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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tilidine
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Accession:CHEBI:77823 term browser browse the term
Definition:A racemate that is an equimolar mixture of the two trans diastereoisomers of ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate, namely dextilidine and ent-dextilidine. It is used (commonly as the hydrochloride hemihydrate) as an opioid analgesic for the management of moderate to severe pain. A prodrug, it is metabolised in the body to nortilidine, which is responsible for the analgesic activity; virtually all of the opioid activity resides in the (1S,2R) isomer.
Synonyms:exact_synonym: rac-ethyl (1R,2S)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate;   rac-ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
 related_synonym: ethyl trans-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate;   tilidina;   tilidinum
 xref: CAS:51931-66-9;   KEGG:D08597;   PMID:11144998;   PMID:21140136;   PMID:212687;   PMID:22381043;   PMID:23844964;   PMID:2610722;   PMID:3803198;   PMID:6852098;   PMID:720208;   Patent:GB1120186;   Patent:US3557127;   Reaxys:2813935;   Wikipedia:Tilidine



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Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      application 19679
        pro-agent 11524
          prodrug 11285
            tilidine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    main group molecular entity 19806
                      s-block molecular entity 19616
                        hydrogen molecular entity 19596
                          hydrides 19108
                            inorganic hydride 18111
                              pnictogen hydride 18100
                                nitrogen hydride 18008
                                  azane 17815
                                    ammonia 17837
                                      organic amino compound 17814
                                        amino acid 15950
                                          non-proteinogenic amino acid 3987
                                            beta-amino acid 205
                                              beta-amino acid ester 141
                                                ethyl 2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate 0
                                                  ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate 0
                                                    dextilidine 0
                                                      tilidine 0
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