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ONTOLOGY REPORT - ANNOTATIONS


Term:temafloxacin
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Accession:CHEBI:77788 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-temafloxacin. Both enantiomers both exhibit similar pharmacological profiles. Temafloxacin was briefly used (either as the free base or as the hydrochloride salt) as an antibacterial drug but was withdrawn worldwide in 1992 following reports of serious side effects, including severe hypoglycaemia, haemolytic anaemia, liver and kidney dysfunction, anaphylaxis, and death.
Synonyms:exact_synonym: rac-1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: (+-)-1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;   A 62254;   T 1258;   rac-temafloxacin;   temafloxacine;   temafloxacino;   temafloxacinum
 xref: CAS:108319-06-8;   DrugBank:DB01405;   PMID:1318680;   PMID:1319872;   PMID:1662889;   PMID:1662893;   PMID:1662895;   PMID:1666497;   PMID:1846917;   Patent:EP131839;   Patent:US4730000;   Reaxys:4301726;   Wikipedia:Temafloxacin


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Term Annotations click to browse term
  CHEBI ontology 225
    chemical entity 225
      chemical substance 26
        mixture 26
          racemate 12
            temafloxacin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    main group molecular entity 218
                      s-block molecular entity 173
                        hydrogen molecular entity 171
                          hydrides 111
                            inorganic hydride 74
                              pnictogen hydride 73
                                nitrogen hydride 73
                                  azane 68
                                    ammonia 68
                                      organic amino compound 68
                                        aromatic amine 29
                                          N-arylpiperazine 10
                                            1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 0
                                              (R)-temafloxacin 0
                                                temafloxacin 0
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