CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: oripavine
Accession: CHEBI:7782
browse the term
Definition: A morphinane alkaloid with formula C18H19NO3. It is the major metabolite of thebaine.
Synonyms: exact_synonym: 6-methoxy-17-methyl-5alpha-6,7,8,14-tetradehydro-4,5-epoxymorphinan-3-ol
related_synonym: (5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol; 3-O-demethylthebaine; 6,7,8,14-tetradehydro-4,5alpha-epoxy-6-methoxy-17-methyl-morphinan-3-ol; Formula=C18H19NO3; InChI=1S/C18H19NO3/c1-19-8-7-18-11-4-6-14(21-2)17(18)22-16-13(20)5-3-10(15(16)18)9-12(11)19/h3-6,12,17,20H,7-9H2,1-2H3/t12-,17+,18+/m1/s1; InChIKey=ZKLXUUYLEHCAMF-UUWFMWQGSA-N; SMILES=COC1=CC=C2[C@H]3CC4=CC=C(O)C5=C4[C@@]2(CCN3C)[C@H]1O5
xref: CAS:467-04-9; FooDB:FDB002075; HMDB:HMDB0030251; KEGG:C06175; KNApSAcK:C00028775; PMID:1177252; PMID:16135; PMID:17912784; PMID:21186398; PMID:21495679; PMID:28095631; PMID:37132502; Patent:AU2008203048; Patent:AU2008231127; Patent:US2010113787; Wikipedia:Oripavine
cyclic_relationship: is_conjugate_base_of CHEBI:194499
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Abca8
ATP binding cassette subfamily A member 8
increases expression
EXP
Oxycodone results in increased expression of ABCA8 mRNA
CTD
PMID:23439660
NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
EXP
Oxycodone results in increased expression of ABCB1A mRNA; Oxycodone results in increased expression of ABCB1A protein
CTD
PMID:23439660
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb4
ATP binding cassette subfamily B member 4
increases expression
EXP
Oxycodone results in increased expression of ABCB4 mRNA
CTD
PMID:23439660
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcg1
ATP binding cassette subfamily G member 1
decreases expression
EXP
Oxycodone results in decreased expression of ABCG1 mRNA
CTD
PMID:23439660
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Abcg5
ATP binding cassette subfamily G member 5
increases expression
EXP
Oxycodone results in increased expression of ABCG5 mRNA
CTD
PMID:23439660
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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Abhd6
abhydrolase domain containing 6, acylglycerol lipase
increases expression
EXP
Oxycodone results in increased expression of ABHD6 mRNA
CTD
PMID:23439660
NCBI chr15:16,859,740...16,907,094
Ensembl chr15:16,859,738...16,906,985
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Acsm2
acyl-CoA synthetase medium-chain family member 2
increases expression
EXP
Oxycodone results in increased expression of ACSM2A mRNA
CTD
PMID:23439660
NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
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Actn1
actinin, alpha 1
decreases expression
EXP
Oxycodone results in decreased expression of ACTN1 mRNA
CTD
PMID:23439660
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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Adam17
ADAM metallopeptidase domain 17
decreases expression
EXP
Oxycodone results in decreased expression of ADAM17 mRNA
CTD
PMID:23439660
NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
increases expression
EXP
Oxycodone results in increased expression of ADAMTS1 mRNA
CTD
PMID:23439660
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Adgre1
adhesion G protein-coupled receptor E1
decreases expression
EXP
Oxycodone results in decreased expression of ADGRE1 mRNA
CTD
PMID:23439660
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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Ahr
aryl hydrocarbon receptor
increases expression
EXP
Oxycodone results in increased expression of AHR mRNA
CTD
PMID:23439660
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akr1c3
aldo-keto reductase family 1, member C3
decreases expression
EXP
Oxycodone results in decreased expression of AKR1C3 mRNA
CTD
PMID:23439660
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Akt1
AKT serine/threonine kinase 1
increases expression
EXP ISO
Oxycodone increases expression of Akt1 mRNA in the hippocampal formation Oxycodone increases expression of Akt1 mRNA in the hippocampus
RGD
PMID:31071414 PMID:25446355
RGD:405866388 , RGD:407445976
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Anxa3
annexin A3
decreases expression
EXP
Oxycodone results in decreased expression of ANXA3 mRNA
CTD
PMID:23439660
NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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Arhgdib
Rho GDP dissociation inhibitor beta
decreases expression
EXP
Oxycodone results in decreased expression of ARHGDIB mRNA
CTD
PMID:23439660
NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658
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Asl
argininosuccinate lyase
increases expression
EXP
Oxycodone results in increased expression of ASL mRNA
CTD
PMID:23439660
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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Atf4
activating transcription factor 4
increases expression
ISO EXP
Oxycodone results in increased expression of ATF4 protein
CTD
PMID:26377394
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
increases expression
EXP
Oxycodone results in increased expression of ATP1B1 mRNA
CTD
PMID:23439660
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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B4galnt1
beta-1,4-N-acetyl-galactosaminyl transferase 1
increases expression
EXP
Oxycodone results in increased expression of B4GALNT1 mRNA
CTD
PMID:23439660
NCBI chr 7:62,988,429...62,996,190
Ensembl chr 7:62,988,930...62,996,190
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Bcl2a1
BCL2-related protein A1
decreases expression
EXP
Oxycodone results in decreased expression of BCL2A1 mRNA
CTD
PMID:23439660
NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
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Blvra
biliverdin reductase A
decreases expression
EXP
Oxycodone results in decreased expression of BLVRA mRNA
CTD
PMID:23439660
NCBI chr 3:114,340,778...114,366,048
Ensembl chr 3:114,340,838...114,366,033
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Car3
carbonic anhydrase 3
decreases expression
EXP
Oxycodone results in decreased expression of CA3 mRNA
CTD
PMID:23439660
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
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Cav2
caveolin 2
decreases expression
EXP
Oxycodone results in decreased expression of CAV2 mRNA
CTD
PMID:23439660
NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
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Ccl9
C-C motif chemokine ligand 9
decreases expression
EXP
Oxycodone results in decreased expression of CCL6 mRNA
CTD
PMID:23439660
NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
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Cd5l
Cd5 molecule-like
decreases expression
EXP
Oxycodone results in decreased expression of CD5L mRNA
CTD
PMID:23439660
NCBI chr 2:172,791,007...172,802,018
Ensembl chr 2:172,790,934...172,829,753
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
EXP
Oxycodone results in increased expression of CDKN1A mRNA
CTD
PMID:23439660
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Ces2h
carboxylesterase 2H
affects expression increases expression
EXP
Oxycodone affects the expression of CES2 mRNA Oxycodone results in increased expression of CES2 mRNA
CTD
PMID:20487198 PMID:23439660
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Chd1l
chromodomain helicase DNA binding protein 1-like
increases expression
EXP
Oxycodone results in increased expression of CHD1L mRNA
CTD
PMID:23439660
NCBI chr 2:185,138,526...185,217,498
Ensembl chr 2:185,139,308...185,217,595
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Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
decreases expression
EXP
Oxycodone results in decreased expression of CMTM6 mRNA
CTD
PMID:23439660
NCBI chr 8:114,422,934...114,441,034
Ensembl chr 8:114,422,921...114,441,033
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
decreases expression
EXP
Oxycodone results in decreased expression of CNP1 mRNA
CTD
PMID:23439660
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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Cotl1
coactosin-like F-actin binding protein 1
decreases expression
EXP
Oxycodone results in decreased expression of COTL1 mRNA
CTD
PMID:23439660
NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
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Csrp1
cysteine and glycine-rich protein 1
decreases expression
EXP
Oxycodone results in decreased expression of CSRP1 mRNA
CTD
PMID:23439660
NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
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Ctsc
cathepsin C
decreases expression
EXP
Oxycodone results in decreased expression of CTSC mRNA
CTD
PMID:23439660
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Ctsl
cathepsin L
increases expression
EXP
Oxycodone results in increased expression of CTSL mRNA
CTD
PMID:23439660
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cyba
cytochrome b-245 alpha chain
decreases expression
EXP
Oxycodone results in decreased expression of CYBA mRNA
CTD
PMID:23439660
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
affects expression increases expression
EXP
Oxycodone affects the expression of CYP17A1 mRNA Oxycodone results in increased expression of CYP17A1 mRNA
CTD
PMID:20487198 PMID:23439660
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
increases expression
EXP
Oxycodone results in increased expression of CYP27A1 mRNA
CTD
PMID:23439660
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
increases expression
EXP
Oxycodone results in increased expression of CYP2A1 mRNA
CTD
PMID:23439660
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
affects expression increases expression
EXP
Oxycodone affects the expression of CYP2B2 mRNA Oxycodone results in increased expression of CYP2B2 mRNA; Oxycodone results in increased expression of CYP2B2 protein
CTD
PMID:20487198 PMID:23439660
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases expression
EXP
Oxycodone results in decreased expression of CYP2C11 mRNA
CTD
PMID:23439660
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c13
cytochrome P450, family 2, subfamily c, polypeptide 13
affects expression decreases expression
EXP
Oxycodone affects the expression of CYP2C13 mRNA Oxycodone results in decreased expression of CYP2C13 mRNA
CTD
PMID:20487198 PMID:23439660
NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
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Cyp2c7
cytochrome P450, family 2, subfamily c, polypeptide 7
decreases expression
EXP
Oxycodone results in decreased expression of CYP2C9 mRNA
CTD
PMID:23439660
NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
affects response to substance multiple interactions
ISO
CYP2D6 gene polymorphism affects the susceptibility to Oxycodone [Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone
CTD
PMID:20590588
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Oxycodone results in increased expression of CYP2E1 mRNA
CTD
PMID:23439660
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
increases expression
EXP
Oxycodone results in increased expression of CYP2J4 mRNA
CTD
PMID:23439660
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions decreases expression affects metabolic processing
EXP ISO
Oxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone] Oxycodone results in decreased expression of CYP3A2 mRNA; Oxycodone results in decreased expression of CYP3A2 protein telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone] CYP3A4 protein alternative form affects the metabolism of Oxycodone
CTD
PMID:19755414 PMID:20487198 PMID:33393779
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Oxycodone results in increased expression of CYP3A23-3A1 mRNA; Oxycodone results in increased expression of CYP3A23-3A1 protein
CTD
PMID:23439660
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
increases expression
EXP
Oxycodone results in increased expression of CYP4B1 mRNA
CTD
PMID:23439660
NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348
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Dbt
dihydrolipoamide branched chain transacylase E2
increases expression
EXP
Oxycodone results in increased expression of DBT mRNA
CTD
PMID:23439660
NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
increases expression
EXP
Oxycodone results in increased expression of EHHADH mRNA
CTD
PMID:23439660
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
multiple interactions increases phosphorylation
ISO EXP
Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein]
CTD
PMID:26377394
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Ell2
elongation factor for RNA polymerase II 2
increases expression
EXP
Oxycodone results in increased expression of ELL2 mRNA
CTD
PMID:23439660
NCBI chr 2:5,189,375...5,258,781
Ensembl chr 2:5,189,971...5,258,781
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Ephx2
epoxide hydrolase 2
affects expression
EXP
Oxycodone affects the expression of EPHX2 mRNA
CTD
PMID:20487198
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Exosc5
exosome component 5
increases expression
EXP
Oxycodone results in increased expression of EXOSC5 mRNA
CTD
PMID:23439660
NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265
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Fcgr2a
Fc gamma receptor 2A
decreases expression
EXP
Oxycodone results in decreased expression of FCGR2A mRNA
CTD
PMID:23439660
NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967
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Fkbp5
FKBP prolyl isomerase 5
increases expression
EXP
Oxycodone results in increased expression of FKBP5 mRNA
CTD
PMID:23439660
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Fmo1
flavin containing dimethylaniline monoxygenase 1
affects expression increases expression
EXP
Oxycodone affects the expression of FMO1 mRNA Oxycodone results in increased expression of FMO1 mRNA
CTD
PMID:20487198 PMID:23439660
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Oxycodone results in increased expression of FOS protein
CTD
PMID:26377394
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
increases expression
EXP
Oxycodone results in increased expression of GPAM mRNA
CTD
PMID:23439660
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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Gpt
glutamic--pyruvic transaminase
increases expression
EXP
Oxycodone results in increased expression of GPT mRNA
CTD
PMID:23439660
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpt2
glutamic--pyruvic transaminase 2
increases expression
EXP
Oxycodone results in increased expression of GPT2 mRNA
CTD
PMID:23439660
NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
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Gsta3
glutathione S-transferase alpha 3
increases expression
EXP
Oxycodone results in increased expression of GSTA3 mRNA
CTD
PMID:23439660
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
Oxycodone results in increased expression of GSTA5 mRNA; Oxycodone results in increased expression of GSTA5 protein
CTD
PMID:20487198
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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Hacl1
2-hydroxyacyl-CoA lyase 1
increases expression
EXP
Oxycodone results in increased expression of HACL1 mRNA
CTD
PMID:23439660
NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027
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Hao2
hydroxyacid oxidase 2
decreases expression
EXP
Oxycodone results in decreased expression of HAO2 mRNA
CTD
PMID:23439660
NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
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Hck
HCK proto-oncogene, Src family tyrosine kinase
decreases expression
EXP
Oxycodone results in decreased expression of HCK mRNA
CTD
PMID:23439660
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
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Hexb
hexosaminidase subunit beta
increases expression
EXP
Oxycodone results in increased expression of HEXB mRNA
CTD
PMID:23439660
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
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Hnrnpab
heterogeneous nuclear ribonucleoprotein A/B
increases expression
EXP
Oxycodone results in increased expression of HNRNPAB mRNA
CTD
PMID:23439660
NCBI chr10:35,857,040...35,862,935
Ensembl chr10:35,857,041...35,863,344
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Homer1
homer scaffold protein 1
increases expression
EXP
Oxycodone results in increased expression of HOMER1 mRNA
CTD
PMID:23439660
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
decreases expression
EXP
Oxycodone results in decreased expression of HSD11B1 mRNA
CTD
PMID:23439660
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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Hspa5
heat shock protein family A (Hsp70) member 5
increases expression
ISO EXP
Oxycodone results in increased expression of HSPA5 protein
CTD
PMID:26377394
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Igfals
insulin-like growth factor binding protein, acid labile subunit
decreases expression
EXP
Oxycodone results in decreased expression of IGFALS mRNA
CTD
PMID:23439660
NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
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Igfbp1
insulin-like growth factor binding protein 1
increases expression
EXP
Oxycodone results in increased expression of IGFBP1 mRNA
CTD
PMID:23439660
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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Il18bp
interleukin 18 binding protein
decreases expression
EXP
Oxycodone results in decreased expression of IL18BP mRNA
CTD
PMID:23439660
NCBI chr 1:156,372,923...156,374,963
Ensembl chr 1:156,372,883...156,374,963
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Inhbe
inhibin subunit beta E
decreases expression
EXP
Oxycodone results in decreased expression of INHBE mRNA
CTD
PMID:23439660
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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Ip6k2
inositol hexakisphosphate kinase 2
increases expression
EXP
Oxycodone results in increased expression of IP6K2 mRNA
CTD
PMID:23439660
NCBI chr 8:109,483,843...109,510,172
Ensembl chr 8:109,484,310...109,510,166
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Itgb2
integrin subunit beta 2
decreases expression
EXP
Oxycodone results in decreased expression of ITGB2 mRNA
CTD
PMID:23439660
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
G
Itpr1
inositol 1,4,5-trisphosphate receptor, type 1
increases expression
EXP
Oxycodone results in increased expression of ITPR1 mRNA
CTD
PMID:23439660
NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
G
Jchain
joining chain of multimeric IgA and IgM
decreases expression
EXP
Oxycodone results in decreased expression of JCHAIN mRNA
CTD
PMID:23439660
NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298
G
Klc4
kinesin light chain 4
increases expression
EXP
Oxycodone results in increased expression of KLC4 mRNA
CTD
PMID:23439660
NCBI chr 9:14,337,164...14,351,075
Ensembl chr 9:14,337,534...14,351,066
G
Lcp1
lymphocyte cytosolic protein 1
decreases expression
EXP
Oxycodone results in decreased expression of LCP1 mRNA
CTD
PMID:23439660
NCBI chr15:50,443,300...50,544,682
Ensembl chr15:50,488,149...50,544,680
G
Lgals3
galectin 3
decreases expression
EXP
Oxycodone results in decreased expression of LGALS3 mRNA
CTD
PMID:23439660
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
G
Lhpp
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
increases expression
EXP
Oxycodone results in increased expression of LHPP mRNA
CTD
PMID:23439660
NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578
G
Lin7a
lin-7 homolog A, crumbs cell polarity complex component
decreases expression
EXP
Oxycodone results in decreased expression of LIN7A mRNA
CTD
PMID:23439660
NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:42,586,719...42,730,550
G
Ly86
lymphocyte antigen 86
decreases expression
EXP
Oxycodone results in decreased expression of LY86 mRNA
CTD
PMID:23439660
NCBI chr17:27,415,807...27,499,695
Ensembl chr17:27,415,830...27,487,260
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
EXP
Oxycodone results in increased phosphorylation of MAPK1 protein
CTD
PMID:26377394
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
EXP
Oxycodone results in increased phosphorylation of MAPK3 protein
CTD
PMID:26377394
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Masp1
MBL associated serine protease 1
decreases expression
EXP
Oxycodone results in decreased expression of MASP1 mRNA
CTD
PMID:23439660
NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
G
Mtmr7
myotubularin related protein 7
increases expression
EXP
Oxycodone results in increased expression of MTMR7 mRNA
CTD
PMID:23439660
NCBI chr16:51,641,267...51,732,212
Ensembl chr16:51,641,190...51,732,182
G
Myo1b
myosin Ib
increases expression
EXP
Oxycodone results in increased expression of MYO1B mRNA
CTD
PMID:23439660
NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
G
Notch2
notch receptor 2
decreases expression
EXP
Oxycodone results in decreased expression of NOTCH2 mRNA
CTD
PMID:23439660
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases expression
EXP
Oxycodone results in increased expression of NR1I2 mRNA
CTD
PMID:23439660
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression
EXP
Oxycodone results in increased expression of NR1I3 mRNA
CTD
PMID:23439660
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Nrep
neuronal regeneration related protein
decreases expression
EXP
Oxycodone results in decreased expression of NREP mRNA
CTD
PMID:23439660
NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591
G
Oprd1
opioid receptor, delta 1
affects binding
EXP
Oxycodone binds to OPRD1 protein
CTD
PMID:7562497
NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
G
Oprk1
opioid receptor, kappa 1
affects binding
EXP
Oxycodone binds to OPRK1 protein
CTD
PMID:7562497
NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
G
Oprm1
opioid receptor, mu 1
affects binding
EXP
Oxycodone binds to OPRM1 protein
CTD
PMID:7562497
NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
G
Orm1
orosomucoid 1
decreases expression
EXP
Oxycodone results in decreased expression of ORM1 mRNA
CTD
PMID:23439660
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
G
Osgin1
oxidative stress induced growth inhibitor 1
decreases expression
EXP
Oxycodone results in decreased expression of OSGIN1 mRNA
CTD
PMID:23439660
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
G
Pde4b
phosphodiesterase 4B
decreases expression
EXP
Oxycodone results in decreased expression of PDE4B mRNA
CTD
PMID:23439660
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
G
Pdgfra
platelet derived growth factor receptor alpha
increases expression
EXP
Oxycodone results in increased expression of PDGFRA protein
CTD
PMID:26377394
NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
G
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
increases expression
EXP
Oxycodone results in increased expression of PFKFB1 mRNA
CTD
PMID:23439660
NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182
G
Pik3c3
phosphatidylinositol 3-kinase, catalytic subunit type 3
decreases expression
EXP
Oxycodone results in decreased expression of PIK3C3 mRNA
CTD
PMID:23439660
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
G
Pla2g4a
phospholipase A2 group 4A
decreases expression
EXP
Oxycodone results in decreased expression of PLA2G4A mRNA
CTD
PMID:23439660
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
G
Pld1
phospholipase D1
decreases expression
EXP
Oxycodone results in decreased expression of PLD1 mRNA
CTD
PMID:23439660
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
G
Plscr1
phospholipid scramblase 1
decreases expression
EXP
Oxycodone results in decreased expression of PLSCR1 mRNA
CTD
PMID:23439660
NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
G
Pnpla7
patatin-like phospholipase domain containing 7
increases expression
EXP
Oxycodone results in increased expression of PNPLA7 mRNA
CTD
PMID:23439660
NCBI chr 3:7,782,572...7,861,504
Ensembl chr 3:7,782,572...7,861,497
G
Por
cytochrome p450 oxidoreductase
increases expression
EXP
Oxycodone results in increased expression of POR mRNA
CTD
PMID:23439660
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Prkab1
protein kinase AMP-activated non-catalytic subunit beta 1
decreases expression
EXP
Oxycodone results in decreased expression of PRKAB1 mRNA
CTD
PMID:23439660
NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661
G
Prkaca
protein kinase cAMP-activated catalytic subunit alpha
increases phosphorylation
EXP
Oxycodone results in increased phosphorylation of PRKACA protein
CTD
PMID:26377394
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
G
Prlr
prolactin receptor
increases expression
EXP
Oxycodone results in increased expression of PRLR mRNA
CTD
PMID:23439660
NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
G
Ptdss2
phosphatidylserine synthase 2
increases expression
EXP
Oxycodone results in increased expression of PTDSS2 mRNA
CTD
PMID:23439660
NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685
G
Ptp4a1
protein tyrosine phosphatase 4A1
increases expression
EXP
Oxycodone results in increased expression of PTP4A1 mRNA
CTD
PMID:23439660
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
G
Pxmp4
peroxisomal membrane protein 4
increases expression
EXP
Oxycodone results in increased expression of PXMP4 mRNA
CTD
PMID:23439660
NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651
G
Pycard
PYD and CARD domain containing
decreases expression
EXP
Oxycodone results in decreased expression of PYCARD mRNA
CTD
PMID:23439660
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
G
Rab30
RAB30, member RAS oncogene family
increases expression
EXP
Oxycodone results in increased expression of RAB30 mRNA
CTD
PMID:23439660
NCBI chr 1:146,803,719...146,898,369
Ensembl chr 1:146,803,714...146,892,181
G
Rab38
RAB38, member RAS oncogene family
decreases expression
EXP
Oxycodone results in decreased expression of RAB38 mRNA
CTD
PMID:23439660
NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
G
Rac2
Rac family small GTPase 2
decreases expression
EXP
Oxycodone results in decreased expression of RAC2 mRNA
CTD
PMID:23439660
NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720
G
Rcan1
regulator of calcineurin 1
decreases expression
EXP
Oxycodone results in decreased expression of RCAN1 mRNA
CTD
PMID:23439660
NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
G
Serpina7
serpin family A member 7
decreases expression
EXP
Oxycodone results in decreased expression of SERPINA7 mRNA
CTD
PMID:23439660
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
G
Skap2
src kinase associated phosphoprotein 2
decreases expression
EXP
Oxycodone results in decreased expression of SKAP2 mRNA
CTD
PMID:23439660
NCBI chr 4:80,948,832...81,100,900
Ensembl chr 4:80,950,580...81,100,891
G
Slc10a2
solute carrier family 10 member 2
decreases expression
EXP
Oxycodone results in decreased expression of SLC10A2 mRNA
CTD
PMID:23439660
NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
G
Slc15a3
solute carrier family 15 member 3
decreases expression
EXP
Oxycodone results in decreased expression of SLC15A3 mRNA
CTD
PMID:23439660
NCBI chr 1:207,492,365...207,507,158
Ensembl chr 1:207,492,365...207,507,157
G
Slc16a1
solute carrier family 16 member 1
decreases expression
EXP
Oxycodone results in decreased expression of SLC16A1 mRNA
CTD
PMID:23439660
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
G
Slc16a10
solute carrier family 16 member 10
increases expression
EXP
Oxycodone results in increased expression of SLC16A10 mRNA
CTD
PMID:23439660
NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
G
Slc17a5
solute carrier family 17 member 5
increases expression
EXP
Oxycodone results in increased expression of SLC17A5 mRNA
CTD
PMID:23439660
NCBI chr 8:79,394,416...79,429,387
G
Slc1a2
solute carrier family 1 member 2
increases expression
EXP
Oxycodone results in increased expression of SLC1A2 mRNA
CTD
PMID:23439660
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
G
Slc22a5
solute carrier family 22 member 5
increases expression
EXP
Oxycodone results in increased expression of SLC22A5 mRNA
CTD
PMID:23439660
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
G
Slc22a8
solute carrier family 22 member 8
decreases expression
EXP
Oxycodone results in decreased expression of SLC22A8 mRNA
CTD
PMID:23439660
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
G
Slc25a15
solute carrier family 25 member 15
increases expression
EXP
Oxycodone results in increased expression of SLC25A15 mRNA
CTD
PMID:23439660
NCBI chr16:69,631,581...69,654,869
Ensembl chr16:69,634,414...69,653,010
G
Slc25a29
solute carrier family 25 member 29
increases expression
EXP
Oxycodone results in increased expression of SLC25A29 mRNA
CTD
PMID:23439660
NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:127,742,033...127,752,940
G
Slc25a30
solute carrier family 25, member 30
decreases expression
EXP
Oxycodone results in decreased expression of SLC25A30 mRNA
CTD
PMID:23439660
NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
G
Slc27a5
solute carrier family 27 member 5
increases expression
EXP
Oxycodone results in increased expression of SLC27A5 mRNA
CTD
PMID:23439660
NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
G
Slc2a2
solute carrier family 2 member 2
increases expression
EXP
Oxycodone results in increased expression of SLC2A2 mRNA
CTD
PMID:23439660
NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
G
Slc34a2
solute carrier family 34 member 2
decreases expression
EXP
Oxycodone results in decreased expression of SLC34A2 mRNA
CTD
PMID:23439660
NCBI chr14:57,910,931...57,930,236
Ensembl chr14:57,910,480...57,930,436
G
Slc35b2
solute carrier family 35 member B2
decreases expression
EXP
Oxycodone results in decreased expression of SLC35B2 mRNA
CTD
PMID:23439660
NCBI chr 9:15,438,594...15,442,227
Ensembl chr 9:15,438,594...15,442,234
G
Slc37a4
solute carrier family 37 member 4
increases expression
EXP
Oxycodone results in increased expression of SLC37A4 mRNA
CTD
PMID:23439660
NCBI chr 8:44,723,216...44,729,301
Ensembl chr 8:44,723,339...44,729,301
G
Slc38a4
solute carrier family 38, member 4
increases expression
EXP
Oxycodone results in increased expression of SLC38A4 mRNA
CTD
PMID:23439660
NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995
G
Slc39a4
solute carrier family 39 member 4
increases expression
EXP
Oxycodone results in increased expression of SLC39A4 mRNA
CTD
PMID:23439660
NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553
G
Slc41a2
solute carrier family 41 member 2
decreases expression
EXP
Oxycodone results in decreased expression of SLC41A2 mRNA
CTD
PMID:23439660
NCBI chr 7:20,383,714...20,491,178
Ensembl chr 7:20,383,757...20,491,166
G
Slc49a4
solute carrier family 49 member 4
increases expression
EXP
Oxycodone results in increased expression of SLC49A4 mRNA
CTD
PMID:23439660
NCBI chr11:64,995,629...65,068,929
Ensembl chr11:64,995,679...65,068,926
G
Slc6a9
solute carrier family 6 member 9
decreases expression
EXP
Oxycodone results in decreased expression of SLC6A9 mRNA
CTD
PMID:23439660
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
G
Slc7a7
solute carrier family 7 member 7
decreases expression
EXP
Oxycodone results in decreased expression of SLC7A7 mRNA
CTD
PMID:23439660
NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648
G
Slco1b2
solute carrier organic anion transporter family member 1B2
increases expression
EXP
Oxycodone results in increased expression of SLCO1B2 mRNA
CTD
PMID:23439660
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
G
Slpi
secretory leukocyte peptidase inhibitor
decreases expression
EXP
Oxycodone results in decreased expression of SLPI mRNA
CTD
PMID:23439660
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
G
Smarcd2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
increases expression
EXP
Oxycodone results in increased expression of SMARCD2 mRNA
CTD
PMID:23439660
NCBI chr10:91,193,752...91,202,817
Ensembl chr10:91,193,752...91,204,341
G
Stac3
SH3 and cysteine rich domain 3
decreases expression
EXP
Oxycodone results in decreased expression of STAC3 mRNA
CTD
PMID:23439660
NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
G
Sulf2
sulfatase 2
increases expression
EXP
Oxycodone results in increased expression of SULF2 mRNA
CTD
PMID:23439660
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
G
Sult5a1
sulfotransferase family 5A, member 1
decreases expression
EXP
Oxycodone results in decreased expression of SULT1A2 mRNA
CTD
PMID:23439660
NCBI chr19:51,189,287...51,204,275
Ensembl chr19:51,189,287...51,204,362
G
Sycp3
synaptonemal complex protein 3
increases expression
EXP
Oxycodone results in increased expression of SYCP3 mRNA
CTD
PMID:23439660
NCBI chr 7:22,874,055...22,888,512
Ensembl chr 7:22,874,055...22,888,511
G
Tars1
threonyl-tRNA synthetase 1
decreases expression
EXP
Oxycodone results in decreased expression of TARS1 mRNA
CTD
PMID:23439660
NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717
G
Thumpd1
THUMP domain containing 1
decreases expression
EXP
Oxycodone results in decreased expression of THUMPD1 mRNA
CTD
PMID:23439660
NCBI chr 1:174,078,875...174,084,915
Ensembl chr 1:174,078,878...174,084,937
G
Timm8a1
translocase of inner mitochondrial membrane 8A1
increases expression
EXP
Oxycodone results in increased expression of TIMM8A mRNA
CTD
PMID:23439660
NCBI chr X:97,717,932...97,722,170
Ensembl chr X:97,717,920...97,721,960
G
Tle1
TLE family member 1, transcriptional corepressor
increases expression
EXP
Oxycodone results in increased expression of TLE1 mRNA
CTD
PMID:23439660
NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774
G
Tmem19
transmembrane protein 19
decreases expression
EXP
Oxycodone results in decreased expression of TMEM19 mRNA
CTD
PMID:23439660
NCBI chr 7:50,958,884...50,985,601
Ensembl chr 7:50,958,888...50,986,809
G
Tsc22d3
TSC22 domain family, member 3
increases expression
EXP
Oxycodone results in increased expression of TSC22D3 mRNA
CTD
PMID:23439660
NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861
G
Tsku
tsukushi, small leucine rich proteoglycan
increases expression
EXP
Oxycodone results in increased expression of TSKU mRNA
CTD
PMID:23439660
NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
G
Tubb5
tubulin, beta 5 class I
decreases expression
EXP
Oxycodone results in decreased expression of TUBB5 mRNA
CTD
PMID:23439660
NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
EXP
Oxycodone results in increased expression of UGT1A1 mRNA
CTD
PMID:23439660
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Usp12
ubiquitin specific peptidase 12
decreases expression
EXP
Oxycodone results in decreased expression of USP12 mRNA
CTD
PMID:23439660
NCBI chr12:8,309,845...8,363,686
Ensembl chr12:8,309,750...8,363,656
G
Ust5r
integral membrane transport protein UST5r
decreases expression
EXP
Oxycodone results in decreased expression of UST5R mRNA
CTD
PMID:23439660
NCBI chr 1:205,210,558...205,286,868
Ensembl chr 1:205,211,034...205,286,718
G
Vasp
vasodilator-stimulated phosphoprotein
decreases expression
EXP
Oxycodone results in decreased expression of VASP mRNA
CTD
PMID:23439660
NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
G
Vim
vimentin
decreases expression
EXP
Oxycodone results in decreased expression of VIM mRNA
CTD
PMID:23439660
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
G
Zfp354a
zinc finger protein 354A
increases expression
EXP
Oxycodone results in increased expression of ZNF354A mRNA
CTD
PMID:23439660
NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all