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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfaphenazole
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Accession:CHEBI:77780 term browser browse the term
Definition:A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.
Synonyms:exact_synonym: 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
 related_synonym: 1-phenyl-5-sulfanilamidopyrazole;   3-(p-aminobenzenesulfonamido)-2-phenylpyrazole;   5-sulfanilamido-1-phenylpyrazole;   Formula=C15H14N4O2S;   InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2;   InChIKey=QWCJHSGMANYXCW-UHFFFAOYSA-N;   N'-(1-phenylpyrazol-5-yl)sulfanilamide;   N(1)-(1-phenylpyrazol-5-yl)sulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ccnn1-c1ccccc1;   Sulfabid;   sulfafenazol;   sulfaphenazol;   sulfaphenazolum;   sulphaphenazole
 xref: CAS:526-08-9;   DrugBank:DB06729;   Drug_Central:2523;   HMDB:HMDB0015667;   KEGG:D01954;   LINCS:LSM-5279
 xref_mesh: MESH:D013426
 xref: PMID:13873771;   PMID:18845175;   PMID:22785021;   PMID:24519941;   PMID:9864343;   Patent:US2858309;   Reaxys:308518;   Wikipedia:Sulfaphenazole


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sulfaphenazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of BAX mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of BAX mRNA] CTD PMID:37414240 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in decreased expression of BCL2 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in decreased expression of BCL2 mRNA] CTD PMID:37414240 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CASP3 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CASP3 mRNA] CTD PMID:37414240 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CCL2 mRNA] CTD PMID:37414240 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cd44 CD44 molecule multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of CD44 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of CD44 mRNA] CTD PMID:37414240 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Sulfaphenazole results in decreased activity of CYP1A2 protein CTD PMID:15916432 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Sulfaphenazole results in decreased expression of CYP2C11 CTD PMID:15890479 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity
multiple interactions		 EXP
ISO		 Sulfaphenazole results in decreased activity of CYP2C6 protein
Sulfaphenazole inhibits the reaction [CYP2C19 protein results in increased metabolism of triflumuron]		 CTD PMID:12814958 PMID:31082524 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Sulfaphenazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] CTD PMID:31102695 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Sulfaphenazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone] CTD PMID:31102695 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] CTD PMID:12763371 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Sulfaphenazole affects the reaction [nimesulide affects the localization of NFE2L2 protein] CTD PMID:20405857 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [Butyric Acid co-treated with Sulfaphenazole] inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA]; Sulfaphenazole inhibits the reaction [Oxalic Acid results in increased expression of SPP1 mRNA] CTD PMID:37414240 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        antimicrobial agent 18273
          sulfonamide antibiotic 2936
            sulfaphenazole 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    main group molecular entity 19865
                      s-block molecular entity 19697
                        hydrogen molecular entity 19678
                          hydrides 19184
                            inorganic hydride 18194
                              pnictogen hydride 18184
                                nitrogen hydride 18096
                                  azane 17900
                                    ammonia 17899
                                      organic amino compound 17899
                                        aromatic amine 15494
                                          anilines 14429
                                            substituted aniline 14069
                                              sulfaphenazole 14
paths to the root