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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tilidine
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Accession:CHEBI:77823 term browser browse the term
Definition:A racemate that is an equimolar mixture of the two trans diastereoisomers of ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate, namely dextilidine and ent-dextilidine. It is used (commonly as the hydrochloride hemihydrate) as an opioid analgesic for the management of moderate to severe pain. A prodrug, it is metabolised in the body to nortilidine, which is responsible for the analgesic activity; virtually all of the opioid activity resides in the (1S,2R) isomer.
Synonyms:exact_synonym: rac-ethyl (1R,2S)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate;   rac-ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
 related_synonym: ethyl trans-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate;   tilidina;   tilidinum
 xref: CAS:51931-66-9;   KEGG:D08597;   PMID:11144998;   PMID:21140136;   PMID:212687;   PMID:22381043;   PMID:23844964;   PMID:2610722;   PMID:3803198;   PMID:6852098;   PMID:720208;   Patent:GB1120186;   Patent:US3557127;   Reaxys:2813935;   Wikipedia:Tilidine


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Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pro-agent 12349
          prodrug 12109
            tilidine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            inorganic hydride 18602
                              pnictogen hydride 18589
                                nitrogen hydride 18502
                                  azane 18262
                                    ammonia 18261
                                      organic amino compound 18261
                                        amino acid 16340
                                          non-proteinogenic amino acid 4058
                                            beta-amino acid 231
                                              beta-amino acid ester 168
                                                ethyl 2-(methylamino)-1-phenylcyclohex-3-ene-1-carboxylate 0
                                                  ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate 0
                                                    dextilidine 0
                                                      tilidine 0
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