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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.5.1.4 (amidase) inhibitor
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Accession:CHEBI:77941 term browser browse the term
Definition:An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).
Synonyms:related_synonym: EC 3.5.1.4 inhibitor;   EC 3.5.1.4 inhibitors;   N-acetylaminohydrolase inhibitor;   N-acetylaminohydrolase inhibitors;   acylamidase inhibitor;   acylamidase inhibitors;   acylamide amidohydrolase inhibitor;   acylamide amidohydrolase inhibitors;   amidase (EC 3.5.1.4) inhibitors;   amidase inhibitor;   amidase inhibitors;   amidohydrolase inhibitor;   amidohydrolase inhibitors;   deaminase inhibitor;   deaminase inhibitors;   fatty acylamidase inhibitor;   fatty acylamidase inhibitors
 xref: Wikipedia:Amidase


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(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OPRM1 opioid receptor mu 1 multiple interactions EXP Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]; omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]] CTD PMID:12031848 NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
JBrowse link
(S)-nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein] CTD PMID:28506824 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G ADCYAP1R1 ADCYAP receptor type I decreases expression EXP Nicotine results in decreased expression of ADCYAP1R1 protein CTD PMID:28506824 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,402...41,972,301
JBrowse link
G AMH anti-Mullerian hormone decreases expression
decreases secretion
EXP Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein
CTD PMID:32423882 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,405,253...76,418,312
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Nicotine results in decreased expression of BCL2 mRNA CTD PMID:32423882 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein] CTD PMID:28235547 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,191,842...11,207,381
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein] CTD PMID:28235547 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,778...47,384,303
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein] CTD PMID:28235547 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,698...142,937,788
JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein] CTD PMID:28235547 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein] CTD PMID:28235547 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037
JBrowse link
G CYP19A2 cytochrome P450 19A2 decreases expression EXP Nicotine results in decreased expression of CYP19A1 mRNA CTD PMID:32423882 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP Nicotine results in decreased expression of FSHR mRNA CTD PMID:32423882 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G INHBB inhibin subunit beta B decreases expression
decreases secretion
EXP Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein
CTD PMID:32423882 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of ITGB1 mRNA CTD PMID:32423882 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,398...56,173,795
JBrowse link
G LAMB1 laminin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of LAMB1 mRNA CTD PMID:32423882 NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation
decreases expression
EXP Nicotine results in decreased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 mRNA
CTD PMID:32423882 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
decreases expression
EXP Nicotine results in decreased phosphorylation of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA
CTD PMID:32423882 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases phosphorylation
decreases expression
EXP Nicotine results in decreased phosphorylation of MAPK8 protein
Nicotine results in decreased expression of MAPK8 mRNA
CTD PMID:32423882 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Nicotine results in increased expression of MMP9 mRNA CTD PMID:32423882 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G OCLN occludin decreases expression EXP Nicotine results in decreased expression of OCLN mRNA CTD PMID:32423882 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,498...47,654,033
JBrowse link
G RPP38 ribonuclease P/MRP subunit p38 decreases expression EXP Nicotine results in decreased expression of RPP38 mRNA CTD PMID:32423882 NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,195...46,725,920
JBrowse link
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD1 superoxide dismutase 1 multiple interactions EXP SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione] CTD PMID:11861319 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
actinomycin D term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 multiple interactions EXP Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of CAPN1 mRNA] CTD PMID:9728040 NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,516...7,081,432
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of FOS mRNA] CTD PMID:9463523 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium results in increased expression of HSPA5 protein] CTD PMID:16759985 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSNK1A1 casein kinase 1 alpha 1 decreases activity
affects activity
EXP Ageladine A analog results in decreased activity of CSNK1A1 protein
Ageladine A affects the activity of CSNK1A1 protein
CTD PMID:21413800 NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,844...150,662,351
JBrowse link
alachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to alachlor CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082 JBrowse link
alpha-(methylamino)isobutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases uptake
multiple interactions
EXP INS protein results in increased uptake of 2-(methylamino)isobutyric acid
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD PMID:1928324 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
amastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions EXP amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
amiloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator increases activity EXP Amiloride results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950
JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions EXP Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA] CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,534,655...168,690,095
JBrowse link
amino acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN3 claudin 3 multiple interactions EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein] CTD PMID:26338884 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,295...11,019,960
JBrowse link
G CLDN4 claudin 4 multiple interactions EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein] CTD PMID:26338884 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925
JBrowse link
G SLC1A1 solute carrier family 1 member 1 increases expression EXP Amino Acids results in increased expression of SLC1A1 mRNA; Amino Acids results in increased expression of SLC1A1 protein CTD PMID:26338884 NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674
JBrowse link
G TJP2 tight junction protein 2 multiple interactions EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP2 protein] CTD PMID:26338884 NCBI chr 1:222,474,518...222,612,989 JBrowse link
G TJP3 tight junction protein 3 multiple interactions EXP Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP3 protein] CTD PMID:26338884 NCBI chr 2:74,938,153...74,971,431
Ensembl chr 2:74,938,152...74,971,555
JBrowse link
aminoglutethimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone] CTD PMID:22341706 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,316,436...66,452,917
JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
BAPTA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYL9 myosin light chain 9 multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; [Calcium co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased phosphorylation of MYL9 protein CTD PMID:10942722 NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,296
JBrowse link
beauvericin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 increases expression
decreases activity
EXP beauvericin results in increased expression of ABCB1 mRNA
beauvericin results in decreased activity of ABCB1 protein
CTD PMID:27474255 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 increases expression EXP beauvericin results in increased expression of CYP11A1 mRNA CTD PMID:27474255 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I increases expression EXP beauvericin results in increased expression of COX1 mRNA CTD PMID:27474255 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055
JBrowse link
brimonidine tartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
EXP Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]
CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,697,408...110,771,755
JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH5 cadherin 5 decreases expression
increases expression
EXP Carvedilol results in decreased expression of CDH5 mRNA
Carvedilol results in increased expression of CDH5 protein
CTD PMID:16824628 NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,609...27,142,180
JBrowse link
G CTNNB1 catenin beta 1 decreases expression
increases expression
EXP Carvedilol results in decreased expression of CTNNB1 mRNA
Carvedilol results in increased expression of CTNNB1 protein
CTD PMID:16824628 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP Carvedilol results in decreased expression of EDN1 protein
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]
CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G JUP junction plakoglobin increases expression
decreases expression
EXP Carvedilol results in increased expression of JUP protein
Carvedilol results in decreased expression of JUP mRNA
CTD PMID:16824628 NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,211
JBrowse link
chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G HSPA6 heat shock protein family A (Hsp70) member 6 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSP70 protein] CTD PMID:17727805 NCBI chr 4:88,970,592...88,973,109
Ensembl chr 4:88,970,591...88,985,586
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein] CTD PMID:17727805 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
JBrowse link
G IFNB1 interferon beta 1 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA] CTD PMID:27079946 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
JBrowse link
G IFNG interferon gamma multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA] CTD PMID:27079946 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL12B interleukin 12B multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA] CTD PMID:27079946 NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,147,247...64,158,952
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA] CTD PMID:27079946 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G IRF7 interferon regulatory factor 7 multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA] CTD PMID:27079946 NCBI chr 2:372,235...375,572
Ensembl chr 2:371,606...375,381
JBrowse link
G ISG15 ISG15 ubiquitin like modifier multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA] CTD PMID:27079946 NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA] CTD PMID:27079946
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein] CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein] CTD PMID:27079946 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
EXP Chloroquine results in increased expression of SQSTM1 protein
Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]
CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
G TLR7 toll like receptor 7 multiple interactions EXP Chloroquine affects the localization of and results in decreased activity of TLR7 protein CTD PMID:27079946 NCBI chr  X:9,573,178...9,576,987 JBrowse link
chlorpromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP Chlorpromazine results in decreased activity of DAO protein CTD PMID:18615285 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,929,215...41,950,633
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases oxidation EXP FMO1 protein results in increased oxidation of Chlorpromazine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] CTD PMID:20435919 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein] CTD PMID:20435919 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G FASLG Fas ligand (TNF superfamily, member 6) multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] CTD PMID:20435919 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,475
JBrowse link
cinaciguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein] CTD PMID:19466990 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,232...44,518,135
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,704
JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
crizotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTRK1 neurotrophic receptor tyrosine kinase 1 decreases activity EXP Crizotinib results in decreased activity of NTRK1 protein CTD PMID:21812414 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 decreases activity EXP Crizotinib results in decreased activity of NTRK2 protein CTD PMID:21812414 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
cyclosporin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects localization
EXP Vitamin E inhibits the reaction [Cyclosporine affects the localization of BAX protein] CTD PMID:19523970 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G CASP6 caspase 6 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Cyclosporine results in increased expression of CASP6 mRNA] CTD PMID:19523970 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,483,392...112,540,550
JBrowse link
G CYCS cytochrome c, somatic multiple interactions
affects localization
EXP Vitamin E inhibits the reaction [Cyclosporine affects the localization of CYCS protein] CTD PMID:23347876 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DNM1L dynamin 1 like multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Cyclosporine results in increased expression of DNM1L protein] CTD PMID:23347876 NCBI chr 5:41,571,054...41,636,058 JBrowse link
G EDN1 endothelin 1 increases secretion EXP Cyclosporine results in increased secretion of EDN1 protein CTD PMID:16391421 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G MFN2 mitofusin 2 multiple interactions
decreases expression
EXP Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein] CTD PMID:23347876 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,026,722...72,056,439
JBrowse link
G NOS3 nitric oxide synthase 3 decreases expression EXP Cyclosporine results in decreased expression of NOS3 protein CTD PMID:12695417 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase decreases expression
multiple interactions
EXP Cyclosporine results in decreased expression of OPA1 protein
Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein]
CTD PMID:23347876 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,823...130,719,083
JBrowse link
G RAC1 Rac family small GTPase 1 affects localization EXP Cyclosporine affects the localization of RAC1 protein CTD PMID:12695417 NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,771...4,803,687
JBrowse link
G SLC2A1 solute carrier family 2 member 1 decreases response to substance
multiple interactions
increases expression
EXP SLC2A1 protein results in decreased susceptibility to Cyclosporine
Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 protein]
Cyclosporine results in increased expression of SLC2A1 mRNA; Cyclosporine results in increased expression of SLC2A1 protein
CTD PMID:12081571 NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,534,655...168,690,095
JBrowse link
cysteamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of Cysteamine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
dobutamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HK2 hexokinase 2 decreases expression EXP Dobutamine results in decreased expression of HK2 protein CTD PMID:19944370 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,145,890...68,231,615
JBrowse link
G NOS2 nitric oxide synthase 2 affects response to substance EXP NOS2 protein affects the susceptibility to Dobutamine CTD PMID:20141602 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G PYGM glycogen phosphorylase, muscle associated decreases expression EXP Dobutamine results in decreased expression of PYGM protein CTD PMID:19944370 NCBI chr 2:7,409,330...7,421,256
Ensembl chr 2:7,391,064...7,421,261
JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G OPRD1 opioid receptor delta 1 multiple interactions EXP Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [OPRD1 protein results in increased transport of Barium] CTD PMID:12031848 NCBI chr 6:85,775,576...85,827,170
Ensembl chr 6:85,785,227...85,825,592
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Enalapril affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Enalaprilat results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G KNG1 kininogen 1 increases activity EXP Enalaprilat results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
ethylenediaminetetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANPEP alanyl aminopeptidase, membrane multiple interactions EXP Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,083...55,373,881
JBrowse link
G LTA4H leukotriene A4 hydrolase decreases activity EXP Edetic Acid results in decreased activity of LTA4H protein CTD PMID:21670530 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
JBrowse link
folic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CBS cystathionine beta-synthase multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein
Folic Acid deficiency results in increased activity of CBS protein
CTD PMID:16792574 NCBI chr13:206,205,942...206,231,363 JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA CTD PMID:14662146 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G CTH cystathionine gamma-lyase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CTH protein CTD PMID:16792574 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,435,690...142,486,367
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA CTD PMID:16792574 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
increases activity
increases expression
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSR protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSR mRNA
Folic Acid deficiency results in increased activity of GSR protein
Folic Acid deficiency results in increased expression of GSR mRNA
CTD PMID:16792574 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989
JBrowse link
G GSS glutathione synthetase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA CTD PMID:16792574 NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,304
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,636...71,881,820
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of PTGS1 CTD PMID:14662146 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in increased expression of PTGS2 CTD PMID:14662146 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity
multiple interactions
EXP Folic Acid deficiency results in decreased activity of SOD1 protein
[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA; [Ethanol co-treated with Folic Acid deficiency] results in decreased activity of SOD1 protein
CTD PMID:16792574, PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of SOD2 protein
Folic Acid deficiency results in increased activity of SOD2 protein; Folic Acid results in increased activity of SOD2 protein
CTD PMID:16792574, PMID:22889112 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
fumonisin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor increases expression EXP fumonisin B1 results in increased expression of AGER mRNA CTD PMID:32198028 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,116...24,228,756
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with Zearalenone co-treated with deoxynivalenol] results in decreased expression of BCL2 protein; [fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]; fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; fumonisin B1 inhibits the reaction [Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]]; fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]; Zearalenone inhibits the reaction [fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]]; Zearalenone inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]] CTD PMID:29109043 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP10 caspase 10 multiple interactions
increases expression
EXP 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP10 mRNA] CTD PMID:32198028 NCBI chr15:104,858,082...104,895,941
Ensembl chr15:104,858,100...104,894,933
JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
EXP 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP3 protein]; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]; [fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]
fumonisin B1 results in increased expression of CASP3 mRNA; fumonisin B1 results in increased expression of CASP3 protein
CTD PMID:29109043, PMID:32198028 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression
EXP 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP8 mRNA] CTD PMID:32198028 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
increases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]
fumonisin B1 results in decreased expression of CCL2 mRNA
fumonisin B1 metabolite results in increased expression of CCL2 mRNA; fumonisin B1 results in increased expression of CCL2 mRNA
CTD PMID:23688591, PMID:30708112 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CCL20 C-C motif chemokine ligand 20 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of CCL20 mRNA
fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]
CTD PMID:30708112 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex increases expression EXP fumonisin B1 results in increased expression of CHUK mRNA CTD PMID:32198028 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,307,610...111,351,712
JBrowse link
G CLDN1 claudin 1 decreases expression EXP fumonisin B1 results in decreased expression of CLDN1 mRNA; fumonisin B1 results in decreased expression of CLDN1 protein CTD PMID:31557363 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,767...127,730,657
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]
fumonisin B1 results in increased expression of CXCL8 mRNA
CTD PMID:23688591, PMID:30708112 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA] CTD PMID:29109043 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]] CTD PMID:29109043 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989
JBrowse link
G IFNG interferon gamma decreases expression EXP fumonisin B1 metabolite results in decreased expression of IFNG protein CTD PMID:30708112 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL17A interleukin 17A multiple interactions EXP fumonisin B1 inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein] CTD PMID:30708112 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL1A interleukin 1 alpha multiple interactions
increases expression
decreases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in decreased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA
fumonisin B1 results in increased expression of IL1A mRNA
fumonisin B1 results in decreased expression of IL1A mRNA
CTD PMID:23688591 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL6 interleukin 6 multiple interactions
decreases expression
increases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with fumonisin B1] results in decreased expression of IL6 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA
fumonisin B1 results in decreased expression of IL6 mRNA
fumonisin B1 results in increased expression of IL6 mRNA
CTD PMID:23688591, PMID:30708112 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of IL1B mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA
CTD PMID:23688591
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 increases expression EXP fumonisin B1 results in increased expression of MAP3K14 mRNA CTD PMID:32198028 NCBI chr12:18,142,899...18,182,931
Ensembl chr12:18,142,922...18,184,641
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP fumonisin B1 results in increased phosphorylation of MAPK1 protein CTD PMID:31557363 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK10 mitogen-activated protein kinase 10 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of MAPK10 mRNA
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK10 mRNA]
CTD PMID:32198028 NCBI chr 8:132,445,818...132,751,575
Ensembl chr 8:132,249,635...132,776,820
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP fumonisin B1 results in increased phosphorylation of MAPK3 protein CTD PMID:31557363 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of MAPK8 mRNA; fumonisin B1 results in increased expression of MAPK8 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK8 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK8 protein]
CTD PMID:32198028 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of MAPK9 mRNA
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK9 mRNA]
CTD PMID:32198028 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G MUC1 mucin 1, cell surface associated decreases expression EXP fumonisin B1 results in decreased expression of MUC1 mRNA CTD PMID:31557363 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G MUC2 mucin 2, oligomeric mucus/gel-forming increases expression EXP fumonisin B1 results in increased expression of MUC2 mRNA CTD PMID:31557363 NCBI chr 2:689,363...719,542 JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of NFKB1 mRNA; fumonisin B1 results in increased expression of NFKB1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of NFKB1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of NFKB1 protein]
CTD PMID:32198028 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,637...118,506,691
JBrowse link
G OCLN occludin decreases expression EXP fumonisin B1 results in decreased expression of OCLN mRNA; fumonisin B1 results in decreased expression of OCLN protein CTD PMID:31557363 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,498...47,654,033
JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP fumonisin B1 results in decreased expression of TJP1 mRNA; fumonisin B1 results in decreased expression of TJP1 protein CTD PMID:31557363 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression
EXP [deoxynivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF protein; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA
fumonisin B1 results in increased expression of TNF mRNA; fumonisin B1 results in increased expression of TNF protein
CTD PMID:23688591, PMID:30708112, PMID:32198028 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP fumonisin B1 results in increased expression of TP53 mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; fumonisin B1 inhibits the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]]; fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA]; Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]
CTD PMID:29109043 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G TRADD TNFRSF1A associated via death domain increases expression EXP fumonisin B1 results in increased expression of TRADD mRNA CTD PMID:32198028 NCBI chr 6:27,797,594...27,804,654
Ensembl chr 6:27,797,607...27,804,423
JBrowse link
G TRAF2 TNF receptor associated factor 2 increases expression EXP fumonisin B1 results in increased expression of TRAF2 mRNA CTD PMID:32198028
gabapentin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 affects binding EXP Gabapentin binds to CACNA2D1 protein CTD PMID:11687876 NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,780,742...98,266,573
JBrowse link
gefitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FES FES proto-oncogene, tyrosine kinase multiple interactions
decreases phosphorylation
EXP Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]; Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]
Gefitinib results in decreased phosphorylation of FES protein
CTD PMID:19885553 NCBI chr 7:53,472,947...53,485,084
Ensembl chr 7:53,472,946...53,485,082
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein] CTD PMID:19885553 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,878...101,343,916
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein] CTD PMID:19885553 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
G LOC100739163 glutathione S-transferase P-like multiple interactions EXP GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione] CTD PMID:14573868 NCBI chr 2:4,978,761...4,982,233 JBrowse link
glycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSF2 colony stimulating factor 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA CTD PMID:14662146 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of PTGS1 CTD PMID:14662146 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in increased expression of PTGS2 CTD PMID:14662146 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
glycine betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,636...71,881,820
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
histamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HRH2 histamine receptor H2 multiple interactions EXP [Histamine affects the activity of HRH2 protein] which affects the secretion of Chlorides CTD PMID:12665126 NCBI chr 2:81,883,670...81,932,464
Ensembl chr 2:81,883,670...81,932,275
JBrowse link
icatibant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 decreases activity EXP icatibant results in decreased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 3A29 multiple interactions EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121 JBrowse link
KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL4A2 collagen type IV alpha 2 chain multiple interactions
decreases expression
EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]
KT 5823 results in decreased expression of COL4A2 protein
CTD PMID:21307347 NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,615
JBrowse link
G COL4A3 collagen type IV alpha 3 chain decreases expression
multiple interactions
EXP KT 5823 results in decreased expression of COL4A3 mRNA
KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A3 mRNA]
CTD PMID:21307347 NCBI chr15:128,611,640...128,763,331
Ensembl chr15:128,611,866...128,763,122
JBrowse link
G ITGAV integrin subunit alpha V multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,840
JBrowse link
G ITGB3 integrin subunit beta 3 multiple interactions EXP KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]] CTD PMID:21307347 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,505...16,752,292
JBrowse link
mastoparan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SELE selectin E increases expression EXP mastoparan results in increased expression of SELE mRNA CTD PMID:10769290 NCBI chr 4:81,289,061...81,299,657 JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 decreases response to substance EXP IL4 protein results in decreased susceptibility to Melitten CTD PMID:20017192 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G PLA2G1B phospholipase A2 group IB increases activity EXP Melitten results in increased activity of PLA2G1B protein CTD PMID:9092818 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319
JBrowse link
G SELE selectin E increases expression EXP Melitten results in increased expression of SELE mRNA CTD PMID:10769290 NCBI chr 4:81,289,061...81,299,657 JBrowse link
mesulergine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR2C 5-hydroxytryptamine receptor 2C affects binding
multiple interactions
EXP mesulergine binds to HTR2C protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]
CTD PMID:11927170 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,356
JBrowse link
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA5 annexin A5 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]] CTD PMID:10617950 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
JBrowse link
G CASP3 caspase 3 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6 protein] CTD PMID:14519784, PMID:15226458 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases expression
multiple interactions
EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA]
CTD PMID:18845708 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of and results in increased activity of PPARG protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of PPARG mRNA] CTD PMID:14519784 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein
caffeic acid phenethyl ester inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA]
CTD PMID:18845708 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G SELE selectin E multiple interactions
increases expression
EXP Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA] CTD PMID:18845708 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G TNF tumor necrosis factor multiple interactions
increases activity
EXP [2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]] CTD PMID:10617950, PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:15226458 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
N,N-dimethylaniline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of N,N-dimethylaniline CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,697,408...110,771,755
JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
CTD PMID:24105867 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:129,520,397...129,636,207
Ensembl chr 6:129,519,962...129,635,517
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein] CTD PMID:19135140 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]] CTD PMID:19135140, PMID:29109043 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BMP15 bone morphogenetic protein 15 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of BMP15 mRNA] CTD PMID:26386189 NCBI chr  X:44,613,122...44,620,575
Ensembl chr  X:44,613,122...44,620,575
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Acetylcysteine co-treated with Zearalenone] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]] CTD PMID:17383151, PMID:19135140, PMID:29109043 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein] CTD PMID:19135140 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:19265715 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]] CTD PMID:29109043 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA] CTD PMID:18086661 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:18086661 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]] CTD PMID:29109043 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA] CTD PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA] CTD PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:17383151 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:17383151 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] CTD PMID:12712633 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G PTX3 pentraxin 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA] CTD PMID:26386189 NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of TNFAIP6 mRNA] CTD PMID:26386189 NCBI chr15:862,013...881,352
Ensembl chr15:862,013...881,461
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; Acetylcysteine promotes the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]] CTD PMID:29109043 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G ZP3 zona pellucida glycoprotein 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of ZP3 mRNA] CTD PMID:26386189 NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,761...9,944,941
JBrowse link
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 increases expression
multiple interactions
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKT1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of AKT1 protein]
CTD PMID:16239170
G CLIC5 chloride intracellular channel 5 multiple interactions EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein] CTD PMID:20576581 NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886
JBrowse link
G LRP2 LDL receptor related protein 2 multiple interactions EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein] CTD PMID:20576581 NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,301...75,716,694
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
EXP benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of NOS3 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOS3 protein
CTD PMID:16239170 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein] CTD PMID:28506824 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G ADCYAP1R1 ADCYAP receptor type I decreases expression EXP Nicotine results in decreased expression of ADCYAP1R1 protein CTD PMID:28506824 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,402...41,972,301
JBrowse link
G AMH anti-Mullerian hormone decreases expression
decreases secretion
EXP Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein
CTD PMID:32423882 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,405,253...76,418,312
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Nicotine results in decreased expression of BCL2 mRNA CTD PMID:32423882 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein] CTD PMID:28235547 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,191,842...11,207,381
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein] CTD PMID:28235547 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,778...47,384,303
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein] CTD PMID:28235547 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,698...142,937,788
JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein] CTD PMID:28235547 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein] CTD PMID:28235547 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037
JBrowse link
G CYP19A2 cytochrome P450 19A2 decreases expression EXP Nicotine results in decreased expression of CYP19A1 mRNA CTD PMID:32423882 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP Nicotine results in decreased expression of FSHR mRNA CTD PMID:32423882 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G INHBB inhibin subunit beta B decreases expression
decreases secretion
EXP Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein
CTD PMID:32423882 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of ITGB1 mRNA CTD PMID:32423882 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,398...56,173,795
JBrowse link
G LAMB1 laminin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of LAMB1 mRNA CTD PMID:32423882 NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases expression
decreases phosphorylation
EXP Nicotine results in decreased expression of MAPK1 mRNA
Nicotine results in decreased phosphorylation of MAPK1 protein
CTD PMID:32423882 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
decreases expression
EXP Nicotine results in decreased phosphorylation of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA
CTD PMID:32423882 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases expression
decreases phosphorylation
EXP Nicotine results in decreased expression of MAPK8 mRNA
Nicotine results in decreased phosphorylation of MAPK8 protein
CTD PMID:32423882 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Nicotine results in increased expression of MMP9 mRNA CTD PMID:32423882 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G OCLN occludin decreases expression EXP Nicotine results in decreased expression of OCLN mRNA CTD PMID:32423882 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,498...47,654,033
JBrowse link
G RPP38 ribonuclease P/MRP subunit p38 decreases expression EXP Nicotine results in decreased expression of RPP38 mRNA CTD PMID:32423882 NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,195...46,725,920
JBrowse link
norflurazon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 multiple interactions EXP CYP2C49 protein results in increased metabolism of and results in decreased susceptibility to norflurazone CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082 JBrowse link
o-aminoacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A19 cytochrome P450 2A19 multiple interactions EXP 2-aminoacetophenone inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; 2-aminoacetophenone inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin] CTD PMID:30599194 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107
JBrowse link
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 multiple interactions EXP 2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; 2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] CTD PMID:30599194 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of AKT1 protein CTD PMID:30287338
G ANXA5 annexin A5 decreases expression EXP ochratoxin A results in decreased expression of ANXA5 mRNA CTD PMID:14994279 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
JBrowse link
G ATG5 autophagy related 5 multiple interactions
increases expression
EXP ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of ATG5 protein
CTD PMID:28699257, PMID:30287338 NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,453
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
affects expression
multiple interactions
EXP ochratoxin A results in decreased expression of BCL2 mRNA
ochratoxin A affects the expression of BCL2 mRNA
TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]
CTD PMID:28528741, PMID:29080797 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression
EXP BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of BECN1 protein
CTD PMID:30287338 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
EXP 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase decreases expression EXP ochratoxin A results in decreased expression of CAT protein CTD PMID:18547704 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CRYAB crystallin alpha B increases expression EXP ochratoxin A results in increased expression of CRYAB mRNA CTD PMID:14994279 NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,502...39,643,530
JBrowse link
G CYP2A19 cytochrome P450 2A19 decreases expression EXP ochratoxin A results in decreased expression of CYP2A6 mRNA CTD PMID:14994279 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107
JBrowse link
G DAD1 defender against cell death 1 decreases expression EXP ochratoxin A results in decreased expression of DAD1 mRNA CTD PMID:14994279 NCBI chr 7:76,432,040...76,457,403
Ensembl chr 7:76,432,029...76,457,192
JBrowse link
G DNMT1 DNA methyltransferase 1 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of DNMT1 mRNA; ochratoxin A results in increased expression of DNMT1 protein
Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]
CTD PMID:29080797, PMID:30923867 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha increases expression EXP ochratoxin A results in increased expression of DNMT3A mRNA CTD PMID:29080797, PMID:30923867 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of GCLC mRNA
ochratoxin A inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]
CTD PMID:18547363 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GLMN glomulin, FKBP associated protein increases expression EXP ochratoxin A results in increased expression of GLMN mRNA CTD PMID:14994279 NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,979...124,813,337
JBrowse link
G HDAC1 histone deacetylase 1 multiple interactions
increases expression
EXP Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]
ochratoxin A results in increased expression of HDAC1 mRNA; ochratoxin A results in increased expression of HDAC1 protein
CTD PMID:29080797 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
decreases expression
EXP ochratoxin A results in increased expression of HSP90B1 mRNA
ochratoxin A results in decreased expression of HSP90B1 mRNA
CTD PMID:14994279 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP ochratoxin A results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 protein CTD PMID:28699257 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 decreases expression EXP ochratoxin A results in decreased expression of HSPD1 mRNA CTD PMID:14994279 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
JBrowse link
G ID2 inhibitor of DNA binding 2 decreases expression EXP ochratoxin A results in decreased expression of ID2 mRNA CTD PMID:14994279 NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,759...127,503,257
JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 increases expression EXP ochratoxin A results in increased expression of IGFBP2 mRNA CTD PMID:14994279 NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]] CTD PMID:28528741 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL2 interleukin 2 decreases secretion EXP ochratoxin A results in decreased secretion of IL2 protein CTD PMID:28699257 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL4 interleukin 4 increases expression EXP ochratoxin A results in increased expression of IL4 mRNA CTD PMID:14994279 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of IL6 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]
CTD PMID:28710020 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G JAK2 Janus kinase 2 multiple interactions
increases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein] CTD PMID:30923867 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
JBrowse link
G LOC100522201 histone H2AX multiple interactions
increases expression
EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP ochratoxin A results in increased phosphorylation of MAPK1 protein
ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:28528741, PMID:28699257 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
ochratoxin A results in increased phosphorylation of MAPK3 protein
CTD PMID:28528741, PMID:28699257 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of MTOR protein CTD PMID:30287338 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:28528741 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
JBrowse link
G NEIL1 nei like DNA glycosylase 1 decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of NEIL1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]
CTD PMID:30923867 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092
JBrowse link
G NEIL3 nei like DNA glycosylase 3 multiple interactions
decreases expression
EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA] CTD PMID:30923867 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,310
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity
multiple interactions
decreases expression
EXP ochratoxin A results in decreased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]; ochratoxin A inhibits the reaction [sulforafan affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased expression of NFE2L2 mRNA]
ochratoxin A results in decreased expression of NFE2L2 mRNA
CTD PMID:18547363, PMID:18547704, PMID:28710020 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NPM1 nucleophosmin 1 increases expression EXP ochratoxin A results in increased expression of NPM1 mRNA CTD PMID:14994279 NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,296...52,781,740
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of OGG1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]
CTD PMID:30923867 NCBI chr13:66,038,669...66,045,478 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions
EXP ochratoxin A results in increased cleavage of PARP1 protein
3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
CTD PMID:30287338 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP ochratoxin A results in decreased expression of PCK1 mRNA; ochratoxin A results in decreased expression of PCK1 protein CTD PMID:3753873 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896
JBrowse link
G PFDN5 prefoldin subunit 5 decreases expression EXP ochratoxin A results in decreased expression of PFDN5 mRNA CTD PMID:14994279 NCBI chr 5:18,512,637...18,516,928
Ensembl chr 5:18,512,719...18,525,877
JBrowse link
G PPIA peptidylprolyl isomerase A increases expression EXP ochratoxin A results in increased expression of PPIA mRNA CTD PMID:14994279 NCBI chr18:50,563,130...50,566,857 JBrowse link
G PRDX1 peroxiredoxin 1 decreases expression EXP ochratoxin A results in decreased expression of PRDX1 mRNA CTD PMID:14994279 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,520...165,861,442
JBrowse link
G PTMA prothymosin alpha decreases expression EXP ochratoxin A results in decreased expression of PTMA mRNA CTD PMID:14994279 NCBI chr15:132,353,763...132,361,442
Ensembl chr15:132,355,655...132,361,435
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:28528741 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G RPS5 ribosomal protein S5 increases expression EXP ochratoxin A results in increased expression of RPS5 mRNA CTD PMID:14994279 NCBI chr 6:62,967,955...62,974,353
Ensembl chr 6:62,921,635...62,974,354
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of SOCS3 mRNA; ochratoxin A results in increased expression of SOCS3 protein
Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein]
CTD PMID:30923867 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity EXP ochratoxin A results in decreased activity of SOD1 protein CTD PMID:18547704 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression
EXP Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein] CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G SUMO1 small ubiquitin like modifier 1 decreases expression EXP ochratoxin A results in decreased expression of SUMO1 mRNA CTD PMID:14994279 NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,815,281...105,850,943
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of TGFB1 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; sulforafan inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]
CTD PMID:28710020 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP ochratoxin A results in increased expression of TIMP2 mRNA CTD PMID:14994279 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TJP1 tight junction protein 1 affects localization EXP ochratoxin A affects the localization of TJP1 protein CTD PMID:14994279 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836
JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:28528741 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
ochratoxin A results in increased secretion of TNF protein
CTD PMID:28528741, PMID:28699257 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein] CTD PMID:28710020 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G XPA XPA, DNA damage recognition and repair factor decreases expression EXP ochratoxin A results in decreased expression of XPA mRNA CTD PMID:14994279 NCBI chr 1:239,532,331...239,568,589
Ensembl chr 1:239,532,246...239,568,649
JBrowse link
ochratoxin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity EXP ochratoxin B results in decreased activity of NFE2L2 protein CTD PMID:18547704 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
omega-conotoxin GVIA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]] CTD PMID:12031848 NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
JBrowse link
G VIP vasoactive intestinal peptide multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [VIP protein results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269
JBrowse link
orlistat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNLIP pancreatic lipase decreases activity EXP Orlistat results in decreased activity of PNLIP protein CTD PMID:21438711 NCBI chr14:126,771,920...126,789,097
Ensembl chr14:126,771,920...126,789,160
JBrowse link
Oxotremorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP [Oxotremorine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein] CTD PMID:16362429 NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,150...12,600,249
JBrowse link
oxytocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRL ghrelin and obestatin prepropeptide multiple interactions
increases secretion
EXP STAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Oxytocin] CTD PMID:19528263 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,316,436...66,452,917
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions
increases secretion
EXP STAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Oxytocin]
STAT1 protein results in increased secretion of Oxytocin
CTD PMID:19528263 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260
JBrowse link
panobinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC1 histone deacetylase 1 multiple interactions EXP Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein] CTD PMID:29080797 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412
JBrowse link
paracetamol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression EXP Acetaminophen results in decreased expression of CDKN1A protein CTD PMID:16330492 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
JBrowse link
G TP53 tumor protein p53 decreases expression EXP Acetaminophen results in decreased expression of TP53 protein CTD PMID:16330492 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
pendimethalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B22 cytochrome P450 2B22 decreases response to substance EXP CYP2B22 protein results in decreased susceptibility to pendimethalin CTD PMID:16315095 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,413
JBrowse link
Pepstatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTA4H leukotriene A4 hydrolase decreases activity EXP pepstatin results in decreased activity of LTA4H protein CTD PMID:21670530 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1B adrenoceptor alpha 1B increases activity EXP Phenylephrine results in increased activity of ADRA1B protein CTD PMID:19376108 NCBI chr16:63,550,123...64,010,838
Ensembl chr16:63,550,128...63,603,034
JBrowse link
G ADRA1D adrenoceptor alpha 1D increases activity EXP Phenylephrine results in increased activity of ADRA1D protein CTD PMID:19376108 NCBI chr17:31,517,021...31,537,361
Ensembl chr17:31,517,021...31,537,361
JBrowse link
G C5 complement C5 affects response to substance EXP C5 protein affects the susceptibility to Phenylephrine CTD PMID:10750764 NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,662...261,133,483
JBrowse link
putrescine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 increases degradation EXP AOC1 protein results in increased degradation of Putrescine CTD PMID:8144586 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,306,835...6,320,974
JBrowse link
raloxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Raloxifene Hydrochloride results in decreased phosphorylation of AKT1 protein CTD PMID:17348974
G CAV1 caveolin 1 increases expression EXP Raloxifene Hydrochloride results in increased expression of CAV1 protein CTD PMID:16680078 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation EXP Raloxifene Hydrochloride results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:17348974 NCBI chr15:48,423,001...48,443,373
Ensembl chr15:48,422,816...48,443,399
JBrowse link
G ESR1 estrogen receptor 1 decreases expression
affects expression
affects binding
EXP Raloxifene Hydrochloride results in decreased expression of ESR1 protein alternative form
Raloxifene Hydrochloride affects the expression of ESR1 protein
Raloxifene Hydrochloride metabolite binds to ESR1 protein
CTD PMID:15653758, PMID:16680078, PMID:16790557, PMID:17348974 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
G ESR2 estrogen receptor 2 affects expression EXP Raloxifene Hydrochloride affects the expression of ESR2 protein CTD PMID:15653758, PMID:16680078 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,722,164...193,906,565
JBrowse link
G F3 coagulation factor III, tissue factor affects expression EXP Raloxifene Hydrochloride affects the expression of F3 protein CTD PMID:15964915 NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,992...122,837,672
JBrowse link
G MMP2 matrix metallopeptidase 2 affects secretion EXP Raloxifene Hydrochloride affects the secretion of MMP2 protein CTD PMID:15653758 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982
JBrowse link
G NOS3 nitric oxide synthase 3 increases phosphorylation
affects expression
multiple interactions
decreases expression
EXP Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein
Raloxifene Hydrochloride affects the expression of NOS3 mRNA
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein]
Raloxifene Hydrochloride results in decreased expression of NOS3 protein
CTD PMID:15653758, PMID:16680078, PMID:17618301 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G PDGFB platelet derived growth factor subunit B multiple interactions EXP Raloxifene Hydrochloride affects the secretion of [PDGFB protein binds to PDGFB protein] CTD PMID:15653758 Ensembl chr 5:8,986,461...9,007,446 JBrowse link
G SELP selectin P affects expression EXP Raloxifene Hydrochloride affects the expression of SELP protein CTD PMID:15964915 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,406,203
JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression EXP Raloxifene Hydrochloride results in increased expression of TNFRSF11B protein CTD PMID:15713688 NCBI chr 4:19,850,212...19,879,132 JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B22 cytochrome P450 2B22 increases expression EXP Rifampin results in increased expression of CYP2B22 mRNA CTD PMID:19464568 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,413
JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]; Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 protein]; Ritonavir results in decreased expression of and results in decreased activity of NOS3 protein
Ritonavir results in decreased expression of NOS3 mRNA; Ritonavir results in decreased expression of NOS3 protein
CTD PMID:15681703, PMID:16123675, PMID:22037733 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
S-butyl-DL-homocysteine (S,R)-sulfoximine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
decreases activity
EXP Buthionine Sulfoximine inhibits the reaction [sulforafan inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]
Buthionine Sulfoximine results in decreased activity of GCLC protein
CTD PMID:20732396 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link
salubrinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation EXP salubrinal results in increased phosphorylation of EIF2A protein CTD PMID:17464326 NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,276
JBrowse link
saquinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression EXP Saquinavir results in decreased expression of NOS3 mRNA CTD PMID:16123675 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Serotonin results in increased expression of FOS mRNA; Serotonin results in increased expression of FOS protein
sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS protein]
CTD PMID:11426759 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN protein]
Serotonin results in increased expression of JUN mRNA; Serotonin results in increased expression of JUN protein
CTD PMID:11426759 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Serotonin results in increased phosphorylation of MAPK1 protein
sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK1 protein]
CTD PMID:11426759 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK3 protein] CTD PMID:11426759 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
sinefungin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP sinefungin results in decreased activity of COMT protein CTD PMID:26577531 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of CALR protein CTD PMID:16005169 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,225...66,102,340
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 decreases expression EXP sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein CTD PMID:16005169 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein CTD PMID:16005169 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
tamoxifen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 affects binding EXP Tamoxifen metabolite binds to ESR1 protein CTD PMID:16790557 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
JBrowse link
taurocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 increases transport EXP ABCB11 protein results in increased transport of Taurocholic Acid CTD PMID:21056966 NCBI chr15:75,402,296...75,487,092
Ensembl chr15:75,400,766...75,486,403
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of Taurocholic Acid
Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; cefquinome inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Erythromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Penicillins inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
U50488 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G OPRK1 opioid receptor kappa 1 multiple interactions EXP 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [OPRK1 protein results in increased transport of Barium] CTD PMID:12031848 NCBI chr 4:77,399,298...77,429,025
Ensembl chr 4:77,399,198...77,426,522
JBrowse link
verapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
VX nerve agent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions
decreases activity
EXP N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:20888357 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 862
    role 840
      biological role 840
        biochemical role 713
          enzyme inhibitor 307
            EC 3.* (hydrolase) inhibitor 252
              EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor 232
                EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor 230
                  EC 3.5.1.4 (amidase) inhibitor 220
                    acetaldehyde + 1
                    acetone + 0
                    acetonitrile + 0
                    ammonia + 220
                    dimethyl sulfide + 0
                    formaldehyde + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.