CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: SCH-351591
Accession: CHEBI:77774
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Definition: An aromatic amide resulting from the formal condensation of the carboxy group of 8-methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid with the primary amino group of 3,5-dichloropyridin-4-amine 1-oxide. It is a potent inhibitor of phosphodiesterase IV (PDE4).
Synonyms: exact_synonym: N-(3,5-dichloro-1-oxidopyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide
related_synonym: 8-methoxy-2-trifluoromethylquinoline-5-carboxylic acid (3,5-dichloro-1-oxypyridin-4-yl)amide; Formula=C17H10Cl2F3N3O3; InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26); InChIKey=RUOGJYKOQBFJIG-UHFFFAOYSA-N; N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide; SCH351591; SMILES=COc1ccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F
xref: CAS:444659-43-2
xref_mesh: MESH:C459379
xref: PMID:12039576; PMID:12065709; PMID:15204971; PMID:15498513; PMID:18776163; PMID:18776166; PMID:20460440; PMID:20585143; Patent:NZ528621; Reaxys:9159062
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Amy1
amylase alpha 1
increases expression
EXP
SCH 351591 results in increased expression of AMY1A mRNA
CTD
PMID:20585143
NCBI chr 2:201,382,678...201,397,487
Ensembl chr 2:201,382,675...201,397,816
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Ctrl
chymotrypsin-like
increases expression
EXP
SCH 351591 results in increased expression of CTRL mRNA
CTD
PMID:20585143
NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
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Cxcl1
C-X-C motif chemokine ligand 1
increases expression
EXP
SCH 351591 results in increased expression of CXCL1 protein
CTD
PMID:20585143
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Dbp
D-box binding PAR bZIP transcription factor
increases expression
EXP
SCH 351591 results in increased expression of DBP mRNA
CTD
PMID:20585143
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
EXP
SCH 351591 results in increased expression of NR1D1 mRNA
CTD
PMID:20585143
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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Nr1d2
nuclear receptor subfamily 1, group D, member 2
increases expression
EXP
SCH 351591 results in increased expression of NR1D2 mRNA
CTD
PMID:20585143
NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553
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Per1
period circadian regulator 1
increases expression
EXP
SCH 351591 results in increased expression of PER1 mRNA
CTD
PMID:20585143
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
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Prss1
serine protease 1
increases expression
EXP
SCH 351591 results in increased expression of PRSS1 mRNA
CTD
PMID:20585143
NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792
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