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ONTOLOGY REPORT - ANNOTATIONS


Term:SCH-351591
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Accession:CHEBI:77774 term browser browse the term
Definition:An aromatic amide resulting from the formal condensation of the carboxy group of 8-methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid with the primary amino group of 3,5-dichloropyridin-4-amine 1-oxide. It is a potent inhibitor of phosphodiesterase IV (PDE4).
Synonyms:exact_synonym: N-(3,5-dichloro-1-oxidopyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide
 related_synonym: 8-methoxy-2-trifluoromethylquinoline-5-carboxylic acid (3,5-dichloro-1-oxypyridin-4-yl)amide;   Formula=C17H10Cl2F3N3O3;   InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26);   InChIKey=RUOGJYKOQBFJIG-UHFFFAOYSA-N;   N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide;   SCH351591;   SMILES=COc1ccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F
 xref: CAS:444659-43-2 "ChemIDplus"
 xref_mesh: MESH:C459379
 xref: PMID:12039576 "Europe PMC";   PMID:12065709 "Europe PMC";   PMID:15204971 "Europe PMC";   PMID:15498513 "Europe PMC";   PMID:18776163 "Europe PMC";   PMID:18776166 "Europe PMC";   PMID:20460440 "Europe PMC";   PMID:20585143 "Europe PMC";   Patent:NZ528621;   Reaxys:9159062 "Reaxys"


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SCH-351591 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amy2a3 amylase 2a3 JBrowse link 2 216,373,674 216,382,260 RGD:6480464
G Ctrl chymotrypsin-like JBrowse link 19 37,905,864 37,907,714 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Dbp D-box binding PAR bZIP transcription factor JBrowse link 1 101,687,896 101,692,845 RGD:6480464
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 JBrowse link 10 86,683,875 86,690,815 RGD:6480464
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 JBrowse link 15 8,730,871 8,757,165 RGD:6480464
G Per1 period circadian regulator 1 JBrowse link 10 55,681,761 55,696,557 RGD:6480464
G Prss1 serine protease 1 JBrowse link 4 70,776,046 70,779,249 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19734
    chemical entity 19732
      atom 19730
        nonmetal atom 19601
          halogen 17779
            fluorine atom 11234
              fluorine molecular entity 11234
                organofluorine compound 10611
                  SCH-351591 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19734
    subatomic particle 19730
      composite particle 19730
        hadron 19730
          baryon 19730
            nucleon 19730
              atomic nucleus 19730
                atom 19730
                  main group element atom 19614
                    p-block element atom 19614
                      carbon group element atom 19506
                        carbon atom 19500
                          organic molecular entity 19500
                            organic group 18414
                              organic divalent group 18406
                                organodiyl group 18406
                                  carbonyl group 18295
                                    carbonyl compound 18295
                                      carboxylic acid 17963
                                        carboacyl group 17074
                                          univalent carboacyl group 17074
                                            carbamoyl group 16804
                                              carboxamide 16804
                                                monocarboxylic acid amide 14167
                                                  SCH-351591 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.