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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(R)-sulconazole
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Accession:CHEBI:77777 term browser browse the term
Definition:A 1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole that has R configuration.
Synonyms:xref: PMID:11569882;   PMID:11755745;   Reaxys:19783469
 cyclic_relationship: is_enantiomer_of CHEBI:77778


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sulconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP sulconazole results in increased expression of ABCB1 mRNA CTD PMID:31312845 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression
multiple interactions
EXP sulconazole results in increased expression of CYP2B6 mRNA
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA
CTD PMID:31312845 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression
multiple interactions
EXP sulconazole results in increased expression of CYP3A4 mRNA
[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:31312845 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G FASN fatty acid synthase decreases expression EXP sulconazole results in decreased expression of FASN mRNA CTD PMID:31312845 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP sulconazole results in decreased expression of G6PC1 mRNA CTD PMID:31312845 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP sulconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G MED1 mediator complex subunit 1 multiple interactions EXP sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form] CTD PMID:31312845 NCBI chr17:39,404,285...39,451,281
Ensembl chr17:39,404,285...39,451,272
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity
multiple interactions
EXP sulconazole results in increased activity of NR1I2 protein
[sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:31312845 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects binding
multiple interactions
affects localization
EXP sulconazole binds to NR1I3 protein
[sulconazole co-treated with NR1I3 protein alternative form] results in increased expression of CYP2B6 mRNA; [sulconazole co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; sulconazole binds to and results in increased activity of NR1I3 protein alternative form; sulconazole inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; sulconazole promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]
sulconazole affects the localization of NR1I3 protein mutant form
CTD PMID:31312845 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 affects expression EXP sulconazole affects the expression of PCK1 mRNA CTD PMID:31312845 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP sulconazole results in decreased expression of SCD mRNA CTD PMID:31312845 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP sulconazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G THRSP thyroid hormone responsive affects expression EXP sulconazole affects the expression of THRSP mRNA CTD PMID:31312845 NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24382
    chemical entity 24350
      atom 24339
        nonmetal atom 24047
          sulfur atom 17550
            sulfur molecular entity 17550
              sulfide 8228
                organic sulfide 8228
                  1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole 13
                    (R)-sulconazole 13
                      sulconazole 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 24382
    subatomic particle 24339
      composite particle 24339
        hadron 24339
          baryon 24339
            nucleon 24339
              atomic nucleus 24339
                atom 24339
                  main group element atom 24188
                    p-block element atom 24188
                      carbon group element atom 23967
                        carbon atom 23924
                          organic molecular entity 23924
                            organic molecule 23803
                              organic cyclic compound 23079
                                organic heterocyclic compound 21175
                                  heteroarene 18114
                                    monocyclic heteroarene 14640
                                      azole 13919
                                        diazole 8940
                                          imidazoles 8216
                                            1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole 13
                                              (R)-sulconazole 13
                                                sulconazole 13
paths to the root