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ONTOLOGY REPORT - ANNOTATIONS


Term:temafloxacin
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Accession:CHEBI:77788 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-temafloxacin. Both enantiomers both exhibit similar pharmacological profiles. Temafloxacin was briefly used (either as the free base or as the hydrochloride salt) as an antibacterial drug but was withdrawn worldwide in 1992 following reports of serious side effects, including severe hypoglycaemia, haemolytic anaemia, liver and kidney dysfunction, anaphylaxis, and death.
Synonyms:exact_synonym: rac-1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
 related_synonym: (+-)-1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;   A 62254;   T 1258;   rac-temafloxacin;   temafloxacine;   temafloxacino;   temafloxacinum
 xref: CAS:108319-06-8;   DrugBank:DB01405;   PMID:1318680;   PMID:1319872;   PMID:1662889;   PMID:1662893;   PMID:1662895;   PMID:1666497;   PMID:1846917;   Patent:EP131839;   Patent:US4730000;   Reaxys:4301726;   Wikipedia:Temafloxacin


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Path 1
Term Annotations click to browse term
  CHEBI ontology 19758
    chemical entity 19757
      chemical substance 11503
        mixture 10823
          racemate 9704
            temafloxacin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19758
    subatomic particle 19756
      composite particle 19756
        hadron 19756
          baryon 19756
            nucleon 19756
              atomic nucleus 19756
                atom 19756
                  main group element atom 19641
                    main group molecular entity 19641
                      s-block molecular entity 19403
                        hydrogen molecular entity 19392
                          hydrides 18362
                            inorganic hydride 17222
                              pnictogen hydride 17186
                                nitrogen hydride 17020
                                  azane 16711
                                    ammonia 16709
                                      organic amino compound 16708
                                        aromatic amine 13619
                                          N-arylpiperazine 2708
                                            1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 0
                                              (R)-temafloxacin 0
                                                temafloxacin 0
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