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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eugeroic
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Accession:CHEBI:77567 term browser browse the term
Definition:A phsychotropic drug that improves wakefulness and alertness, and reduces tiredness, drowsiness, and the need for sleep. Eugeroics are relatively non-addictive and are used in the treatment of narcolepsy and other sleep disorders.
Synonyms:related_synonym: eugeroics;   vigilance promoting drugs;   vigilance-promoting agent;   vigilance-promoting agents;   vigilance-promoting drug;   wake-promoting agent;   wake-promoting agents;   wake-promoting drug;   wake-promoting drugs;   wakefulness-promoting agent;   wakefulness-promoting agents;   wakefulness-promoting drug;   wakefulness-promoting drugs
 xref: Wikipedia:Wakefulness-promoting_agent


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modafinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions
increases expression
EXP Alendronate inhibits the reaction [modafinil results in increased expression of ACP5 mRNA]
modafinil results in increased expression of ACP5 mRNA; modafinil results in increased expression of ACP5 protein
CTD PMID:29649498 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Adora2a adenosine A2a receptor increases activity EXP modafinil results in increased activity of ADORA2A protein CTD PMID:29649498 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora2b adenosine A2B receptor increases activity EXP modafinil results in increased activity of ADORA2B protein CTD PMID:29649498 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365
JBrowse link
G Comt catechol-O-methyltransferase affects response to substance ISO COMT gene polymorphism affects the susceptibility to modafinil; COMT protein affects the susceptibility to modafinil CTD PMID:20815183 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression ISO modafinil affects the expression of FOS protein CTD PMID:19194377 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression
multiple interactions
EXP modafinil results in increased expression of RUNX2 mRNA
Alendronate promotes the reaction [modafinil results in increased expression of RUNX2 mRNA]
CTD PMID:29649498 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Slc6a3 solute carrier family 6 member 3 decreases response to substance
multiple interactions
affects response to substance
ISO
EXP
SLC6A3 gene mutant form results in decreased susceptibility to modafinil
modafinil inhibits the reaction [SLC6A3 protein affects the uptake of Dopamine]
SLC6A3 gene polymorphism affects the susceptibility to modafinil
CTD PMID:11222668 PMID:19197004 PMID:24403155 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983
JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A increases expression EXP modafinil results in increased expression of TNFRSF11A mRNA CTD PMID:29649498 NCBI chr13:25,778,306...25,835,802
Ensembl chr13:25,778,317...25,835,957
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions
increases expression
EXP Alendronate inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; KT 5720 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; N-(4-cyanophenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)-phenoxy)acetamide inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 mRNA]; ZM 241385 inhibits the reaction [Modafinil results in increased expression of TNFSF11 protein]
Modafinil results in increased expression of TNFSF11 mRNA; Modafinil results in increased expression of TNFSF11 protein
CTD PMID:29649498 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      application 19423
        pharmaceutical 19321
          drug 19321
            central nervous system drug 16526
              psychotropic drug 15177
                eugeroic 9
                  (S)-modafinil + 9
                  armodafinil + 9
                  modafinil 9
paths to the root