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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:food anticaking agent
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Accession:CHEBI:77965 term browser browse the term
Definition:An anticaking agent that is used to reduced the tendency of particles of food to adhere to one another.
Synonyms:related_synonym: food anti-caking agent;   food anti-caking agents


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calcium silicate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO calcium silicate results in increased expression of ADIPOQ mRNA CTD PMID:29279043 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Alb albumin increases expression ISO calcium silicate results in increased expression of ALB mRNA CTD PMID:29279043 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [Zinc binds to calcium silicate] which results in increased expression of ALPL mRNA CTD PMID:23483914 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor increases expression ISO calcium silicate results in increased expression of AMBP mRNA CTD PMID:29279043 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Ankrd39 ankyrin repeat domain 39 increases expression ISO calcium silicate results in increased expression of ANKRD39 mRNA CTD PMID:29279043 NCBI chr 9:38,780,291...38,790,177
Ensembl chr 9:38,781,785...38,790,201 		JBrowse link
G Aoah acyloxyacyl hydrolase increases expression ISO calcium silicate results in increased expression of AOAH mRNA CTD PMID:29279043 NCBI chr17:43,808,110...44,049,458
Ensembl chr17:43,809,638...44,049,148 		JBrowse link
G Apoa2 apolipoprotein A2 increases expression ISO calcium silicate results in increased expression of APOA2 mRNA CTD PMID:29279043 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355 		JBrowse link
G Apob apolipoprotein B increases expression ISO calcium silicate results in increased expression of APOB mRNA CTD PMID:29279043 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Armcx2 armadillo repeat containing, X-linked 2 decreases expression ISO calcium silicate results in decreased expression of ARMCX2 mRNA CTD PMID:29279043 NCBI chr  X:97,980,662...97,985,523
Ensembl chr  X:97,980,660...97,985,552 		JBrowse link
G Aste1 asteroid homolog 1 increases expression ISO calcium silicate results in increased expression of ASTE1 mRNA CTD PMID:29279043 NCBI chr 8:106,026,570...106,044,694
Ensembl chr 8:106,026,515...106,044,430 		JBrowse link
G Bcl9l BCL9 like decreases expression ISO calcium silicate results in decreased expression of BCL9L mRNA CTD PMID:29279043 NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611 		JBrowse link
G Bgn biglycan decreases expression ISO calcium silicate results in decreased expression of BGN mRNA CTD PMID:29279043 NCBI chr  X:151,197,296...151,209,458
Ensembl chr  X:151,197,273...151,209,461 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 increases expression ISO calcium silicate results in increased expression of BMAL1 mRNA CTD PMID:29279043 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Bptf bromodomain PHD finger transcription factor decreases expression ISO calcium silicate results in decreased expression of BPTF mRNA CTD PMID:29279043 NCBI chr10:91,980,279...92,082,731
Ensembl chr10:91,982,758...92,082,769 		JBrowse link
G Capns1 calpain, small subunit 1 decreases expression ISO calcium silicate results in decreased expression of CAPNS1 mRNA CTD PMID:29279043 NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795 		JBrowse link
G Car3 carbonic anhydrase 3 increases expression ISO calcium silicate results in increased expression of CAR3 mRNA CTD PMID:29279043 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP calcium silicate results in increased expression of CCL2 protein CTD PMID:16601788 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP calcium silicate results in increased expression of CCL3 protein CTD PMID:16601788 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit increases expression ISO calcium silicate results in increased expression of CHRNB3 mRNA CTD PMID:29279043 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Clca1 chloride channel accessory 1 increases expression ISO calcium silicate results in increased expression of CLCA1 mRNA CTD PMID:29279043 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [Zinc binds to calcium silicate] which results in increased expression of COL1A1 mRNA CTD PMID:23483914 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression ISO calcium silicate results in increased expression of CYBB mRNA CTD PMID:29279043 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Ddo D-aspartate oxidase decreases expression ISO calcium silicate results in decreased expression of DDO mRNA CTD PMID:29279043 NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095 		JBrowse link
G Dhx35 DEAH-box helicase 35 increases expression ISO calcium silicate results in increased expression of DHX35 mRNA CTD PMID:29279043 NCBI chr 3:147,450,178...147,507,473
Ensembl chr 3:147,450,163...147,507,451 		JBrowse link
G Dpp10 dipeptidyl peptidase like 10 increases expression ISO calcium silicate results in increased expression of DPP10 mRNA CTD PMID:29279043 NCBI chr13:34,584,420...36,269,292
Ensembl chr13:34,595,868...36,269,292 		JBrowse link
G Egfr epidermal growth factor receptor increases activity ISO calcium silicate results in increased activity of EGFR protein CTD PMID:21762757 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Epb42 erythrocyte membrane protein band 4.2 increases expression ISO calcium silicate results in increased expression of EPB42 mRNA CTD PMID:29279043 NCBI chr 3:107,979,709...107,997,932
Ensembl chr 3:107,979,713...107,997,932 		JBrowse link
G Fam83h family with sequence similarity 83, member H increases expression ISO calcium silicate results in increased expression of FAM83H mRNA CTD PMID:29279043 NCBI chr 7:107,716,431...107,724,619
Ensembl chr 7:107,716,431...107,728,672 		JBrowse link
G Fgg fibrinogen gamma chain increases expression ISO calcium silicate results in increased expression of FGG mRNA CTD PMID:29279043 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Fgl1 fibrinogen-like 1 increases expression ISO calcium silicate results in increased expression of FGL1 mRNA CTD PMID:29279043 NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions
increases secretion		 ISO RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of FLT1 protein] CTD PMID:21762757 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Gc GC, vitamin D binding protein increases expression ISO calcium silicate results in increased expression of GC mRNA CTD PMID:29279043 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Glt8d1 glycosyltransferase 8 domain containing 1 increases expression ISO calcium silicate results in increased expression of GLT8D1 mRNA CTD PMID:29279043 NCBI chr16:6,192,269...6,207,227
Ensembl chr16:6,192,300...6,207,229 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity EXP calcium silicate results in increased activity of GSR protein CTD PMID:16601788 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G H1f2 H1.2 linker histone, cluster member decreases expression ISO calcium silicate results in decreased expression of H1F2 mRNA CTD PMID:29279043 NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635 		JBrowse link
G Hlf HLF transcription factor, PAR bZIP family member decreases expression ISO calcium silicate results in decreased expression of HLF mRNA CTD PMID:29279043 NCBI chr10:75,154,244...75,211,884
Ensembl chr10:75,154,507...75,211,935 		JBrowse link
G Hmg20b high mobility group 20 B decreases expression ISO calcium silicate results in decreased expression of HMG20B mRNA CTD PMID:29279043 NCBI chr 7:8,368,934...8,373,650
Ensembl chr 7:8,368,990...8,373,640 		JBrowse link
G Hpcal1 hippocalcin-like 1 increases expression ISO calcium silicate results in increased expression of HPCAL1 mRNA CTD PMID:29279043 NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO [Zinc binds to calcium silicate] which results in increased expression of IGF1 mRNA CTD PMID:23483914 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 ISO Acetylcysteine inhibits the reaction [calcium silicate results in increased secretion of IL6 protein]; prolinedithiocarbamate inhibits the reaction [calcium silicate results in increased secretion of IL6 protein] CTD PMID:21762757 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ipmk inositol polyphosphate multikinase decreases expression ISO calcium silicate results in decreased expression of IPMK mRNA CTD PMID:29279043 NCBI chr20:17,216,988...17,251,675
Ensembl chr20:17,218,037...17,251,705 		JBrowse link
G Kank4 KN motif and ankyrin repeat domains 4 decreases expression ISO calcium silicate results in decreased expression of KANK4 mRNA CTD PMID:29279043 NCBI chr 5:113,401,491...113,465,526
Ensembl chr 5:113,402,468...113,465,555 		JBrowse link
G Kat8 lysine acetyltransferase 8 increases expression ISO calcium silicate results in increased expression of KAT8 mRNA CTD PMID:29279043 NCBI chr 1:182,524,355...182,536,638
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 decreases expression ISO calcium silicate results in decreased expression of KCNMB4 mRNA CTD PMID:29279043 NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278 		JBrowse link
G Kdr kinase insert domain receptor increases secretion ISO calcium silicate results in increased secretion of KDR protein CTD PMID:21762757 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Klhl2 kelch-like family member 2 decreases expression ISO calcium silicate results in decreased expression of KLHL2 mRNA CTD PMID:29279043 NCBI chr16:24,860,744...24,973,348
Ensembl chr16:24,860,667...24,973,341 		JBrowse link
G Ldb1 LIM domain binding 1 decreases expression ISO calcium silicate results in decreased expression of LDB1 mRNA CTD PMID:29279043 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013 		JBrowse link
G Lmo7 LIM domain 7 decreases expression ISO calcium silicate results in decreased expression of LMO7 mRNA CTD PMID:29279043 NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783 		JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression ISO calcium silicate results in decreased expression of LTN1 mRNA CTD PMID:29279043 NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886 		JBrowse link
G Malt1 MALT1 paracaspase increases expression ISO calcium silicate results in increased expression of MALT1 mRNA CTD PMID:29279043 NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO RTKI cpd inhibits the reaction [calcium silicate results in increased phosphorylation of MAPK1 protein] CTD PMID:21762757 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO calcium silicate results in increased phosphorylation of MAPK3 protein
RTKI cpd inhibits the reaction [calcium silicate results in increased phosphorylation of MAPK3 protein]		 CTD PMID:21762757 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Matk megakaryocyte-associated tyrosine kinase increases expression ISO calcium silicate results in increased expression of MATK mRNA CTD PMID:29279043 NCBI chr 7:8,456,990...8,465,947
Ensembl chr 7:8,456,998...8,462,022 		JBrowse link
G Mettl8 methyltransferase 8, tRNA N3-cytidine increases expression ISO calcium silicate results in increased expression of METTL8 mRNA CTD PMID:29279043 NCBI chr 3:55,731,453...55,863,652
Ensembl chr 3:55,770,167...55,863,676 		JBrowse link
G Mfsd11 major facilitator superfamily domain containing 11 decreases expression ISO calcium silicate results in decreased expression of MFSD11 mRNA CTD PMID:29279043 NCBI chr10:102,055,516...102,075,064
Ensembl chr10:102,056,051...102,075,064 		JBrowse link
G Mup18 major urinary protein 18 increases expression ISO calcium silicate results in increased expression of MUP18 mRNA CTD PMID:29279043 NCBI chr 5:74,986,813...74,990,071
Ensembl chr 5:74,842,319...75,061,474 		JBrowse link
G Naa38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit increases expression ISO calcium silicate results in increased expression of NAA38 mRNA CTD PMID:29279043 NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494 		JBrowse link
G Nanp N-acetylneuraminic acid phosphatase decreases expression ISO calcium silicate results in decreased expression of NANP mRNA CTD PMID:29279043 NCBI chr 3:139,826,549...139,841,655
Ensembl chr 3:139,826,549...139,841,648 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor increases expression ISO calcium silicate results in increased expression of NOP53 mRNA CTD PMID:29279043 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO calcium silicate results in decreased expression of NR1D1 mRNA CTD PMID:29279043 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 decreases expression ISO calcium silicate results in decreased expression of NR1D2 mRNA CTD PMID:29279043 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553 		JBrowse link
G Ntrk3 neurotrophic receptor tyrosine kinase 3 increases expression ISO calcium silicate results in increased expression of NTRK3 mRNA CTD PMID:29279043 NCBI chr 1:132,116,472...132,503,849
Ensembl chr 1:132,132,849...132,503,286 		JBrowse link
G Oaf out at first homolog increases expression ISO calcium silicate results in increased expression of OAF mRNA CTD PMID:29279043 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334 		JBrowse link
G Ormdl2 ORMDL sphingolipid biosynthesis regulator 2 increases expression ISO calcium silicate results in increased expression of ORMDL2 mRNA CTD PMID:29279043 NCBI chr 7:1,247,869...1,250,999
Ensembl chr 7:1,246,479...1,250,907 		JBrowse link
G Osbpl3 oxysterol binding protein-like 3 increases expression ISO calcium silicate results in increased expression of OSBPL3 mRNA CTD PMID:29279043 NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393 		JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 decreases expression ISO calcium silicate results in decreased expression of P4HA2 mRNA CTD PMID:29279043 NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,243,139...38,287,314 		JBrowse link
G Pag1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 decreases expression ISO calcium silicate results in decreased expression of PAG1 mRNA CTD PMID:29279043 NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849 		JBrowse link
G Per3 period circadian regulator 3 decreases expression ISO calcium silicate results in decreased expression of PER3 mRNA CTD PMID:29279043 NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607 		JBrowse link
G Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 decreases expression ISO calcium silicate results in decreased expression of PFKFB3 mRNA CTD PMID:29279043 NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125 		JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression ISO calcium silicate results in increased expression of PHGDH mRNA CTD PMID:29279043 NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression ISO calcium silicate results in increased expression of PIK3CG mRNA CTD PMID:29279043 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Plaa phospholipase A2, activating protein increases expression ISO calcium silicate results in increased expression of PLAA mRNA CTD PMID:29279043 NCBI chr 5:109,428,600...109,460,373
Ensembl chr 5:109,428,265...109,460,282 		JBrowse link
G Pmm2 phosphomannomutase 2 increases expression ISO calcium silicate results in increased expression of PMM2 mRNA CTD PMID:29279043 NCBI chr10:6,961,521...6,982,913
Ensembl chr10:6,961,709...6,983,098 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 decreases expression ISO calcium silicate results in decreased expression of PRPF19 mRNA CTD PMID:29279043 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases localization ISO calcium silicate results in increased localization of RELA protein CTD PMID:21762757 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rhobtb2 Rho-related BTB domain containing 2 increases expression ISO calcium silicate results in increased expression of RHOBTB2 mRNA CTD PMID:29279043 NCBI chr15:44,868,251...44,888,436
Ensembl chr15:44,870,376...44,888,651 		JBrowse link
G Rnmt RNA (guanine-7-) methyltransferase decreases expression ISO calcium silicate results in decreased expression of RNMT mRNA CTD PMID:29279043 NCBI chr18:61,886,230...61,909,775
Ensembl chr18:61,886,292...61,909,775 		JBrowse link
G Rps25 ribosomal protein s25 decreases expression ISO calcium silicate results in decreased expression of RPS25 mRNA CTD PMID:29279043 NCBI chr 8:44,733,623...44,735,999
Ensembl chr 8:44,733,029...44,737,271
Ensembl chr 8:44,733,029...44,737,271 		JBrowse link
G Rwdd3 RWD domain containing 3 increases expression ISO calcium silicate results in increased expression of RWDD3 mRNA CTD PMID:29279043 NCBI chr 2:209,233,622...209,254,842
Ensembl chr 2:209,233,622...209,248,853 		JBrowse link
G Scgb3a1 secretoglobin, family 3A, member 1 increases expression ISO calcium silicate results in increased expression of SCGB3A1 mRNA CTD PMID:29279043 NCBI chr10:33,968,059...33,969,366
Ensembl chr10:33,968,059...33,969,476 		JBrowse link
G Schip1 schwannomin interacting protein 1 decreases expression ISO calcium silicate results in decreased expression of SCHIP1 mRNA CTD PMID:29279043 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585 		JBrowse link
G Sgms1 sphingomyelin synthase 1 decreases expression ISO calcium silicate results in decreased expression of SGMS1 mRNA CTD PMID:29279043 NCBI chr 1:229,996,673...230,259,591
Ensembl chr 1:229,998,119...230,259,603 		JBrowse link
G Slc1a5 solute carrier family 1 member 5 decreases expression ISO calcium silicate results in decreased expression of SLC1A5 mRNA CTD PMID:29279043 NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952 		JBrowse link
G Slc38a10 solute carrier family 38, member 10 decreases expression ISO calcium silicate results in decreased expression of SLC38A10 mRNA CTD PMID:29279043 NCBI chr10:105,386,836...105,436,636
Ensembl chr10:105,386,836...105,436,636 		JBrowse link
G Slc6a13 solute carrier family 6 member 13 increases expression ISO calcium silicate results in increased expression of SLC6A13 mRNA CTD PMID:29279043 NCBI chr 4:154,539,246...154,577,784
Ensembl chr 4:154,540,468...154,576,152 		JBrowse link
G Snord61 small nucleolar RNA, C/D box 61 decreases expression ISO calcium silicate results in decreased expression of SNORD61 mRNA CTD PMID:29279043 NCBI chr  X:135,313,247...135,313,319
Ensembl chr  X:135,313,247...135,313,319 		JBrowse link
G Sod1 superoxide dismutase 1 decreases activity EXP calcium silicate results in decreased activity of SOD1 protein CTD PMID:16601788 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Ssbp3 single stranded DNA binding protein 3 decreases expression ISO calcium silicate results in decreased expression of SSBP3 mRNA CTD PMID:29279043 NCBI chr 5:121,691,370...121,828,035
Ensembl chr 5:121,691,393...121,827,992 		JBrowse link
G Taf10 TATA-box binding protein associated factor 10 increases expression ISO calcium silicate results in increased expression of TAF10 mRNA CTD PMID:29279043 NCBI chr 1:160,095,108...160,096,401
Ensembl chr 1:160,095,108...160,096,376 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Zinc binds to calcium silicate] which results in increased expression of TGFB1 mRNA CTD PMID:23483914 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Them7 thioesterase superfamily member 7 increases expression ISO calcium silicate results in increased expression of THEM7 mRNA CTD PMID:29279043 NCBI chr 3:91,666,144...91,834,783
Ensembl chr 3:91,666,152...91,834,783 		JBrowse link
G Tmem171 transmembrane protein 171 increases expression ISO calcium silicate results in increased expression of TMEM171 mRNA CTD PMID:29279043 NCBI chr 2:30,035,278...30,045,996
Ensembl chr 2:30,035,278...30,045,049 		JBrowse link
G Tmem54 transmembrane protein 54 increases expression ISO calcium silicate results in increased expression of TMEM54 mRNA CTD PMID:29279043 NCBI chr 5:141,449,191...141,455,683
Ensembl chr 5:141,449,191...141,455,682 		JBrowse link
G Tmod4 tropomodulin 4 increases expression ISO calcium silicate results in increased expression of TMOD4 mRNA CTD PMID:29279043 NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO calcium silicate results in increased expression of TRP53 mRNA CTD PMID:29279043 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tuba1c tubulin, alpha 1C decreases expression ISO calcium silicate results in decreased expression of TUBA1C mRNA CTD PMID:29279043 NCBI chr 7:130,192,050...130,199,655
Ensembl chr 7:130,192,016...130,199,647
Ensembl chr  X:130,192,016...130,199,647 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases secretion		 ISO RTKI cpd inhibits the reaction [calcium silicate results in increased secretion of VEGFA protein] CTD PMID:21762757 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vps35l VPS35 endosomal protein sorting factor like increases expression ISO calcium silicate results in increased expression of VPS35L mRNA CTD PMID:29279043 NCBI chr 1:173,076,219...173,179,663
Ensembl chr 1:173,076,099...173,180,610 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A decreases expression ISO calcium silicate results in decreased expression of ZC3H12A mRNA CTD PMID:29279043 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
G Zmynd8 zinc finger, MYND-type containing 8 increases expression ISO calcium silicate results in increased expression of ZMYND8 mRNA CTD PMID:29279043 NCBI chr 3:154,528,917...154,629,532
Ensembl chr 3:154,529,043...154,628,463 		JBrowse link
D-mannitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1 mRNA]; Mannitol inhibits the reaction [Vitamin A results in decreased expression of ABCB1A mRNA] CTD PMID:15327746 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acacb acetyl-CoA carboxylase beta decreases expression ISO Mannitol results in decreased expression of ACACB mRNA CTD PMID:25270620 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Acly ATP citrate lyase increases expression ISO Mannitol results in increased expression of ACLY mRNA CTD PMID:25270620 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 increases expression ISO Mannitol results in increased expression of ADAMTS18 mRNA CTD PMID:25270620 NCBI chr19:41,686,951...41,840,035
Ensembl chr19:41,688,617...41,839,781 		JBrowse link
G Aida axin interactor, dorsalization associated decreases expression ISO Mannitol results in decreased expression of AIDA mRNA CTD PMID:25270620 NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920 		JBrowse link
G Aire autoimmune regulator decreases expression ISO Mannitol results in decreased expression of AIRE mRNA CTD PMID:25270620 NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060 		JBrowse link
G Aqp9 aquaporin 9 increases uptake EXP AQP9 protein results in increased uptake of Mannitol CTD PMID:9733774 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395 		JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression ISO Mannitol results in increased expression of ARHGAP1 mRNA CTD PMID:25270620 NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396 		JBrowse link
G Arr3 arrestin 3 increases expression ISO Mannitol results in increased expression of ARR3 mRNA CTD PMID:25270620 NCBI chr  X:65,699,881...65,712,224
Ensembl chr  X:65,698,699...65,712,153 		JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation
multiple interactions		 EXP Mannitol results in increased phosphorylation of BAD protein
wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]		 CTD PMID:15786717 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of BAX protein] CTD PMID:29803612 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression ISO Mannitol results in decreased expression of BBOX1 mRNA CTD PMID:25270620 NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Mannitol results in increased expression of BCL2 protein CTD PMID:15786717 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cables2 Cdk5 and Abl enzyme substrate 2 decreases expression ISO Mannitol results in decreased expression of CABLES2 mRNA CTD PMID:25270620 NCBI chr 3:167,347,527...167,362,274
Ensembl chr 3:167,347,461...167,362,279 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein]; Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased activity of CASP3 protein] CTD PMID:10567913 PMID:12011046 PMID:29803612 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO Mannitol results in increased activity of CASP9 protein CTD PMID:12011046 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cbx1 chromobox 1 increases expression ISO Mannitol results in increased expression of CBX1 mRNA CTD PMID:25270620 NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096 		JBrowse link
G Ccdc127 coiled-coil domain containing 127 decreases expression ISO Mannitol results in decreased expression of CCDC127 mRNA CTD PMID:25270620 NCBI chr 1:28,928,420...28,935,885
Ensembl chr 1:28,928,325...28,935,893 		JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO Mannitol results in decreased expression of CCN3 mRNA CTD PMID:25270620 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Ckap5 cytoskeleton associated protein 5 increases expression ISO Mannitol results in increased expression of CKAP5 mRNA CTD PMID:25270620 NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 affects response to substance ISO CLCN3 protein affects the susceptibility to Mannitol deficiency CTD PMID:22108225 NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119 		JBrowse link
G Ctnna2 catenin alpha 2 decreases expression ISO Mannitol results in decreased expression of CTNNA2 mRNA CTD PMID:25270620 NCBI chr 4:109,294,249...110,443,409
Ensembl chr 4:109,293,978...110,443,522 		JBrowse link
G Dbh dopamine beta-hydroxylase increases expression ISO Mannitol results in increased expression of DBH mRNA CTD PMID:25270620 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Dctn2 dynactin subunit 2 increases expression ISO Mannitol results in increased expression of DCTN2 mRNA CTD PMID:25270620 NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543 		JBrowse link
G Defb4 defensin beta 4 decreases expression ISO Mannitol results in decreased expression of DEFB7 mRNA CTD PMID:25270620 NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665 		JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO Mannitol results in increased expression of DGKA mRNA CTD PMID:25270620 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110 		JBrowse link
G Elf2 E74 like ETS transcription factor 2 increases expression ISO Mannitol results in increased expression of ELF2 mRNA CTD PMID:25270620 NCBI chr 2:135,292,291...135,385,942
Ensembl chr 2:135,294,906...135,385,947 		JBrowse link
G Fam185a family with sequence similarity 185, member A increases expression ISO Mannitol results in increased expression of FAM185A mRNA CTD PMID:25270620 NCBI chr 4:13,542,022...13,662,967
Ensembl chr 4:13,608,464...13,662,967 		JBrowse link
G Fam222a family with sequence similarity 222, member A decreases expression ISO Mannitol results in decreased expression of FAM222A mRNA CTD PMID:25270620 NCBI chr12:41,982,064...42,033,085
Ensembl chr12:41,986,780...42,033,682 		JBrowse link
G Fgf23 fibroblast growth factor 23 decreases export
decreases expression
multiple interactions		 EXP
ISO		 Mannitol results in decreased export of FGF23 protein
Mannitol results in decreased expression of FGF23 mRNA
Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 mRNA]; Mannitol inhibits the reaction [Sodium Chloride deficiency results in increased expression of FGF23 protein]		 CTD PMID:37992803 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mannitol results in increased expression of FOS mRNA CTD PMID:11557636 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gal3st2 galactose-3-O-sulfotransferase 2 decreases expression ISO Mannitol results in decreased expression of GAL3ST2 mRNA CTD PMID:25270620 NCBI chr 9:94,382,456...94,387,990 JBrowse link
G Gas2l2 growth arrest-specific 2 like 2 decreases expression ISO Mannitol results in decreased expression of GAS2L2 mRNA CTD PMID:25270620 NCBI chr10:68,222,475...68,229,877
Ensembl chr10:68,222,475...68,229,881 		JBrowse link
G Gpc6 glypican 6 increases expression ISO Mannitol results in increased expression of GPC6 mRNA CTD PMID:25270620 NCBI chr15:94,030,218...95,027,883
Ensembl chr15:94,029,884...95,024,006 		JBrowse link
G Gpr19 G protein-coupled receptor 19 decreases expression ISO Mannitol results in decreased expression of GPR19 mRNA CTD PMID:25270620 NCBI chr 4:167,710,944...167,739,232
Ensembl chr 4:167,710,666...167,741,036 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Mannitol results in increased expression of HMOX1 mRNA CTD PMID:11592956 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression ISO Mannitol results in increased expression of HPRT1 mRNA CTD PMID:25270620 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Hrh2 histamine receptor H 2 increases expression ISO Mannitol results in increased expression of HRH2 mRNA CTD PMID:25270620 NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:16285992 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO IGF1 inhibits the reaction [Mannitol results in increased activity of CASP3 protein] CTD PMID:10567913 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Rotenone inhibits the reaction [Mannitol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] CTD PMID:23867654 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Mannitol results in increased expression of JUN mRNA CTD PMID:11557636 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member increases expression ISO Mannitol results in increased expression of KHDC3 mRNA CTD PMID:25270620 NCBI chr 8:73,842,344...73,844,248
Ensembl chr 8:73,842,344...73,844,248 		JBrowse link
G Krtap11-1 keratin associated protein 11-1 increases expression ISO Mannitol results in increased expression of KRTAP11-1 mRNA CTD PMID:25270620 NCBI chr11:28,809,940...28,810,944
Ensembl chr11:28,810,341...28,810,892 		JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression ISO Mannitol results in decreased expression of LSM6 mRNA CTD PMID:25270620 NCBI chr19:29,098,254...29,112,858
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K1 protein] CTD PMID:16510265 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of MAP2K2 protein] CTD PMID:16510265 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK1 protein] CTD PMID:10910949 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Mannitol promotes the reaction [potassium chromate(VI) results in increased phosphorylation of MAPK8 protein] CTD PMID:10910949 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mta2 metastasis associated 1 family, member 2 increases expression ISO Mannitol results in increased expression of MTA2 mRNA CTD PMID:25270620 NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946 		JBrowse link
G Myl9 myosin light chain 9 decreases phosphorylation EXP Mannitol results in decreased phosphorylation of MYL9 protein CTD PMID:17272349 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Mylk3 myosin light chain kinase 3 increases expression ISO Mannitol results in increased expression of MYLK3 mRNA CTD PMID:25270620 NCBI chr19:21,685,085...21,743,587
Ensembl chr19:21,691,929...21,742,954 		JBrowse link
G Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 increases expression ISO Mannitol results in increased expression of NAALAD2 mRNA CTD PMID:25270620 NCBI chr 8:15,406,119...15,479,714
Ensembl chr 8:15,407,043...15,479,714 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 decreases expression ISO Mannitol results in decreased expression of NDUFA13 mRNA CTD PMID:25270620 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
Ensembl chr 7:19,526,565...19,535,726 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 increases expression
multiple interactions		 ISO
EXP		 Mannitol results in increased expression of NFAT5 mRNA
Mannitol results in increased expression of NFAT5 mRNA; Mannitol results in increased expression of NFAT5 protein
Mannitol inhibits the reaction [Sodium Chloride deficiency results in decreased expression of NFAT5 mRNA]		 CTD PMID:23867654 PMID:37992803 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nkg7 natural killer cell granule protein 7 increases expression ISO Mannitol results in increased expression of NKG7 mRNA CTD PMID:25270620 NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983 		JBrowse link
G Nppa natriuretic peptide A increases expression ISO Mannitol results in increased expression of NPPA protein CTD PMID:2177369 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nts neurotensin increases transport EXP NTS protein results in increased transport of Mannitol CTD PMID:11208724 NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423 		JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Mannitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Pcp2 Purkinje cell protein 2 increases expression ISO Mannitol results in increased expression of PCP2 mRNA CTD PMID:25270620 NCBI chr12:1,681,659...1,683,899
Ensembl chr12:1,681,659...1,683,899 		JBrowse link
G Pdcd4 programmed cell death 4 increases expression
decreases expression		 ISO Mannitol results in increased expression of PDCD4 mRNA
Mannitol results in decreased expression of PDCD4 mRNA		 CTD PMID:21873647 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression EXP Mannitol results in increased expression of PHEX mRNA CTD PMID:37992803 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Plcl2 phospholipase C-like 2 decreases expression ISO Mannitol results in decreased expression of PLCL2 mRNA CTD PMID:25270620 NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009 		JBrowse link
G Plekho1 pleckstrin homology domain containing O1 increases expression ISO Mannitol results in increased expression of PLEKHO1 mRNA CTD PMID:25270620 NCBI chr 2:183,544,487...183,552,928
Ensembl chr 2:183,544,499...183,552,785 		JBrowse link
G Pou1f1 POU class 1 homeobox 1 increases expression ISO Mannitol results in increased expression of POU1F1 mRNA CTD PMID:25270620 NCBI chr11:3,316,818...3,334,804
Ensembl chr11:3,317,058...3,334,801 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO Mannitol results in decreased expression of PPP1R10 mRNA CTD PMID:25270620 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
G Ppp4c protein phosphatase 4, catalytic subunit increases expression ISO Mannitol results in increased expression of PPP4C mRNA CTD PMID:25270620 NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein alternative form]; Mannitol inhibits the reaction [Glucose results in increased expression of PRKCB protein] CTD PMID:16285992 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of PRKCD protein] CTD PMID:16285992 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Ptger1 prostaglandin E receptor 1 increases expression EXP Mannitol results in increased expression of PTGER1 mRNA CTD PMID:12888618 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559 		JBrowse link
G Ptger4 prostaglandin E receptor 4 decreases expression EXP Mannitol results in decreased expression of PTGER4 mRNA CTD PMID:12888618 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptk2 protein tyrosine kinase 2 multiple interactions ISO benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein]; Mannitol results in decreased phosphorylation of and results in increased degradation of PTK2 protein CTD PMID:12011046 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ralgdsl3 ral guanine nucleotide dissociation stimulator like 3 increases expression ISO Mannitol results in increased expression of RGL3 mRNA CTD PMID:25270620 NCBI chr 8:20,500,846...20,520,471
Ensembl chr 8:20,500,846...20,520,471 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 decreases expression ISO Mannitol results in decreased expression of RBL1 mRNA CTD PMID:25270620 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330 		JBrowse link
G Rbp2 retinol binding protein 2 decreases expression ISO Mannitol results in decreased expression of RBP2 mRNA CTD PMID:25270620 NCBI chr 8:99,079,293...99,104,489
Ensembl chr 8:99,079,104...99,104,473 		JBrowse link
G Samd10 sterile alpha motif domain containing 10 decreases expression ISO Mannitol results in decreased expression of SAMD10 mRNA CTD PMID:25270620 NCBI chr 3:168,700,280...168,704,427
Ensembl chr 3:168,700,284...168,705,248 		JBrowse link
G Sbsn suprabasin decreases expression ISO Mannitol results in decreased expression of SBSN mRNA CTD PMID:25270620 NCBI chr 1:85,978,970...86,006,034
Ensembl chr 1:86,001,567...86,006,034 		JBrowse link
G Sele selectin E multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of SELE mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of SELE protein] CTD PMID:16285992 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sgsm3 small G protein signaling modulator 3 decreases expression ISO Mannitol results in decreased expression of SGSM3 mRNA CTD PMID:25270620 NCBI chr 7:112,514,453...112,544,109
Ensembl chr 7:112,514,630...112,544,108 		JBrowse link
G Slc12a1 solute carrier family 12 member 1 increases activity
multiple interactions		 EXP Mannitol results in increased activity of SLC12A1 protein
[Mannitol results in increased activity of SLC12A1 protein] which results in increased import of Water		 CTD PMID:12433675 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899 		JBrowse link
G Slc2a8 solute carrier family 2 member 8 decreases expression ISO Mannitol results in decreased expression of SLC2A8 mRNA CTD PMID:25270620 NCBI chr 3:16,274,918...16,284,536
Ensembl chr 3:16,274,925...16,284,464 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Mannitol inhibits the reaction [Vitamin A results in increased phosphorylation of SRC protein] CTD PMID:16510265 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Stx8 syntaxin 8 decreases expression ISO Mannitol results in decreased expression of STX8 mRNA CTD PMID:25270620 NCBI chr10:52,655,643...52,900,048
Ensembl chr10:52,654,990...52,894,993 		JBrowse link
G Timd4 T-cell immunoglobulin and mucin domain containing 4 decreases expression ISO Mannitol results in decreased expression of TIMD4 mRNA CTD PMID:25270620 NCBI chr10:31,185,751...31,221,843
Ensembl chr10:31,185,731...31,220,966 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Mannitol inhibits the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]; Mannitol inhibits the reaction [Quartz results in increased secretion of TNF protein] CTD PMID:19298665 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip3 TNF alpha induced protein 3 increases expression ISO Mannitol results in increased expression of TNFAIP3 mRNA CTD PMID:21873647 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Mannitol inhibits the reaction [[cupric chloride co-treated with di(2-picolyl)amine-3(bromoacetyl)coumarin] results in increased expression of TP53 protein] CTD PMID:29803612 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpd52 tumor protein D52 decreases expression
increases expression		 ISO Mannitol results in decreased expression of TPD52 mRNA
Mannitol results in increased expression of TPD52 mRNA		 CTD PMID:21873647 NCBI chr 2:92,735,365...92,816,079
Ensembl chr 2:92,735,620...92,816,622 		JBrowse link
G Triml1 tripartite motif family-like 1 increases expression ISO Mannitol results in increased expression of TRIML1 mRNA CTD PMID:25270620 NCBI chr16:48,994,968...49,005,343
Ensembl chr16:48,997,252...49,005,417 		JBrowse link
G Ulbp1 UL16 binding protein 1 increases expression ISO Mannitol results in increased expression of ULBP1 mRNA CTD PMID:25270620 NCBI chr 1:1,694,255...1,716,160 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA]; Mannitol inhibits the reaction [Glucose results in increased expression of VCAM1 protein] CTD PMID:16285992 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Wdr20 WD repeat domain 20 decreases expression ISO Mannitol results in decreased expression of WDR20 mRNA CTD PMID:25270620 NCBI chr 6:129,751,952...129,821,464
Ensembl chr 6:129,752,014...129,847,339 		JBrowse link
G Zfp13 zinc finger protein 13 decreases expression ISO Mannitol results in decreased expression of ZFP13 mRNA CTD PMID:25270620 NCBI chr10:12,615,455...12,623,615
Ensembl chr10:12,615,190...12,623,615 		JBrowse link
G Zg16 zymogen granule protein 16 decreases expression ISO Mannitol results in decreased expression of ZG16 mRNA CTD PMID:25270620 NCBI chr 1:181,657,722...181,660,079
Ensembl chr 1:181,657,722...181,660,079 		JBrowse link
sodium hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Sodium Bicarbonate results in increased expression of ABCC2 mRNA CTD PMID:29126803 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression EXP Sodium Bicarbonate results in decreased expression of ABCG2 mRNA CTD PMID:29126803 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Car2 carbonic anhydrase 2 decreases expression EXP Sodium Bicarbonate results in decreased expression of CAR2 mRNA CTD PMID:31569818 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Cat catalase multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in decreased activity of CAT protein CTD PMID:25559736 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of FN1 protein] CTD PMID:10430982 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Sodium Bicarbonate affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of NFKB2 mRNA] CTD PMID:25559736 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of RELA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of RELA mRNA] CTD PMID:25559736 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC15A1 mRNA CTD PMID:29126803 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc22a19 solute carrier family 22, member 19 increases expression EXP Sodium Bicarbonate results in increased expression of SLC22A24 mRNA CTD PMID:29126803 NCBI chr 1:204,910,450...204,965,538
Ensembl chr 1:204,910,455...204,965,538 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC22A6 mRNA CTD PMID:29126803 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc39a8 solute carrier family 39 member 8 multiple interactions EXP SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of Cadmium Chloride]; SLC39A8 protein affects the reaction [Sodium Bicarbonate results in increased uptake of manganese chloride] CTD PMID:21509381 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) decreases expression EXP Sodium Bicarbonate results in decreased expression of SLC4A1 mRNA CTD PMID:31569818 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 increases transport
decreases expression		 ISO
EXP		 SLC4A4 protein results in increased transport of Sodium Bicarbonate
Sodium Bicarbonate results in decreased expression of SLC4A4 mRNA		 CTD PMID:18614622 PMID:31569818 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA] CTD PMID:10430982 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TNF mRNA] CTD PMID:25559736 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein; [Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of and affects the localization of TRP53 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Folic Acid co-treated with Sodium Bicarbonate] results in increased expression of TRP53 mRNA] CTD PMID:25559736 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vim vimentin multiple interactions EXP Sodium Bicarbonate inhibits the reaction [Doxorubicin results in increased expression of VIM protein] CTD PMID:10430982 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        food additive 16831
          food anticaking agent 204
            D-mannitol + 94
            calcium silicate 100
            dimethicone polymer 0
            potassium bitartrate 0
            sodium hydrogencarbonate 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        physiological role 19841
          food component 19841
            food additive 16831
              food anticaking agent 204
                D-mannitol + 94
                calcium silicate 100
                dimethicone polymer 0
                potassium bitartrate 0
                sodium hydrogencarbonate 18
paths to the root