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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tranilast
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Accession:CHEBI:77572 term browser browse the term
Definition:An amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 3,4-dimethoxycinnamoyl group.
Synonyms:exact_synonym: 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
 related_synonym: Formula=C18H17NO5;   InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+;   InChIKey=NZHGWWWHIYHZNX-CSKARUKUSA-N;   MK-341;   N-(3,4-Dimethoxycinnamoyl)anthranilic acid;   Rizaben;   SMILES=COc1ccc(\\C=C\\C(=O)Nc2ccccc2C(O)=O)cc1OC;   tranilastum
 xref: CAS:53902-12-8;   Drug_Central:2714;   KEGG:D02027
 xref_mesh: MESH:C012293
 xref: PDBeChem:D27;   PMID:22753703;   PMID:23121382;   PMID:23273396;   PMID:23363021;   PMID:23679559;   PMID:23694807;   PMID:23715805;   PMID:23821545;   PMID:23977380;   PMID:24055688;   PMID:24092987;   PMID:24143895;   PMID:24157455;   PMID:24374452;   PMID:24377619;   PMID:24384948;   PMID:24389486;   PMID:24389817;   PMID:24420060;   PMID:24448965;   PMID:24475260;   PMID:24476069;   Reaxys:3085768;   Wikipedia:Tranilast



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tranilast term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases response to substance
increases expression
multiple interactions
ISO AHR protein results in increased susceptibility to tranilast
tranilast results in increased expression of AHR mRNA
AHR protein promotes the reaction [tranilast results in increased expression of AHR mRNA]; AHR protein promotes the reaction [tranilast results in increased expression of CYP1A1 mRNA]; tranilast promotes the reaction [AHR protein binds to CYP1A1 promoter]
CTD PMID:25826687 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Casp8 caspase 8 multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of CASP8 protein] CTD PMID:34047436 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO tranilast results in decreased expression of CXCR4 mRNA CTD PMID:25826687 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO AHR protein promotes the reaction [tranilast results in increased expression of CYP1A1 mRNA]; tranilast promotes the reaction [AHR protein binds to CYP1A1 promoter] CTD PMID:25826687 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects expression ISO tranilast affects the expression of CYP1B1 mRNA CTD PMID:25826687 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO tranilast inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:34047436 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of TNF protein] CTD PMID:34047436 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions EXP tranilast inhibits the reaction [Cisplatin results in increased expression of TNFSF10 protein] CTD PMID:34047436 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 decreases activity ISO tranilast results in decreased activity of TRPV2 protein CTD PMID:30235802 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      application 19781
        anti-asthmatic agent 9295
          anti-asthmatic drug 8664
            tranilast 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        carboacyl group 17730
                                          univalent carboacyl group 17710
                                            carbamoyl group 17550
                                              carboxamide 17570
                                                alpha,beta-unsaturated carboxylic acid amide 6724
                                                  enamide 6716
                                                    cinnamamides 1346
                                                      tranilast 10
paths to the root