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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(S)-modafinil
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Accession:CHEBI:77591 term browser browse the term
Definition:A 2-[(diphenylmethyl)sulfinyl]acetamide that has S configuration at the sulfur atom. The racemate comprising (S)-modafinil and its enantiomer, armodafinil, is known as modafinil and is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. The enantiomers have similar pharmacological actions in animals.
Synonyms:exact_synonym: 2-[(S)-(diphenylmethyl)sulfinyl]acetamide
 related_synonym: (+)-modafinil;   Formula=C15H15NO2S;   InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m0/s1;   InChIKey=YFGHCGITMMYXAQ-IBGZPJMESA-N;   SMILES=NC(=O)C[S@](=O)C(c1ccccc1)c1ccccc1
 xref: PMID:22210169;   PMID:22537794;   Reaxys:9767971
 cyclic_relationship: is_enantiomer_of CHEBI:77590


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modafinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
increases expression
EXP Alendronate inhibits the reaction [modafinil results in increased expression of ACP5 mRNA]
modafinil results in increased expression of ACP5 mRNA; modafinil results in increased expression of ACP5 protein
CTD PMID:29649498 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Adora2a adenosine A2a receptor increases activity EXP modafinil results in increased activity of ADORA2A protein CTD PMID:29649498 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora2b adenosine A2B receptor increases activity EXP modafinil results in increased activity of ADORA2B protein CTD PMID:29649498 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Comt catechol-O-methyltransferase affects response to substance ISO COMT gene polymorphism affects the susceptibility to modafinil; COMT protein affects the susceptibility to modafinil CTD PMID:20815183 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression ISO modafinil affects the expression of FOS protein CTD PMID:19194377 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
EXP modafinil results in increased expression of RUNX2 mRNA
Alendronate promotes the reaction [modafinil results in increased expression of RUNX2 mRNA]
CTD PMID:29649498 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases response to substance
multiple interactions
affects response to substance
ISO
EXP
SLC6A3 gene mutant form results in decreased susceptibility to modafinil
modafinil inhibits the reaction [SLC6A3 protein affects the uptake of Dopamine]
SLC6A3 gene polymorphism affects the susceptibility to modafinil
CTD PMID:11222668, PMID:19197004, PMID:24403155 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A increases expression EXP modafinil results in increased expression of TNFRSF11A mRNA CTD PMID:29649498 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
increases expression
EXP Alendronate inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; KT 5720 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]
Modafinil results in increased expression of TNFSF11 mRNA; Modafinil results in increased expression of TNFSF11 protein
CTD PMID:29649498 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            central nervous system drug 16431
              central nervous system stimulant 6656
                (S)-modafinil 9
                  modafinil 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  2-[(diphenylmethyl)sulfinyl]acetamide 9
                                                    (S)-modafinil 9
                                                      modafinil 9
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