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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(R)-sulconazole
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Accession:CHEBI:77777 term browser browse the term
Definition:A 1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole that has R configuration.
Synonyms:xref: PMID:11569882;   PMID:11755745;   Reaxys:19783469
 cyclic_relationship: is_enantiomer_of CHEBI:77778


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sulconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO sulconazole results in increased expression of ABCB1 mRNA CTD PMID:31312845 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression
multiple interactions
ISO sulconazole results in increased expression of CYP2B6 mRNA
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA
CTD PMID:31312845 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
multiple interactions
ISO sulconazole results in increased expression of CYP3A4 mRNA
[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:31312845 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Fasn fatty acid synthase decreases expression ISO sulconazole results in decreased expression of FASN mRNA CTD PMID:31312845 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO sulconazole results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO [sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
affects binding
multiple interactions
ISO sulconazole affects the localization of NR1I3 protein mutant form
sulconazole binds to NR1I3 protein
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; sulconazole binds to and results in increased activity of NR1I3 protein alternative form; sulconazole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
CTD PMID:31312845 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 affects expression ISO sulconazole affects the expression of PCK1 mRNA CTD PMID:31312845 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression ISO sulconazole results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO sulconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Thrsp thyroid hormone responsive affects expression ISO sulconazole affects the expression of THRSP mRNA CTD PMID:31312845 NCBI chr 1:162,381,251...162,385,575
Ensembl chr 1:162,381,253...162,385,575
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          sulfur atom 16303
            sulfur molecular entity 16303
              sulfide 8142
                organic sulfide 8142
                  1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole 13
                    (R)-sulconazole 13
                      sulconazole 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  heteroarene 16534
                                    monocyclic heteroarene 13322
                                      azole 12491
                                        diazole 8150
                                          imidazoles 7666
                                            1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole 13
                                              (R)-sulconazole 13
                                                sulconazole 13
paths to the root