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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:SCH-351591
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Accession:CHEBI:77774 term browser browse the term
Definition:An aromatic amide resulting from the formal condensation of the carboxy group of 8-methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid with the primary amino group of 3,5-dichloropyridin-4-amine 1-oxide. It is a potent inhibitor of phosphodiesterase IV (PDE4).
Synonyms:exact_synonym: N-(3,5-dichloro-1-oxidopyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide
 related_synonym: 8-methoxy-2-trifluoromethylquinoline-5-carboxylic acid (3,5-dichloro-1-oxypyridin-4-yl)amide;   Formula=C17H10Cl2F3N3O3;   InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26);   InChIKey=RUOGJYKOQBFJIG-UHFFFAOYSA-N;   N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide;   SCH351591;   SMILES=COc1ccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F
 xref: CAS:444659-43-2
 xref_mesh: MESH:C459379
 xref: PMID:12039576;   PMID:12065709;   PMID:15204971;   PMID:15498513;   PMID:18776163;   PMID:18776166;   PMID:20460440;   PMID:20585143;   Patent:NZ528621;   Reaxys:9159062



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SCH-351591 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amy1 amylase alpha 1 increases expression EXP SCH 351591 results in increased expression of AMY1A mRNA CTD PMID:20585143 NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816
JBrowse link
G Ctrl chymotrypsin-like increases expression EXP SCH 351591 results in increased expression of CTRL mRNA CTD PMID:20585143 NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP SCH 351591 results in increased expression of CXCL1 protein CTD PMID:20585143 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP SCH 351591 results in increased expression of DBP mRNA CTD PMID:20585143 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP SCH 351591 results in increased expression of NR1D1 mRNA CTD PMID:20585143 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP SCH 351591 results in increased expression of NR1D2 mRNA CTD PMID:20585143 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
JBrowse link
G Per1 period circadian regulator 1 increases expression EXP SCH 351591 results in increased expression of PER1 mRNA CTD PMID:20585143 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Prss1 serine protease 1 increases expression EXP SCH 351591 results in increased expression of PRSS1 mRNA CTD PMID:20585143 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    chemical entity 19916
      molecular entity 19916
        polyatomic entity 19874
          heteroatomic molecular entity 19830
            halide 18692
              organohalogen compound 18561
                organofluorine compound 14673
                  SCH-351591 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                monocarboxylic acid amide 15699
                                                  SCH-351591 8
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