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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:olsalazine
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Accession:CHEBI:7770 term browser browse the term
Definition:An azobenzene that consists of two molecules of 4-aminosalicylic acid joined by an azo linkage. A prodrug for mesalazine, an anti-inflammatory drug, it is used (as the disodium salt) in the treatment of inflammatory bowel disease.
Synonyms:exact_synonym: 3,3'-diazene-1,2-diylbis(6-hydroxybenzoic acid)
 related_synonym: 3,3'-Azobis(6-hydroxybenzoic acid);   5,5'-Azobis(salicylic acid);   Formula=C14H10N2O6;   InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22);   InChIKey=QQBDLJCYGRGAKP-UHFFFAOYSA-N;   Olsalazina;   Olsalazinum;   SMILES=OC(=O)c1cc(ccc1O)N=Nc1ccc(O)c(c1)C(O)=O
 xref: CAS:15722-48-2;   DrugBank:DB01250;   Drug_Central:1988;   KEGG:C07323;   KEGG:D08295
 xref_mesh: MESH:C032587
 xref: Patent:DE278613;   Patent:EP36636;   Patent:US1157169;   Patent:US4528367;   Reaxys:3218651;   Wikipedia:Olsalazine
 cyclic_relationship: is_conjugate_acid_of CHEBI:63719



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olsalazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO olsalazine results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19863
    role 19835
      application 19677
        pro-agent 11550
          prodrug 11311
            olsalazine 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19863
    subatomic particle 19861
      composite particle 19861
        hadron 19861
          baryon 19861
            nucleon 19861
              atomic nucleus 19861
                atom 19861
                  main group element atom 19807
                    p-block element atom 19807
                      carbon group element atom 19748
                        carbon atom 19744
                          organic molecular entity 19744
                            heteroorganic entity 19498
                              organochalcogen compound 19259
                                organooxygen compound 19175
                                  carbon oxoacid 18642
                                    carboxylic acid 18639
                                      aromatic carboxylic acid 12696
                                        benzoic acids 12673
                                          benzoic acid 5498
                                            hydroxybenzoic acid 4974
                                              monohydroxybenzoic acid 2813
                                                salicylic acid 1567
                                                  olsalazine 1
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