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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:armodafinil
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Accession:CHEBI:77590 term browser browse the term
Definition:A 2-[(diphenylmethyl)sulfinyl]acetamide that has R configuration at the sulfur atom. Like its racemate, modafinil, it is used for the treatment of sleeping disorders such as narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. Peak concentration in the blood later occurs later following administration than with modafinil, so it is thought that armodafinil may be more effective than modafinil in treating people with excessive daytime sleepiness.
Synonyms:exact_synonym: 2-[(R)-(diphenylmethyl)sulfinyl]acetamide
 related_synonym: (-)-modafinil;   (R)-modafinil;   CEP 10953;   Formula=C15H15NO2S;   InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1;   InChIKey=YFGHCGITMMYXAQ-LJQANCHMSA-N;   Nuvigil;   SMILES=NC(=O)C[S@@](=O)C(c1ccccc1)c1ccccc1;   armodafinilo;   armodafinilum
 xref: CAS:112111-43-0;   Drug_Central:4501;   KEGG:D03215;   PMID:19663523;   PMID:19689169;   PMID:20697340;   PMID:20816042;   PMID:21427431;   PMID:22039290;   PMID:22128728;   PMID:22210169;   PMID:22537794;   PMID:22803602;   PMID:22917711;   PMID:22960434;   PMID:22967783;   PMID:23251870;   PMID:23983964;   PMID:24122734;   Reaxys:9767970;   Wikipedia:Armodafinil
 cyclic_relationship: is_enantiomer_of CHEBI:77591



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modafinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
increases expression
EXP Alendronate inhibits the reaction [modafinil results in increased expression of ACP5 mRNA]
modafinil results in increased expression of ACP5 mRNA; modafinil results in increased expression of ACP5 protein
CTD PMID:29649498 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Adora2a adenosine A2a receptor increases activity EXP modafinil results in increased activity of ADORA2A protein CTD PMID:29649498 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adora2b adenosine A2B receptor increases activity EXP modafinil results in increased activity of ADORA2B protein CTD PMID:29649498 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Comt catechol-O-methyltransferase affects response to substance ISO COMT gene polymorphism affects the susceptibility to modafinil; COMT protein affects the susceptibility to modafinil CTD PMID:20815183 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression ISO modafinil affects the expression of FOS protein CTD PMID:19194377 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
EXP modafinil results in increased expression of RUNX2 mRNA
Alendronate promotes the reaction [modafinil results in increased expression of RUNX2 mRNA]
CTD PMID:29649498 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases response to substance
multiple interactions
affects response to substance
ISO
EXP
SLC6A3 gene mutant form results in decreased susceptibility to modafinil
modafinil inhibits the reaction [SLC6A3 protein affects the uptake of Dopamine]
SLC6A3 gene polymorphism affects the susceptibility to modafinil
CTD PMID:11222668 PMID:19197004 PMID:24403155 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A increases expression EXP modafinil results in increased expression of TNFRSF11A mRNA CTD PMID:29649498 NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
increases expression
EXP Alendronate inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; KT 5720 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]
Modafinil results in increased expression of TNFSF11 mRNA; Modafinil results in increased expression of TNFSF11 protein
CTD PMID:29649498 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19808
    role 19757
      application 19467
        pharmaceutical 19315
          drug 19315
            central nervous system drug 16520
              central nervous system stimulant 6864
                armodafinil 9
                  modafinil 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19807
      composite particle 19807
        hadron 19807
          baryon 19807
            nucleon 19807
              atomic nucleus 19807
                atom 19807
                  main group element atom 19704
                    p-block element atom 19704
                      carbon group element atom 19626
                        carbon atom 19616
                          organic molecular entity 19616
                            organic group 18725
                              organic divalent group 18716
                                organodiyl group 18716
                                  carbonyl group 18664
                                    carbonyl compound 18664
                                      carboxylic acid 18361
                                        carboacyl group 17481
                                          univalent carboacyl group 17481
                                            carbamoyl group 17297
                                              carboxamide 17297
                                                monocarboxylic acid amide 15014
                                                  2-[(diphenylmethyl)sulfinyl]acetamide 9
                                                    armodafinil 9
                                                      modafinil 9
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