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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:toxaphene
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Accession:CHEBI:77850 term browser browse the term
Definition:A highly complex mixture of several hundred polychlorinated compounds obtained by chlorination of camphene to an overall chlorine content of 67-69% by weight and having an overall empirical formula of C10H10Cl8 (including optical isomers, it could theoretically contain over 32,000 congeners). Toxaphene was used from the mid-1940s as an agricultural insecticide (mostly in the USA, particularly on corn and soybeans). Use increased with the phasing out of DDT in the 1970s (it became the most heavily manufactured pesticide in the US) but it is now banned due to concerns about toxicity and carcinogenicity. Total production since its first use is estimated at around 500,000 tons. In the environment, most of the components of toxaphene get metabolised, but from 10 to >100 resist biodegradation, depending on the medium and the specialisation of the enzyme system. Breathing, drinking or eating high levels of toxaphene can damage the lungs, kidneys, and nervous system.
Synonyms:related_synonym: Toxaphen;   camphechlor;   camphechlore;   chlorinated camphene;   chlorocamphene;   polychlorocamphene
 xref: CAS:8001-35-2;   KEGG:C15470
 xref_mesh: MESH:D014112
 xref: PMID:11254057;   PMID:15295903;   PMID:20221755;   PMID:21470655;   PMID:21863113;   PMID:22162326;   PMID:22366425;   PMID:22498080;   PMID:23859873;   PMID:23939819;   PMID:24056452;   PMID:24164036;   PMID:24274290;   PMID:385896;   Patent:US2565471;   Reaxys:8188730;   Wikipedia:Toxaphene


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toxaphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 increases expression EXP Toxaphene results in increased expression of AGPAT3 mRNA CTD PMID:23153324 NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358
JBrowse link
G Ar androgen receptor multiple interactions ISO [DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Hydrocarbons, Chlorinated] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Toxaphene binds to and results in increased activity of AR protein; Toxaphene inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Toxaphene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:10696776 PMID:18324785 PMID:21295777 PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arl4a ADP-ribosylation factor like GTPase 4A decreases expression EXP Toxaphene results in decreased expression of ARL4A mRNA CTD PMID:23153324 NCBI chr 6:57,079,496...57,084,156
Ensembl chr 6:57,078,812...57,085,066
JBrowse link
G Aurkb aurora kinase B decreases expression EXP Toxaphene results in decreased expression of AURKB mRNA CTD PMID:23153324 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO Toxaphene results in increased expression of BRCA1 mRNA CTD PMID:12473173 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Cab39l calcium binding protein 39-like decreases expression EXP Toxaphene results in decreased expression of CAB39L mRNA CTD PMID:23153324 NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Toxaphene results in increased degradation of GSN protein]; CAT protein inhibits the reaction [Toxaphene results in increased degradation of PXN protein]; CAT protein inhibits the reaction [Toxaphene results in increased degradation of VIM protein] CTD PMID:12139946 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdca8 cell division cycle associated 8 decreases expression EXP Toxaphene results in decreased expression of CDCA8 mRNA CTD PMID:23153324 NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Toxaphene results in decreased expression of CDKN1A protein CTD PMID:12473173 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cfd complement factor D decreases expression EXP Toxaphene results in decreased expression of CFD mRNA CTD PMID:23153324 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression EXP Toxaphene results in increased expression of COL3A1 mRNA CTD PMID:23153324 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Toxaphene results in decreased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Toxaphene results in increased expression of CYP1A1 mRNA
NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP1A1 mRNA]
CTD PMID:26187448 PMID:28218408 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
multiple interactions
ISO Toxaphene results in increased expression of CYP1A2 mRNA
NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP1A2 mRNA]
CTD PMID:26187448 PMID:28218408 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP2B10 mRNA] CTD PMID:26187448 PMID:28218408 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression
ISO NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP2B9 mRNA] CTD PMID:28218408 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Toxaphene results in decreased expression of DUSP1 mRNA CTD PMID:23153324 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
increases expression
affects binding
ISO
EXP
[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Toxaphene co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; [Toxaphene co-treated with Dieldrin co-treated with Chlordan] inhibits the reaction [Estradiol binds to ESR1 protein]; Toxaphene binds to and results in increased activity of ESR1 protein; Toxaphene inhibits the reaction [Estradiol binds to ESR1 protein]
Toxaphene results in increased activity of ESR1 protein
Toxaphene results in increased expression of ESR1 mRNA
Toxaphene binds to ESR1 protein
CTD PMID:9168004 PMID:9860891 PMID:10774817 PMID:11356845 PMID:14579009 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity
multiple interactions
EXP
ISO
Toxaphene results in increased activity of ESR2 protein
Toxaphene binds to and results in increased activity of ESR2 protein
CTD PMID:9860891 PMID:16626760 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
decreases activity
ISO Toxaphene binds to and results in decreased activity of ESRRA protein; Toxaphene binds to and results in increased activity of ESRRA protein mutant form; Toxaphene inhibits the reaction [NCOA2 protein results in increased activity of ESRRA protein]
Toxaphene results in decreased activity of ESRRA protein
CTD PMID:10493499 PMID:11356845 PMID:11850205 PMID:15955695 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Fmn2 formin 2 affects response to substance ISO FMN2 gene SNP affects the susceptibility to Toxaphene CTD PMID:25622337 NCBI chr13:86,454,256...86,771,437 JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression ISO Toxaphene results in decreased expression of GJA1 protein CTD PMID:8820588 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Glis2 GLIS family zinc finger 2 decreases expression EXP Toxaphene results in decreased expression of GLIS2 mRNA CTD PMID:23153324 NCBI chr10:10,951,157...10,978,524
Ensembl chr10:10,951,371...10,971,578
JBrowse link
G Gsn gelsolin increases degradation
multiple interactions
ISO Toxaphene results in increased degradation of GSN protein
CAT protein inhibits the reaction [Toxaphene results in increased degradation of GSN protein]
CTD PMID:12139946 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G H2ax H2A.X variant histone decreases expression EXP Toxaphene results in decreased expression of H2AX mRNA CTD PMID:23153324 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Kbtbd2 kelch repeat and BTB domain containing 2 decreases expression EXP Toxaphene results in decreased expression of KBTBD2 mRNA CTD PMID:23153324 NCBI chr 4:86,027,947...86,050,266
Ensembl chr 4:86,027,947...86,050,211
JBrowse link
G Kctd9 potassium channel tetramerization domain containing 9 decreases expression EXP Toxaphene results in decreased expression of KCTD9 mRNA CTD PMID:23153324 NCBI chr15:41,942,165...41,969,862
Ensembl chr15:41,942,381...41,969,862
JBrowse link
G Kif22 kinesin family member 22 decreases expression EXP Toxaphene results in decreased expression of KIF22 mRNA CTD PMID:23153324 NCBI chr 1:181,635,347...181,650,351
Ensembl chr 1:181,635,183...181,650,401
JBrowse link
G Ldha lactate dehydrogenase A increases expression EXP Toxaphene results in increased expression of LDHA protein CTD PMID:1269500 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
JBrowse link
G Ldhb lactate dehydrogenase B increases expression EXP Toxaphene results in increased expression of LDHB protein CTD PMID:1269500 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Ldhc lactate dehydrogenase C increases expression EXP Toxaphene results in increased expression of LDHC protein CTD PMID:1269500 NCBI chr 1:97,385,984...97,403,382
Ensembl chr 1:97,382,379...97,403,378
JBrowse link
G Ldhd lactate dehydrogenase D decreases expression EXP Toxaphene results in decreased expression of LDHD protein CTD PMID:1269500 NCBI chr19:39,573,621...39,595,575
Ensembl chr19:39,573,621...39,595,575
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component increases expression EXP Toxaphene results in increased expression of LIN7C mRNA CTD PMID:23153324 NCBI chr 3:96,406,825...96,414,137
Ensembl chr 3:96,406,813...96,417,728
JBrowse link
G Lrig3 leucine-rich repeats and immunoglobulin-like domains 3 increases expression EXP Toxaphene results in increased expression of LRIG3 mRNA CTD PMID:23153324 NCBI chr 7:61,816,313...61,866,275
Ensembl chr 7:61,816,342...61,866,481
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [NR1I2 gene mutant form affects the susceptibility to Toxaphene] which results in increased expression of MYC mRNA CTD PMID:28218408 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Toxaphene inhibits the reaction [NCOA2 protein results in increased activity of ESRRA protein] CTD PMID:10493499 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nnmt nicotinamide N-methyltransferase decreases expression EXP Toxaphene results in decreased expression of NNMT mRNA CTD PMID:23153324 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Toxaphene results in increased activity of NR1I2 protein
[NR1I2 gene mutant form affects the susceptibility to Toxaphene] which results in increased expression of MYC mRNA
CTD PMID:16565514 PMID:25680588 PMID:28218408 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects response to substance
multiple interactions
ISO NR1I3 gene affects the susceptibility to Toxaphene
NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP1A1 mRNA]; NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP1A2 mRNA]; NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP2B9 mRNA]; NR1I3 gene mutant form inhibits the reaction [Toxaphene results in increased expression of CYP3A11 mRNA]
CTD PMID:26187448 PMID:28218408 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
affects binding
ISO
EXP
Toxaphene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Toxaphene inhibits the reaction [Progesterone binds to PGR protein]
Toxaphene results in increased expression of PGR mRNA
Toxaphene binds to PGR protein
CTD PMID:10774817 PMID:14579009 PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Prl prolactin increases expression EXP Toxaphene results in increased expression of PRL mRNA CTD PMID:12804517 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Pxn paxillin multiple interactions
increases degradation
ISO CAT protein inhibits the reaction [Toxaphene results in increased degradation of PXN protein] CTD PMID:12139946 NCBI chr12:41,060,791...41,107,962
Ensembl chr12:41,060,791...41,107,931
JBrowse link
G Pygb glycogen phosphorylase B decreases expression EXP Toxaphene results in decreased expression of PYGB mRNA CTD PMID:23153324 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553
JBrowse link
G Rab34 RAB34, member RAS oncogene family decreases expression EXP Toxaphene results in decreased expression of RAB34 mRNA CTD PMID:23153324 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Toxaphene results in decreased expression of RB1 protein CTD PMID:10048758 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Sema3c semaphorin 3C decreases expression EXP Toxaphene results in decreased expression of SEMA3C mRNA CTD PMID:23153324 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
JBrowse link
G Sesn3 sestrin 3 increases expression EXP Toxaphene results in increased expression of SESN3 mRNA CTD PMID:23153324 NCBI chr 8:11,133,822...11,189,436
Ensembl chr 8:11,133,678...11,185,842
JBrowse link
G Slc10a7 solute carrier family 10, member 7 increases expression EXP Toxaphene results in increased expression of SLC10A7 mRNA CTD PMID:23153324 NCBI chr19:29,183,143...29,407,470
Ensembl chr19:29,183,155...29,407,464
JBrowse link
G Slmap sarcolemma associated protein decreases expression EXP Toxaphene results in decreased expression of SLMAP mRNA CTD PMID:23153324 NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149
JBrowse link
G Tbc1d13 TBC1 domain family, member 13 increases expression EXP Toxaphene results in increased expression of TBC1D13 mRNA CTD PMID:23153324 NCBI chr 3:13,408,935...13,425,524
Ensembl chr 3:13,408,920...13,425,517
JBrowse link
G Tenm2 teneurin transmembrane protein 2 affects response to substance ISO TENM2 gene SNP affects the susceptibility to Toxaphene CTD PMID:25622337 NCBI chr10:20,480,662...21,706,415
Ensembl chr10:20,481,854...21,705,597
JBrowse link
G Tff1 trefoil factor 1 decreases expression
increases expression
decreases secretion
ISO Toxaphene results in decreased expression of TFF1 mRNA
Toxaphene results in increased expression of TFF1 mRNA
Toxaphene results in decreased secretion of TFF1 protein
CTD PMID:9276643 PMID:12473173 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Tmem63a transmembrane protein 63a increases expression EXP Toxaphene results in increased expression of TMEM63A mRNA CTD PMID:23153324 NCBI chr13:92,662,872...92,696,186
Ensembl chr13:92,663,968...92,696,183
JBrowse link
G Trim29 tripartite motif-containing 29 decreases expression EXP Toxaphene results in decreased expression of TRIM29 mRNA CTD PMID:23153324 NCBI chr 8:43,682,221...43,706,992
Ensembl chr 8:43,682,221...43,706,992
JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases expression EXP Toxaphene results in increased expression of TSHB protein CTD PMID:8933632 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tubb6 tubulin, beta 6 class V decreases expression EXP Toxaphene results in decreased expression of TUBB6 mRNA CTD PMID:23153324 NCBI chr18:60,943,394...60,953,031
Ensembl chr18:60,943,375...60,954,418
JBrowse link
G Ube4b ubiquitination factor E4B increases expression EXP Toxaphene results in increased expression of UBE4B mRNA CTD PMID:23153324 NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509
JBrowse link
G Upb1 beta-ureidopropionase 1 affects response to substance ISO UPB1 gene SNP affects the susceptibility to Toxaphene CTD PMID:25622337 NCBI chr20:13,217,252...13,243,590
Ensembl chr20:13,217,258...13,243,590
JBrowse link
G Vim vimentin increases degradation
multiple interactions
ISO Toxaphene results in increased degradation of VIM protein
CAT protein inhibits the reaction [Toxaphene results in increased degradation of VIM protein]
CTD PMID:12139946 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 decreases expression EXP Toxaphene results in decreased expression of WSB1 mRNA CTD PMID:23153324 NCBI chr10:64,202,761...64,219,039
Ensembl chr10:64,202,763...64,219,019
JBrowse link
G Zfp36 zinc finger protein 36 decreases expression EXP Toxaphene results in decreased expression of ZFP36 mRNA CTD PMID:23153324 NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
JBrowse link
G Zfyve1 zinc finger FYVE-type containing 1 increases expression EXP Toxaphene results in increased expression of ZFYVE1 mRNA CTD PMID:23153324 NCBI chr 6:103,184,938...103,234,111
Ensembl chr 6:103,184,938...103,234,039
JBrowse link
G Zfyve26 zinc finger FYVE-type containing 26 increases expression EXP Toxaphene results in increased expression of ZFYVE26 mRNA CTD PMID:23153324 NCBI chr 6:98,031,874...98,095,538
Ensembl chr 6:98,032,520...98,095,480
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        agrochemical 15037
          toxaphene 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        pesticide 16979
          acaricide 12037
            toxaphene 63
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