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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfaphenazole
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Accession:CHEBI:77780 term browser browse the term
Definition:A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.
Synonyms:exact_synonym: 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
 related_synonym: 1-phenyl-5-sulfanilamidopyrazole;   3-(p-aminobenzenesulfonamido)-2-phenylpyrazole;   5-sulfanilamido-1-phenylpyrazole;   Formula=C15H14N4O2S;   InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2;   InChIKey=QWCJHSGMANYXCW-UHFFFAOYSA-N;   N'-(1-phenylpyrazol-5-yl)sulfanilamide;   N(1)-(1-phenylpyrazol-5-yl)sulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ccnn1-c1ccccc1;   Sulfabid;   sulfafenazol;   sulfaphenazol;   sulfaphenazolum;   sulphaphenazole
 xref: CAS:526-08-9;   DrugBank:DB06729;   Drug_Central:2523;   HMDB:HMDB0015667;   KEGG:D01954;   LINCS:LSM-5279
 xref_mesh: MESH:D013426
 xref: PMID:13873771;   PMID:18845175;   PMID:22785021;   PMID:24519941;   PMID:9864343;   Patent:US2858309;   Reaxys:308518;   Wikipedia:Sulfaphenazole


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sulfaphenazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Sulfaphenazole results in decreased activity of CYP1A2 protein CTD PMID:15916432 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Sulfaphenazole results in decreased expression of CYP2C11 CTD PMID:15890479 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity
multiple interactions
EXP
ISO
Sulfaphenazole results in decreased activity of CYP2C6V1 protein
Sulfaphenazole inhibits the reaction [CYP2C19 protein results in increased metabolism of triflumuron]
CTD PMID:12814958, PMID:31082524 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO Sulfaphenazole inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone] CTD PMID:31102695 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] CTD PMID:24246759 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Sulfaphenazole inhibits the reaction [Diclofenac results in increased expression of HMOX1 mRNA] CTD PMID:12763371 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Sulfaphenazole affects the reaction [nimesulide affects the localization of NFE2L2 protein] CTD PMID:20405857 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          sulfonamide antibiotic 248
            sulfaphenazole 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        aromatic amine 13616
                                          anilines 12327
                                            substituted aniline 11823
                                              sulfaphenazole 7
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