37992803 NCBI chr19:52,108,982...52,196,418
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nkg7 natural killer cell granule protein 7 increases expression ISO Mannitol results in increased expression of NKG7 mRNA CTD PMID:25270620 NCBI chr 1:102,981,497...102,982,564
Ensembl chr 1:93,844,902...93,845,983 		JBrowse link
G Nppa natriuretic peptide A increases expression ISO Mannitol results in increased expression of NPPA protein CTD PMID:2177369 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nts neurotensin increases transport EXP NTS protein results in increased transport of Mannitol CTD PMID:11208724 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Mannitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Pcp2 Purkinje cell protein 2 increases expression ISO Mannitol results in increased expression of PCP2 mRNA CTD PMID:25270620 NCBI chr12:6,479,554...6,481,550
Ensembl chr12:1,681,659...1,683,899 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression
decreases expression		 ISO Mannitol results in increased expression of PDCD4 mRNA
Mannitol results in decreased expression of PDCD4 mRNA		 CTD PMID:21873647 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression EXP Mannitol results in increased expression of PHEX mRNA CTD PMID:37992803 NCBI chr  X:41,422,561...41,671,226
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Plcl2 phospholipase C-like 2 decreases expression ISO Mannitol results in decreased expression of PLCL2 mRNA CTD PMID:25270620 NCBI chr 9:3,529,117...3,713,712
Ensembl chr 9:3,292,695...3,477,009 		JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Mannitol results in increased expression of PLEKHO1 mRNA CTD PMID:25270620 NCBI chr 2:186,233,435...186,242,114
Ensembl chr 2:183,544,499...183,552,785 		JBrowse link
G Pou1f1 POU class 1 homeobox 1 increases expression ISO Mannitol results in increased expression of POU1F1 mRNA CTD PMID:25270620 NCBI chr11:16,763,312...16,781,295
Ensembl chr11:3,317,058...3,334,801 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO Mannitol results in decreased expression of PPP1R10 mRNA CTD PMID:25270620 NCBI chr20:2,827,802...2,842,418
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
G Ppp4c protein phosphatase 4, catalytic subunit increases expression ISO Mannitol results in increased expression of PPP4C mRNA CTD PMID:25270620 NCBI chr 1:190,823,447...190,830,247
Ensembl chr 1:181,392,923...181,399,659 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]; Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein] CTD PMID:16285992 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of PRKCD protein] CTD PMID:16285992 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptger1 prostaglandin E receptor 1 increases expression EXP Mannitol results in increased expression of PTGER1 mRNA CTD PMID:12888618 NCBI chr19:41,374,983...41,379,593
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression EXP Mannitol results in decreased expression of PTGER4 mRNA CTD PMID:12888618 NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein]; Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein CTD PMID:12011046 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ralgdsl3 ral guanine nucleotide dissociation stimulator like 3 increases expression ISO Mannitol results in increased expression of RGL3 mRNA CTD PMID:25270620 NCBI chr 8:28,775,187...28,796,765
Ensembl chr 8:20,500,846...20,520,471 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Mannitol results in decreased expression of RBL1 mRNA CTD PMID:25270620 NCBI chr 3:166,226,187...166,289,862
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Rbp2 retinol binding protein 2 decreases expression ISO Mannitol results in decreased expression of RBP2 mRNA CTD PMID:25270620 NCBI chr 8:107,958,670...107,983,850
Ensembl chr 8:99,079,104...99,104,473 		JBrowse link
G Samd10 sterile alpha motif domain containing 10 decreases expression ISO Mannitol results in decreased expression of SAMD10 mRNA CTD PMID:25270620 NCBI chr 3:189,077,795...189,082,069
Ensembl chr 3:168,700,284...168,705,248 		JBrowse link
G Sbsn suprabasin decreases expression ISO Mannitol results in decreased expression of SBSN mRNA CTD PMID:25270620 NCBI chr 1:95,106,390...95,133,448
Ensembl chr 1:86,001,567...86,006,034 		JBrowse link
G Sele selectin E multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of SELE mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of SELE protein] CTD PMID:16285992 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sgsm3 small G protein signaling modulator 3 decreases expression ISO Mannitol results in decreased expression of SGSM3 mRNA CTD PMID:25270620 NCBI chr 7:114,394,724...114,424,285
Ensembl chr 7:112,514,630...112,544,108 		JBrowse link
G Slc12a1 solute carrier family 12 member 1 increases activity
multiple interactions		 EXP Mannitol results in increased activity of SLC12A1 protein
[Mannitol results in increased activity of SLC12A1 protein] which results in increased import of Water		 CTD PMID:12433675 NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc2a8 solute carrier family 2 member 8 decreases expression ISO Mannitol results in decreased expression of SLC2A8 mRNA CTD PMID:25270620 NCBI chr 3:36,672,589...36,682,206
Ensembl chr 3:16,274,925...16,284,464 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of SRC protein] CTD PMID:16510265 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stx8 syntaxin 8 decreases expression ISO Mannitol results in decreased expression of STX8 mRNA CTD PMID:25270620 NCBI chr10:53,154,572...53,393,912
Ensembl chr10:52,654,990...52,894,993 		JBrowse link
G Timd4 T-cell immunoglobulin and mucin domain containing 4 decreases expression ISO Mannitol results in decreased expression of TIMD4 mRNA CTD PMID:25270620 NCBI chr10:31,686,994...31,723,095
Ensembl chr10:31,185,731...31,220,966 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Mannitol inhibits the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; Mannitol inhibits the reaction [Quartz results in increased secretion of TNF protein] CTD PMID:19298665 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Mannitol results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpd52 tumor protein D52 decreases expression
increases expression		 ISO Mannitol results in decreased expression of TPD52 mRNA
Mannitol results in increased expression of TPD52 mRNA		 CTD PMID:21873647 NCBI chr 2:94,642,514...94,723,442
Ensembl chr 2:92,735,620...92,816,622 		JBrowse link
G Triml1 tripartite motif family-like 1 increases expression ISO Mannitol results in increased expression of TRIML1 mRNA CTD PMID:25270620 NCBI chr16:55,727,383...55,737,770
Ensembl chr16:48,997,252...49,005,417 		JBrowse link
G Ulbp1 UL16 binding protein 1 increases expression ISO Mannitol results in increased expression of ULBP1 mRNA CTD PMID:25270620 NCBI chr 1:3,506,106...3,527,982 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 protein] CTD PMID:16285992 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Wdr20 WD repeat domain 20 decreases expression ISO Mannitol results in decreased expression of WDR20 mRNA CTD PMID:25270620 NCBI chr 6:135,572,502...135,642,688
Ensembl chr 6:129,752,014...129,847,339 		JBrowse link
G Zfp13 zinc finger protein 13 decreases expression ISO Mannitol results in decreased expression of ZFP13 mRNA CTD PMID:25270620 NCBI chr10:13,119,707...13,128,284
Ensembl chr10:12,615,190...12,623,615 		JBrowse link
G Zg16 zymogen granule protein 16 decreases expression ISO Mannitol results in decreased expression of ZG16 mRNA CTD PMID:25270620 NCBI chr 1:191,088,248...191,090,605
Ensembl chr 1:181,657,722...181,660,079 		JBrowse link
triacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Biofuels co-treated with Triacetin] results in decreased expression of BCL2 mRNA CTD PMID:30738890 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Biofuels co-treated with Triacetin] results in decreased expression of CASP3 mRNA CTD PMID:30738890 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [Biofuels co-treated with Triacetin] affects the expression of CYP1A1 mRNA CTD PMID:30738890 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Triacetin results in increased expression of DDIT3 mRNA CTD PMID:21703327 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Biofuels co-treated with Triacetin] affects the expression of HMOX1 mRNA CTD PMID:30738890 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      application 19720
        humectant 130
          food humectant + 130
paths to the root