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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor
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Accession:CHEBI:77758 term browser browse the term
Definition:An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor that interferes with the action of a 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53).
Synonyms:related_synonym: 3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitor;   3',5'-cyclic-AMP 5'-nucleotidohydrolase inhibitors;   3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitors;   3',5'-cyclic-AMP phosphodiesterase inhibitor;   3',5'-cyclic-AMP phosphodiesterase inhibitors;   EC 3.1.4.53 inhibitor;   EC 3.1.4.53 inhibitors;   cAMP-specific PDE inhibitor;   cAMP-specific PDE inhibitors;   cAMP-specific phosphodiesterase inhibitor;   cAMP-specific phosphodiesterase inhibitors
 xref: Wikipedia:3'\,5'-cyclic-AMP_phosphodiesterase


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etazolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il13 interleukin 13 decreases expression
decreases secretion
ISO Etazolate results in decreased expression of IL13 mRNA
Etazolate results in decreased secretion of IL13 protein
CTD PMID:16083514 NCBI chr10:37,790,130...37,792,687 JBrowse link
G Ltc4s leukotriene C4 synthase decreases secretion ISO Etazolate results in decreased secretion of LTC4S protein CTD PMID:16083514 NCBI chr10:34,560,476...34,562,790 JBrowse link
piclamilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of piclamilast CTD PMID:12464242 NCBI chr 1:81,652,762...81,732,153 JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP piclamilast inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:72,666,865...72,677,952 JBrowse link
roflumilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein] CTD PMID:18276108 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Aqp1 aquaporin 1 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein] CTD PMID:31301536 NCBI chr 4:84,482,512...84,494,690 JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein] CTD PMID:31301536 NCBI chr 7:130,722,675...130,726,207 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of BAX protein]
[Cisplatin co-treated with Roflumilast] results in increased expression of BAX mRNA; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX mRNA]; Cisplatin promotes the reaction [Roflumilast results in increased expression of BAX protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of BAX protein]
Roflumilast results in increased expression of BAX mRNA; Roflumilast results in increased expression of BAX protein
CTD PMID:33757793 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 mRNA]; Cisplatin promotes the reaction [Roflumilast results in decreased expression of BCL2 protein]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in decreased expression of BCL2 protein]
Roflumilast results in decreased expression of BCL2 mRNA; Roflumilast results in decreased expression of BCL2 protein
Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Roflumilast inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD PMID:33757793 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression
increases activity
multiple interactions
ISO
EXP
Roflumilast results in increased expression of CASP3 mRNA
Roflumilast results in increased activity of CASP3 protein
Roflumilast inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Roflumilast inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]
[Cisplatin co-treated with Roflumilast] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Roflumilast results in increased activity of CASP3 protein]; Cisplatin promotes the reaction [Roflumilast results in increased expression of CASP3 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased activity of CASP3 protein]
CTD PMID:33757793 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Cat catalase multiple interactions EXP Roflumilast inhibits the reaction [Cisplatin results in decreased activity of CAT protein] CTD PMID:33757793 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein] CTD PMID:21913898 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein] CTD PMID:21913898 NCBI chr10:68,451,388...68,452,938 JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein] CTD PMID:21913898 NCBI chr10:68,466,469...68,467,941 JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; Roflumilast inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein] CTD PMID:31301536 NCBI chr 4:46,561,269...46,728,759 JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]
Roflumilast results in increased phosphorylation of CREB1 protein
CTD PMID:18276108 NCBI chr 9:65,903,511...65,972,562 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL10 protein] CTD PMID:21913898 NCBI chr14:15,704,772...15,706,969 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
Cisplatin promotes the reaction [Roflumilast results in increased expression of HMOX1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
Roflumilast promotes the reaction [Cisplatin results in increased activity of HMOX1 protein]; Roflumilast promotes the reaction [Cisplatin results in increased expression of HMOX1 mRNA]
CTD PMID:33757793 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Roflumilast inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:33757793 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases expression
EXP
ISO
Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
Roflumilast results in increased expression of NFE2L2 mRNA
Cisplatin promotes the reaction [Roflumilast results in increased expression of NFE2L2 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NFE2L2 mRNA]
CTD PMID:33757793 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO
EXP
Cisplatin promotes the reaction [Roflumilast results in increased expression of NQO1 mRNA]; Roflumilast promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA] CTD PMID:33757793 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Pde3a phosphodiesterase 3A decreases activity ISO Roflumilast results in decreased activity of PDE3A protein CTD PMID:15901792 NCBI chr 4:174,172,804...174,443,944 JBrowse link
G Pde3b phosphodiesterase 3B decreases activity ISO Roflumilast results in decreased activity of PDE3B protein CTD PMID:15901792 NCBI chr 1:168,606,762...168,770,078 JBrowse link
G Pde4a phosphodiesterase 4A decreases activity ISO Roflumilast results in decreased activity of PDE4A protein CTD PMID:15901792 NCBI chr 8:19,706,649...19,751,937 JBrowse link
G Pde4b phosphodiesterase 4B decreases activity ISO Roflumilast results in decreased activity of PDE4B protein CTD PMID:15901792 NCBI chr 5:116,799,827...117,367,707 JBrowse link
G Pde4c phosphodiesterase 4C decreases activity ISO Roflumilast results in decreased activity of PDE4C protein CTD PMID:15901792 NCBI chr16:18,690,727...18,711,555 JBrowse link
G Pde4d phosphodiesterase 4D decreases activity ISO Roflumilast results in decreased activity of PDE4D protein CTD PMID:15901792 NCBI chr 2:40,014,933...41,529,190 JBrowse link
G Pde7a phosphodiesterase 7A decreases activity ISO Roflumilast results in decreased activity of PDE7A protein CTD PMID:15901792 NCBI chr 2:101,714,767...101,806,853 JBrowse link
G Pde8b phosphodiesterase 8B decreases activity ISO Roflumilast results in decreased activity of PDE8B protein CTD PMID:15901792 NCBI chr 2:26,275,117...26,479,725 JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor 3 multiple interactions
increases expression
EXP RAPGEF3 mutant form inhibits the reaction [Roflumilast results in increased phosphorylation of AKT1 protein]
Roflumilast results in increased expression of RAPGEF3 protein
CTD PMID:18276108 NCBI chr 7:128,875,772...128,898,203 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
EXP
ISO
Roflumilast inhibits the reaction [Cisplatin results in increased expression of RELA mRNA]
Roflumilast results in decreased expression of RELA mRNA
Cisplatin promotes the reaction [Roflumilast results in decreased expression of RELA mRNA]
CTD PMID:33757793 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Roflumilast inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:21913898 PMID:33757793 NCBI chr20:3,622,011...3,624,629 JBrowse link
SCH-351591 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctrl chymotrypsin-like increases expression EXP SCH 351591 results in increased expression of CTRL mRNA CTD PMID:20585143 NCBI chr19:33,827,279...33,829,129 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP SCH 351591 results in increased expression of CXCL1 protein CTD PMID:20585143 NCBI chr14:17,193,364...17,195,143 JBrowse link
G Dbp D-box binding PAR bZIP transcription factor increases expression EXP SCH 351591 results in increased expression of DBP mRNA CTD PMID:20585143 NCBI chr 1:96,175,796...96,180,745 JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP SCH 351591 results in increased expression of NR1D1 mRNA CTD PMID:20585143 NCBI chr10:83,728,348...83,735,562 JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP SCH 351591 results in increased expression of NR1D2 mRNA CTD PMID:20585143 NCBI chr15:7,524,257...7,550,553 JBrowse link
G Per1 period circadian regulator 1 increases expression EXP SCH 351591 results in increased expression of PER1 mRNA CTD PMID:20585143 NCBI chr10:53,800,126...53,814,963 JBrowse link
G Prss1 serine protease 1 increases expression EXP SCH 351591 results in increased expression of PRSS1 mRNA CTD PMID:20585143 NCBI chr 4:70,364,589...70,367,792 JBrowse link

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  CHEBI ontology 19762
    role 19708
      biological role 19708
        biochemical role 19312
          enzyme inhibitor 18247
            EC 3.* (hydrolase) inhibitor 17711
              EC 3.1.* (ester hydrolase) inhibitor 13143
                EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 1353
                  EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor 39
                    phosphodiesterase IV inhibitor + 39
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