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Accession:CHEBI:77774 term browser browse the term
Definition:An aromatic amide resulting from the formal condensation of the carboxy group of 8-methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid with the primary amino group of 3,5-dichloropyridin-4-amine 1-oxide. It is a potent inhibitor of phosphodiesterase IV (PDE4).
Synonyms:exact_synonym: N-(3,5-dichloro-1-oxidopyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide
 related_synonym: 8-methoxy-2-trifluoromethylquinoline-5-carboxylic acid (3,5-dichloro-1-oxypyridin-4-yl)amide;   Formula=C17H10Cl2F3N3O3;   InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26);   InChIKey=RUOGJYKOQBFJIG-UHFFFAOYSA-N;   N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide;   SCH351591;   SMILES=COc1ccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F
 xref: CAS:444659-43-2 "ChemIDplus"
 xref_mesh: MESH:C459379
 xref: PMID:12039576 "Europe PMC";   PMID:12065709 "Europe PMC";   PMID:15204971 "Europe PMC";   PMID:15498513 "Europe PMC";   PMID:18776163 "Europe PMC";   PMID:18776166 "Europe PMC";   PMID:20460440 "Europe PMC";   PMID:20585143 "Europe PMC";   Patent:NZ528621;   Reaxys:9159062 "Reaxys"

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SCH-351591 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ctrl chymotrypsin-like JBrowse link 8 105,931,994 105,933,862 RGD:6480464
G Cxcl1 chemokine (C-X-C motif) ligand 1 JBrowse link 5 90,891,245 90,893,121 RGD:6480464
G Dbp D site albumin promoter binding protein JBrowse link 7 45,705,100 45,710,203 RGD:6480464
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 JBrowse link 11 98,767,932 98,775,377 RGD:6480464
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 JBrowse link 14 18,204,056 18,239,106 RGD:6480464
G Per1 period circadian clock 1 JBrowse link 11 69,095,108 69,109,965 RGD:6480464
G Try10 trypsin 10 JBrowse link 6 41,354,105 41,357,944 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21025
    chemical entity 21023
      atom 21019
        nonmetal atom 20834
          halogen 18738
            fluorine atom 11676
              fluorine molecular entity 11676
                organofluorine compound 10742
                  SCH-351591 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 21025
    subatomic particle 21019
      composite particle 21019
        hadron 21019
          baryon 21019
            nucleon 21019
              atomic nucleus 21019
                atom 21019
                  main group element atom 20860
                    p-block element atom 20860
                      carbon group element atom 20601
                        carbon atom 20578
                          organic molecular entity 20578
                            organic group 19174
                              organic divalent group 19164
                                organodiyl group 19164
                                  carbonyl group 19134
                                    carbonyl compound 19134
                                      carboxylic acid 18814
                                        carboacyl group 17452
                                          univalent carboacyl group 17452
                                            carbamoyl group 17153
                                              carboxamide 17153
                                                monocarboxylic acid amide 14453
                                                  SCH-351591 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.