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ONTOLOGY REPORT - ANNOTATIONS


Term:SCH-351591
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Accession:CHEBI:77774 term browser browse the term
Definition:An aromatic amide resulting from the formal condensation of the carboxy group of 8-methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid with the primary amino group of 3,5-dichloropyridin-4-amine 1-oxide. It is a potent inhibitor of phosphodiesterase IV (PDE4).
Synonyms:exact_synonym: N-(3,5-dichloro-1-oxidopyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide
 related_synonym: 8-methoxy-2-trifluoromethylquinoline-5-carboxylic acid (3,5-dichloro-1-oxypyridin-4-yl)amide;   Formula=C17H10Cl2F3N3O3;   InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26);   InChIKey=RUOGJYKOQBFJIG-UHFFFAOYSA-N;   N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide;   SCH351591;   SMILES=COc1ccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F
 xref: CAS:444659-43-2 "ChemIDplus"
 xref_mesh: MESH:C459379
 xref: PMID:12039576 "Europe PMC";   PMID:12065709 "Europe PMC";   PMID:15204971 "Europe PMC";   PMID:15498513 "Europe PMC";   PMID:18776163 "Europe PMC";   PMID:18776166 "Europe PMC";   PMID:20460440 "Europe PMC";   PMID:20585143 "Europe PMC";   Patent:NZ528621;   Reaxys:9159062 "Reaxys"


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SCH-351591 term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amy2a3 amylase 2a3 JBrowse link 2 216,373,674 216,382,260 RGD:6480464
G Ctrl chymotrypsin-like JBrowse link 19 37,905,864 37,907,714 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Dbp D-box binding PAR bZIP transcription factor JBrowse link 1 101,687,896 101,692,845 RGD:6480464
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 JBrowse link 10 86,683,875 86,690,815 RGD:6480464
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 JBrowse link 15 8,730,871 8,757,165 RGD:6480464
G Per1 period circadian regulator 1 JBrowse link 10 55,681,761 55,696,557 RGD:6480464
G Prss1 serine protease 1 JBrowse link 4 70,776,046 70,779,249 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    chemical entity 19660
      atom 19658
        nonmetal atom 19525
          halogen 17742
            fluorine atom 11228
              fluorine molecular entity 11228
                organofluorine compound 10604
                  SCH-351591 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                monocarboxylic acid amide 13187
                                                  SCH-351591 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.