Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(R)-sulconazole
go back to main search page
Accession:CHEBI:77777 term browser browse the term
Definition:A 1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole that has R configuration.
Synonyms:xref: PMID:11569882;   PMID:11755745;   Reaxys:19783469
 cyclic_relationship: is_enantiomer_of CHEBI:77778


show annotations for term's descendants           Sort by:
 
sulconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases expression ISO sulconazole results in increased expression of ABCB1 mRNA CTD PMID:31312845 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression
multiple interactions
ISO sulconazole results in increased expression of CYP2B6 mRNA
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA
CTD PMID:31312845 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Fasn fatty acid synthase decreases expression ISO sulconazole results in decreased expression of FASN mRNA CTD PMID:31312845 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G G6pc glucose-6-phosphatase, catalytic decreases expression ISO sulconazole results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO sulconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr11:98,152,154...98,193,313
Ensembl chr11:98,152,154...98,193,293
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO sulconazole results in increased activity of NR1I2 protein
[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:31312845 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects localization
affects binding
multiple interactions
ISO sulconazole affects the localization of NR1I3 protein mutant form
sulconazole binds to NR1I3 protein
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; sulconazole binds to and results in increased activity of NR1I3 protein alternative form; sulconazole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
CTD PMID:31312845 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic affects expression ISO sulconazole affects the expression of PCK1 mRNA CTD PMID:31312845 NCBI chr 2:173,153,073...173,159,274
Ensembl chr 2:173,153,048...173,159,273
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 decreases expression ISO sulconazole results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr19:44,293,676...44,306,864
Ensembl chr19:44,293,674...44,306,864
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO sulconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,584,189...12,628,489
Ensembl chr17:12,584,132...12,628,488
JBrowse link
G Thrsp thyroid hormone responsive affects expression ISO sulconazole affects the expression of THRSP mRNA CTD PMID:31312845 NCBI chr 7:97,412,933...97,417,550
Ensembl chr 7:97,412,938...97,417,730
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21560
    chemical entity 21558
      atom 21546
        nonmetal atom 21426
          sulfur atom 16914
            sulfur molecular entity 16914
              sulfide 8467
                organic sulfide 8467
                  1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole 12
                    (R)-sulconazole 12
                      sulconazole 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 21560
    subatomic particle 21546
      composite particle 21546
        hadron 21546
          baryon 21546
            nucleon 21546
              atomic nucleus 21546
                atom 21546
                  main group element atom 21449
                    p-block element atom 21449
                      carbon group element atom 21240
                        carbon atom 21135
                          organic molecular entity 21135
                            organic molecule 21027
                              organic cyclic compound 20576
                                organic heterocyclic compound 19401
                                  heteroarene 16948
                                    monocyclic heteroarene 13465
                                      azole 12723
                                        diazole 8276
                                          imidazoles 7775
                                            1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole 12
                                              (R)-sulconazole 12
                                                sulconazole 12
paths to the root