1,1-bis(phosphonic acid) - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	1,1-bis(phosphonic acid)	go back to main search page
Accession:	CHEBI:77383	browse the term
Definition:	Any member of the class of phosphonic acids in which a carbon atom is directly attached to two phosphonic acid groups. They are analogues of pyrophosphates (with the central oxygen atom replaced by a carbon atom) and like pyrophosphates they tend to have a strong affinity for bone, so are frequently used for their antiresorptive and hypocalcaemic properties.
Synonyms:	related_synonym:	1,1-bis(phosphonic acid)s; 1,1-diphosphonate; 1,1-diphosphonates; 1,1-diphosphonic acid; 1,1-diphosphonic acids; Formula=CH4O6P2R2; SMILES=OP(O)(=O)C([])([])P(O)(O)=O; bis(phosphonic acid); bis(phosphonic acid)s; bisphosphonate; bisphosphonates; diphosphonic acid
	xref:	Wikipedia:Bisphosphonate

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Genes (1696)

alendronic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

Alendronate inhibits the reaction [Streptozocin results in increased activity of ACHE protein]

NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728

G

acid phosphatase 5, tartrate resistant

multiple interactions

Alendronate inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]; Alendronate inhibits the reaction [modafinil results in increased expression of ACP5 mRNA]

PMID:27387537 PMID:29649498

NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007

G

adenylate cyclase activating polypeptide 1

affects expression

Alendronate affects the expression of ADCYAP1 mRNA

NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965

G

alkaline phosphatase, liver/bone/kidney

multiple interactions

Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]]

NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695

G

amyloid beta precursor protein

multiple interactions

Alendronate inhibits the reaction [Streptozocin results in increased expression of APP protein]

NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654

G

ATPase, Na+/K+ transporting, alpha 1 polypeptide

affects expression

Alendronate affects the expression of ATP1A1 mRNA

NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000

G

beta-site APP cleaving enzyme 1

multiple interactions

Alendronate inhibits the reaction [Streptozocin results in increased expression of BACE1 protein]

NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697

G

bone gamma carboxyglutamate protein

multiple interactions

[Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein]

NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771

G

caspase 9

multiple interactions

TNFSF11 inhibits the reaction [Alendronate results in increased expression of CASP9 protein]

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Alendronate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

PMID:30291735 PMID:30481507

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

CD3 antigen, gamma polypeptide

affects expression

Alendronate affects the expression of CD3G mRNA

NCBI chr 9:44,880,870...44,891,729
Ensembl chr 9:44,880,870...44,891,729

G

cadherin 2

affects expression

Alendronate affects the expression of CDH2 mRNA

NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303

G

cadherin 6

affects expression

Alendronate affects the expression of CDH6 mRNA

NCBI chr15:13,028,785...13,176,493
Ensembl chr15:13,028,787...13,173,761

G

CDK5 regulatory subunit associated protein 3

affects expression

Alendronate affects the expression of CDK5RAP3 mRNA

NCBI chr11:96,798,251...96,807,359
Ensembl chr11:96,798,252...96,807,322

G

collagen, type XI, alpha 1

affects expression

Alendronate affects the expression of COL11A1 mRNA

NCBI chr 3:113,823,933...114,014,405
Ensembl chr 3:113,824,189...114,014,367

G

collagen, type V, alpha 1

affects expression

Alendronate affects the expression of COL5A1 mRNA

NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526

G

collagen, type V, alpha 2

affects expression

Alendronate affects the expression of COL5A2 mRNA

NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442

G

carboxypeptidase E

affects expression

Alendronate affects the expression of CPE mRNA

NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088

G

crystallin, beta B2

affects expression

Alendronate affects the expression of CRYBB2 mRNA

NCBI chr 5:113,206,124...113,217,983
Ensembl chr 5:113,206,124...113,217,983

G

cytochrome P450, family 2, subfamily a, polypeptide 22

affects expression

Alendronate affects the expression of CYP2A1 mRNA

NCBI chr 7:26,631,564...26,638,838
Ensembl chr 7:26,631,056...26,638,809

G

dual specificity phosphatase 6

affects expression

Alendronate affects the expression of DUSP6 mRNA

NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351

G

egl-9 family hypoxia-inducible factor 3

affects expression

Alendronate affects the expression of EGLN3 mRNA

NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646

G

farnesyl diphosphate synthetase

decreases activity

Alendronate results in decreased activity of FDPS protein

NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266

G

fibroblast growth factor 9

affects expression

Alendronate affects the expression of FGF9 mRNA

NCBI chr14:58,308,543...58,350,311
Ensembl chr14:58,308,004...58,350,177

G

FK506 binding protein 3

affects expression

Alendronate affects the expression of FKBP3 mRNA

NCBI chr12:65,109,206...65,120,712
Ensembl chr12:65,109,198...65,120,781

G

gamma-aminobutyric acid type A receptor subunit gamma 1

affects expression

Alendronate affects the expression of GABRG1 mRNA

NCBI chr 5:70,906,512...70,999,960
Ensembl chr 5:70,908,390...70,999,960

G

growth hormone releasing hormone

affects expression

Alendronate affects the expression of GHRH mRNA

NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426

G

growth hormone releasing hormone receptor

affects expression

Alendronate affects the expression of GHRHR mRNA

NCBI chr 6:55,353,204...55,365,515
Ensembl chr 6:55,353,280...55,365,515

G

guanine nucleotide binding protein (G protein), beta 1

affects expression

Alendronate affects the expression of GNB1 mRNA

NCBI chr 4:155,575,514...155,643,726
Ensembl chr 4:155,575,818...155,643,726

G

histidine ammonia lyase

affects expression

Alendronate affects the expression of HAL mRNA

NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166

G

high mobility group box 1

affects expression

Alendronate affects the expression of HMGB1 mRNA

NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299

G

homeobox A1

affects expression

Alendronate affects the expression of HOXA1 mRNA

NCBI chr 6:52,132,573...52,135,299
Ensembl chr 6:52,132,570...52,135,297

G

Harvey rat sarcoma virus oncogene

decreases prenylation

Alendronate results in decreased prenylation of HRAS protein

NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918

G

5-hydroxytryptamine (serotonin) receptor 5A

affects expression

Alendronate affects the expression of HTR5A mRNA

NCBI chr 5:28,046,836...28,059,403
Ensembl chr 5:28,047,147...28,060,086

G

isocitrate dehydrogenase 2 (NADP+), mitochondrial

affects expression

Alendronate affects the expression of IDH2 mRNA

NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140

G

interleukin 18

multiple interactions

[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]

NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140

G

interleukin 1 beta

increases expression
multiple interactions

Alendronate results in increased expression of IL1B protein
Alendronate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]
[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; Alendronate inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Alendronate promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Clodronic Acid inhibits the reaction [Alendronate results in increased expression of IL1B protein]; Farnesol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geranylgeraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Menthol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]

PMID:17375077 PMID:20304105 PMID:20804833 PMID:21430599 PMID:30481507

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor antagonist

multiple interactions

Alendronate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]

NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506

G

interleukin 6

multiple interactions

Alendronate inhibits the reaction [Streptozocin results in increased expression of IL6 protein]

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

potassium voltage-gated channel, subfamily H (eag-related), member 5

affects expression

Alendronate affects the expression of KCNH5 mRNA

NCBI chr12:74,943,991...75,224,625
Ensembl chr12:74,943,994...75,224,106

G

lysyl oxidase

affects expression

Alendronate affects the expression of LOX mRNA

NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939

G

mitogen-activated protein kinase 14

affects expression

Alendronate affects the expression of MAPK14 mRNA

NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380

G

matrix metallopeptidase 2

decreases expression
affects expression
decreases secretion

Alendronate results in decreased expression of MMP2 mRNA
Alendronate affects the expression of MMP2 mRNA
Alendronate results in decreased secretion of MMP2 protein

PMID:15049011 PMID:16079270

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

mucin 1, transmembrane

affects expression

Alendronate affects the expression of MUC1 mRNA

NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688

G

myosin, light polypeptide 9, regulatory

affects expression

Alendronate affects the expression of MYL9 mRNA

NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578

G

nectin cell adhesion molecule 1

affects expression

Alendronate affects the expression of NECTIN1 mRNA

NCBI chr 9:43,655,251...43,718,758
Ensembl chr 9:43,655,281...43,743,955

G

nitric oxide synthase 2, inducible

multiple interactions

Alendronate affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

olfactory receptor family 10 subfamily AL member 6

affects expression

Alendronate affects the expression of OR10AL6 mRNA

NCBI chr17:38,079,533...38,083,511
Ensembl chr17:38,079,498...38,084,640

G

procollagen C-endopeptidase enhancer protein

affects expression

Alendronate affects the expression of PCOLCE mRNA

NCBI chr 5:137,603,369...137,609,666
Ensembl chr 5:137,603,365...137,612,046

G

peroxisomal biogenesis factor 5

affects expression

Alendronate affects the expression of PEX5 mRNA

NCBI chr 6:124,373,774...124,392,878
Ensembl chr 6:124,373,775...124,392,026

G

PH domain and leucine rich repeat protein phosphatase 1

affects expression

Alendronate affects the expression of PHLPP mRNA

NCBI chr 1:106,099,599...106,321,975
Ensembl chr 1:106,099,482...106,321,980

G

protein inhibitor of activated STAT 3

affects expression

Alendronate affects the expression of PIAS3 mRNA

NCBI chr 3:96,603,679...96,613,386
Ensembl chr 3:96,603,700...96,613,386

G

polymeric immunoglobulin receptor

affects expression

Alendronate affects the expression of PIGR mRNA

NCBI chr 1:130,754,421...130,779,986
Ensembl chr 1:130,754,421...130,779,986

G

phospholipid phosphatase 1

affects expression

Alendronate affects the expression of PLPP1 mRNA

NCBI chr13:112,937,311...113,004,428
Ensembl chr13:112,937,326...113,004,428

G

paraoxonase 1

decreases activity
multiple interactions

Alendronate results in decreased activity of PON1 protein
[Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

prosaposin

affects expression

Alendronate affects the expression of PSAP mRNA

NCBI chr10:60,113,436...60,138,379
Ensembl chr10:60,113,449...60,138,376

G

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

affects expression

Alendronate affects the expression of PSME1 mRNA

NCBI chr14:55,815,951...55,818,984
Ensembl chr14:55,815,580...55,818,986

G

prostaglandin F2 receptor negative regulator

affects expression

Alendronate affects the expression of PTGFRN mRNA

NCBI chr 3:100,947,546...101,018,061
Ensembl chr 3:100,947,548...101,017,594

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Alendronate affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

RAS-related protein 1a

decreases prenylation

Alendronate results in decreased prenylation of RAP1A protein

NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652

G

retinoic acid receptor, alpha

affects expression

Alendronate affects the expression of RARA mRNA

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

runt related transcription factor 2

multiple interactions

Alendronate promotes the reaction [modafinil results in increased expression of RUNX2 mRNA]

NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684

G

sodium channel, voltage-gated, type IV, alpha

affects expression

Alendronate affects the expression of SCN4A mRNA

NCBI chr11:106,208,374...106,256,385
Ensembl chr11:106,209,418...106,244,114

G

serine (or cysteine) peptidase inhibitor, clade E, member 2

affects expression

Alendronate affects the expression of SERPINE2 mRNA

NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897

G

serine (or cysteine) peptidase inhibitor, clade H, member 1

affects expression

Alendronate affects the expression of SERPINH1 mRNA

NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446

G

solute carrier family 18 (vesicular monoamine), member 2

affects expression

Alendronate affects the expression of SLC18A2 mRNA

NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444

G

solute carrier family 19 (folate transporter), member 1

affects expression

Alendronate affects the expression of SLC19A1 mRNA

NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836

G

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

affects expression

Alendronate affects the expression of SLC6A4 mRNA

NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166

G

slit guidance ligand 1

affects expression

Alendronate affects the expression of SLIT1 mRNA

NCBI chr19:41,586,263...41,735,714
Ensembl chr19:41,588,696...41,732,104

G

stannin

affects expression

Alendronate affects the expression of SNN mRNA

NCBI chr16:10,884,162...10,892,849
Ensembl chr16:10,878,809...10,892,849

G

secreted acidic cysteine rich glycoprotein

affects expression

Alendronate affects the expression of SPARC mRNA

NCBI chr11:55,284,985...55,310,906
Ensembl chr11:55,285,326...55,314,009

G

serine/threonine kinase 4

increases cleavage

Alendronate results in increased cleavage of STK4 protein

NCBI chr 2:163,916,033...163,997,444
Ensembl chr 2:163,912,242...163,997,444

G

transforming growth factor, beta 1

multiple interactions

[Alendronate co-treated with zoledronic acid] results in increased expression of TGFB1 protein

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

tissue inhibitor of metalloproteinase 1

affects expression

Alendronate affects the expression of TIMP1 mRNA

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tumor necrosis factor

multiple interactions

[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein; Alendronate inhibits the reaction [Streptozocin results in increased expression of TNF protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]

PMID:21430599 PMID:30481507

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

multiple interactions

Alendronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; Alendronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]

NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880

G

tumor necrosis factor (ligand) superfamily, member 11

multiple interactions

TNFSF11 inhibits the reaction [Alendronate results in increased expression of CASP9 protein]
Alendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; Alendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; Alendronate inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA]

PMID:19405951 PMID:27387537 PMID:29649498

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

G

troponin I, cardiac 3

affects expression

Alendronate affects the expression of TNNI3 mRNA

NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228

G

vitamin D (1,25-dihydroxyvitamin D3) receptor

affects response to substance
multiple interactions

VDR gene polymorphism affects the susceptibility to Alendronate
VDR gene polymorphism affects the susceptibility to [Alendronate co-treated with Estrogens, Conjugated (USP) co-treated with Medroxyprogesterone Acetate]; VDR gene polymorphism affects the susceptibility to [Alendronate co-treated with Raloxifene Hydrochloride]

PMID:12608943 PMID:15739035

NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511

clodronic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

decreases expression

Clodronic Acid results in decreased expression of AARS1 mRNA

NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296

G

ATP-binding cassette, sub-family B member 9

increases expression

Clodronic Acid results in increased expression of ABCB9 mRNA

NCBI chr 5:124,199,920...124,234,009
Ensembl chr 5:124,199,593...124,233,861

G

ATP-binding cassette, sub-family C member 3

increases expression

Clodronic Acid results in increased expression of ABCC3 mRNA

NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823

G

ATP binding cassette subfamily G member 1

decreases expression

Clodronic Acid results in decreased expression of ABCG1 mRNA

NCBI chr17:31,276,668...31,336,958
Ensembl chr17:31,276,649...31,336,962

G

abhydrolase domain containing 4

increases expression

Clodronic Acid results in increased expression of ABHD4 mRNA

NCBI chr14:54,491,586...54,506,626
Ensembl chr14:54,491,645...54,508,094

G

acyl-CoA synthetase long-chain family member 1

decreases expression

Clodronic Acid results in decreased expression of ACSL1 mRNA

NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088

G

actin alpha 2, smooth muscle, aorta

multiple interactions

[Clodronic Acid co-treated with Thioacetamide] results in increased expression of ACTA2 protein

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

agrin

increases expression

Clodronic Acid results in increased expression of AGRN mRNA

NCBI chr 4:156,249,747...156,281,997
Ensembl chr 4:156,249,747...156,281,945

G

aryl-hydrocarbon receptor

affects activity

Clodronic Acid affects the activity of AHR protein

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

apoptosis-inducing factor, mitochondrion-associated 2

affects expression

Clodronic Acid affects the expression of AIFM2 mRNA

NCBI chr10:61,551,042...61,575,474
Ensembl chr10:61,551,042...61,575,039

G

adenylate kinase 3

increases expression

Clodronic Acid results in increased expression of AK3 mRNA

NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361

G

aldo-keto reductase family 1, member C21

increases expression

Clodronic Acid results in increased expression of AKR1C2 mRNA

NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540

G

aldehyde dehydrogenase family 1, subfamily A3

increases expression

Clodronic Acid results in increased expression of ALDH1A3 mRNA

NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265

G

ALS2 C-terminal like

affects expression

Clodronic Acid affects the expression of ALS2CL mRNA

NCBI chr 9:110,709,203...110,729,598
Ensembl chr 9:110,708,938...110,729,598

G

angiopoietin-like 4

decreases expression

Clodronic Acid results in decreased expression of ANGPTL4 mRNA

NCBI chr17:33,993,874...34,000,549
Ensembl chr17:33,992,724...34,000,804

G

ankyrin repeat family A member 2

decreases expression

Clodronic Acid results in decreased expression of ANKRA2 mRNA

NCBI chr13:98,399,584...98,411,262
Ensembl chr13:98,399,582...98,411,262

G

ADP ribosylation factor guanine nucleotide exchange factor 2

affects expression

Clodronic Acid affects the expression of ARFGEF2 mRNA

NCBI chr 2:166,647,371...166,739,972
Ensembl chr 2:166,647,508...166,739,972

G

Rho guanine nucleotide exchange factor 10

decreases expression

Clodronic Acid results in decreased expression of ARHGEF10 mRNA

NCBI chr 8:14,956,405...15,051,085
Ensembl chr 8:14,961,663...15,051,085

G

ADP-ribosylation factor-like 1

increases expression

Clodronic Acid results in increased expression of ARL1 mRNA

NCBI chr10:88,566,720...88,579,956
Ensembl chr10:88,566,720...88,579,956

G

asparagine synthetase

decreases expression

Clodronic Acid results in decreased expression of ASNS mRNA

NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254

G

astrotactin 2

increases expression

Clodronic Acid results in increased expression of ASTN2 mRNA

NCBI chr 4:65,299,040...66,322,774
Ensembl chr 4:65,299,040...66,322,848

G

ATPase family, AAA domain containing 2

increases expression

Clodronic Acid results in increased expression of ATAD2 mRNA

NCBI chr15:57,957,440...57,998,516
Ensembl chr15:57,957,440...57,998,478

G

activating transcription factor 3

decreases expression

Clodronic Acid results in decreased expression of ATF3 mRNA

NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236

G

activating transcription factor 4

affects activity

Clodronic Acid affects the activity of ATF4 protein

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

atos homolog A

decreases expression

Clodronic Acid results in decreased expression of ATOSA mRNA

NCBI chr 9:74,860,162...74,939,750
Ensembl chr 9:74,860,166...74,939,750

G

ataxin 1

decreases expression

Clodronic Acid results in decreased expression of ATXN1 mRNA

NCBI chr13:45,703,231...46,118,467
Ensembl chr13:45,703,231...46,118,484

G

aurora kinase B

increases expression

Clodronic Acid results in increased expression of AURKB mRNA

NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490

G

AXL receptor tyrosine kinase

increases expression

Clodronic Acid results in increased expression of AXL mRNA

NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130

G

basic leucine zipper transcription factor, ATF-like

decreases expression

Clodronic Acid results in decreased expression of BATF mRNA

NCBI chr12:85,733,494...85,755,861
Ensembl chr12:85,733,443...85,755,861

G

BCL2-associated X protein

increases expression

Clodronic Acid results in increased expression of BAX mRNA

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

branched chain aminotransferase 1, cytosolic

increases expression

Clodronic Acid results in increased expression of BCAT1 mRNA

NCBI chr 6:144,939,561...145,021,883
Ensembl chr 6:144,939,561...145,021,910

G

branched chain aminotransferase 2, mitochondrial

increases expression

Clodronic Acid results in increased expression of BCAT2 mRNA

NCBI chr 7:45,219,773...45,239,134
Ensembl chr 7:45,219,577...45,239,135

G

B cell leukemia/lymphoma 3

decreases expression

Clodronic Acid results in decreased expression of BCL3 mRNA

NCBI chr 7:19,542,387...19,556,691
Ensembl chr 7:19,542,387...19,556,695

G

BEN domain containing 5

increases expression

Clodronic Acid results in increased expression of BEND5 mRNA

NCBI chr 4:111,271,993...111,317,495
Ensembl chr 4:111,272,203...111,317,495

G

BCL2/adenovirus E1B interacting protein 3

decreases expression

Clodronic Acid results in decreased expression of BNIP3 mRNA

NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248

G

bromodomain containing 2

decreases expression

Clodronic Acid results in decreased expression of BRD2 mRNA

NCBI chr17:34,330,993...34,341,581
Ensembl chr17:34,330,997...34,341,608

G

BTG anti-proliferation factor 2

increases expression

Clodronic Acid results in increased expression of BTG2 mRNA

NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858

G

calcium/calmodulin-dependent protein kinase kinase 2, beta

increases expression

Clodronic Acid results in increased expression of CAMKK2 mRNA

NCBI chr 5:122,856,064...122,918,295
Ensembl chr 5:122,869,233...122,917,472

G

cysteinyl-tRNA synthetase 1

decreases expression

Clodronic Acid results in decreased expression of CARS1 mRNA

NCBI chr 7:143,110,967...143,153,827
Ensembl chr 7:143,110,967...143,153,827

G

caspase 3

increases expression
multiple interactions

Clodronic Acid results in increased expression of CASP3
Suramin inhibits the reaction [Clodronic Acid results in increased expression of CASP3]

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

coiled-coil domain containing 90B

decreases expression

Clodronic Acid results in decreased expression of CCDC90B mRNA

NCBI chr 7:92,210,350...92,231,502
Ensembl chr 7:92,210,357...92,231,502

G

cyclin E2

increases expression

Clodronic Acid results in increased expression of CCNE2 mRNA

NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779

G

cyclin G2

decreases expression

Clodronic Acid results in decreased expression of CCNG2 mRNA

NCBI chr 5:93,415,432...93,424,090
Ensembl chr 5:93,415,116...93,424,090

G

CD68 antigen

multiple interactions

Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA]

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

CD80 antigen

multiple interactions

Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD80 protein]

NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697

G

CD86 antigen

multiple interactions

Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD86 protein]

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

cyclin dependent kinase 6

affects expression

Clodronic Acid affects the expression of CDK6 mRNA

NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008

G

cyclin dependent kinase inhibitor 1A

increases expression

Clodronic Acid results in increased expression of CDKN1A mRNA

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

ceramide synthase 5

increases expression

Clodronic Acid results in increased expression of CERS5 mRNA

NCBI chr15:99,633,473...99,670,396
Ensembl chr15:99,632,762...99,670,766

G

CAP-GLY domain containing linker protein family, member 4

increases expression

Clodronic Acid results in increased expression of CLIP4 mRNA

NCBI chr17:72,076,674...72,171,205
Ensembl chr17:72,075,468...72,171,268

G

carboxymethylenebutenolidase homolog

increases expression

Clodronic Acid results in increased expression of CMBL mRNA

NCBI chr15:31,565,314...31,590,266
Ensembl chr15:31,565,535...31,590,265

G

collagen, type I, alpha 1

multiple interactions

Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of COL1A1 mRNA]

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

cysteine-rich secretory protein LCCL domain containing 2

increases expression

Clodronic Acid results in increased expression of CRISPLD2 mRNA

NCBI chr 8:120,719,177...120,779,533
Ensembl chr 8:120,719,177...120,779,532

G

CTD phosphatase subunit 1

decreases expression

Clodronic Acid results in decreased expression of CTDP1 mRNA

NCBI chr18:80,451,174...80,522,959
Ensembl chr18:80,451,174...80,512,910

G

cystathionine gamma lyase

decreases expression

Clodronic Acid results in decreased expression of CTH mRNA

NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714

G

cathepsin C

increases expression

Clodronic Acid results in increased expression of CTSC mRNA

NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096

G

cortactin

increases expression

Clodronic Acid results in increased expression of CTTN mRNA

NCBI chr 7:143,989,468...144,024,743
Ensembl chr 7:143,989,470...144,024,746

G

C-X-C motif chemokine receptor 2

multiple interactions

Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]; IL10 protein inhibits the reaction [Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]]

NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

Clodronic Acid results in increased expression of CYP1A2 mRNA

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

Clodronic Acid results in increased expression of CYP1B1 mRNA

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

damage specific DNA binding protein 2

decreases expression

Clodronic Acid results in decreased expression of DDB2 mRNA

NCBI chr 2:91,041,924...91,067,465
Ensembl chr 2:91,041,917...91,067,327

G

DNA-damage inducible transcript 3

affects expression

Clodronic Acid affects the expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DNA-damage-inducible transcript 4

increases expression

Clodronic Acid results in increased expression of DDIT4 mRNA

NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656

G

DEAD box helicase 17

decreases expression

Clodronic Acid results in decreased expression of DDX17 mRNA

NCBI chr15:79,411,897...79,430,976
Ensembl chr15:79,411,937...79,430,942

G

desmin

multiple interactions

[Clodronic Acid co-treated with Thioacetamide] results in increased expression of DES protein

NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223

G

diacylglycerol kinase, alpha

increases expression

Clodronic Acid results in increased expression of DGKA mRNA

NCBI chr10:128,556,000...128,581,002
Ensembl chr10:128,556,003...128,580,724

G

DEAH-box helicase 37

decreases expression

Clodronic Acid results in decreased expression of DHX37 mRNA

NCBI chr 5:125,490,811...125,511,203
Ensembl chr 5:125,490,922...125,511,185

G

DLG associated protein 5

increases expression

Clodronic Acid results in increased expression of DLGAP5 mRNA

NCBI chr14:47,625,238...47,655,657
Ensembl chr14:47,625,236...47,655,864

G

dynein axonemal intermediate chain 3

decreases expression

Clodronic Acid results in decreased expression of DNAI3 mRNA

NCBI chr 3:145,746,281...145,813,855
Ensembl chr 3:145,746,281...145,813,885

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Clodronic Acid results in increased expression of DNAJB9 mRNA

NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109

G

dolichyl-phosphate mannosyltransferase polypeptide 3

increases expression

Clodronic Acid results in increased expression of DPM3 mRNA

NCBI chr 3:89,166,567...89,174,386
Ensembl chr 3:89,166,665...89,174,386

G

dihydropyrimidinase-like 3

increases expression

Clodronic Acid results in increased expression of DPYSL3 mRNA

NCBI chr18:43,454,044...43,571,354
Ensembl chr18:43,454,049...43,571,351

G

dual specificity phosphatase 22

increases expression

Clodronic Acid results in increased expression of DUSP22 mRNA

NCBI chr13:30,844,042...30,895,215
Ensembl chr13:30,843,982...30,895,214

G

ephrin A1

decreases expression

Clodronic Acid results in decreased expression of EFNA1 mRNA

NCBI chr 3:89,179,037...89,188,258
Ensembl chr 3:89,179,040...89,188,449

G

eukaryotic translation initiation factor 1

increases expression

Clodronic Acid results in increased expression of EIF1 mRNA

NCBI chr11:100,210,775...100,212,925
Ensembl chr11:100,210,711...100,212,922

G

eukaryotic translation initiation factor 2 subunit 2 beta

increases expression

Clodronic Acid results in increased expression of EIF2S2 mRNA

NCBI chr 2:154,713,330...154,734,826
Ensembl chr 2:154,713,330...154,734,855

G

eukaryotic translation initiation factor 3, subunit C

decreases expression

Clodronic Acid results in decreased expression of EIF3C mRNA

NCBI chr 7:126,146,083...126,165,538
Ensembl chr 7:126,145,627...126,165,583

G

E74 like ETS transcription factor 4

decreases expression

Clodronic Acid results in decreased expression of ELF4 mRNA

NCBI chr X:47,499,926...47,552,009
Ensembl chr X:47,499,923...47,552,009

G

ELK4, member of ETS oncogene family

decreases expression

Clodronic Acid results in decreased expression of ELK4 mRNA

NCBI chr 1:131,935,129...131,954,186
Ensembl chr 1:131,935,345...131,960,350

G

enolase 2, gamma neuronal

increases expression

Clodronic Acid results in increased expression of ENO2 mRNA

NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636

G

E1A binding protein p400

decreases expression

Clodronic Acid results in decreased expression of EP400 mRNA

NCBI chr 5:110,812,239...110,918,583
Ensembl chr 5:110,812,239...110,918,583

G

glutamyl-prolyl-tRNA synthetase 1

decreases expression

Clodronic Acid results in decreased expression of EPRS1 mRNA

NCBI chr 1:185,093,614...185,160,557
Ensembl chr 1:185,095,241...185,160,557

G

family with sequence similarity 162, member A

decreases expression

Clodronic Acid results in decreased expression of FAM162A mRNA

NCBI chr16:35,864,214...35,891,931
Ensembl chr16:35,864,131...35,891,964

G

family with sequence similarity 210, member A

affects expression

Clodronic Acid affects the expression of FAM210A mRNA

NCBI chr18:68,393,248...68,433,404
Ensembl chr18:68,393,258...68,433,404

G

family with sequence similarity 89, member A

increases expression

Clodronic Acid results in increased expression of FAM89A mRNA

NCBI chr 8:125,466,996...125,478,605
Ensembl chr 8:125,466,996...125,478,571

G

Fas cell surface death receptor

decreases expression

Clodronic Acid results in decreased expression of FAS mRNA

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

F-box protein 22

increases expression

Clodronic Acid results in increased expression of FBXO22 mRNA

NCBI chr 9:55,116,219...55,131,717
Ensembl chr 9:55,116,209...55,131,717

G

F-box protein 30

decreases expression

Clodronic Acid results in decreased expression of FBXO30 mRNA

NCBI chr10:11,157,009...11,181,494
Ensembl chr10:11,157,074...11,173,796

G

ferrochelatase

decreases expression

Clodronic Acid results in decreased expression of FECH mRNA

NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322

G

feline leukemia virus subgroup C cellular receptor 2

increases expression

Clodronic Acid results in increased expression of FLVCR2 mRNA

NCBI chr12:85,793,313...85,860,359
Ensembl chr12:85,793,313...85,860,359

G

fos-like antigen 1

increases expression

Clodronic Acid results in increased expression of FOSL1 mRNA

NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974

G

fos-like antigen 2

decreases expression

Clodronic Acid results in decreased expression of FOSL2 mRNA

NCBI chr 5:32,292,599...32,315,184
Ensembl chr 5:32,293,145...32,315,186

G

Fras1 related extracellular matrix protein 2

decreases expression

Clodronic Acid results in decreased expression of FREM2 mRNA

NCBI chr 3:53,421,359...53,566,014
Ensembl chr 3:53,421,359...53,564,776

G

ferritin heavy polypeptide 1

decreases expression

Clodronic Acid results in decreased expression of FTH1 mRNA

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

GABA type A receptor associated protein like 1

increases expression

Clodronic Acid results in increased expression of GABARAPL1 mRNA

NCBI chr 6:129,510,155...129,519,294
Ensembl chr 6:129,510,123...129,519,309

G

glycyl-tRNA synthetase 1

increases expression

Clodronic Acid results in increased expression of GARS1 mRNA

NCBI chr 6:55,014,986...55,056,489
Ensembl chr 6:55,014,992...55,056,485

G

glutamate-cysteine ligase, catalytic subunit

decreases expression

Clodronic Acid results in decreased expression of GCLC mRNA

NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767

G

glutamate-cysteine ligase, modifier subunit

increases expression

Clodronic Acid results in increased expression of GCLM mRNA

NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381

G

growth differentiation factor 15

decreases expression

Clodronic Acid results in decreased expression of GDF15 mRNA

NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106

G

predicted gene, 20348

increases expression

Clodronic Acid results in increased expression of TP53I3 mRNA

NCBI chr12:4,860,475...4,867,155
Ensembl chr12:4,860,494...4,867,142

G

golgi integral membrane protein 4

increases expression

Clodronic Acid results in increased expression of GOLIM4 mRNA

NCBI chr 3:75,783,490...75,864,256
Ensembl chr 3:75,782,391...75,864,256

G

glycerol-3-phosphate acyltransferase 3

increases expression

Clodronic Acid results in increased expression of GPAT3 mRNA

NCBI chr 5:100,994,095...101,046,968
Ensembl chr 5:100,993,579...101,046,968

G

glycoprotein (transmembrane) nmb

increases expression

Clodronic Acid results in increased expression of GPNMB mRNA

NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863

G

G protein-coupled receptor 87

decreases expression

Clodronic Acid results in decreased expression of GPR87 mRNA

NCBI chr 3:59,086,325...59,102,583
Ensembl chr 3:59,086,344...59,102,525

G

glutamic pyruvic transaminase, soluble

multiple interactions

Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein]; Clodronic Acid promotes the reaction [Acetaminophen results in increased activity of GPT protein]
Clodronic Acid promotes the reaction [Thioacetamide results in increased expression of GPT protein]

PMID:26957569 PMID:27022031 PMID:34724096

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione reductase

increases expression

Clodronic Acid results in increased expression of GSR mRNA

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

hypoxia inducible factor 1, alpha subunit

multiple interactions
affects activity

Clodronic Acid inhibits the reaction [Dopamine results in decreased expression of HIF1A protein]
Clodronic Acid affects the activity of HIF1A protein

PMID:25596134 PMID:25818600

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

heme oxygenase 1

decreases expression
increases expression

Clodronic Acid results in decreased expression of HMOX1 mRNA
Clodronic Acid results in increased expression of HMOX1 mRNA

PMID:21690482 PMID:25596134

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

isoleucyl-tRNA synthetase 1

affects expression

Clodronic Acid affects the expression of IARS1 mRNA

NCBI chr13:49,835,606...49,887,743
Ensembl chr13:49,835,576...49,887,743

G

intercellular adhesion molecule 1

multiple interactions

Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

iduronate 2-sulfatase

decreases expression

Clodronic Acid results in decreased expression of IDS mRNA

NCBI chr X:69,386,675...69,429,437
Ensembl chr X:69,386,675...69,408,690

G

interferon gamma

multiple interactions

Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of IFNG protein]

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

insulin-like growth factor I receptor

increases expression

Clodronic Acid results in increased expression of IGF1R mRNA

NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416

G

interleukin 10

multiple interactions

Clodronic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]; IL10 protein inhibits the reaction [Clodronic Acid inhibits the reaction [Acetaminophen results in increased expression of CXCR2 protein]]

PMID:32385136 PMID:34724096

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 1 beta

multiple interactions
increases expression

Clodronic Acid inhibits the reaction [Alendronate results in increased expression of IL1B protein]
Clodronic Acid results in increased expression of IL1B mRNA

PMID:20804833 PMID:25187657

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

multiple interactions

Clodronic Acid inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of IL6 mRNA]

PMID:20382593 PMID:27022031

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

lysine (K)-specific demethylase 3A

decreases expression

Clodronic Acid results in decreased expression of KDM3A mRNA

NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974

G

kelch-like ECH-associated protein 1

increases expression

Clodronic Acid results in increased expression of KEAP1 mRNA

NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657

G

laminin, alpha 3

increases expression

Clodronic Acid results in increased expression of LAMA3 mRNA

NCBI chr18:12,466,806...12,716,070
Ensembl chr18:12,466,876...12,716,070

G

listerin E3 ubiquitin protein ligase 1

decreases expression

Clodronic Acid results in decreased expression of LTN1 mRNA

NCBI chr16:87,173,539...87,229,504
Ensembl chr16:87,173,539...87,229,500

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)

increases expression

Clodronic Acid results in increased expression of MAFG mRNA

NCBI chr11:120,515,943...120,525,771
Ensembl chr11:120,515,943...120,524,426

G

microtubule-associated protein, RP/EB family, member 2

increases expression

Clodronic Acid results in increased expression of MAPRE2 mRNA

NCBI chr18:23,885,390...24,026,918
Ensembl chr18:23,885,390...24,026,918

G

mucolipin 2

decreases expression

Clodronic Acid results in decreased expression of MCOLN2 mRNA

NCBI chr 3:145,855,552...145,901,269
Ensembl chr 3:145,855,588...145,901,268

G

malic enzyme 1, NADP(+)-dependent, cytosolic

decreases expression

Clodronic Acid results in decreased expression of ME1 mRNA

NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006

G

metadherin

decreases expression

Clodronic Acid results in decreased expression of MTDH mRNA

NCBI chr15:34,082,613...34,143,683
Ensembl chr15:34,082,840...34,145,770

G

mucin 2

decreases expression

Clodronic Acid results in decreased expression of MUC2 mRNA

NCBI chr 7:141,276,583...141,308,428
Ensembl chr 7:141,276,583...141,308,430

G

MAX interactor 1, dimerization protein

decreases expression

Clodronic Acid results in decreased expression of MXI1 mRNA

NCBI chr19:53,298,509...53,361,724
Ensembl chr19:53,298,949...53,364,241

G

asparaginyl-tRNA synthetase 1

decreases expression

Clodronic Acid results in decreased expression of NARS1 mRNA

NCBI chr18:64,632,726...64,649,586
Ensembl chr18:64,632,718...64,649,723

G

neural precursor cell expressed, developmentally down-regulated gene 9

decreases expression

Clodronic Acid results in decreased expression of NEDD9 mRNA

NCBI chr13:41,463,392...41,640,836
Ensembl chr13:41,463,057...41,640,838

G

nuclear factor, erythroid derived 2, like 2

affects activity

Clodronic Acid affects the activity of NFE2L2 protein

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

ninein

decreases expression

Clodronic Acid results in decreased expression of NIN mRNA

NCBI chr12:70,058,209...70,160,575
Ensembl chr12:70,058,209...70,160,491

G

NAD(P)H dehydrogenase, quinone 1

decreases expression

Clodronic Acid results in decreased expression of NQO1 mRNA

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 3, group C, member 1

decreases expression

Clodronic Acid results in decreased expression of NR3C1 mRNA

NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474

G

neuronal regeneration related protein

increases expression

Clodronic Acid results in increased expression of NREP mRNA

NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082

G

nucleoside-triphosphatase, cancer-related

increases expression

Clodronic Acid results in increased expression of NTPCR mRNA

NCBI chr 8:126,456,724...126,474,974
Ensembl chr 8:126,456,702...126,474,974

G

NUAK family, SNF1-like kinase, 1

decreases expression

Clodronic Acid results in decreased expression of NUAK1 mRNA

NCBI chr10:84,206,764...84,282,028
Ensembl chr10:84,206,769...84,276,461

G

ORAI calcium release-activated calcium modulator 3

decreases expression

Clodronic Acid results in decreased expression of ORAI3 mRNA

NCBI chr 7:127,368,987...127,374,322
Ensembl chr 7:127,368,987...127,374,322

G

oxidative stress induced growth inhibitor 1

decreases expression

Clodronic Acid results in decreased expression of OSGIN1 mRNA

NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995

G

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide

decreases expression

Clodronic Acid results in decreased expression of P4HA1 mRNA

NCBI chr10:59,159,019...59,209,126
Ensembl chr10:59,159,118...59,209,126

G

phosphodiesterase 8A

decreases expression

Clodronic Acid results in decreased expression of PDE8A mRNA

NCBI chr 7:80,863,013...80,984,283
Ensembl chr 7:80,863,344...80,984,281

G

protein disulfide isomerase associated 5

increases expression

Clodronic Acid results in increased expression of PDIA5 mRNA

NCBI chr16:35,217,678...35,311,289
Ensembl chr16:35,217,682...35,311,243

G

pyruvate dehydrogenase kinase, isoenzyme 1

decreases expression

Clodronic Acid results in decreased expression of PDK1 mRNA

NCBI chr 2:71,703,398...71,734,202
Ensembl chr 2:71,703,568...71,734,202

G

pyruvate dehydrogenase kinase, isoenzyme 4

increases expression

Clodronic Acid results in increased expression of PDK4 mRNA

NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309

G

PDZ and LIM domain 1 (elfin)

increases expression

Clodronic Acid results in increased expression of PDLIM1 mRNA

NCBI chr19:40,210,683...40,260,060
Ensembl chr19:40,209,617...40,260,286

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

decreases expression

Clodronic Acid results in decreased expression of PFKFB4 mRNA

NCBI chr 9:108,817,336...108,861,302
Ensembl chr 9:108,820,846...108,861,296

G

3-phosphoglycerate dehydrogenase

decreases expression

Clodronic Acid results in decreased expression of PHGDH mRNA

NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306

G

phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma

affects expression

Clodronic Acid affects the expression of PIP5K1C mRNA

NCBI chr10:81,128,669...81,155,808
Ensembl chr10:81,128,797...81,155,807

G

pirin

increases expression

Clodronic Acid results in increased expression of PIR mRNA

NCBI chr X:163,052,427...163,156,009
Ensembl chr X:163,052,367...163,156,007

G

plectin

decreases expression

Clodronic Acid results in decreased expression of PLEC mRNA

NCBI chr15:76,055,174...76,115,578
Ensembl chr15:76,055,174...76,116,774

G

polo like kinase 3

increases expression

Clodronic Acid results in increased expression of PLK3 mRNA

NCBI chr 4:116,985,852...116,991,244
Ensembl chr 4:116,985,852...116,991,160

G

phorbol-12-myristate-13-acetate-induced protein 1

decreases expression

Clodronic Acid results in decreased expression of PMAIP1 mRNA

NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636

G

prostate transmembrane protein, androgen induced 1

affects expression

Clodronic Acid affects the expression of PMEPA1 mRNA

NCBI chr 2:173,066,251...173,118,329
Ensembl chr 2:173,066,251...173,118,326

G

patatin-like phospholipase domain containing 6

decreases expression

Clodronic Acid results in decreased expression of PNPLA6 mRNA

NCBI chr 8:3,565,341...3,594,267
Ensembl chr 8:3,565,384...3,594,267

G

polymerase (RNA) III (DNA directed) polypeptide F

decreases expression

Clodronic Acid results in decreased expression of POLR3F mRNA

NCBI chr 2:144,369,665...144,383,699
Ensembl chr 2:144,369,638...144,383,915

G

paraoxonase 1

decreases activity
multiple interactions

Clodronic Acid results in decreased activity of PON1 protein
[Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Clodronic Acid results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

peroxisome proliferator activated receptor gamma

affects activity

Clodronic Acid affects the activity of PPARG protein

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

PTPRF interacting protein, binding protein 1 (liprin beta 1)

affects expression

Clodronic Acid affects the expression of PPFIBP1 mRNA

NCBI chr 6:146,788,107...146,933,523
Ensembl chr 6:146,789,985...146,933,523

G

peptidyl-prolyl isomerase G (cyclophilin G)

decreases expression

Clodronic Acid results in decreased expression of PPIG mRNA

NCBI chr 2:69,553,152...69,584,356
Ensembl chr 2:69,552,889...69,584,356

G

protein phosphatase 1D magnesium-dependent, delta isoform

decreases expression

Clodronic Acid results in decreased expression of PPM1D mRNA

NCBI chr11:85,202,080...85,237,897
Ensembl chr11:85,202,070...85,237,892

G

protein phosphatase 1, regulatory subunit 15A

decreases expression

Clodronic Acid results in decreased expression of PPP1R15A mRNA

NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692

G

protein phosphatase 4, regulatory subunit 2

decreases expression

Clodronic Acid results in decreased expression of PPP4R2 mRNA

NCBI chr 6:100,810,596...100,846,891
Ensembl chr 6:100,810,583...100,846,895

G

protein regulator of cytokinesis 1

increases expression

Clodronic Acid results in increased expression of PRC1 mRNA

NCBI chr 7:79,944,224...79,966,007
Ensembl chr 7:79,944,198...79,966,007

G

PR domain containing 1, with ZNF domain

decreases expression

Clodronic Acid results in decreased expression of PRDM1 mRNA

NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497

G

protein kinase, AMP-activated, beta 1 non-catalytic subunit

increases expression

Clodronic Acid results in increased expression of PRKAB1 mRNA

NCBI chr 5:116,151,654...116,162,449
Ensembl chr 5:116,151,645...116,162,567

G

protein kinase, AMP-activated, beta 2 non-catalytic subunit

decreases expression

Clodronic Acid results in decreased expression of PRKAB2 mRNA

NCBI chr 3:97,565,527...97,581,128
Ensembl chr 3:97,565,509...97,581,128

G

phosphoserine aminotransferase 1

increases expression

Clodronic Acid results in increased expression of PSAT1 mRNA

NCBI chr19:15,882,487...15,902,423
Ensembl chr19:15,882,042...15,924,701

G

paraspeckle protein 1

decreases expression

Clodronic Acid results in decreased expression of PSPC1 mRNA

NCBI chr14:56,959,898...57,015,775
Ensembl chr14:56,958,167...57,015,773

G

phosphatase and tensin homolog

multiple interactions

Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of CD68 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of COL1A1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of IL6 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TGFB1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TIMP1 mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TNF mRNA]; Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased secretion of GPT protein]

NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560

G

pyrroline-5-carboxylate reductase 1

increases expression

Clodronic Acid results in increased expression of PYCR1 mRNA

NCBI chr11:120,527,591...120,534,602
Ensembl chr11:120,526,538...120,534,595

G

RAB26, member RAS oncogene family

increases expression

Clodronic Acid results in increased expression of RAB26 mRNA

NCBI chr17:24,748,038...24,752,696
Ensembl chr17:24,746,215...24,753,184

G

RAB31, member RAS oncogene family

increases expression

Clodronic Acid results in increased expression of RAB31 mRNA

NCBI chr17:65,958,721...66,079,747
Ensembl chr17:65,958,724...66,079,747

G

retinoic acid receptor, alpha

decreases expression

Clodronic Acid results in decreased expression of RARA mRNA

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

ring finger and FYVE like domain containing protein

increases expression

Clodronic Acid results in increased expression of RFFL mRNA

NCBI chr11:82,694,645...82,762,065
Ensembl chr11:82,693,275...82,762,036

G

Ras-like without CAAX 1

increases expression

Clodronic Acid results in increased expression of RIT1 mRNA

NCBI chr 3:88,624,154...88,638,354
Ensembl chr 3:88,624,145...88,638,356

G

Rho family GTPase 3

affects expression

Clodronic Acid affects the expression of RND3 mRNA

NCBI chr 2:51,020,451...51,039,123
Ensembl chr 2:51,020,450...51,039,123

G

Ro60, Y RNA binding protein

decreases expression

Clodronic Acid results in decreased expression of RO60 mRNA

NCBI chr 1:143,626,528...143,652,794
Ensembl chr 1:143,626,528...143,652,806

G

ribonucleotide reductase M2 B (TP53 inducible)

decreases expression

Clodronic Acid results in decreased expression of RRM2B mRNA

NCBI chr15:37,924,196...37,961,562
Ensembl chr15:37,924,196...37,961,562

G

ribosomal RNA processing 12 homolog

decreases expression

Clodronic Acid results in decreased expression of RRP12 mRNA

NCBI chr19:41,847,922...41,884,592
Ensembl chr19:41,851,290...41,884,612

G

arginine/serine-rich coiled-coil 2

affects expression

Clodronic Acid affects the expression of RSRC2 mRNA

NCBI chr 5:123,866,489...123,887,522
Ensembl chr 5:123,866,489...123,887,477

G

runt related transcription factor 1

increases expression

Clodronic Acid results in increased expression of RUNX1 mRNA

NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037

G

runt related transcription factor 2

increases expression

Clodronic Acid results in increased expression of RUNX2 mRNA

NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684

G

secretory carrier membrane protein 1

increases expression

Clodronic Acid results in increased expression of SCAMP1 mRNA

NCBI chr13:94,337,818...94,422,339
Ensembl chr13:94,337,818...94,422,365

G

secreted and transmembrane 1A

increases expression

Clodronic Acid results in increased expression of SECTM1 mRNA

NCBI chr11:120,958,221...120,988,023
Ensembl chr11:120,958,233...120,972,046

G

SERTA domain containing 1

increases expression

Clodronic Acid results in increased expression of SERTAD1 mRNA

NCBI chr 7:27,186,378...27,189,741
Ensembl chr 7:27,186,335...27,189,741

G

senataxin

decreases expression

Clodronic Acid results in decreased expression of SETX mRNA

NCBI chr 2:29,013,600...29,072,483
Ensembl chr 2:29,014,193...29,072,483

G

stratifin

increases expression

Clodronic Acid results in increased expression of SFN mRNA

NCBI chr 4:133,327,867...133,329,163
Ensembl chr 4:133,327,867...133,329,479

G

SH3 and multiple ankyrin repeat domains 3

decreases expression

Clodronic Acid results in decreased expression of SHANK3 mRNA

NCBI chr15:89,376,929...89,444,464
Ensembl chr15:89,383,826...89,444,464

G

siah E3 ubiquitin protein ligase 2

increases expression

Clodronic Acid results in increased expression of SIAH2 mRNA

NCBI chr 3:58,582,370...58,599,857
Ensembl chr 3:58,582,359...58,599,821

G

signal-induced proliferation-associated 1 like 2

decreases expression

Clodronic Acid results in decreased expression of SIPA1L2 mRNA

NCBI chr 8:126,144,807...126,296,602
Ensembl chr 8:126,144,802...126,296,547

G

SIVA1, apoptosis-inducing factor

increases expression

Clodronic Acid results in increased expression of SIVA1 mRNA

NCBI chr12:112,611,262...112,615,586
Ensembl chr12:112,611,113...112,615,583

G

solute carrier family 12 (potassium/chloride transporters), member 8

decreases expression

Clodronic Acid results in decreased expression of SLC12A8 mRNA

NCBI chr16:33,337,440...33,484,508
Ensembl chr16:33,337,698...33,484,505

G

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

decreases expression

Clodronic Acid results in decreased expression of SLC1A4 mRNA

NCBI chr11:20,252,180...20,282,713
Ensembl chr11:20,252,180...20,282,713

G

solute carrier family 1 (neutral amino acid transporter), member 5

decreases expression

Clodronic Acid results in decreased expression of SLC1A5 mRNA

NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199

G

solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20

increases expression

Clodronic Acid results in increased expression of SLC25A20 mRNA

NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840

G

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

affects expression

Clodronic Acid affects the expression of SLC3A2 mRNA

NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733

G

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

decreases expression

Clodronic Acid results in decreased expression of SLC6A9 mRNA

NCBI chr 4:117,692,240...117,726,502
Ensembl chr 4:117,691,703...117,732,395

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

affects expression

Clodronic Acid affects the expression of SLC7A5 mRNA

NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433

G

small ArfGAP 1

increases expression

Clodronic Acid results in increased expression of SMAP1 mRNA

NCBI chr 1:23,883,925...23,961,462
Ensembl chr 1:23,883,927...23,961,398

G

Son DNA binding protein

decreases expression

Clodronic Acid results in decreased expression of SON mRNA

NCBI chr16:91,444,712...91,476,080
Ensembl chr16:91,444,394...91,476,109

G

sortilin-related receptor, LDLR class A repeats-containing

increases expression

Clodronic Acid results in increased expression of SORL1 mRNA

NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593

G

sprouty RTK signaling antagonist 1

increases expression

Clodronic Acid results in increased expression of SPRY1 mRNA

NCBI chr 3:37,694,096...37,698,748
Ensembl chr 3:37,694,096...37,698,747

G

steroid 5 alpha-reductase 3

decreases expression

Clodronic Acid results in decreased expression of SRD5A3 mRNA

NCBI chr 5:76,285,296...76,303,350
Ensembl chr 5:76,288,118...76,303,351

G

sulfiredoxin 1 homolog (S. cerevisiae)

increases expression

Clodronic Acid results in increased expression of SRXN1 mRNA

NCBI chr 2:151,946,738...151,953,296
Ensembl chr 2:151,947,436...151,953,296

G

sulfatase 2

decreases expression

Clodronic Acid results in decreased expression of SULF2 mRNA

NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583

G

TAO kinase 1

affects expression

Clodronic Acid affects the expression of TAOK1 mRNA

NCBI chr11:77,419,988...77,516,185
Ensembl chr11:77,419,988...77,498,641

G

threonyl-tRNA synthetase 1

decreases expression

Clodronic Acid results in decreased expression of TARS1 mRNA

NCBI chr15:11,383,749...11,399,744
Ensembl chr15:11,382,387...11,399,751

G

thromboxane A synthase 1, platelet

affects expression

Clodronic Acid affects the expression of TBXAS1 mRNA

NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519

G

transcription factor AP-2, alpha

decreases expression

Clodronic Acid results in decreased expression of TFAP2A mRNA

NCBI chr13:40,867,278...40,891,715
Ensembl chr13:40,868,778...40,891,852

G

transcription factor E3

decreases expression

Clodronic Acid results in decreased expression of TFE3 mRNA

NCBI chr X:7,628,769...7,641,441
Ensembl chr X:7,628,799...7,641,441

G

transforming growth factor, beta 1

multiple interactions

Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TGFB1 mRNA]

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

Trp53 induced glycolysis regulatory phosphatase

increases expression

Clodronic Acid results in increased expression of TIGAR mRNA

NCBI chr 6:127,062,079...127,086,564
Ensembl chr 6:127,062,079...127,086,520

G

translocase of inner mitochondrial membrane 17b

decreases expression

Clodronic Acid results in decreased expression of TIMM17B mRNA

NCBI chr X:7,765,575...7,773,891
Ensembl chr X:7,765,596...7,776,168

G

tissue inhibitor of metalloproteinase 1

multiple interactions

Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TIMP1 mRNA]

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

Clodronic Acid results in increased expression of TIPARP mRNA

NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939

G

transmembrane protein 45b

decreases expression

Clodronic Acid results in decreased expression of TMEM45B mRNA

NCBI chr 9:31,336,445...31,375,534
Ensembl chr 9:31,337,492...31,375,758

G

transmembrane protein 94

affects expression

Clodronic Acid affects the expression of TMEM94 mRNA

NCBI chr11:115,656,245...115,689,859
Ensembl chr11:115,656,259...115,690,192

G

tumor necrosis factor

multiple interactions
increases expression

Clodronic Acid inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
Clodronic Acid inhibits the reaction [PTEN gene mutant form results in increased expression of TNF mRNA]
Clodronic Acid results in increased expression of TNF mRNA

PMID:20382593 PMID:25187657 PMID:27022031

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor, alpha-induced protein 8

increases expression

Clodronic Acid results in increased expression of TNFAIP8 mRNA

NCBI chr18:50,112,494...50,226,296
Ensembl chr18:50,112,494...50,240,240

G

two pore channel 1

increases expression

Clodronic Acid results in increased expression of TPCN1 mRNA

NCBI chr 5:120,672,222...120,726,731
Ensembl chr 5:120,672,218...120,726,738

G

tumor protein D52-like 1

increases expression

Clodronic Acid results in increased expression of TPD52L1 mRNA

NCBI chr10:31,208,369...31,321,989
Ensembl chr10:31,208,372...31,321,954

G

TRAF type zinc finger domain containing 1

affects expression

Clodronic Acid affects the expression of TRAFD1 mRNA

NCBI chr 5:121,509,788...121,524,543
Ensembl chr 5:121,509,788...121,523,695

G

transformation related protein 53

affects activity

Clodronic Acid affects the activity of TP53 protein

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 inducible nuclear protein 1

increases expression

Clodronic Acid results in increased expression of TP53INP1 mRNA

NCBI chr 4:11,156,441...11,174,379
Ensembl chr 4:11,156,431...11,174,379

G

tetraspanin 12

decreases expression

Clodronic Acid results in decreased expression of TSPAN12 mRNA

NCBI chr 6:21,771,390...21,879,557
Ensembl chr 6:21,771,394...21,852,514

G

thioredoxin 1

increases expression

Clodronic Acid results in increased expression of TXN mRNA

NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411

G

thioredoxin reductase 1

increases expression

Clodronic Acid results in increased expression of TXNRD1 mRNA

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

ubiquitin-conjugating enzyme E2G 2

increases expression

Clodronic Acid results in increased expression of UBE2G2 mRNA

NCBI chr10:77,458,155...77,481,824
Ensembl chr10:77,458,109...77,481,827

G

ubiquitin-conjugating enzyme E2O

decreases expression

Clodronic Acid results in decreased expression of UBE2O mRNA

NCBI chr11:116,428,500...116,472,281
Ensembl chr11:116,428,566...116,472,273

G

unkempt family like zinc finger

increases expression

Clodronic Acid results in increased expression of UNKL mRNA

NCBI chr17:25,407,336...25,453,417
Ensembl chr17:25,407,371...25,453,417

G

valyl-tRNA synthetase 1

increases expression

Clodronic Acid results in increased expression of VARS1 mRNA

NCBI chr17:35,219,895...35,235,304
Ensembl chr17:35,219,963...35,235,298

G

vascular endothelial growth factor B

decreases expression

Clodronic Acid results in decreased expression of VEGFB mRNA

NCBI chr19:6,959,840...6,965,019
Ensembl chr19:6,959,841...6,965,019

G

vimentin

multiple interactions

[Clodronic Acid co-treated with Thioacetamide] results in increased expression of VIM protein

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

V-set domain containing T cell activation inhibitor 1

increases expression

Clodronic Acid results in increased expression of VTCN1 mRNA

NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238

G

tryptophanyl-tRNA synthetase1

affects expression

Clodronic Acid affects the expression of WARS1 mRNA

NCBI chr12:108,825,956...108,860,095
Ensembl chr12:108,825,956...108,860,100

G

WW, C2 and coiled-coil domain containing 2

decreases expression

Clodronic Acid results in decreased expression of WWC2 mRNA

NCBI chr 8:48,279,117...48,443,579
Ensembl chr 8:48,276,994...48,443,959

G

X-box binding protein 1

affects activity
decreases expression

Clodronic Acid affects the activity of XBP1 protein
Clodronic Acid results in decreased expression of XBP1 mRNA

NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893

G

tyrosyl-tRNA synthetase 1

decreases expression

Clodronic Acid results in decreased expression of YARS1 mRNA

NCBI chr 4:129,083,595...129,113,033
Ensembl chr 4:129,083,553...129,113,400

G

YEATS domain containing 2

affects expression

Clodronic Acid affects the expression of YEATS2 mRNA

NCBI chr16:19,959,803...20,051,323
Ensembl chr16:19,959,813...20,051,323

G

YTH domain containing 2

affects expression

Clodronic Acid affects the expression of YTHDC2 mRNA

NCBI chr18:44,961,521...45,022,782
Ensembl chr18:44,960,813...45,022,791

G

zinc finger protein X-linked

increases expression

Clodronic Acid results in increased expression of ZFX mRNA

NCBI chr X:93,118,237...93,194,250
Ensembl chr X:93,118,237...93,167,308

etidronic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

matrix Gla protein

increases expression

Etidronic Acid results in increased expression of MGP mRNA

NCBI chr 6:136,849,433...136,852,821
Ensembl chr 6:136,849,433...136,852,821

G

nuclear receptor subfamily 1, group I, member 2

increases activity

Etidronic Acid results in increased activity of NR1I2 protein

NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186

G

tumor necrosis factor

multiple interactions

Etidronic Acid inhibits the reaction [Polyethylene affects the secretion of TNF protein]

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

Risedronate sodium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

Risedronic Acid results in increased activity of CASP3 protein

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

increases activity

Risedronic Acid results in increased activity of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

increases activity

Risedronic Acid results in increased activity of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

cell division cycle 42

multiple interactions

Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]

NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031

G

colony stimulating factor 1 (macrophage)

multiple interactions

Risedronic Acid promotes the reaction [CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]]

NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785

G

farnesyl diphosphate synthetase

decreases activity
affects binding

Risedronic Acid results in decreased activity of FDPS protein
Risedronic Acid binds to FDPS protein

PMID:11160603 PMID:16684881

NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266

G

Harvey rat sarcoma virus oncogene

decreases prenylation

Risedronic Acid results in decreased prenylation of HRAS protein

NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918

G

mitogen-activated protein kinase 1

increases phosphorylation

Risedronic Acid results in increased phosphorylation of MAPK1 protein

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

increases phosphorylation

Risedronic Acid results in increased phosphorylation of MAPK3 protein

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

paraoxonase 1

increases activity
multiple interactions

Risedronic Acid results in increased activity of PON1 protein
[Risedronic Acid results in increased activity of PON1 protein] which results in increased metabolism of homocysteine thiolactone; [Risedronic Acid results in increased activity of PON1 protein] which results in increased metabolism of Paraoxon; [Risedronic Acid results in increased activity of PON1 protein] which results in increased metabolism of phenyl acetate

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

RAB6A, member RAS oncogene family

decreases prenylation

Risedronic Acid results in decreased prenylation of RAB6A protein

NCBI chr 7:100,256,778...100,290,475
Ensembl chr 7:100,256,617...100,290,475

G

Rac family small GTPase 1

multiple interactions
decreases geranoylation

Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]
Risedronic Acid results in decreased geranoylation of RAC1 protein
Risedronic Acid promotes the reaction [CSF1 protein results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]]; Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]

NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791

G

RAS-related protein 1a

decreases prenylation

Risedronic Acid results in decreased prenylation of RAP1A protein

PMID:11595616 PMID:16619218 PMID:16675582 PMID:18751388

NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652

G

ras homolog family member A

multiple interactions
increases localization

Risedronic Acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]
Risedronic Acid results in increased localization of RHOA protein

PMID:16734383 PMID:19505369

NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133

zoledronic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 0610040J01 gene

increases expression

zoledronic acid results in increased expression of C4ORF19 mRNA

NCBI chr 5:63,969,833...64,056,968
Ensembl chr 5:63,969,706...64,056,968

G

RIKEN cDNA 2310009B15 gene

decreases expression

zoledronic acid results in decreased expression of C1ORF53 mRNA

NCBI chr 1:138,779,717...138,784,592
Ensembl chr 1:138,779,721...138,784,590

G

RIKEN cDNA 2310057J18 gene

increases expression

zoledronic acid results in increased expression of C6ORF58 mRNA

NCBI chr10:28,848,284...28,862,302
Ensembl chr10:28,848,284...28,862,299

G

RIKEN cDNA 5031439G07 gene

decreases expression

zoledronic acid results in decreased expression of KIAA0930 mRNA

NCBI chr15:84,828,137...84,872,503
Ensembl chr15:84,828,137...84,872,752

G

alpha 1,4-galactosyltransferase

increases expression

zoledronic acid results in increased expression of A4GALT mRNA

NCBI chr15:83,110,923...83,135,930
Ensembl chr15:83,110,923...83,135,975

G

expressed sequence AA467197

increases expression

zoledronic acid results in increased expression of C15ORF48 mRNA

NCBI chr 2:122,479,807...122,482,996
Ensembl chr 2:122,478,906...122,483,111

G

aminoadipate aminotransferase

decreases expression

zoledronic acid results in decreased expression of AADAT mRNA

NCBI chr 8:60,958,877...60,998,711
Ensembl chr 8:60,958,966...60,998,711

G

alanyl-tRNA synthetase 1

decreases expression

Zoledronic Acid results in decreased expression of AARS1 mRNA

NCBI chr 8:111,759,781...111,784,237
Ensembl chr 8:111,759,776...111,784,296

G

ATP-binding cassette, sub-family A member 12

increases expression

zoledronic acid results in increased expression of ABCA12 mRNA

NCBI chr 1:71,282,249...71,454,069
Ensembl chr 1:71,281,435...71,454,069

G

ATP-binding cassette, sub-family A member 4

increases expression

zoledronic acid results in increased expression of ABCA4 mRNA

PMID:20977926 PMID:24714768

NCBI chr 3:121,837,547...121,973,719
Ensembl chr 3:121,838,092...121,973,772

G

ATP-binding cassette, sub-family B member 6

decreases expression

zoledronic acid results in decreased expression of ABCB6 mRNA

PMID:24714768 PMID:25596134

NCBI chr 1:75,148,284...75,157,066
Ensembl chr 1:75,148,361...75,157,036

G

ATP-binding cassette, sub-family C member 5

decreases expression

zoledronic acid results in decreased expression of ABCC5 mRNA

NCBI chr16:20,150,053...20,245,178
Ensembl chr16:20,150,053...20,245,144

G

ATP binding cassette subfamily G member 2 (Junior blood group)

increases expression

zoledronic acid results in increased expression of ABCG2 mRNA

NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661

G

abhydrolase domain containing 17C

decreases expression

zoledronic acid results in decreased expression of ABHD17C mRNA

NCBI chr 7:83,758,564...83,801,101
Ensembl chr 7:83,758,564...83,801,101

G

ABI family member 3 binding protein

decreases expression

zoledronic acid results in decreased expression of ABI3BP mRNA

NCBI chr16:56,298,179...56,510,498
Ensembl chr16:56,298,241...56,510,498

G

ankyrin repeat and BTB domain containing 3

decreases expression

Zoledronic Acid results in decreased expression of ABTB3 mRNA

NCBI chr10:85,220,835...85,496,156
Ensembl chr10:85,222,678...85,496,156

G

acetyl-Coenzyme A acyltransferase 1B

decreases expression

zoledronic acid results in decreased expression of ACAA1 mRNA

NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161

G

acyl-Coenzyme A dehydrogenase, long-chain

decreases expression

zoledronic acid results in decreased expression of ACADL mRNA

NCBI chr 1:66,869,998...66,902,468
Ensembl chr 1:66,869,998...66,902,436

G

acyl-Coenzyme A dehydrogenase, medium chain

decreases expression

zoledronic acid results in decreased expression of ACADM mRNA

NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269

G

acetyl-Coenzyme A acetyltransferase 2

increases expression

zoledronic acid results in increased expression of ACAT2 mRNA

NCBI chr17:13,161,929...13,179,612
Ensembl chr17:13,161,777...13,179,634

G

acyl-Coenzyme A binding domain containing 4

decreases expression

zoledronic acid results in decreased expression of ACBD4 mRNA

NCBI chr11:102,992,524...103,003,026
Ensembl chr11:102,992,508...103,005,229

G

amino carboxymuconate semialdehyde decarboxylase

decreases expression

zoledronic acid results in decreased expression of ACMSD mRNA

NCBI chr 1:127,657,149...127,695,723
Ensembl chr 1:127,657,150...127,695,715

G

acyl-Coenzyme A oxidase 1, palmitoyl

multiple interactions
decreases expression

Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of ACOX1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of ACOX1 mRNA]
zoledronic acid results in decreased expression of ACOX1 mRNA; zoledronic acid results in decreased expression of ACOX1 protein

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

acyl-Coenzyme A oxidase 2, branched chain

decreases expression
multiple interactions

zoledronic acid results in decreased expression of ACOX2 mRNA
Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of ACOX2 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of ACOX2 mRNA]

NCBI chr14:14,210,406...14,244,262
Ensembl chr14:14,210,420...14,244,262

G

acid phosphatase 3

decreases expression

Zoledronic Acid results in decreased expression of ACP3 mRNA

NCBI chr 9:104,165,439...104,214,921
Ensembl chr 9:104,165,450...104,214,947

G

acyl-CoA synthetase long-chain family member 1

decreases expression

zoledronic acid results in decreased expression of ACSL1 mRNA; zoledronic acid results in decreased expression of ACSL1 protein

PMID:25596134 PMID:28871336

NCBI chr 8:46,924,214...46,989,088
Ensembl chr 8:46,924,074...46,989,088

G

acyl-CoA synthetase long-chain family member 3

decreases expression

zoledronic acid results in decreased expression of ACSL3 protein

NCBI chr 1:78,635,600...78,685,462
Ensembl chr 1:78,635,542...78,685,460

G

acyl-CoA synthetase long-chain family member 5

increases expression

zoledronic acid results in increased expression of ACSL5 mRNA

NCBI chr19:55,240,298...55,285,060
Ensembl chr19:55,240,370...55,286,152

G

acyl-CoA synthetase medium-chain family member 3

decreases expression

zoledronic acid results in decreased expression of ACSM3 mRNA

NCBI chr 7:119,360,106...119,384,119
Ensembl chr 7:119,360,146...119,386,736

G

acyl-CoA synthetase short-chain family member 2

increases expression

zoledronic acid results in increased expression of ACSS2 mRNA

NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644

G

actin alpha 2, smooth muscle, aorta

multiple interactions
increases expression

Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein]
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein]

NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990

G

actin, beta-like 2

increases expression

zoledronic acid results in increased expression of ACTBL2 mRNA

NCBI chr13:111,391,547...111,394,283
Ensembl chr13:111,391,547...111,394,283

G

actin, gamma 2, smooth muscle, enteric

decreases expression

zoledronic acid results in decreased expression of ACTG2 mRNA

NCBI chr 6:83,489,891...83,513,233
Ensembl chr 6:83,489,887...83,513,247

G

actinin, alpha 1

decreases expression

zoledronic acid results in decreased expression of ACTN1 protein

NCBI chr12:80,214,316...80,307,165
Ensembl chr12:80,214,321...80,307,145

G

actinin alpha 4

decreases expression

zoledronic acid results in decreased expression of ACTN4 protein

NCBI chr 7:28,592,673...28,661,799
Ensembl chr 7:28,592,673...28,661,765

G

a disintegrin and metallopeptidase domain 17

multiple interactions
increases expression
decreases activity

ADAM17 protein promotes the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]
zoledronic acid results in increased expression of ADAM17 protein
zoledronic acid results in decreased activity of ADAM17 protein

NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633

G

ADAM metallopeptidase domain 19

decreases expression

zoledronic acid results in decreased expression of ADAM19 mRNA

NCBI chr11:45,945,329...46,038,174
Ensembl chr11:45,946,819...46,038,170

G

a disintegrin and metallopeptidase domain 28

increases expression

zoledronic acid results in increased expression of ADAM28 mRNA

NCBI chr14:68,842,447...68,893,338
Ensembl chr14:68,843,476...68,893,291

G

ADAM metallopeptidase with thrombospondin type 1 motif 1

increases expression

zoledronic acid results in increased expression of ADAMTS1 mRNA

NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001

G

ADAM metallopeptidase with thrombospondin type 1 motif 9

increases expression

zoledronic acid results in increased expression of ADAMTS9 mRNA

NCBI chr 6:92,749,680...92,921,431
Ensembl chr 6:92,749,680...92,920,473

G

ADAMTS-like 3

decreases expression

zoledronic acid results in decreased expression of ADAMTSL3 mRNA

NCBI chr 7:81,984,612...82,263,658
Ensembl chr 7:81,984,902...82,263,658

G

adhesion G protein-coupled receptor F1

increases expression

zoledronic acid results in increased expression of ADGRF1 mRNA

NCBI chr17:43,581,174...43,636,767
Ensembl chr17:43,581,220...43,635,628

G

adhesion G protein-coupled receptor G1

decreases expression

zoledronic acid results in decreased expression of ADGRG1 mRNA

NCBI chr 8:95,701,321...95,740,836
Ensembl chr 8:95,701,379...95,740,845

G

adhesion G protein-coupled receptor L1

decreases expression

zoledronic acid results in decreased expression of ADGRL1 mRNA

NCBI chr 8:84,626,598...84,668,583
Ensembl chr 8:84,626,734...84,668,583

G

adhesion G protein-coupled receptor V1

increases expression

zoledronic acid results in increased expression of ADGRV1 mRNA

NCBI chr13:81,243,187...81,781,504
Ensembl chr13:81,243,187...81,781,273

G

alcohol dehydrogenase 6B (class V)

decreases expression

zoledronic acid results in decreased expression of ADH6 mRNA

NCBI chr 3:138,047,176...138,064,621
Ensembl chr 3:138,047,536...138,064,622

G

adrenomedullin 2

decreases expression

zoledronic acid results in decreased expression of ADM2 mRNA

NCBI chr15:89,206,923...89,208,934
Ensembl chr15:89,206,923...89,208,934

G

adenylosuccinate lyase

decreases expression

zoledronic acid results in decreased expression of ADSL mRNA

NCBI chr15:80,832,691...80,855,148
Ensembl chr15:80,832,691...80,855,147

G

alpha fetoprotein

increases expression

zoledronic acid results in increased expression of AFP protein

NCBI chr 5:90,638,573...90,656,766
Ensembl chr 5:90,638,596...90,656,766

G

1-acylglycerol-3-phosphate O-acyltransferase 5

increases expression

zoledronic acid results in increased expression of AGPAT5 mRNA

NCBI chr 8:18,896,295...18,934,429
Ensembl chr 8:18,896,293...18,941,377

G

anterior gradient 2

decreases expression

zoledronic acid results in decreased expression of AGR2 mRNA

NCBI chr12:36,042,924...36,054,080
Ensembl chr12:36,042,906...36,054,086

G

agrin

increases expression

zoledronic acid results in increased expression of AGRN protein

NCBI chr 4:156,249,747...156,281,997
Ensembl chr 4:156,249,747...156,281,945

G

AHNAK nucleoprotein 2

decreases expression

zoledronic acid results in decreased expression of AHNAK2 mRNA

NCBI chr12:112,738,631...112,766,278
Ensembl chr12:112,738,628...112,766,277

G

aryl-hydrocarbon receptor

affects activity

zoledronic acid affects the activity of AHR protein

NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037

G

alpha-2-HS-glycoprotein

increases expression

zoledronic acid results in increased expression of AHSG protein

NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199

G

adenylate kinase 3

decreases expression

zoledronic acid results in decreased expression of AK3 mRNA

NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361

G

adenylate kinase 5

decreases expression

zoledronic acid results in decreased expression of AK5 mRNA

NCBI chr 3:152,168,461...152,373,992
Ensembl chr 3:152,168,452...152,373,997

G

A kinase anchor protein 7

decreases expression

zoledronic acid results in decreased expression of AKAP7 mRNA

NCBI chr10:25,044,988...25,175,115
Ensembl chr10:25,044,988...25,183,768

G

A kinase interacting protein 1

increases expression

zoledronic acid results in increased expression of AKIP1 mRNA

NCBI chr 7:109,302,885...109,311,393
Ensembl chr 7:109,302,897...109,311,396

G

akirin 2

decreases expression

zoledronic acid results in decreased expression of AKIRIN2 mRNA

NCBI chr 4:34,550,615...34,566,930
Ensembl chr 4:34,550,937...34,566,908

G

aldo-keto reductase family 1, member A1

increases expression

zoledronic acid results in increased expression of AKR1A1 mRNA

NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877

G

aldo-keto reductase family 1 member B

increases expression

zoledronic acid results in increased expression of AKR1B1 mRNA

NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413

G

aldo-keto reductase family 1, member C21

decreases expression

zoledronic acid results in decreased expression of AKR1C2 mRNA

NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540

G

thymoma viral proto-oncogene 1

multiple interactions

CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

AKT1 substrate 1

increases expression

zoledronic acid results in increased expression of AKT1S1 mRNA

NCBI chr 7:44,498,648...44,504,845
Ensembl chr 7:44,498,415...44,504,845

G

albumin

increases expression

zoledronic acid results in increased expression of ALB protein

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

aldehyde dehydrogenase 18 family, member A1

decreases expression

zoledronic acid results in decreased expression of ALDH18A1 mRNA

NCBI chr19:40,538,701...40,576,907
Ensembl chr19:40,538,701...40,576,907

G

aldehyde dehydrogenase family 1, subfamily A3

increases expression

zoledronic acid results in increased expression of ALDH1A3 mRNA

PMID:24714768 PMID:25596134

NCBI chr 7:66,040,640...66,077,225
Ensembl chr 7:66,040,638...66,077,265

G

aldehyde dehydrogenase family 3, subfamily A2

decreases expression

zoledronic acid results in decreased expression of ALDH3A2 mRNA

NCBI chr11:61,114,240...61,158,267
Ensembl chr11:61,114,243...61,158,290

G

aldehyde dehydrogenase 8 family, member A1

increases expression

zoledronic acid results in increased expression of ALDH8A1 mRNA

NCBI chr10:21,253,199...21,272,477
Ensembl chr10:21,253,190...21,272,484

G

arachidonate 5-lipoxygenase

increases expression

zoledronic acid results in increased expression of ALOX5 mRNA

NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139

G

arachidonate 5-lipoxygenase activating protein

increases expression

zoledronic acid results in increased expression of ALOX5AP mRNA

PMID:20977926 PMID:24714768

NCBI chr 5:149,201,814...149,224,963
Ensembl chr 5:149,201,577...149,224,963

G

alpha-kinase 2

increases expression

zoledronic acid results in increased expression of ALPK2 mRNA

NCBI chr18:65,398,600...65,526,959
Ensembl chr18:65,398,600...65,527,137

G

alkaline phosphatase, liver/bone/kidney

decreases activity
multiple interactions

zoledronic acid results in decreased activity of ALPL protein
TNFRSF11B protein affects the reaction [zoledronic acid results in decreased activity of ALPL protein]

NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695

G

ALS2 C-terminal like

increases expression

zoledronic acid results in increased expression of ALS2CL mRNA

PMID:24714768 PMID:25596134

NCBI chr 9:110,709,203...110,729,598
Ensembl chr 9:110,708,938...110,729,598

G

ankyrin 2, brain

decreases expression

zoledronic acid results in decreased expression of ANK2 mRNA

NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999

G

ankyrin repeat and EF-hand domain containing 1

increases expression

zoledronic acid results in increased expression of ANKEF1 mRNA

NCBI chr 2:136,374,241...136,397,774
Ensembl chr 2:136,343,830...136,404,011

G

ankyrin repeat family A member 2

increases expression

zoledronic acid results in increased expression of ANKRA2 mRNA

NCBI chr13:98,399,584...98,411,262
Ensembl chr13:98,399,582...98,411,262

G

ankyrin repeat domain 10

increases expression

zoledronic acid results in increased expression of ANKRD10 mRNA

NCBI chr 8:11,661,581...11,694,617
Ensembl chr 8:11,661,583...11,685,757

G

ankyrin repeat domain 22

increases expression

zoledronic acid results in increased expression of ANKRD22 mRNA

NCBI chr19:34,099,949...34,143,441
Ensembl chr19:34,098,869...34,143,453

G

anillin, actin binding protein

decreases expression

zoledronic acid results in decreased expression of ANLN mRNA

NCBI chr 9:22,243,305...22,302,132
Ensembl chr 9:22,243,308...22,300,484

G

alanyl aminopeptidase, membrane

increases expression

zoledronic acid results in increased expression of ANPEP mRNA

NCBI chr 7:79,471,551...79,497,958
Ensembl chr 7:79,471,551...79,510,807

G

annexin A2

decreases expression

zoledronic acid results in decreased expression of ANXA2 protein

NCBI chr 9:69,360,978...69,399,074
Ensembl chr 9:69,360,902...69,399,077

G

adaptor-related protein complex 1, sigma 2 subunit

increases expression

zoledronic acid results in increased expression of AP1S2 mRNA

NCBI chr X:162,691,427...162,716,662
Ensembl chr X:162,692,013...162,716,662

G

adaptor-related protein complex AP-1, sigma 3

increases expression

zoledronic acid results in increased expression of AP1S3 mRNA

NCBI chr 1:79,584,593...79,649,736
Ensembl chr 1:79,584,593...79,649,689

G

adaptor-related protein complex AP-4, beta 1

increases expression

zoledronic acid results in increased expression of AP4B1 mRNA

NCBI chr 3:103,716,375...103,729,341
Ensembl chr 3:103,716,889...103,745,964
Ensembl chr 3:103,716,889...103,745,964

G

apoptotic peptidase activating factor 1

increases expression

zoledronic acid results in increased expression of APAF1 mRNA

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

amyloid beta precursor protein binding family A member 3

decreases expression

zoledronic acid results in decreased expression of APBA3 mRNA

NCBI chr10:81,102,799...81,109,081
Ensembl chr10:81,102,794...81,109,080

G

aph1 homolog A, gamma secretase subunit

increases expression

zoledronic acid results in increased expression of APH1A mRNA

NCBI chr 3:95,801,233...95,805,904
Ensembl chr 3:95,801,281...95,805,600

G

apoptosis inhibitor 5

increases expression

zoledronic acid results in increased expression of API5 mRNA

NCBI chr 2:94,242,073...94,268,490
Ensembl chr 2:94,242,027...94,268,481

G

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

decreases expression

zoledronic acid results in decreased expression of ARAP1 mRNA

NCBI chr 7:100,997,296...101,061,793
Ensembl chr 7:100,997,274...101,061,793

G

Rho GTPase activating protein 18

decreases expression

zoledronic acid results in decreased expression of ARHGAP18 mRNA

NCBI chr10:26,648,363...26,794,644
Ensembl chr10:26,629,417...26,794,644

G

Rho GTPase activating protein 19

decreases expression

zoledronic acid results in decreased expression of ARHGAP19 mRNA

NCBI chr19:41,755,027...41,790,523
Ensembl chr19:41,755,027...41,790,486

G

Rho GTPase activating protein 22

increases expression

zoledronic acid results in increased expression of ARHGAP22 mRNA

NCBI chr14:32,935,952...33,091,893
Ensembl chr14:32,935,983...33,091,891

G

Rho GTPase activating protein 24

decreases expression

zoledronic acid results in decreased expression of ARHGAP24 mRNA

NCBI chr 5:102,355,043...103,053,743
Ensembl chr 5:102,629,257...103,045,803

G

Rho GTPase activating protein 26

increases expression

zoledronic acid results in increased expression of ARHGAP26 mRNA

NCBI chr18:38,734,531...39,509,338
Ensembl chr18:39,126,198...39,509,337
Ensembl chr18:39,126,198...39,509,337

G

Rho GTPase activating protein 29

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGAP29 mRNA

NCBI chr 3:121,746,752...121,810,326
Ensembl chr 3:121,746,190...121,810,402

G

Rho GDP dissociation inhibitor alpha

decreases expression

zoledronic acid results in decreased expression of ARHGDIA protein

NCBI chr11:120,468,925...120,472,450
Ensembl chr11:120,468,930...120,472,450

G

Rho guanine nucleotide exchange factor 12

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF12 mRNA

NCBI chr 9:42,875,138...43,017,069
Ensembl chr 9:42,875,138...43,018,534

G

Rho guanine nucleotide exchange factor 3

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ARHGEF3 mRNA

NCBI chr14:26,836,418...27,125,873
Ensembl chr14:26,836,856...27,125,868

G

Rho guanine nucleotide exchange factor 4

decreases expression

zoledronic acid results in decreased expression of ARHGEF4 mRNA

NCBI chr 1:34,717,263...34,851,819
Ensembl chr 1:34,717,269...34,852,390

G

AT-rich interaction domain 2

decreases expression

zoledronic acid results in decreased expression of ARID2 mRNA

NCBI chr15:96,185,403...96,303,344
Ensembl chr15:96,185,399...96,302,873

G

ADP-ribosylation factor-like 14

decreases expression

zoledronic acid results in decreased expression of ARL14 mRNA

NCBI chr 3:69,129,752...69,130,951
Ensembl chr 3:69,129,752...69,130,951

G

ADP-ribosylation factor-like 4C

decreases expression

zoledronic acid results in decreased expression of ARL4C mRNA

NCBI chr 1:88,625,947...88,629,913
Ensembl chr 1:88,600,847...88,629,943

G

ADP-ribosylation factor-like 5B

increases expression

zoledronic acid results in increased expression of ARL5B mRNA

NCBI chr 2:15,060,066...15,087,267
Ensembl chr 2:15,054,206...15,087,267

G

aryl hydrocarbon receptor nuclear translocator 2

decreases expression

zoledronic acid results in decreased expression of ARNT2 mRNA

NCBI chr 7:83,895,486...84,059,201
Ensembl chr 7:83,895,486...84,059,384

G

arrestin domain containing 3

increases expression

zoledronic acid results in increased expression of ARRDC3 mRNA

NCBI chr13:81,031,508...81,044,161
Ensembl chr13:81,031,503...81,044,161

G

arrestin domain containing 4

increases expression

zoledronic acid results in increased expression of ARRDC4 mRNA

NCBI chr 7:68,386,742...68,398,986
Ensembl chr 7:68,386,743...68,398,989

G

acid-sensing ion channel 1

multiple interactions
decreases expression

zoledronic acid inhibits the reaction [Freund's Adjuvant results in increased expression of ASIC1 mRNA]
zoledronic acid results in decreased expression of ASIC1 mRNA

PMID:16769263 PMID:17323179

NCBI chr15:99,568,090...99,599,011
Ensembl chr15:99,568,249...99,599,011

G

asparagine synthetase

decreases expression

zoledronic acid results in decreased expression of ASNS mRNA

PMID:24714768 PMID:25596134

NCBI chr 6:7,675,169...7,693,209
Ensembl chr 6:7,675,169...7,693,254

G

aspartate beta-hydroxylase domain containing 2

decreases expression

zoledronic acid results in decreased expression of ASPHD2 mRNA

NCBI chr 5:112,532,220...112,543,236
Ensembl chr 5:112,532,220...112,542,732

G

abnormal spindle microtubule assembly

decreases expression

zoledronic acid results in decreased expression of ASPM mRNA

NCBI chr 1:139,381,450...139,421,826
Ensembl chr 1:139,382,510...139,421,829

G

activating transcription factor 4

decreases expression

zoledronic acid results in decreased expression of ATF4 mRNA

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

activating transcription factor 5

increases expression

zoledronic acid results in increased expression of ATF5 mRNA

NCBI chr 7:44,461,680...44,466,082
Ensembl chr 7:44,461,680...44,466,082

G

autophagy related 2A

increases expression

zoledronic acid results in increased expression of ATG2A protein

NCBI chr19:6,291,508...6,312,332
Ensembl chr19:6,291,698...6,312,365

G

atonal bHLH transcription factor 8

increases expression

zoledronic acid results in increased expression of ATOH8 mRNA

NCBI chr 6:72,183,158...72,212,765
Ensembl chr 6:72,183,161...72,212,561

G

atos homolog A

increases expression

Zoledronic Acid results in increased expression of ATOSA mRNA

NCBI chr 9:74,860,162...74,939,750
Ensembl chr 9:74,860,166...74,939,750

G

ATPase, class V, type 10B

increases expression

zoledronic acid results in increased expression of ATP10B mRNA

NCBI chr11:42,902,991...43,153,112
Ensembl chr11:43,040,704...43,153,112

G

ATPase, Na+/K+ transporting, alpha 1 polypeptide

decreases expression

zoledronic acid results in decreased expression of ATP1A1 mRNA

NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000

G

ATPase, H+ transporting, lysosomal V0 subunit A4

decreases expression

zoledronic acid results in decreased expression of ATP6V0A4 mRNA

NCBI chr 6:38,025,418...38,101,521
Ensembl chr 6:38,025,418...38,101,521

G

ATPase, H+ transporting, lysosomal V1 subunit B1

decreases expression

zoledronic acid results in decreased expression of ATP6V1B1 mRNA

NCBI chr 6:83,719,999...83,735,837
Ensembl chr 6:83,719,972...83,735,837

G

ATPase, Cu++ transporting, beta polypeptide

decreases expression

zoledronic acid results in decreased expression of ATP7B mRNA

NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321

G

ATRX, chromatin remodeler

decreases expression

zoledronic acid results in decreased expression of ATRX mRNA

NCBI chr X:104,841,221...104,972,978
Ensembl chr X:104,841,221...104,973,009

G

ataxin 1

increases expression

zoledronic acid results in increased expression of ATXN1 mRNA

PMID:24714768 PMID:25596134

NCBI chr13:45,703,231...46,118,467
Ensembl chr13:45,703,231...46,118,484

G

aurora kinase B

decreases expression

zoledronic acid results in decreased expression of AURKB mRNA

NCBI chr11:68,936,477...68,942,490
Ensembl chr11:68,936,473...68,942,490

G

arginine vasopressin-induced 1

decreases expression

zoledronic acid results in decreased expression of AVPI1 mRNA

NCBI chr19:42,111,714...42,117,432
Ensembl chr19:42,111,712...42,117,498

G

AXL receptor tyrosine kinase

decreases expression

zoledronic acid results in decreased expression of AXL mRNA

PMID:24714768 PMID:25596134

NCBI chr 7:25,455,925...25,488,502
Ensembl chr 7:25,456,698...25,488,130

G

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5

decreases expression

zoledronic acid results in decreased expression of B3GALT5 mRNA

NCBI chr16:96,037,001...96,121,059
Ensembl chr16:96,037,001...96,121,059

G

bile acid-Coenzyme A: amino acid N-acyltransferase

increases expression

zoledronic acid results in increased expression of BAAT mRNA

NCBI chr 4:49,489,416...49,507,915
Ensembl chr 4:49,489,422...49,506,557

G

BCL2-associated agonist of cell death

multiple interactions
increases expression

[Tretinoin co-treated with zoledronic acid] results in increased expression of BAD protein
zoledronic acid results in increased expression of BAD mRNA

PMID:19036117 PMID:20349282

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

BCL2-associated athanogene 1

increases expression

zoledronic acid results in increased expression of BAG1 mRNA

NCBI chr 4:40,936,398...40,948,294
Ensembl chr 4:40,936,398...40,948,294

G

BCL2-associated athanogene 3

increases expression

zoledronic acid results in increased expression of BAG3 mRNA

NCBI chr 7:128,125,307...128,148,705
Ensembl chr 7:128,125,340...128,148,705

G

brain abundant, membrane attached signal protein 1

increases expression

zoledronic acid results in increased expression of BASP1 mRNA

NCBI chr15:25,363,363...25,413,850
Ensembl chr15:25,363,363...25,413,850

G

BCL2-associated X protein

decreases expression
multiple interactions
increases expression

zoledronic acid results in decreased expression of BAX mRNA
[Tretinoin co-treated with zoledronic acid] results in increased expression of BAX protein
[zoledronic acid co-treated with Doxorubicin] results in increased expression of BAX protein
Zoledronic Acid results in increased expression of BAX mRNA
zoledronic acid results in increased expression of BAX mRNA

PMID:19036117 PMID:19789217 PMID:20349282 PMID:28871336 PMID:35587103

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

bublin coiled coil protein

increases expression

Zoledronic Acid results in increased expression of BBLN mRNA

NCBI chr 2:32,269,120...32,271,877
Ensembl chr 2:32,267,109...32,271,950

G

gamma-butyrobetaine hydroxylase 1

decreases expression

zoledronic acid results in decreased expression of BBOX1 mRNA

NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905

G

bobby sox HMG box containing

decreases expression

zoledronic acid results in decreased expression of BBX mRNA

NCBI chr16:50,012,207...50,252,829
Ensembl chr16:50,012,207...50,252,753

G

cDNA sequence BC004004

increases expression

zoledronic acid results in increased expression of C6ORF89 mRNA

NCBI chr17:29,487,762...29,521,862
Ensembl chr17:29,487,762...29,533,039

G

B cell receptor associated protein 29

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of BCAP29 mRNA

NCBI chr12:31,645,353...31,684,657
Ensembl chr12:31,640,966...31,684,657

G

breast cancer anti-estrogen resistance 3

decreases expression

Zoledronic Acid results in decreased expression of BCAR3 mRNA

NCBI chr 3:122,213,406...122,323,840
Ensembl chr 3:122,087,785...122,323,840

G

butyrylcholinesterase

decreases expression

zoledronic acid results in decreased expression of BCHE mRNA

NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748

G

B cell leukemia/lymphoma 2

decreases response to substance
multiple interactions
decreases expression
affects expression
increases expression

BCL2 protein results in decreased susceptibility to zoledronic acid
[Tretinoin co-treated with zoledronic acid] results in decreased expression of BCL2 protein; [zoledronic acid co-treated with docetaxel] results in decreased expression of BCL2 protein
zoledronic acid results in decreased expression of BCL2 mRNA
zoledronic acid affects the expression of BCL2 mRNA
Zoledronic Acid results in increased expression of BCL2 mRNA
[zoledronic acid co-treated with Doxorubicin] results in decreased expression of BCL2 protein

PMID:11986784 PMID:18225567 PMID:19036117 PMID:19103299 PMID:19789217 More...

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

B cell leukemia/lymphoma 2 related protein A1b

decreases expression

zoledronic acid results in decreased expression of BCL2A1 mRNA

NCBI chr 9:89,081,326...89,089,891
Ensembl chr 9:89,081,262...89,089,880

G

BCL2-like 1

increases expression

zoledronic acid results in increased expression of BCL2L1 mRNA

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

Bcl2-like 10

affects expression

zoledronic acid affects the expression of BCL2L10 mRNA

NCBI chr 9:75,255,040...75,258,922
Ensembl chr 9:75,255,040...75,258,931

G

BCL2 like 11

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of BCL2L11 mRNA

NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467

G

BCLl2-like 15

increases expression

zoledronic acid results in increased expression of BCL2L15 mRNA

NCBI chr 3:103,738,331...103,761,934
Ensembl chr 3:103,739,917...103,761,934

G

BCL2-like 2

increases expression

zoledronic acid results in increased expression of BCL2L2 mRNA

NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691

G

beclin 1, autophagy related

decreases expression

zoledronic acid results in decreased expression of BECN1 protein

NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112

G

BEN domain containing 5

decreases expression

zoledronic acid results in decreased expression of BEND5 mRNA

PMID:24714768 PMID:25596134

NCBI chr 4:111,271,993...111,317,495
Ensembl chr 4:111,272,203...111,317,495

G

beaded filament structural protein 1, in lens-CP94

decreases expression

zoledronic acid results in decreased expression of BFSP1 mRNA

NCBI chr 2:143,668,448...143,757,320
Ensembl chr 2:143,668,448...143,705,093

G

bone gamma carboxyglutamate protein

increases expression

zoledronic acid results in increased expression of BGLAP mRNA

NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771

G

basic helix-loop-helix family, member e40

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of BHLHE40 mRNA

NCBI chr 6:108,637,590...108,643,886
Ensembl chr 6:108,637,590...108,643,886

G

BICD family like cargo adaptor 1

increases expression

zoledronic acid results in increased expression of BICDL1 mRNA

NCBI chr 5:115,786,233...115,869,824
Ensembl chr 5:115,786,234...115,869,680

G

BH3 interacting domain death agonist

increases expression

zoledronic acid results in increased expression of BID mRNA

NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814

G

baculoviral IAP repeat-containing 2

multiple interactions
decreases expression

[Tretinoin co-treated with zoledronic acid] results in decreased expression of BIRC2 mRNA
zoledronic acid results in decreased expression of BIRC2 mRNA

PMID:19036117 PMID:20349282

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

baculoviral IAP repeat-containing 3

increases expression

zoledronic acid results in increased expression of BIRC3 mRNA

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

[Tretinoin co-treated with zoledronic acid] results in decreased expression of BIRC5 mRNA; [Tretinoin co-treated with zoledronic acid] results in decreased expression of BIRC5 protein
zoledronic acid results in decreased expression of BIRC5 mRNA; zoledronic acid results in decreased expression of BIRC5 protein

PMID:19036117 PMID:20349282 PMID:24714768

NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569

G

baculoviral IAP repeat-containing 6

decreases expression

zoledronic acid results in decreased expression of BIRC6 mRNA

NCBI chr17:74,835,247...75,010,351
Ensembl chr17:74,835,290...75,010,351

G

basic, immunoglobulin-like variable motif containing

decreases expression

zoledronic acid results in decreased expression of BIVM mRNA

NCBI chr 1:44,158,032...44,183,931
Ensembl chr 1:44,158,117...44,183,930

G

biogenesis of lysosomal organelles complex-1, subunit 5, muted

increases expression

zoledronic acid results in increased expression of BLOC1S5 mRNA

NCBI chr13:38,786,674...38,821,093
Ensembl chr13:38,776,818...38,819,085

G

basic helix-loop-helix ARNT like 1

increases expression

Zoledronic Acid results in increased expression of BMAL1 mRNA

NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333

G

BCL2 modifying factor

increases expression

zoledronic acid results in increased expression of BMF mRNA

PMID:24714768 PMID:25596134

NCBI chr 2:118,359,238...118,385,240
Ensembl chr 2:118,359,238...118,380,168

G

bone morphogenetic protein 1

increases expression

zoledronic acid results in increased expression of BMP1 mRNA

NCBI chr14:70,711,998...70,758,280
Ensembl chr14:70,711,998...70,757,674

G

bone morphogenetic protein 2

increases expression

zoledronic acid results in increased expression of BMP2 mRNA

PMID:14751568 PMID:24714768

NCBI chr 2:133,394,079...133,404,816
Ensembl chr 2:133,394,079...133,404,805

G

bone morphogenetic protein receptor, type 1A

increases expression

zoledronic acid results in increased expression of BMPR1A mRNA

NCBI chr14:34,133,018...34,225,335
Ensembl chr14:34,132,691...34,225,298

G

bone morphogenetic protein receptor type 2

increases expression

zoledronic acid results in increased expression of BMPR2 mRNA

NCBI chr 1:59,802,721...59,917,240
Ensembl chr 1:59,802,559...59,918,173

G

BCL2/adenovirus E1B interacting protein 3

decreases expression
increases expression

zoledronic acid results in decreased expression of BNIP3 mRNA
zoledronic acid results in increased expression of BNIP3 mRNA

PMID:19036117 PMID:25596134

NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248

G

BCL2 interacting protein 5

increases expression

Zoledronic Acid results in increased expression of BNIP5 mRNA

NCBI chr17:29,114,248...29,134,310
Ensembl chr17:29,115,366...29,134,298

G

bolA family member 2

increases expression

zoledronic acid results in increased expression of BOLA2 mRNA

NCBI chr 7:126,295,172...126,295,865
Ensembl chr 7:126,294,573...126,298,970

G

2,3-bisphosphoglycerate mutase

increases expression

zoledronic acid results in increased expression of BPGM mRNA

NCBI chr 6:34,453,291...34,482,071
Ensembl chr 6:34,453,142...34,482,548

G

breast cancer 2, early onset

increases expression

zoledronic acid results in increased expression of BRCA2 mRNA

NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794

G

BRCA1 interacting protein C-terminal helicase 1

increases expression

zoledronic acid results in increased expression of BRIP1 mRNA

NCBI chr11:85,948,957...86,092,041
Ensembl chr11:85,948,964...86,092,019

G

BTG anti-proliferation factor 2

decreases expression
increases expression

zoledronic acid results in decreased expression of BTG2 mRNA
zoledronic acid results in increased expression of BTG2 mRNA

PMID:20977926 PMID:25596134

NCBI chr 1:134,002,603...134,006,893
Ensembl chr 1:134,002,908...134,006,858

G

BUB1, mitotic checkpoint serine/threonine kinase

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of BUB1 mRNA

NCBI chr 2:127,642,117...127,673,790
Ensembl chr 2:127,643,036...127,673,785

G

complement component 1, q subcomponent-like 4

decreases expression

zoledronic acid results in decreased expression of C1QL4 mRNA

NCBI chr15:98,981,967...98,988,555
Ensembl chr15:98,981,967...98,985,698

G

C1q and tumor necrosis factor related protein 1

increases expression

zoledronic acid results in increased expression of C1QTNF1 mRNA

NCBI chr11:118,319,187...118,342,608
Ensembl chr11:118,319,029...118,340,789

G

C1q and tumor necrosis factor related protein 6

decreases expression

zoledronic acid results in decreased expression of C1QTNF6 mRNA

NCBI chr15:78,407,546...78,416,370
Ensembl chr15:78,407,546...78,415,616

G

complement component 1, r subcomponent B

increases expression

zoledronic acid results in increased expression of C1R mRNA

NCBI chr 6:124,547,389...124,558,003
Ensembl chr 6:124,547,253...124,558,130

G

complement component 1, s subcomponent 1

increases expression

Zoledronic Acid results in increased expression of C1S mRNA

NCBI chr 6:124,507,303...124,519,340
Ensembl chr 6:124,507,304...124,519,318

G

C2 calcium-dependent domain containing 4A

increases expression

zoledronic acid results in increased expression of C2CD4A mRNA

NCBI chr 9:67,737,814...67,739,612
Ensembl chr 9:67,737,771...67,739,612

G

C2 calcium-dependent domain containing 4B

increases expression

zoledronic acid results in increased expression of NLF2 mRNA

NCBI chr 9:67,623,506...67,668,215
Ensembl chr 9:67,666,719...67,668,212

G

complement component 3

increases expression

zoledronic acid results in increased expression of C3 mRNA

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

calcium channel, voltage-dependent, alpha2/delta subunit 3

increases expression

zoledronic acid results in increased expression of CACNA2D3 mRNA

NCBI chr14:28,626,900...29,444,732
Ensembl chr14:28,626,900...29,443,821

G

cactin, spliceosome C complex subunit

decreases expression

zoledronic acid results in decreased expression of CACTIN protein

NCBI chr10:81,156,937...81,162,085
Ensembl chr10:81,156,937...81,162,076

G

calmodulin 1

decreases expression

zoledronic acid results in decreased expression of CALM1 protein

NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073

G

calmodulin-like 4

decreases expression

zoledronic acid results in decreased expression of CALML4 mRNA

NCBI chr 9:62,765,068...62,783,203
Ensembl chr 9:62,765,362...62,783,203

G

calcium/calmodulin-dependent protein kinase ID

increases expression

zoledronic acid results in increased expression of CAMK1D mRNA

NCBI chr 2:5,298,268...5,719,665
Ensembl chr 2:5,298,268...5,719,326

G

calcium/calmodulin-dependent protein kinase II, delta

decreases expression

zoledronic acid results in decreased expression of CAMK2D mRNA

NCBI chr 3:126,389,136...126,639,975
Ensembl chr 3:126,389,951...126,639,975

G

calcium/calmodulin-dependent protein kinase II inhibitor 1

decreases expression

zoledronic acid results in decreased expression of CAMK2N1 mRNA

NCBI chr 4:138,182,459...138,187,437
Ensembl chr 4:138,181,625...138,187,434

G

calcium/calmodulin-dependent protein kinase IV

decreases expression

zoledronic acid results in decreased expression of CAMK4 protein

NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281

G

calmodulin regulated spectrin-associated protein 1

decreases expression

zoledronic acid results in decreased expression of CAMSAP1 protein

NCBI chr 2:25,816,850...25,873,574
Ensembl chr 2:25,816,850...25,873,294

G

calcium activated nucleotidase 1

increases expression

zoledronic acid results in increased expression of CANT1 mRNA

NCBI chr11:118,297,115...118,309,971
Ensembl chr11:118,297,115...118,309,912

G

cyclase associated actin cytoskeleton regulatory protein 2

decreases expression

zoledronic acid results in decreased expression of CAP2 mRNA

NCBI chr13:46,655,379...46,803,757
Ensembl chr13:46,655,324...46,803,757

G

calpain 13

increases expression

zoledronic acid results in increased expression of CAPN13 mRNA

NCBI chr17:73,613,451...73,706,376
Ensembl chr17:73,613,459...73,707,861

G

calpain 6

decreases expression

zoledronic acid results in decreased expression of CAPN6 mRNA

NCBI chr X:142,585,232...142,610,408
Ensembl chr X:142,585,227...142,610,410

G

cell cycle associated protein 1

increases expression

zoledronic acid results in increased expression of CAPRIN1 mRNA

NCBI chr 2:103,593,292...103,627,946
Ensembl chr 2:103,593,286...103,627,994

G

caspase recruitment domain family, member 10

decreases expression

zoledronic acid results in decreased expression of CARD10 mRNA

NCBI chr15:78,659,323...78,687,261
Ensembl chr15:78,659,338...78,687,242

G

cysteinyl-tRNA synthetase 1

increases expression

Zoledronic Acid results in increased expression of CARS1 mRNA

NCBI chr 7:143,110,967...143,153,827
Ensembl chr 7:143,110,967...143,153,827

G

caspase 1

affects expression
increases expression
multiple interactions

zoledronic acid affects the expression of CASP1 mRNA
zoledronic acid results in increased expression of CASP1 mRNA
[zoledronic acid co-treated with fluvastatin] results in increased expression of CASP1 mRNA

PMID:16996129 PMID:19036117 PMID:24714768

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 14

decreases expression

zoledronic acid results in decreased expression of CASP14 mRNA

NCBI chr10:78,547,829...78,554,181
Ensembl chr10:78,547,825...78,554,128

G

caspase 2

affects expression

zoledronic acid affects the expression of CASP2 mRNA

NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442

G

caspase 3

multiple interactions
decreases expression
increases activity
increases cleavage
increases expression

[Tretinoin co-treated with zoledronic acid] results in increased activity of CASP3 protein; [vorinostat co-treated with zoledronic acid] results in increased activity of CASP3 protein; [zoledronic acid co-treated with arsenic trioxide] results in increased cleavage of CASP3 protein; [zoledronic acid co-treated with docetaxel] results in decreased expression of CASP3 protein; [zoledronic acid co-treated with Doxorubicin] results in increased expression of CASP3 protein; [zoledronic acid co-treated with Gossypol] results in increased activity of CASP3 protein; vorinostat promotes the reaction [zoledronic acid results in increased activity of CASP3 protein]; zoledronic acid results in increased cleavage of and results in increased activity of CASP3 protein; zoledronic acid results in increased expression of and results in increased activity of CASP3 protein
zoledronic acid results in decreased expression of CASP3 protein
[zoledronic acid co-treated with Doxorubicin] results in increased activity of CASP3 protein
zoledronic acid results in increased cleavage of CASP3 protein
Zoledronic Acid results in increased expression of CASP3 mRNA

PMID:11986784 PMID:12796698 PMID:17070308 PMID:17562444 PMID:18025282 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 4, apoptosis-related cysteine peptidase

increases expression

Zoledronic Acid results in increased expression of CASP4 mRNA

NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783

G

caspase 6

increases activity

zoledronic acid results in increased activity of CASP6 protein

NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752

G

caspase 7

multiple interactions
increases activity

[Tretinoin co-treated with zoledronic acid] results in increased activity of CASP7 protein; [zoledronic acid co-treated with Gossypol] results in increased activity of CASP7 protein
zoledronic acid results in increased activity of CASP7 protein

PMID:19825521 PMID:20349282

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

increases expression
multiple interactions

zoledronic acid results in increased expression of CASP8 mRNA
[zoledronic acid co-treated with Doxorubicin] results in increased activity of CASP8 protein

PMID:19036117 PMID:19789217 PMID:20977926

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

increases activity
affects expression
multiple interactions

zoledronic acid results in increased activity of CASP9 protein
Zoledronic Acid affects the expression of CASP9 mRNA
zoledronic acid results in increased cleavage of and results in increased activity of CASP9 protein
[zoledronic acid co-treated with Doxorubicin] results in increased activity of CASP9 protein

PMID:12799645 PMID:19036117 PMID:19789217 PMID:35587103

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

calcium-sensing receptor

decreases expression

zoledronic acid results in decreased expression of CASR mRNA

NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503

G

cytosolic arginine sensor for mTORC1 subunit 1

increases expression

zoledronic acid results in increased expression of CASTOR1 mRNA

NCBI chr11:4,167,401...4,172,409
Ensembl chr11:4,168,225...4,172,409

G

caveolae associated 2

decreases expression

zoledronic acid results in decreased expression of CAVIN2 mRNA

NCBI chr 1:51,328,285...51,342,119
Ensembl chr 1:51,328,285...51,342,119

G

carbonyl reductase 1

decreases expression

zoledronic acid results in decreased expression of CBR1 mRNA

NCBI chr16:93,404,752...93,407,226
Ensembl chr16:93,402,741...93,407,393

G

cystathionine beta-synthase

decreases expression

zoledronic acid results in decreased expression of CBS mRNA

NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212

G

chromobox 5

increases expression

zoledronic acid results in increased expression of CBX5 mRNA

NCBI chr15:103,099,973...103,148,337
Ensembl chr15:103,099,971...103,148,243

G

coiled-coil and C2 domain containing 2A

decreases expression

zoledronic acid results in decreased expression of CC2D2A mRNA

NCBI chr 5:43,819,715...43,898,317
Ensembl chr 5:43,819,688...43,898,314

G

coiled-coil domain containing 138

increases expression

zoledronic acid results in increased expression of CCDC138 mRNA

NCBI chr10:58,333,523...58,412,066
Ensembl chr10:58,333,770...58,412,066

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

zoledronic acid promotes the reaction [Gossypol results in decreased expression of CCL2 mRNA]
zoledronic acid results in increased expression of CCL2 mRNA

PMID:19825521 PMID:24714768

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 20

increases expression

zoledronic acid results in increased expression of CCL20 mRNA

PMID:20977926 PMID:24714768

NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888

G

C-C motif chemokine ligand 28

increases expression

zoledronic acid results in increased expression of CCL28 mRNA

NCBI chr13:120,085,355...120,115,895
Ensembl chr13:120,085,355...120,115,895

G

C-C motif chemokine ligand 8

increases expression

Zoledronic Acid results in increased expression of CCL8 mRNA

NCBI chr11:82,006,011...82,007,625
Ensembl chr11:82,006,011...82,007,625

G

C-C motif chemokine ligand 9

increases expression

Zoledronic Acid results in increased expression of CCL23 mRNA

NCBI chr11:83,463,743...83,469,462
Ensembl chr11:83,463,745...83,469,462

G

cellular communication network factor 1

multiple interactions
decreases expression

CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; CCN1 protein affects the reaction [Zoledronic Acid results in increased expression of CDKN1A protein]; geranylgeraniol inhibits the reaction [Zoledronic Acid results in decreased expression of CCN1 protein]; Zoledronic Acid promotes the reaction [CCN1 protein affects the expression of CDKN1B protein]
Zoledronic Acid results in decreased expression of CCN1 mRNA; Zoledronic Acid results in decreased expression of CCN1 protein

NCBI chr 3:145,352,726...145,355,740
Ensembl chr 3:145,352,731...145,355,736

G

cyclin A2

decreases expression

zoledronic acid results in decreased expression of CCNA2 mRNA

NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299

G

cyclin B1

multiple interactions
decreases expression

[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNB1 protein
zoledronic acid results in decreased expression of CCNB1 mRNA

PMID:19789217 PMID:20977926

NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078

G

cyclin B2

decreases expression

zoledronic acid results in decreased expression of CCNB2 mRNA

NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829

G

cyclin D1

decreases expression
multiple interactions

zoledronic acid results in decreased expression of CCND1 mRNA
zoledronic acid results in decreased expression of CCND1 protein
[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCND1 protein

PMID:16621245 PMID:19789217 PMID:24714768

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

cyclin D3

multiple interactions
decreases expression

[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCND3 protein
zoledronic acid results in decreased expression of CCND3 protein

NCBI chr17:47,815,976...47,910,614
Ensembl chr17:47,815,976...47,910,616

G

cyclin E1

multiple interactions

[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNE1 protein

NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959

G

cyclin E2

decreases expression
increases expression

zoledronic acid results in decreased expression of CCNE2 mRNA
zoledronic acid results in increased expression of CCNE2 mRNA

PMID:20977926 PMID:25596134

NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779

G

CD14 antigen

increases expression

zoledronic acid results in increased expression of CD14 mRNA; zoledronic acid results in increased expression of CD14 protein

PMID:24714768 PMID:28871336

NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851

G

CD27 antigen

affects expression

zoledronic acid affects the expression of CD27 mRNA

NCBI chr 6:125,209,583...125,214,014
Ensembl chr 6:125,209,585...125,213,973

G

CD34 antigen

increases expression

zoledronic acid results in increased expression of CD34 mRNA

NCBI chr 1:194,621,239...194,643,587
Ensembl chr 1:194,621,127...194,643,587

G

CD40 antigen

increases expression

zoledronic acid results in increased expression of CD40 mRNA

NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868

G

CD40 ligand

decreases expression

zoledronic acid results in decreased expression of CD40LG mRNA

NCBI chr X:56,257,448...56,269,402
Ensembl chr X:56,257,503...56,269,402

G

CD44 antigen

increases expression

zoledronic acid results in increased expression of CD44 mRNA

NCBI chr 2:102,641,486...102,732,014
Ensembl chr 2:102,641,486...102,732,010

G

CD55 molecule, decay accelerating factor for complement

increases expression

zoledronic acid results in increased expression of CD55 mRNA; zoledronic acid results in increased expression of CD55 protein

PMID:20977926 PMID:24714768 PMID:28871336

NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481

G

CD59b antigen

increases expression

zoledronic acid results in increased expression of CD59 mRNA

NCBI chr 2:103,900,127...103,920,619
Ensembl chr 2:103,896,142...103,921,534

G

CD68 antigen

increases expression

zoledronic acid results in increased expression of CD68 mRNA

NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979

G

CD69 antigen

increases expression

zoledronic acid results in increased expression of CD69 mRNA

NCBI chr 6:129,244,287...129,252,332
Ensembl chr 6:129,244,288...129,252,399

G

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

increases expression

zoledronic acid results in increased expression of CD74 mRNA

NCBI chr18:60,936,921...60,945,724
Ensembl chr18:60,936,920...60,945,724

G

CD80 antigen

increases expression

zoledronic acid results in increased expression of CD80 protein

NCBI chr16:38,277,793...38,316,682
Ensembl chr16:38,275,923...38,316,697

G

CD83 antigen

increases expression

zoledronic acid results in increased expression of CD83 mRNA

NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608

G

CD86 antigen

increases expression

zoledronic acid results in increased expression of CD86 protein

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

CDC14 cell division cycle 14A

increases expression

zoledronic acid results in increased expression of CDC14A mRNA

NCBI chr 3:116,066,202...116,222,390
Ensembl chr 3:116,066,202...116,222,394

G

cell division cycle 20

decreases expression

zoledronic acid results in decreased expression of CDC20 mRNA

PMID:20977926 PMID:24714768

NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549

G

cell division cycle 25C

increases expression

zoledronic acid results in increased expression of CDC25C mRNA

NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586

G

cell division cycle 26

decreases expression

zoledronic acid results in decreased expression of CDC26 protein

NCBI chr 4:62,310,581...62,326,862
Ensembl chr 4:62,301,891...62,326,879

G

cell division cycle 42

multiple interactions

zoledronic acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein]
zoledronic acid results in increased expression of [CDC42 protein binds to Guanosine Triphosphate]; zoledronic acid results in increased expression of and affects the localization of CDC42 protein

PMID:16734383 PMID:28871336

NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031

G

CDC42 effector protein 2

increases expression

zoledronic acid results in increased expression of CDC42EP2 mRNA

NCBI chr19:5,967,584...5,974,844
Ensembl chr19:5,965,664...5,974,844

G

CDC42 effector protein 5

increases expression

zoledronic acid results in increased expression of CDC42EP5 mRNA

NCBI chr 7:4,154,259...4,167,830
Ensembl chr 7:4,154,259...4,167,859

G

cell division cycle 45

decreases expression

Zoledronic Acid results in decreased expression of CDC45 mRNA

NCBI chr16:18,599,202...18,632,371
Ensembl chr16:18,599,197...18,630,737

G

cell division cycle associated 5

increases expression

zoledronic acid results in increased expression of CDCA5 protein

NCBI chr19:6,135,127...6,141,803
Ensembl chr19:6,135,013...6,141,807

G

cell division cycle associated 7

decreases expression

zoledronic acid results in decreased expression of CDCA7 mRNA

NCBI chr 2:72,306,540...72,317,237
Ensembl chr 2:72,306,503...72,317,237

G

cell division cycle associated 8

decreases expression

zoledronic acid results in decreased expression of CDCA8 mRNA

NCBI chr 4:124,812,258...124,830,710
Ensembl chr 4:124,812,258...124,833,104

G

cadherin 4

increases expression

zoledronic acid results in increased expression of CDH4 mRNA

NCBI chr 2:179,084,228...179,541,166
Ensembl chr 2:179,084,224...179,541,166

G

cyclin dependent kinase 1

decreases expression

zoledronic acid results in decreased expression of CDK1 mRNA

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cyclin dependent kinase 2

multiple interactions

[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CDK2 protein

NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900

G

cyclin dependent kinase 2 associated protein 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of CDK2AP2 mRNA

NCBI chr19:4,146,204...4,149,019
Ensembl chr19:4,147,182...4,149,019

G

cyclin dependent kinase 4

multiple interactions

[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CDK4 protein

NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789

G

cyclin dependent kinase inhibitor 1A

multiple interactions
increases expression

CCN1 protein affects the reaction [Zoledronic Acid results in increased expression of CDKN1A protein]
zoledronic acid results in increased expression of CDKN1A protein

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

cyclin dependent kinase inhibitor 1B

multiple interactions

[Zoledronic Acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of CDKN1B protein; Gefitinib promotes the reaction [[Zoledronic Acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of CDKN1B protein]; Zoledronic Acid promotes the reaction [CCN1 protein affects the expression of CDKN1B protein]

PMID:16322342 PMID:19530242

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

cyclin dependent kinase inhibitor 1C

increases expression

zoledronic acid results in increased expression of CDKN1C mRNA

NCBI chr 7:143,012,076...143,014,735
Ensembl chr 7:143,012,076...143,014,787

G

CDKN2A interacting protein

decreases expression

zoledronic acid results in decreased expression of CDKN2AIP mRNA

NCBI chr 8:48,162,379...48,166,966
Ensembl chr 8:48,162,379...48,166,967

G

cyclin dependent kinase inhibitor 2B

increases expression

zoledronic acid results in increased expression of CDKN2B mRNA

NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276

G

cyclin dependent kinase inhibitor 3

decreases expression

zoledronic acid results in decreased expression of CDKN3 mRNA

NCBI chr14:46,997,912...47,008,987
Ensembl chr14:46,997,998...47,009,126

G

chromatin licensing and DNA replication factor 1

decreases expression

zoledronic acid results in decreased expression of CDT1 mRNA

NCBI chr 8:123,294,754...123,299,869
Ensembl chr 8:123,294,754...123,300,293

G

carnitine deficiency-associated gene expressed in ventricle 3

increases expression

zoledronic acid results in increased expression of CDV3 mRNA

NCBI chr 9:103,230,301...103,243,034
Ensembl chr 9:103,230,293...103,243,039

G

CCAAT/enhancer binding protein alpha

increases expression

zoledronic acid results in increased expression of CEBPA mRNA

NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353

G

CCAAT/enhancer binding protein beta

increases expression

zoledronic acid results in increased expression of CEBPB mRNA

NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338

G

CCAAT/enhancer binding protein delta

increases expression

zoledronic acid results in increased expression of CEBPD mRNA

NCBI chr16:15,705,150...15,707,409
Ensembl chr16:15,705,150...15,708,895

G

centromere protein A

decreases expression

zoledronic acid results in decreased expression of CENPA mRNA

NCBI chr 5:30,824,214...30,832,181
Ensembl chr 5:30,824,121...30,832,174

G

centromere protein F

decreases expression
decreases farnesylation

zoledronic acid results in decreased expression of CENPF mRNA
zoledronic acid results in decreased farnesylation of CENPF protein

PMID:20015195 PMID:24714768

NCBI chr 1:189,372,803...189,420,302
Ensembl chr 1:189,372,803...189,420,283

G

centromere protein I

increases expression

zoledronic acid results in increased expression of CENPI mRNA

NCBI chr X:133,206,777...133,263,853
Ensembl chr X:133,208,833...133,263,388

G

centromere protein M

decreases expression

zoledronic acid results in decreased expression of CENPM mRNA

NCBI chr15:82,115,694...82,128,974
Ensembl chr15:82,117,980...82,128,949

G

centrosomal protein 120

increases expression

zoledronic acid results in increased expression of CEP120 mRNA

NCBI chr18:53,814,795...53,877,825
Ensembl chr18:53,814,795...53,877,680

G

centrosomal protein 20

increases expression

Zoledronic Acid results in increased expression of CEP20 mRNA

NCBI chr16:14,117,105...14,136,093
Ensembl chr16:14,117,108...14,135,269

G

centrosomal protein 295

increases expression

zoledronic acid results in increased expression of CEP295 mRNA

NCBI chr 9:15,228,210...15,269,145
Ensembl chr 9:15,228,211...15,269,084

G

centrosomal protein 55

decreases expression

zoledronic acid results in decreased expression of CEP55 mRNA

NCBI chr19:38,043,423...38,062,873
Ensembl chr19:38,043,459...38,062,871

G

centrosomal protein 57

increases expression

zoledronic acid results in increased expression of CEP57 mRNA

NCBI chr 9:13,717,979...13,738,698
Ensembl chr 9:13,719,088...13,738,403

G

choline/ethanolaminephosphotransferase 1

increases expression

zoledronic acid results in increased expression of CEPT1 mRNA

NCBI chr 3:106,409,576...106,455,118
Ensembl chr 3:106,409,576...106,455,118

G

complement factor B

increases expression

zoledronic acid results in increased expression of CFB mRNA

NCBI chr17:35,075,350...35,081,492
Ensembl chr17:35,075,350...35,081,494

G

cofilin 1, non-muscle

increases expression

zoledronic acid results in increased expression of CFL1 protein

NCBI chr19:5,540,483...5,544,059
Ensembl chr19:5,540,483...5,545,229

G

CASP8 and FADD-like apoptosis regulator

increases expression

zoledronic acid results in increased expression of CFLAR mRNA

NCBI chr 1:58,750,353...58,798,043
Ensembl chr 1:58,750,667...58,798,043

G

cingulin

decreases expression

zoledronic acid results in decreased expression of CGN mRNA

NCBI chr 3:94,667,376...94,695,036
Ensembl chr 3:94,667,376...94,693,826

G

cingulin-like 1

decreases expression

zoledronic acid results in decreased expression of CGNL1 mRNA

NCBI chr 9:71,533,789...71,716,582
Ensembl chr 9:71,533,791...71,678,884

G

ChaC, cation transport regulator 1

increases expression

zoledronic acid results in increased expression of CHAC1 mRNA

NCBI chr 2:119,181,723...119,184,807
Ensembl chr 2:119,181,710...119,184,862

G

charged multivesicular body protein 4B

increases expression

zoledronic acid results in increased expression of CHMP4B mRNA

NCBI chr 2:154,498,949...154,536,703
Ensembl chr 2:154,493,625...154,536,705

G

charged multivesicular body protein 6

increases expression

zoledronic acid results in increased expression of CHMP6 protein

NCBI chr11:119,803,874...119,810,378
Ensembl chr11:119,804,267...119,810,374

G

carbohydrate sulfotransferase 4

increases expression

zoledronic acid results in increased expression of CHST4 mRNA

NCBI chr 8:110,755,776...110,766,033
Ensembl chr 8:110,755,785...110,766,372

G

class II transactivator

increases expression

zoledronic acid results in increased expression of CIITA mRNA

NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282

G

ciliary microtubule inner protein 2C

decreases expression

Zoledronic Acid results in decreased expression of CIMIP2C mRNA

NCBI chr 5:30,623,395...30,641,433
Ensembl chr 5:30,623,391...30,641,432

G

CDC28 protein kinase regulatory subunit 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of CKS2 mRNA

NCBI chr13:51,799,268...51,804,698
Ensembl chr13:51,799,268...51,804,696

G

chloride channel accessory 4C, pseudogene

decreases expression

zoledronic acid results in decreased expression of CLCA3 mRNA

NCBI chr 3:144,585,083...144,601,772
Ensembl chr 3:144,585,083...144,601,772
Ensembl chr 3:144,585,083...144,601,772

G

chloride channel, voltage-sensitive 5

decreases expression

zoledronic acid results in decreased expression of CLCN5 mRNA

NCBI chr X:7,020,049...7,185,597
Ensembl chr X:7,020,049...7,185,597

G

chloride channel, voltage-sensitive Ka

decreases expression

zoledronic acid results in decreased expression of CLCNKA mRNA

NCBI chr 4:141,111,922...141,126,017
Ensembl chr 4:141,111,921...141,126,035

G

chloride channel, voltage-sensitive Kb

decreases expression

zoledronic acid results in decreased expression of CLCNKB mRNA

NCBI chr 4:141,131,668...141,143,440
Ensembl chr 4:141,131,664...141,143,325

G

claudin 14

increases expression

zoledronic acid results in increased expression of CLDN14 mRNA

NCBI chr16:93,715,919...93,809,733
Ensembl chr16:93,715,919...93,809,696

G

claudin 16

decreases expression

zoledronic acid results in decreased expression of CLDN16 mRNA

NCBI chr16:26,281,885...26,301,515
Ensembl chr16:26,281,885...26,301,515

G

claudin 2

decreases expression

zoledronic acid results in decreased expression of CLDN2 mRNA

NCBI chr X:138,701,552...138,712,135
Ensembl chr X:138,701,577...138,712,135

G

claudin 3

increases expression

zoledronic acid results in increased expression of CLDN3 mRNA

NCBI chr 5:135,015,068...135,016,330
Ensembl chr 5:135,015,068...135,016,326

G

C-type lectin domain family 4, member e

increases expression

zoledronic acid results in increased expression of CLEC4E mRNA

NCBI chr 6:123,258,748...123,266,830
Ensembl chr 6:123,258,748...123,266,829

G

CLN3 lysosomal/endosomal transmembrane protein, battenin

increases expression

zoledronic acid results in increased expression of CLN3 mRNA

NCBI chr 7:126,170,571...126,184,991
Ensembl chr 7:126,170,379...126,184,989

G

cyclic nucleotide gated channel beta 1

increases expression

zoledronic acid results in increased expression of CNGB1 mRNA

NCBI chr 8:95,965,671...96,033,213
Ensembl chr 8:95,965,673...96,033,213

G

contactin associated protein-like 1

increases expression

zoledronic acid results in increased expression of CNTNAP1 mRNA

NCBI chr11:101,065,429...101,081,550
Ensembl chr11:101,061,349...101,081,550

G

collagen, type XVI, alpha 1

increases expression

zoledronic acid results in increased expression of COL16A1 mRNA

NCBI chr 4:129,941,638...129,993,070
Ensembl chr 4:129,941,633...129,993,076

G

collagen, type XVIII, alpha 1

decreases expression

zoledronic acid results in decreased expression of COL18A1 mRNA

NCBI chr10:76,888,013...77,002,351
Ensembl chr10:76,888,012...77,002,382

G

collagen, type I, alpha 1

decreases expression
increases expression
multiple interactions

zoledronic acid results in decreased expression of COL1A1 mRNA; zoledronic acid results in decreased expression of COL1A1 protein
zoledronic acid results in increased expression of COL1A1 mRNA
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL1A1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL1A1 mRNA]

PMID:19597852 PMID:28871336

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type III, alpha 1

increases expression
multiple interactions

zoledronic acid results in increased expression of COL3A1 mRNA
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL3A1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL3A1 mRNA]

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

collagen, type IV, alpha 1

increases expression
multiple interactions

zoledronic acid results in increased expression of COL4A1 mRNA
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]

NCBI chr 8:11,248,423...11,362,889
Ensembl chr 8:11,248,423...11,362,826

G

collagen, type IV, alpha 3

decreases expression

zoledronic acid results in decreased expression of COL4A3 mRNA

NCBI chr 1:82,564,647...82,699,778
Ensembl chr 1:82,564,642...82,699,780

G

collagen, type IV, alpha 5

decreases expression

zoledronic acid results in decreased expression of COL4A5 mRNA

NCBI chr X:140,258,367...140,472,232
Ensembl chr X:140,258,381...140,472,230

G

collagen, type V, alpha 1

increases expression

zoledronic acid results in increased expression of COL5A1 protein

NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526

G

collagen, type IX, alpha 2

increases expression

zoledronic acid results in increased expression of COL9A2 mRNA

NCBI chr 4:120,896,763...120,912,522
Ensembl chr 4:120,896,582...120,912,519

G

cartilage oligomeric matrix protein

increases expression

zoledronic acid results in increased expression of COMP protein

NCBI chr 8:70,826,186...70,834,721
Ensembl chr 8:70,826,208...70,834,716

G

coenzyme Q3 methyltransferase

decreases expression

zoledronic acid results in decreased expression of COQ3 mRNA

NCBI chr 4:21,879,646...21,912,163
Ensembl chr 4:21,879,673...21,912,162

G

coenzyme Q4

decreases expression

zoledronic acid results in decreased expression of COQ4 mRNA

NCBI chr 2:29,677,505...29,687,947
Ensembl chr 2:29,677,505...29,687,947

G

cytochrome c oxidase assembly protein 17, copper chaperone

decreases expression

zoledronic acid results in decreased expression of COX17 mRNA

NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659

G

ceruloplasmin

increases expression

zoledronic acid results in increased expression of CP mRNA

PMID:24714768 PMID:25596134

NCBI chr 3:20,011,097...20,063,914
Ensembl chr 3:20,011,218...20,063,309

G

carboxypeptidase A4

decreases expression

zoledronic acid results in decreased expression of CPA4 mRNA

NCBI chr 6:30,568,368...30,592,417
Ensembl chr 6:30,568,368...30,592,417

G

carboxypeptidase D

increases expression

zoledronic acid results in increased expression of CPD mRNA

NCBI chr11:76,668,034...76,737,834
Ensembl chr11:76,669,250...76,737,844

G

cytoplasmic polyadenylation element binding protein 2

decreases expression

zoledronic acid results in decreased expression of CPEB2 mRNA

NCBI chr 5:43,382,692...43,447,067
Ensembl chr 5:43,390,513...43,447,067

G

copine III

increases expression

zoledronic acid results in increased expression of CPNE3 mRNA

NCBI chr 4:19,519,252...19,570,108
Ensembl chr 4:19,519,254...19,570,108

G

copine VIII

decreases expression

zoledronic acid results in decreased expression of CPNE8 mRNA

NCBI chr15:90,371,684...90,563,591
Ensembl chr15:90,371,685...90,563,635

G

carboxypeptidase Q

decreases expression

zoledronic acid results in decreased expression of PGCP mRNA

NCBI chr15:33,083,275...33,594,698
Ensembl chr15:33,083,275...33,594,698

G

carnitine palmitoyltransferase 1a, liver

multiple interactions
decreases expression

Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of CPT1A mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of CPT1A mRNA]
zoledronic acid results in decreased expression of CPT1A mRNA; zoledronic acid results in decreased expression of CPT1A protein

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

carnitine palmitoyltransferase 2

decreases expression
multiple interactions

zoledronic acid results in decreased expression of CPT2 mRNA
Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of CPT2 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of CPT2 mRNA]

NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807

G

carboxypeptidase, vitellogenic-like

decreases expression

zoledronic acid results in decreased expression of CPVL mRNA

NCBI chr 6:53,850,106...53,955,658
Ensembl chr 6:53,850,264...53,955,656

G

carnitine acetyltransferase

decreases expression

zoledronic acid results in decreased expression of CRAT mRNA

NCBI chr 2:30,290,483...30,305,602
Ensembl chr 2:30,290,483...30,305,825

G

cAMP responsive element binding protein 5

decreases expression

zoledronic acid results in decreased expression of CREB5 mRNA

NCBI chr 6:53,264,154...53,677,349
Ensembl chr 6:53,264,255...53,677,361

G

cardiolipin synthase 1

decreases expression

zoledronic acid results in decreased expression of CRLS1 mRNA

NCBI chr 2:132,688,557...132,708,706
Ensembl chr 2:132,688,586...132,708,705

G

crystallin, alpha B

increases expression

zoledronic acid results in increased expression of CRYAB mRNA

NCBI chr 9:50,657,251...50,667,936
Ensembl chr 9:50,662,625...50,667,936

G

colony stimulating factor 1 (macrophage)

increases expression
decreases expression

zoledronic acid results in increased expression of CSF1 mRNA
zoledronic acid results in decreased expression of CSF1 mRNA

PMID:20977926 PMID:24714768

NCBI chr 3:107,648,364...107,668,048
Ensembl chr 3:107,648,364...107,667,785

G

colony stimulating factor 2 (granulocyte-macrophage)

increases expression

zoledronic acid results in increased expression of CSF2 mRNA

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

cysteine and glycine-rich protein 2

decreases expression

zoledronic acid results in decreased expression of CSRP2 mRNA

NCBI chr10:110,756,037...110,775,375
Ensembl chr10:110,755,650...110,775,483

G

cystatin C

increases expression

zoledronic acid results in increased expression of CST3 protein

NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612

G

chitobiase

increases expression

zoledronic acid results in increased expression of CTBS mRNA

NCBI chr 3:146,156,204...146,171,604
Ensembl chr 3:146,155,550...146,171,604

G

cystathionine gamma lyase

decreases expression

zoledronic acid results in decreased expression of CTH mRNA

PMID:24714768 PMID:25596134

NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714

G

cathepsin B

decreases expression

zoledronic acid results in decreased expression of CTSB protein

NCBI chr14:63,359,911...63,383,372
Ensembl chr14:63,359,911...63,383,372

G

cathepsin C

increases expression

zoledronic acid results in increased expression of CTSC mRNA

NCBI chr 7:87,927,233...87,960,083
Ensembl chr 7:87,927,293...87,960,096

G

cathepsin E

increases expression

zoledronic acid results in increased expression of CTSE mRNA

NCBI chr 1:131,566,052...131,603,245
Ensembl chr 1:131,566,044...131,603,243

G

cathepsin S

increases expression

zoledronic acid results in increased expression of CTSS mRNA

NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714

G

cortactin

decreases expression

zoledronic acid results in decreased expression of CTTN mRNA

NCBI chr 7:143,989,468...144,024,743
Ensembl chr 7:143,989,470...144,024,746

G

cytosolic thiouridylase subunit 2

decreases expression

zoledronic acid results in decreased expression of CTU2 mRNA

NCBI chr 8:123,202,882...123,209,831
Ensembl chr 8:123,202,882...123,210,877

G

cubilin

increases expression

zoledronic acid results in increased expression of CUBN mRNA

NCBI chr 2:13,281,149...13,496,687
Ensembl chr 2:13,281,149...13,496,624

G

cullin 4A

increases expression

zoledronic acid results in increased expression of CUL4A mRNA

NCBI chr 8:13,155,623...13,197,940
Ensembl chr 8:13,155,621...13,197,940

G

C-X3-C motif chemokine ligand 1

increases expression

zoledronic acid results in increased expression of CX3CL1 mRNA

NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055

G

C-X-C motif chemokine ligand 1

multiple interactions
increases expression

[zoledronic acid co-treated with Gossypol] results in decreased expression of CXCL1 mRNA
zoledronic acid results in increased expression of CXCL1 mRNA

PMID:19825521 PMID:24714768

NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974

G

C-X-C motif chemokine ligand 10

increases expression

zoledronic acid results in increased expression of CXCL10 mRNA

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 12

decreases expression

zoledronic acid results in decreased expression of CXCL12 mRNA

NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328

G

C-X-C motif chemokine ligand 14

decreases expression

zoledronic acid results in decreased expression of CXCL14 mRNA

NCBI chr13:56,436,456...56,444,624
Ensembl chr13:56,436,456...56,444,364

G

C-X-C motif chemokine ligand 15

increases expression

zoledronic acid results in increased expression of CXCL8 mRNA

NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926

G

C-X-C motif chemokine ligand 16

increases expression

zoledronic acid results in increased expression of CXCL16 mRNA

NCBI chr11:70,345,215...70,350,810
Ensembl chr11:70,344,809...70,350,810

G

C-X-C motif chemokine ligand 2

increases expression

zoledronic acid results in increased expression of CXCL2 mRNA

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

[zoledronic acid co-treated with Gossypol] results in decreased expression of CXCL1 mRNA
zoledronic acid results in increased expression of CXCL1 mRNA

PMID:19825521 PMID:24714768

NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459

G

C-X-C motif chemokine receptor 4

increases expression

zoledronic acid results in increased expression of CXCR4 mRNA

NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030

G

cytochrome b5 reductase 3

increases expression

zoledronic acid results in increased expression of CYB5R3 mRNA

NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793

G

cytochrome c, somatic

increases expression

Zoledronic Acid results in increased expression of CYCS mRNA

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytoplasmic FMR1 interacting protein 2

decreases expression

zoledronic acid results in decreased expression of CYFIP2 mRNA

NCBI chr11:46,084,676...46,203,686
Ensembl chr11:46,084,677...46,203,686

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

zoledronic acid results in increased expression of CYP1A1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

zoledronic acid results in increased expression of CYP1A2 mRNA

PMID:24714768 PMID:25596134

NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

zoledronic acid results in increased expression of CYP1B1 mRNA

PMID:24714768 PMID:25596134

NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490

G

cytochrome P450, family 2, subfamily c, polypeptide 65

increases expression

zoledronic acid results in increased expression of CYP2C9 mRNA

NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388

G

cytochrome P450, family 3, subfamily a, polypeptide 13

increases expression

Zoledronic Acid results in increased expression of CYP3A7 mRNA
Zoledronic Acid results in increased expression of CYP3A5 mRNA

NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881

G

cytochrome P450, family 4, subfamily b, polypeptide 1

increases expression

zoledronic acid results in increased expression of CYP4B1 mRNA

NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920

G

cytochrome P450, family 51

increases expression

zoledronic acid results in increased expression of CYP51A1 mRNA

NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746

G

cystin 1

decreases expression

zoledronic acid results in decreased expression of CYS1 mRNA

NCBI chr12:24,715,832...24,731,794
Ensembl chr12:24,715,832...24,731,812

G

cytohesin 1 interacting protein

increases expression

zoledronic acid results in increased expression of CYTIP mRNA

NCBI chr 2:58,019,151...58,085,559
Ensembl chr 2:58,019,149...58,085,544

G

RIKEN cDNA D430019H16 gene

decreases expression

zoledronic acid results in decreased expression of C14ORF132 mRNA

NCBI chr12:105,420,115...105,459,354
Ensembl chr12:105,420,115...105,459,354

G

death associated protein kinase 1

decreases expression

zoledronic acid results in decreased expression of DAPK1 mRNA

NCBI chr13:60,749,506...60,911,005
Ensembl chr13:60,749,761...60,911,005

G

dual adaptor for phosphotyrosine and 3-phosphoinositides 1

increases expression

zoledronic acid results in increased expression of DAPP1 mRNA

PMID:20977926 PMID:24714768

NCBI chr 3:137,636,768...137,687,331
Ensembl chr 3:137,636,768...137,687,306

G

DDB1 and CUL4 associated factor 15

increases expression

zoledronic acid results in increased expression of DCAF15 mRNA

NCBI chr 8:84,823,698...84,831,426
Ensembl chr 8:84,823,701...84,831,397

G

doublecortin domain containing 2a

decreases expression

zoledronic acid results in decreased expression of DCDC2 mRNA

NCBI chr13:25,239,126...25,394,689
Ensembl chr13:25,239,987...25,394,689

G

defective in cullin neddylation 1 domain containing 4

increases expression

zoledronic acid results in increased expression of DCUN1D4 mRNA

NCBI chr 5:73,638,353...73,718,137
Ensembl chr 5:73,638,343...73,718,137

G

dimethylarginine dimethylaminohydrolase 1

decreases expression

zoledronic acid results in decreased expression of DDAH1 mRNA

NCBI chr 3:145,464,447...145,600,032
Ensembl chr 3:145,464,430...145,600,032

G

DNA-damage inducible transcript 3

increases expression

Zoledronic Acid results in increased expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DNA-damage-inducible transcript 4

decreases expression

zoledronic acid results in decreased expression of DDIT4 mRNA

NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656

G

DNA-damage-inducible transcript 4-like

increases expression

zoledronic acid results in increased expression of DDIT4L mRNA

NCBI chr 3:137,329,433...137,334,093
Ensembl chr 3:137,327,373...137,334,094

G

discoidin domain receptor family, member 1

increases expression
decreases expression

zoledronic acid results in increased expression of DDR1 mRNA
zoledronic acid monohydrate decreases expression of DDR1 mRNA and protein in human PC3 cancer cell line

CTD
RGD

PMID:24714768 PMID:26366216

NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513

G

DEAD box helicase 10

decreases expression

zoledronic acid results in decreased expression of DDX10 mRNA

NCBI chr 9:53,009,754...53,159,423
Ensembl chr 9:53,009,935...53,159,353

G

DEAD box helicase 42

increases expression

zoledronic acid results in increased expression of DDX42 mRNA

NCBI chr11:106,107,715...106,139,966
Ensembl chr11:106,107,752...106,139,965

G

defensin beta 1

increases expression

zoledronic acid results in increased expression of DEFB1 mRNA

NCBI chr 8:22,266,571...22,285,201
Ensembl chr 8:22,266,615...22,285,201

G

defensin beta 4

increases expression

zoledronic acid results in increased expression of DEFB4 mRNA

NCBI chr 8:19,248,720...19,251,563
Ensembl chr 8:19,248,722...19,251,561

G

DENN domain containing 2A

decreases expression

zoledronic acid results in decreased expression of DENND2A mRNA

NCBI chr 6:39,439,308...39,535,067
Ensembl chr 6:39,439,312...39,534,801

G

DENN domain containing 2B

increases expression

Zoledronic Acid results in increased expression of DENND2B mRNA

NCBI chr 7:109,123,118...109,302,828
Ensembl chr 7:109,123,118...109,302,812

G

DENN domain containing 2D

increases expression

zoledronic acid results in increased expression of DENND2D mRNA

NCBI chr 3:106,389,745...106,410,346
Ensembl chr 3:106,389,721...106,410,346

G

DEP domain containing 1a

decreases expression

zoledronic acid results in decreased expression of DEPDC1 mRNA

NCBI chr 3:159,201,042...159,235,690
Ensembl chr 3:159,201,070...159,235,592

G

DEPP1 autophagy regulator

increases expression

zoledronic acid results in increased expression of DEPP1 mRNA

NCBI chr 6:116,627,645...116,629,808
Ensembl chr 6:116,627,570...116,629,755

G

DEP domain containing MTOR-interacting protein

decreases expression

Zoledronic Acid results in decreased expression of DEPTOR mRNA

NCBI chr15:54,975,824...55,122,667
Ensembl chr15:54,975,713...55,122,667

G

DNA fragmentation factor, alpha subunit

decreases expression

zoledronic acid results in decreased expression of DFFA mRNA

NCBI chr 4:149,188,599...149,205,110
Ensembl chr 4:149,188,603...149,205,104

G

7-dehydrocholesterol reductase

increases expression

zoledronic acid results in increased expression of DHCR7 mRNA

NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147

G

dehydrogenase/reductase 11

decreases expression

zoledronic acid results in decreased expression of DHRS11 mRNA

NCBI chr11:84,711,547...84,719,880
Ensembl chr11:84,711,682...84,719,820

G

dehydrogenase/reductase 3

decreases expression

zoledronic acid results in decreased expression of DHRS3 mRNA

NCBI chr 4:144,618,712...144,654,214
Ensembl chr 4:144,619,397...144,654,779

G

DEAH-box helicase 35

increases expression

zoledronic acid results in increased expression of DHX35 mRNA

NCBI chr 2:158,636,674...158,700,141
Ensembl chr 2:158,636,727...158,700,134

G

diablo, IAP-binding mitochondrial protein

multiple interactions

[Tretinoin co-treated with zoledronic acid] results in decreased expression of DIABLO protein

NCBI chr 5:123,649,393...123,664,825
Ensembl chr 5:123,647,828...123,662,239

G

diaphanous related formin 3

decreases expression

zoledronic acid results in decreased expression of DIAPH3 mRNA

NCBI chr14:86,892,793...87,378,683
Ensembl chr14:86,892,803...87,378,671

G

deiodinase, iodothyronine, type II

decreases expression

zoledronic acid results in decreased expression of DIO2 mRNA

NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

zoledronic acid results in decreased expression of DKK1 mRNA

NCBI chr19:30,523,276...30,526,896
Ensembl chr19:30,523,263...30,527,065

G

deleted in liver cancer 1

decreases expression

zoledronic acid results in decreased expression of DLC1 mRNA

NCBI chr 8:37,034,893...37,420,343
Ensembl chr 8:37,034,905...37,420,297

G

discs large MAGUK scaffold protein 1

increases expression

zoledronic acid results in increased expression of DLG1 mRNA

NCBI chr16:31,482,261...31,692,174
Ensembl chr16:31,482,261...31,693,947

G

DLG associated protein 4

decreases expression

zoledronic acid results in decreased expression of DLGAP4 mRNA

NCBI chr 2:156,455,431...156,606,283
Ensembl chr 2:156,455,625...156,606,283

G

DLG associated protein 5

decreases expression

zoledronic acid results in decreased expression of DLGAP5 mRNA

PMID:24714768 PMID:25596134

NCBI chr14:47,625,238...47,655,657
Ensembl chr14:47,625,236...47,655,864

G

distal-less homeobox 1

decreases expression

zoledronic acid results in decreased expression of DLX1 mRNA

NCBI chr 2:71,358,457...71,364,325
Ensembl chr 2:71,358,457...71,364,325

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

zoledronic acid results in increased expression of DNAJB9 mRNA

NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109

G

deoxyribonuclease 1-like 1

increases expression

zoledronic acid results in increased expression of DNASE1L1 mRNA

NCBI chr X:73,316,823...73,325,939
Ensembl chr X:73,316,823...73,325,943

G

delta/notch-like EGF repeat containing

increases expression

zoledronic acid results in increased expression of DNER mRNA

NCBI chr 1:84,347,560...84,673,942
Ensembl chr 1:84,347,560...84,673,942

G

dedicator of cytokinesis 10

increases expression

zoledronic acid results in increased expression of DOCK10 mRNA

NCBI chr 1:80,478,785...80,736,482
Ensembl chr 1:80,478,790...80,736,244

G

dipeptidylpeptidase 9

increases expression

zoledronic acid results in increased expression of DPP9 mRNA

NCBI chr17:56,493,674...56,525,927
Ensembl chr17:56,493,807...56,525,905

G

dermatan sulfate epimerase

increases expression

zoledronic acid results in increased expression of DSE mRNA

NCBI chr10:34,027,385...34,084,267
Ensembl chr10:34,027,389...34,083,711

G

dermatan sulfate epimerase-like

decreases expression

zoledronic acid results in decreased expression of DSEL mRNA

NCBI chr 1:111,786,431...111,792,782
Ensembl chr 1:111,786,432...111,792,648

G

DTW domain containing 2

decreases expression

zoledronic acid results in decreased expression of DTWD2 mRNA

NCBI chr18:49,829,212...49,890,255
Ensembl chr18:49,829,212...49,888,668

G

deltex 3, E3 ubiquitin ligase

increases expression

zoledronic acid results in increased expression of DTX3 mRNA

NCBI chr10:127,026,242...127,032,367
Ensembl chr10:127,026,247...127,031,597

G

dual specificity phosphatase 18

increases expression

zoledronic acid results in increased expression of DUSP18 mRNA

NCBI chr11:3,844,940...3,851,299
Ensembl chr11:3,845,240...3,851,296

G

dual specificity phosphatase 4

decreases expression

zoledronic acid results in decreased expression of DUSP4 mRNA

NCBI chr 8:35,274,448...35,289,106
Ensembl chr 8:35,274,451...35,287,048

G

dual specificity phosphatase 5

decreases expression

zoledronic acid results in decreased expression of DUSP5 mRNA

PMID:24714768 PMID:25596134

NCBI chr19:53,517,576...53,530,240
Ensembl chr19:53,517,540...53,530,862

G

dual specificity phosphatase 6

decreases expression

zoledronic acid results in decreased expression of DUSP6 mRNA

NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351

G

dynein cytoplasmic 2 light intermediate chain 1

decreases expression

zoledronic acid results in decreased expression of DYNC2LI1 mRNA

NCBI chr17:84,933,903...84,962,996
Ensembl chr17:84,933,924...84,963,016

G

E2F transcription factor 2

increases expression

zoledronic acid results in increased expression of E2F2 mRNA

NCBI chr 4:135,899,585...135,923,368
Ensembl chr 4:135,899,705...135,923,368

G

Epstein-Barr virus induced gene 3

increases expression

zoledronic acid results in increased expression of EBI3 mRNA

NCBI chr17:56,259,623...56,264,022
Ensembl chr17:56,259,640...56,264,022

G

EBP cholestenol delta-isomerase

increases expression

zoledronic acid results in increased expression of EBP mRNA

NCBI chr X:8,051,568...8,059,751
Ensembl chr X:8,051,568...8,059,751

G

endothelin converting enzyme 1

increases expression

zoledronic acid results in increased expression of ECE1 mRNA

NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540

G

enoyl coenzyme A hydratase 1, peroxisomal

decreases expression

zoledronic acid results in decreased expression of ECH1 mRNA

NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672

G

extracellular matrix protein 1

increases expression

zoledronic acid results in increased expression of ECM1 mRNA

NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881

G

endothelin 1

increases expression

zoledronic acid results in increased expression of EDN1 mRNA

NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466

G

EF hand domain containing 1

decreases expression

zoledronic acid results in decreased expression of EFHD1 mRNA

NCBI chr 1:87,192,075...87,238,563
Ensembl chr 1:87,192,085...87,238,561

G

ephrin A1

increases expression

zoledronic acid results in increased expression of EFNA1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 3:89,179,037...89,188,258
Ensembl chr 3:89,179,040...89,188,449

G

ephrin B2

decreases expression

zoledronic acid results in decreased expression of EFNB2 mRNA

NCBI chr 8:8,667,235...8,711,242
Ensembl chr 8:8,667,434...8,711,242

G

EGF-like-domain, multiple 6

decreases expression

zoledronic acid results in decreased expression of EGFL6 mRNA

NCBI chr X:165,306,003...165,368,712
Ensembl chr X:165,306,003...165,368,716

G

egl-9 family hypoxia-inducible factor 2

increases expression

zoledronic acid results in increased expression of EGLN2 mRNA

NCBI chr 7:26,858,083...26,866,227
Ensembl chr 7:26,858,083...26,866,227

G

early growth response 1

increases expression
decreases expression

zoledronic acid results in increased expression of EGR1 mRNA
zoledronic acid results in decreased expression of EGR1 mRNA

PMID:20977926 PMID:24714768

NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037

G

early growth response 2

increases expression

zoledronic acid results in increased expression of EGR2 mRNA

NCBI chr10:67,370,334...67,383,354
Ensembl chr10:67,371,305...67,378,018

G

early growth response 4

increases expression

zoledronic acid results in increased expression of EGR4 mRNA

NCBI chr 6:85,488,103...85,490,571
Ensembl chr 6:85,488,103...85,490,571

G

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

decreases expression

zoledronic acid results in decreased expression of EHHADH mRNA

NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557

G

ELK1, member of ETS oncogene family

increases expression

zoledronic acid results in increased expression of ELK1 mRNA

NCBI chr X:20,799,634...20,816,847
Ensembl chr X:20,799,634...20,816,847

G

elongation factor for RNA polymerase II 2

increases expression

zoledronic acid results in increased expression of ELL2 mRNA

NCBI chr13:75,855,603...75,920,480
Ensembl chr13:75,854,876...75,920,483

G

elongin B

decreases expression

zoledronic acid results in decreased expression of ELOB mRNA

NCBI chr17:24,043,714...24,048,083
Ensembl chr17:24,043,712...24,048,110

G

ELOVL fatty acid elongase 6

increases expression

zoledronic acid results in increased expression of ELOVL6 mRNA

NCBI chr 3:129,326,035...129,432,144
Ensembl chr 3:129,326,004...129,432,144

G

echinoderm microtubule associated protein like 4

increases expression

zoledronic acid results in increased expression of EML4 mRNA

NCBI chr17:83,658,341...83,787,790
Ensembl chr17:83,658,360...83,787,790

G

epithelial membrane protein 3

multiple interactions
increases expression

[zoledronic acid co-treated with fluvastatin] results in increased expression of EMP3 mRNA
zoledronic acid results in increased expression of EMP3 mRNA

PMID:16996129 PMID:20977926

NCBI chr 7:45,567,447...45,570,850
Ensembl chr 7:45,567,447...45,570,828

G

ectonucleotide pyrophosphatase/phosphodiesterase 6

increases expression

zoledronic acid results in increased expression of ENPP6 mRNA

NCBI chr 8:47,439,920...47,549,797
Ensembl chr 8:47,439,922...47,549,797

G

E1A binding protein p400

decreases expression

zoledronic acid results in decreased expression of EP400 mRNA

NCBI chr 5:110,812,239...110,918,583
Ensembl chr 5:110,812,239...110,918,583

G

Eph receptor A4

increases expression

zoledronic acid results in increased expression of EPHA4 mRNA

NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725

G

Eph receptor B3

decreases expression

zoledronic acid results in decreased expression of EPHB3 mRNA

NCBI chr16:21,023,530...21,042,054
Ensembl chr16:21,023,505...21,042,055

G

Eph receptor B4

multiple interactions

[zoledronic acid co-treated with Gossypol] results in decreased expression of EPHB4 mRNA

NCBI chr 5:137,348,371...137,372,784
Ensembl chr 5:137,348,371...137,376,931

G

epoxide hydrolase 2, cytoplasmic

decreases expression
increases expression

zoledronic acid results in decreased expression of EPHX2 mRNA
zoledronic acid results in increased expression of EPHX2 protein

PMID:24714768 PMID:28871336

NCBI chr14:66,321,821...66,361,971
Ensembl chr14:66,321,823...66,361,949

G

glutamyl-prolyl-tRNA synthetase 1

decreases expression

Zoledronic Acid results in decreased expression of EPRS1 mRNA

NCBI chr 1:185,093,614...185,160,557
Ensembl chr 1:185,095,241...185,160,557

G

epithelial stromal interaction 1

increases expression

zoledronic acid results in increased expression of EPSTI1 mRNA

NCBI chr14:78,141,679...78,240,096
Ensembl chr14:78,141,679...78,240,097

G

excision repair cross-complementing rodent repair deficiency, complementation group 5

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ERCC5 mRNA

NCBI chr 1:44,184,084...44,220,399
Ensembl chr 1:44,186,904...44,220,420

G

ETS transcription factor

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of ERG mRNA

NCBI chr16:95,160,028...95,387,452
Ensembl chr16:95,160,028...95,387,452

G

ERGIC and golgi 2

decreases expression

zoledronic acid results in decreased expression of ERGIC2 mRNA

NCBI chr 6:148,080,816...148,113,886
Ensembl chr 6:148,080,577...148,113,872

G

ER lipid raft associated 1

increases expression

zoledronic acid results in increased expression of ERLIN1 mRNA

NCBI chr19:44,023,382...44,058,580
Ensembl chr19:44,023,383...44,058,224

G

endoplasmic reticulum to nucleus signalling 1

increases expression

Zoledronic Acid results in increased expression of ERN1 mRNA; Zoledronic Acid results in increased expression of ERN1 protein

NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Zoledronic Acid results in increased expression of ERO1A mRNA

PMID:24714768 PMID:25596134

NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228

G

endoplasmic reticulum protein 27

increases expression

zoledronic acid results in increased expression of ERP27 mRNA

NCBI chr 6:136,884,312...136,899,465
Ensembl chr 6:136,884,309...136,899,178

G

establishment of sister chromatid cohesion N-acetyltransferase 2

increases expression

zoledronic acid results in increased expression of ESCO2 mRNA

NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443

G

estrogen-related receptor gamma

decreases expression

zoledronic acid results in decreased expression of ESRRG mRNA

NCBI chr 1:187,340,707...187,947,082
Ensembl chr 1:187,340,988...187,947,082

G

E26 avian leukemia oncogene 1, 5' domain

increases expression

zoledronic acid results in increased expression of ETS1 mRNA

NCBI chr 9:32,547,501...32,669,116
Ensembl chr 9:32,547,517...32,669,116

G

E26 avian leukemia oncogene 2, 3' domain

decreases expression

zoledronic acid results in decreased expression of ETS2 mRNA

NCBI chr16:95,503,274...95,522,093
Ensembl chr16:95,502,942...95,522,095

G

ets variant 4

decreases expression

zoledronic acid results in decreased expression of ETV4 mRNA

NCBI chr11:101,660,573...101,677,963
Ensembl chr11:101,660,568...101,676,197

G

eva-1 homolog A, regulator of programmed cell death

decreases expression

zoledronic acid results in decreased expression of EVA1A mRNA

NCBI chr 6:82,018,058...82,070,079
Ensembl chr 6:82,018,024...82,070,080

G

exocyst complex component 5

increases expression

zoledronic acid results in increased expression of EXOC5 mRNA

NCBI chr14:49,249,379...49,304,124
Ensembl chr14:49,241,547...49,304,110

G

ezrin

increases expression

zoledronic acid results in increased expression of EZR mRNA

NCBI chr17:7,005,530...7,050,179
Ensembl chr17:7,005,440...7,050,183

G

coagulation factor III

decreases expression

zoledronic acid results in decreased expression of F3 mRNA

NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697

G

fatty acid binding protein 1, liver

increases expression

Zoledronic Acid results in increased expression of FABP1 mRNA

NCBI chr 6:71,176,863...71,182,018
Ensembl chr 6:71,176,811...71,182,007

G

Fas associated via death domain

multiple interactions

[Tretinoin co-treated with zoledronic acid] results in increased expression of FADD protein

NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200

G

fatty acid desaturase 2

increases expression

zoledronic acid results in increased expression of FADS2 mRNA

NCBI chr19:10,040,129...10,078,867
Ensembl chr19:10,040,129...10,079,110

G

fatty acid desaturase 3

increases expression

zoledronic acid results in increased expression of FADS3 mRNA

NCBI chr19:10,018,189...10,037,477
Ensembl chr19:10,018,933...10,037,474

G

family with sequence similarity 107, member A

increases expression

zoledronic acid results in increased expression of FAM107A mRNA

NCBI chr14:14,152,166...14,173,503
Ensembl chr14:14,151,750...14,173,499

G

family with sequence similarity 167, member A

decreases expression

zoledronic acid results in decreased expression of FAM167A mRNA

NCBI chr14:63,673,843...63,702,951
Ensembl chr14:63,673,843...63,702,947

G

family with sequence similarity 171, member B

decreases expression

zoledronic acid results in decreased expression of FAM171B mRNA

NCBI chr 2:83,642,889...83,713,878
Ensembl chr 2:83,642,980...83,713,830

G

FAM20A, golgi associated secretory pathway pseudokinase

increases expression

zoledronic acid results in increased expression of FAM20A mRNA

NCBI chr11:109,563,752...109,613,989
Ensembl chr11:109,560,575...109,613,105

G

family with sequence similarity 222, member B

decreases expression

zoledronic acid results in decreased expression of FAM222B mRNA

NCBI chr11:77,985,516...78,048,165
Ensembl chr11:77,985,486...78,047,526

G

family with sequence similarity 43, member A

decreases expression

zoledronic acid results in decreased expression of FAM43A mRNA

NCBI chr16:30,418,541...30,421,615
Ensembl chr16:30,418,541...30,421,615

G

Fas cell surface death receptor

increases expression
multiple interactions

zoledronic acid results in increased expression of FAS mRNA
[Tretinoin co-treated with zoledronic acid] results in increased expression of FAS protein

PMID:19036117 PMID:20349282 PMID:25596134

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

Fas ligand

affects expression

zoledronic acid affects the expression of FASLG mRNA

NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064

G

filamin binding LIM protein 1

decreases expression

zoledronic acid results in decreased expression of FBLIM1 protein

NCBI chr 4:141,303,373...141,333,351
Ensembl chr 4:141,303,373...141,333,407

G

fibulin 1

increases expression

zoledronic acid results in increased expression of FBLN1 mRNA; zoledronic acid results in increased expression of FBLN1 protein

PMID:24714768 PMID:28871336

NCBI chr15:85,090,150...85,170,495
Ensembl chr15:85,090,150...85,170,736

G

fibulin 5

increases expression

zoledronic acid results in increased expression of FBLN5 mRNA

NCBI chr12:101,712,820...101,785,541
Ensembl chr12:101,712,824...101,785,314

G

fibrillin 1

increases expression

zoledronic acid results in increased expression of FBN1 mRNA

PMID:20977926 PMID:24714768

NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913

G

Fc fragment of IgG binding protein

increases expression

zoledronic acid results in increased expression of FCGBP mRNA

NCBI chr 7:27,770,661...27,820,289
Ensembl chr 7:27,770,661...27,820,287

G

Fc fragment of IgG receptor and transporter

decreases expression

zoledronic acid results in decreased expression of FCGRT mRNA

NCBI chr 7:44,742,417...44,753,246
Ensembl chr 7:44,742,414...44,753,275

G

Fc fragment of IgM receptor

increases expression

zoledronic acid results in increased expression of FCMR mRNA

NCBI chr 1:130,793,514...130,808,528
Ensembl chr 1:130,793,406...130,808,528

G

Fc receptor like 2

increases expression

zoledronic acid results in increased expression of FCRL2 mRNA

NCBI chr 3:87,158,318...87,171,046
Ensembl chr 3:87,158,065...87,171,045

G

Fc receptor-like A

increases expression

zoledronic acid results in increased expression of FCRLA mRNA

NCBI chr 1:170,745,163...170,755,169
Ensembl chr 1:170,745,145...170,755,152

G

farnesyl diphosphate farnesyl transferase 1

multiple interactions
increases expression

[zoledronic acid co-treated with fluvastatin] results in increased expression of FDFT1 mRNA
zoledronic acid results in increased expression of FDFT1 mRNA

PMID:16996129 PMID:18325729

NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027

G

farnesyl diphosphate synthetase

affects binding
increases expression
decreases activity
increases activity
multiple interactions

zoledronic acid binds to FDPS protein
zoledronic acid results in increased expression of FDPS mRNA
zoledronic acid results in decreased activity of FDPS protein
zoledronic acid results in increased activity of FDPS protein
[zoledronic acid results in decreased activity of FDPS protein] which results in increased abundance of isopentenyl pyrophosphate

PMID:11160603 PMID:12846887 PMID:16684881 PMID:17208200 PMID:18325729 More...

NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266

G

ferrochelatase

decreases expression

zoledronic acid results in decreased expression of FECH mRNA

NCBI chr18:64,589,613...64,622,169
Ensembl chr18:64,585,985...64,623,322

G

fem 1 homolog b

increases expression

zoledronic acid results in increased expression of FEM1B mRNA

NCBI chr 9:62,699,106...62,718,930
Ensembl chr 9:62,699,103...62,719,216

G

fasciculation and elongation protein zeta 1

increases expression

zoledronic acid results in increased expression of FEZ1 mRNA

NCBI chr 9:36,732,694...36,790,220
Ensembl chr 9:36,733,160...36,790,220

G

fibroblast growth factor 18

increases expression

zoledronic acid results in increased expression of FGF18 mRNA

NCBI chr11:33,066,970...33,097,400
Ensembl chr11:33,067,430...33,097,400

G

fibroblast growth factor 2

decreases expression
multiple interactions

zoledronic acid results in decreased expression of FGF2 mRNA
zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGF2 mRNA]

PMID:19825521 PMID:24714768

NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257

G

fibroblast growth factor 9

decreases expression

zoledronic acid results in decreased expression of FGF9 mRNA

NCBI chr14:58,308,543...58,350,311
Ensembl chr14:58,308,004...58,350,177

G

fibroblast growth factor binding protein 1

increases expression

zoledronic acid results in increased expression of FGFBP1 mRNA

NCBI chr 5:44,136,200...44,139,173
Ensembl chr 5:44,136,200...44,139,121

G

fibroblast growth factor receptor 3

multiple interactions
decreases expression

zoledronic acid promotes the reaction [Gossypol results in decreased expression of FGFR3 mRNA]
zoledronic acid results in decreased expression of FGFR3 mRNA

PMID:19825521 PMID:24714768

NCBI chr 5:33,879,068...33,894,412
Ensembl chr 5:33,879,018...33,894,412

G

fibroblast growth factor receptor 4

decreases expression

zoledronic acid results in decreased expression of FGFR4 mRNA

NCBI chr13:55,300,631...55,316,572
Ensembl chr13:55,300,453...55,316,572

G

fibrinogen-like protein 2

decreases expression

zoledronic acid results in decreased expression of FGL2 mRNA

NCBI chr 5:21,577,671...21,583,384
Ensembl chr 5:21,577,640...21,583,372

G

four and a half LIM domains 1

increases expression

zoledronic acid results in increased expression of FHL1 mRNA

NCBI chr X:55,776,569...55,838,704
Ensembl chr X:55,777,147...55,838,706

G

four and a half LIM domains 2

decreases expression

zoledronic acid results in decreased expression of FHL2 mRNA

NCBI chr 1:43,162,233...43,237,501
Ensembl chr 1:43,162,234...43,236,144

G

fidgetin-like 1

increases expression

zoledronic acid results in increased expression of FIGNL1 mRNA

NCBI chr11:11,737,429...11,758,962
Ensembl chr11:11,737,431...11,758,962

G

filamin A interacting protein 1-like

decreases expression

zoledronic acid results in decreased expression of FILIP1L mRNA

NCBI chr16:57,173,376...57,393,167
Ensembl chr16:57,173,456...57,393,489

G

four jointed box 1

decreases expression

zoledronic acid results in decreased expression of FJX1 mRNA

NCBI chr 2:102,279,711...102,282,137
Ensembl chr 2:102,279,711...102,282,844

G

FK506 binding protein 1a

increases expression

zoledronic acid results in increased expression of FKBP1A mRNA

NCBI chr 2:151,384,403...151,403,611
Ensembl chr 2:151,384,403...151,403,612

G

formin-like 3

increases expression

zoledronic acid results in increased expression of FMNL3 mRNA

NCBI chr15:99,215,091...99,268,375
Ensembl chr15:99,215,106...99,268,363

G

fibronectin 1

multiple interactions
increases expression

4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased expression of FN1 protein]
zoledronic acid results in increased expression of FN1 mRNA; zoledronic acid results in increased expression of FN1 protein
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of FN1 protein]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of FN1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of FN1 protein]

NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359

G

formin binding protein 1

increases expression

zoledronic acid results in increased expression of FNBP1 mRNA

NCBI chr 2:30,916,218...31,032,046
Ensembl chr 2:30,916,218...31,032,020

G

farnesyltransferase, CAAX box, alpha

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of FNTA mRNA

NCBI chr 8:26,488,716...26,505,638
Ensembl chr 8:26,488,750...26,505,678

G

folate receptor alpha

decreases expression

zoledronic acid results in decreased expression of FOLR1 mRNA

NCBI chr 7:101,507,551...101,519,974
Ensembl chr 7:101,507,538...101,519,995

G

FBJ osteosarcoma oncogene

decreases expression
multiple interactions

zoledronic acid results in decreased expression of FOS mRNA
zoledronic acid inhibits the reaction [Freund's Adjuvant results in increased expression of FOS protein]
zoledronic acid results in decreased expression of FOS protein

PMID:16769263 PMID:17323179 PMID:24714768

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

forkhead box J1

decreases expression

zoledronic acid results in decreased expression of FOXJ1 mRNA

NCBI chr11:116,221,530...116,226,331
Ensembl chr11:116,221,530...116,226,225

G

forkhead box O1

decreases expression

zoledronic acid results in decreased expression of FOXO1 mRNA

NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642

G

Fras1 related extracellular matrix protein 2

decreases expression

zoledronic acid results in decreased expression of FREM2 mRNA

NCBI chr 3:53,421,359...53,566,014
Ensembl chr 3:53,421,359...53,564,776

G

fyn-related kinase

increases expression

zoledronic acid results in increased expression of FRK mRNA

NCBI chr10:34,359,396...34,487,530
Ensembl chr10:34,359,395...34,487,274

G

fascin actin-bundling protein 1

increases expression

zoledronic acid results in increased expression of FSCN1 mRNA

NCBI chr 5:142,946,110...142,958,944
Ensembl chr 5:142,946,098...142,958,940

G

fibronectin type III and SPRY domain containing 1-like

increases expression

zoledronic acid results in increased expression of FSD1L mRNA

NCBI chr 4:53,631,383...53,707,009
Ensembl chr 4:53,631,471...53,707,009

G

follistatin-like 1

increases expression

zoledronic acid results in increased expression of FSTL1 mRNA

NCBI chr16:37,597,417...37,656,878
Ensembl chr16:37,597,235...37,656,876

G

follistatin-like 3

decreases expression

zoledronic acid results in decreased expression of FSTL3 mRNA

NCBI chr10:79,613,108...79,618,464
Ensembl chr10:79,613,106...79,618,464

G

ferritin heavy polypeptide 1

increases expression

zoledronic acid results in increased expression of FTH1 mRNA

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

fucosidase, alpha-L- 1, tissue

increases expression

zoledronic acid results in increased expression of FUCA1 mRNA

NCBI chr 4:135,648,037...135,667,611
Ensembl chr 4:135,648,046...135,667,622

G

fucosyltransferase 8

increases expression

zoledronic acid results in increased expression of FUT8 mRNA

NCBI chr12:77,284,878...77,522,770
Ensembl chr12:77,284,899...77,523,112

G

FXYD domain-containing ion transport regulator 2

decreases expression

zoledronic acid results in decreased expression of FXYD2 mRNA

NCBI chr 9:45,311,007...45,321,576
Ensembl chr 9:45,310,967...45,321,576

G

FYN binding protein 1

decreases expression

zoledronic acid results in decreased expression of FYB1 mRNA

NCBI chr15:6,552,280...6,695,089
Ensembl chr15:6,552,334...6,692,794

G

frizzled class receptor 5

increases expression

zoledronic acid results in increased expression of FZD5 mRNA

NCBI chr 1:64,769,717...64,776,907
Ensembl chr 1:64,769,717...64,776,910

G

GABA type A receptor associated protein like 1

decreases expression

zoledronic acid results in decreased expression of GABARAPL1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 6:129,510,155...129,519,294
Ensembl chr 6:129,510,123...129,519,309

G

gamma-aminobutyric acid type A receptor subunit pi

decreases expression

zoledronic acid results in decreased expression of GABRP mRNA

NCBI chr11:33,500,781...33,528,978
Ensembl chr11:33,500,781...33,528,959

G

growth arrest and DNA-damage-inducible 45 alpha

decreases expression

zoledronic acid results in decreased expression of GADD45A mRNA

PMID:24714768 PMID:25596134

NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441

G

growth arrest and DNA-damage-inducible 45 beta

multiple interactions
increases expression

[zoledronic acid co-treated with fluvastatin] results in increased expression of GADD45B mRNA
zoledronic acid results in increased expression of GADD45B mRNA

PMID:16996129 PMID:20977926

NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038

G

growth arrest and DNA-damage-inducible 45 gamma

increases expression

zoledronic acid results in increased expression of GADD45G mRNA

NCBI chr13:52,000,711...52,002,511
Ensembl chr13:52,000,714...52,002,504

G

polypeptide N-acetylgalactosaminyltransferase 10

decreases expression

zoledronic acid results in decreased expression of GALNT10 mRNA

NCBI chr11:57,536,268...57,678,327
Ensembl chr11:57,536,268...57,678,340

G

polypeptide N-acetylgalactosaminyltransferase 11

decreases expression

zoledronic acid results in decreased expression of GALNT11 mRNA

NCBI chr 5:25,427,732...25,470,916
Ensembl chr 5:25,426,902...25,470,916

G

polypeptide N-acetylgalactosaminyltransferase 16

decreases expression

zoledronic acid results in decreased expression of GALNT16 mRNA

PMID:24714768 PMID:25596134

NCBI chr12:80,565,245...80,650,672
Ensembl chr12:80,565,051...80,677,746

G

polypeptide N-acetylgalactosaminyltransferase 18

increases expression

Zoledronic Acid results in increased expression of GALNT18 mRNA

NCBI chr 7:111,070,863...111,379,274
Ensembl chr 7:111,070,868...111,379,184

G

guanylate binding protein 2

increases expression

zoledronic acid results in increased expression of GBP2 mRNA

NCBI chr 3:142,326,424...142,343,769
Ensembl chr 3:142,326,363...142,343,769

G

guanylate binding protein 3

increases expression

zoledronic acid results in increased expression of GBP4 mRNA

NCBI chr 3:142,265,781...142,278,974
Ensembl chr 3:142,265,787...142,278,970

G

guanylate binding protein 5

increases expression

zoledronic acid results in increased expression of GBP5 mRNA

NCBI chr 3:142,202,695...142,228,105
Ensembl chr 3:142,199,739...142,228,105

G

vitamin D binding protein

increases expression

zoledronic acid results in increased expression of GC protein

NCBI chr 5:89,565,370...89,605,757
Ensembl chr 5:89,565,381...89,605,757

G

glucosaminyl (N-acetyl) transferase 1, core 2

decreases expression

zoledronic acid results in decreased expression of GCNT1 mRNA

NCBI chr19:17,303,505...17,350,208
Ensembl chr19:17,303,505...17,350,208

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

zoledronic acid results in increased expression of GCNT3 mRNA

PMID:24714768 PMID:25596134

NCBI chr 9:69,938,777...69,947,172
Ensembl chr 9:69,938,778...69,945,370

G

growth differentiation factor 15

decreases expression

zoledronic acid results in decreased expression of GDF15 mRNA

PMID:24714768 PMID:25596134

NCBI chr 8:71,082,043...71,085,106
Ensembl chr 8:71,082,043...71,085,106

G

GDP dissociation inhibitor 2

increases expression

zoledronic acid results in increased expression of GDI2 protein

NCBI chr13:3,588,075...3,616,261
Ensembl chr13:3,588,063...3,617,871

G

GTP binding protein overexpressed in skeletal muscle

decreases expression

zoledronic acid results in decreased expression of GEM mRNA

NCBI chr 4:11,702,379...11,714,993
Ensembl chr 4:11,704,457...11,714,752

G

geranylgeranyl diphosphate synthase 1

decreases activity

zoledronic acid results in decreased activity of GGPS1 protein

NCBI chr13:14,224,375...14,238,319
Ensembl chr13:14,225,244...14,238,073

G

gamma-glutamyltransferase 1

decreases expression

zoledronic acid results in decreased expression of GGT1 mRNA

NCBI chr10:75,396,910...75,422,027
Ensembl chr10:75,397,438...75,422,034

G

GINS complex subunit 2

decreases expression

zoledronic acid results in decreased expression of GINS2 mRNA

NCBI chr 8:121,308,005...121,315,814
Ensembl chr 8:121,305,372...121,316,043

G

gap junction protein, beta 1

decreases expression

zoledronic acid results in decreased expression of GJB1 mRNA

NCBI chr X:100,419,982...100,429,235
Ensembl chr X:100,419,984...100,429,235

G

gap junction protein, beta 2

increases expression

zoledronic acid results in increased expression of GJB2 mRNA

NCBI chr14:57,336,059...57,342,159
Ensembl chr14:57,336,057...57,342,159

G

glycerol kinase

increases expression

zoledronic acid results in increased expression of GK mRNA

NCBI chr X:84,745,543...84,820,425
Ensembl chr X:84,745,543...84,820,425

G

galactosidase, alpha

decreases expression

zoledronic acid results in decreased expression of GLA protein

NCBI chr X:133,488,912...133,501,707
Ensembl chr X:133,488,898...133,501,874

G

glucuronyl C5-epimerase

increases expression

zoledronic acid results in increased expression of GLCE mRNA

NCBI chr 9:61,964,526...62,029,891
Ensembl chr 9:61,964,530...62,029,937

G

golgi apparatus protein 1

decreases expression

zoledronic acid results in decreased expression of GLG1 mRNA

NCBI chr 8:111,879,916...111,985,842
Ensembl chr 8:111,881,053...111,985,848

G

GLI pathogenesis related 1

decreases expression

zoledronic acid results in decreased expression of GLIPR1 mRNA

NCBI chr10:111,821,353...111,838,539
Ensembl chr10:111,821,353...111,838,536

G

glutaredoxin 3

decreases expression

zoledronic acid results in decreased expression of GLRX3 mRNA

NCBI chr 7:137,039,302...137,071,360
Ensembl chr 7:137,039,343...137,070,323

G

predicted gene 11992

decreases expression

zoledronic acid results in decreased expression of C7ORF57 mRNA

NCBI chr11:8,998,592...9,019,354
Ensembl chr11:8,998,594...9,019,356

G

predicted gene 13377

decreases expression

zoledronic acid results in decreased expression of PRTFDC1 mRNA

NCBI chr 2:21,049,620...21,144,493
Ensembl chr 2:21,049,619...21,146,765

G

predicted gene 14137

increases expression

zoledronic acid results in increased expression of C15ORF62 mRNA

NCBI chr 2:119,004,990...119,008,049
Ensembl chr 2:119,004,990...119,008,056

G

predicted gene, 35938

increases expression

zoledronic acid results in increased expression of HHLA2 mRNA

NCBI chr16:49,384,216...49,387,359

G

predicted gene, 38656

increases expression

Zoledronic Acid results in increased expression of SCGB1D2 mRNA

NCBI chr19:9,162,589...9,164,383

G

predicted gene, 40318

decreases expression

Zoledronic Acid results in decreased expression of S100P protein

NCBI chr 5:36,919,848...36,924,763
Ensembl chr 5:36,919,961...36,924,039

G

predicted gene, 49817

increases expression

Zoledronic Acid results in increased expression of PLEKHG7 mRNA

NCBI chr10:95,888,057...95,962,580

G

predicted gene 7030

increases expression

Zoledronic Acid results in increased expression of HLA-F mRNA

NCBI chr17:36,438,501...36,440,317
Ensembl chr17:36,420,611...36,440,317

G

guanine nucleotide binding protein (G protein), beta 2

increases expression

zoledronic acid results in increased expression of GNB2 protein

NCBI chr 5:137,526,389...137,533,085
Ensembl chr 5:137,526,389...137,531,772

G

guanine nucleotide binding protein (G protein), beta 4

increases expression

zoledronic acid results in increased expression of GNB4 mRNA

NCBI chr 3:32,632,736...32,670,813
Ensembl chr 3:32,634,481...32,670,734

G

guanine nucleotide binding protein (G protein), gamma 10

increases expression

zoledronic acid results in increased expression of GNG10 protein

NCBI chr 4:59,035,156...59,041,899
Ensembl chr 4:59,035,088...59,041,903

G

guanine nucleotide binding protein (G protein), gamma 7

decreases expression

zoledronic acid results in decreased expression of GNG7 mRNA

NCBI chr10:80,784,463...80,850,742
Ensembl chr10:80,784,458...80,850,779

G

golgi transport 1A

decreases expression

zoledronic acid results in decreased expression of GOLT1A mRNA

NCBI chr 1:133,237,561...133,250,764
Ensembl chr 1:133,237,538...133,250,764
Ensembl chr 1:133,237,538...133,250,764

G

glutamic-oxaloacetic transaminase 1, soluble

increases expression

zoledronic acid results in increased expression of GOT1 mRNA

NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044

G

glypican 3

decreases expression

zoledronic acid results in decreased expression of GPC3 mRNA

NCBI chr X:51,361,303...51,702,851
Ensembl chr X:51,361,303...51,702,827

G

glypican 4

decreases expression

zoledronic acid results in decreased expression of GPC4 mRNA

NCBI chr X:51,139,884...51,253,800
Ensembl chr X:51,141,898...51,254,129

G

glycoprotein (transmembrane) nmb

decreases expression

zoledronic acid results in decreased expression of GPNMB mRNA

NCBI chr 6:49,013,449...49,044,413
Ensembl chr 6:49,013,480...49,047,863

G

G protein-coupled receptor 141

increases expression

zoledronic acid results in increased expression of GPR141 mRNA

NCBI chr13:19,933,850...20,008,499
Ensembl chr13:19,933,852...20,008,427

G

G protein-coupled receptor 37-like 1

increases expression

zoledronic acid results in increased expression of GPR37L1 mRNA

NCBI chr 1:135,087,988...135,095,419
Ensembl chr 1:135,087,972...135,095,419

G

G protein-coupled receptor, family C, group 5, member A

decreases expression

zoledronic acid results in decreased expression of GPRC5A mRNA

NCBI chr 6:135,042,660...135,061,707
Ensembl chr 6:135,042,649...135,061,707

G

growth factor receptor bound protein 14

decreases expression

zoledronic acid results in decreased expression of GRB14 mRNA

NCBI chr 2:64,742,820...64,853,143
Ensembl chr 2:64,742,820...64,855,331

G

glutamate receptor interacting protein 2

increases expression

zoledronic acid results in increased expression of GRIP2 mRNA

NCBI chr 6:91,738,433...91,820,884
Ensembl chr 6:91,738,490...91,804,231

G

G protein-coupled receptor kinase 5

increases expression

zoledronic acid results in increased expression of GRK5 mRNA

NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406

G

glutamate receptor, metabotropic 8

decreases expression

zoledronic acid results in decreased expression of GRM8 mRNA

NCBI chr 6:27,275,120...28,135,094
Ensembl chr 6:27,275,118...28,135,177

G

general transcription factor II I

increases expression

zoledronic acid results in increased expression of GTF2I mRNA

NCBI chr 5:134,266,686...134,346,571
Ensembl chr 5:134,266,688...134,343,614

G

general transcription factor II I repeat domain-containing 1

decreases expression

zoledronic acid results in decreased expression of GTF2IRD1 mRNA

NCBI chr 5:134,386,515...134,485,628
Ensembl chr 5:134,386,510...134,485,570

G

general transcription factor IIIC, polypeptide 4

increases expression

zoledronic acid results in increased expression of GTF3C4 mRNA

NCBI chr 2:28,712,311...28,730,628
Ensembl chr 2:28,712,311...28,730,372

G

GTP binding protein 2

increases expression

zoledronic acid results in increased expression of GTPBP2 mRNA

NCBI chr17:46,470,153...46,480,294
Ensembl chr17:46,471,958...46,480,296

G

granzyme B

affects expression
multiple interactions

zoledronic acid affects the expression of GZMB mRNA
IL2 protein affects the reaction [zoledronic acid affects the expression of GZMB mRNA]

NCBI chr14:56,496,293...56,499,791
Ensembl chr14:56,496,295...56,499,717

G

H1.2 linker histone, cluster member

increases expression

Zoledronic Acid results in increased expression of H1-2 mRNA

PMID:24714768 PMID:25596134

NCBI chr13:23,922,790...23,923,514
Ensembl chr13:23,922,791...23,924,350

G

histocompatibility 2, class II, locus DMa

increases expression

zoledronic acid results in increased expression of HLA-DMA mRNA

NCBI chr17:34,338,667...34,358,075
Ensembl chr17:34,338,515...34,358,075

G

histocompatibility 2, class II, locus Mb1

increases expression

Zoledronic Acid results in increased expression of HLA-DMB mRNA

NCBI chr17:34,372,165...34,379,203
Ensembl chr17:34,372,046...34,379,204

G

histocompatibility 2, class II antigen E alpha

increases expression

zoledronic acid results in increased expression of HLA-DRA mRNA

NCBI chr17:34,560,926...34,563,619
Ensembl chr17:34,560,926...34,563,618

G

histocompatibility 2, class II antigen E beta

increases expression

zoledronic acid results in increased expression of HLA-DRB1 mRNA

NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648

G

histocompatibility 2, Q region locus 1

increases expression

zoledronic acid results in increased expression of HLA-A mRNA

NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075

G

histocompatibility 2, T region locus 23

increases expression

zoledronic acid results in increased expression of HLA-E mRNA

NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747

G

H2A clustered histone 18

increases expression

Zoledronic Acid results in increased expression of H2AC18 mRNA

NCBI chr 3:96,152,853...96,153,439
Ensembl chr 3:96,152,813...96,153,398

G

H2A clustered histone 20

increases expression

Zoledronic Acid results in increased expression of H2AC20 mRNA

NCBI chr 3:96,127,728...96,128,209
Ensembl chr 3:96,127,677...96,128,196

G

H2A.X variant histone

increases expression

Zoledronic Acid results in increased expression of H2AX mRNA

NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374

G

H2B clustered histone 12

increases expression

Zoledronic Acid results in increased expression of H2BC12 mRNA

NCBI chr13:22,219,991...22,220,490
Ensembl chr13:22,220,040...22,220,515

G

H2B clustered histone 14

increases expression

Zoledronic Acid results in increased expression of H2BC5 mRNA

NCBI chr13:21,906,214...21,906,696
Ensembl chr13:21,906,214...21,906,737

G

H4 clustered histone 12

increases expression

Zoledronic Acid results in increased expression of H4C8 mRNA

NCBI chr13:21,934,315...21,934,723
Ensembl chr13:21,934,364...21,934,675

G

H4 clustered histone 14

decreases expression

Zoledronic Acid results in decreased expression of H4C3 mRNA

NCBI chr 3:96,170,250...96,170,633
Ensembl chr 3:96,168,998...96,170,627

G

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha

decreases expression

zoledronic acid results in decreased expression of HADHA mRNA

NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160

G

hyaluronan and proteoglycan link protein 3

increases expression

zoledronic acid results in increased expression of HAPLN3 mRNA

NCBI chr 7:78,766,775...78,783,100
Ensembl chr 7:78,764,850...78,780,766

G

hepatitis A virus cellular receptor 1

increases expression

zoledronic acid results in increased expression of HAVCR1 mRNA

NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405

G

histone deacetylase 9

increases expression

zoledronic acid results in increased expression of HDAC9 mRNA

NCBI chr12:34,097,579...34,967,094
Ensembl chr12:34,097,579...34,967,094

G

heparin binding growth factor

increases expression

zoledronic acid results in increased expression of HDGF mRNA

NCBI chr 3:87,813,844...87,823,439
Ensembl chr 3:87,813,628...87,823,439

G

heart development protein with EGF-like domains 1

increases expression

zoledronic acid results in increased expression of HEG1 mRNA

NCBI chr16:33,504,754...33,591,946
Ensembl chr16:33,504,740...33,591,946

G

hect domain and RLD 4

decreases expression

zoledronic acid results in decreased expression of HERC4 mRNA

NCBI chr10:63,079,122...63,153,660
Ensembl chr10:63,079,589...63,153,657

G

hes family bHLH transcription factor 1

decreases expression

zoledronic acid results in decreased expression of HES1 mRNA

NCBI chr16:29,883,259...29,886,614
Ensembl chr16:29,883,202...29,886,614

G

hes family bHLH transcription factor 2

decreases expression

zoledronic acid results in decreased expression of HES2 mRNA

NCBI chr 4:152,243,324...152,246,926
Ensembl chr 4:152,243,324...152,246,926

G

homogentisate 1, 2-dioxygenase

decreases expression

zoledronic acid results in decreased expression of HGD mRNA

NCBI chr16:37,400,104...37,452,388
Ensembl chr16:37,400,515...37,452,382

G

hypoxia inducible factor 1, alpha subunit

multiple interactions

zoledronic acid inhibits the reaction [Dopamine results in decreased expression of HIF1A protein]

NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304

G

histidine triad nucleotide binding protein 2

increases expression

zoledronic acid results in increased expression of HINT2 protein

NCBI chr 4:43,654,227...43,656,445
Ensembl chr 4:43,654,227...43,656,466

G

hepatic leukemia factor

decreases expression

zoledronic acid results in decreased expression of HLF mRNA

NCBI chr11:90,227,361...90,281,745
Ensembl chr11:90,227,362...90,281,721

G

hemicentin 1

decreases expression

zoledronic acid results in decreased expression of HMCN1 mRNA

NCBI chr 1:150,438,251...150,869,568
Ensembl chr 1:150,438,275...150,869,186

G

high mobility group box 3

increases expression

zoledronic acid results in increased expression of HMGB3 mRNA

NCBI chr X:70,599,523...70,604,261
Ensembl chr X:70,599,524...70,604,282

G

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

increases expression

zoledronic acid results in increased expression of HMGCS1 mRNA

NCBI chr13:120,151,887...120,169,796
Ensembl chr13:120,151,915...120,169,796

G

hyaluronan mediated motility receptor (RHAMM)

decreases expression

zoledronic acid results in decreased expression of HMMR mRNA

NCBI chr11:40,592,215...40,624,290
Ensembl chr11:40,592,222...40,624,249

G

heme oxygenase 1

decreases expression
increases expression

zoledronic acid results in decreased expression of HMOX1 mRNA
Zoledronic Acid results in increased expression of HMOX1 mRNA

PMID:24714768 PMID:25596134 PMID:35587103

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

heme oxygenase 2

multiple interactions

[Tretinoin co-treated with zoledronic acid] results in increased expression of HMOX2 protein

NCBI chr16:4,544,225...4,584,606
Ensembl chr16:4,544,225...4,584,606

G

heterochromatin protein 1, binding protein 3

increases expression

zoledronic acid results in increased expression of HP1BP3 mRNA

NCBI chr 4:137,943,781...137,971,994
Ensembl chr 4:137,943,607...137,971,994

G

hippocalcin-like 4

decreases expression

zoledronic acid results in decreased expression of HPCAL4 mRNA

NCBI chr 4:123,077,297...123,088,492
Ensembl chr 4:123,077,020...123,088,494

G

hydroxyprostaglandin dehydrogenase 15 (NAD)

decreases expression

zoledronic acid results in decreased expression of HPGD mRNA

NCBI chr 8:56,747,587...56,774,081
Ensembl chr 8:56,747,620...56,774,078

G

Harvey rat sarcoma virus oncogene

decreases localization
increases expression

zoledronic acid results in decreased localization of HRAS protein
zoledronic acid results in increased expression of HRAS protein

PMID:11986784 PMID:28871336

NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918

G

heparan sulfate (glucosamine) 3-O-sulfotransferase 1

increases expression

zoledronic acid results in increased expression of HS3ST1 mRNA

NCBI chr 5:39,771,278...39,802,791
Ensembl chr 5:39,771,278...39,912,818

G

heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1

increases expression

zoledronic acid results in increased expression of HS3ST3A1 mRNA

NCBI chr11:64,326,158...64,413,667
Ensembl chr11:64,326,158...64,413,667

G

heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1

decreases expression

zoledronic acid results in decreased expression of HS3ST3B1 mRNA

NCBI chr11:63,775,519...63,813,110
Ensembl chr11:63,776,618...63,813,116

G

hydroxysteroid 11-beta dehydrogenase 1

increases expression

zoledronic acid results in increased expression of HSD11B1 mRNA

NCBI chr 1:192,903,917...192,946,345
Ensembl chr 1:192,903,942...192,946,383

G

hydroxysteroid 11-beta dehydrogenase 2

decreases expression

zoledronic acid results in decreased expression of HSD11B2 mRNA

NCBI chr 8:106,245,378...106,250,620
Ensembl chr 8:106,245,387...106,250,620

G

hydroxysteroid (17-beta) dehydrogenase 2

increases expression

zoledronic acid results in increased expression of HSD17B2 mRNA

NCBI chr 8:118,427,752...118,485,767
Ensembl chr 8:118,428,643...118,485,766

G

hydroxysteroid (17-beta) dehydrogenase 4

decreases expression

zoledronic acid results in decreased expression of HSD17B4 mRNA

NCBI chr18:50,261,268...50,329,337
Ensembl chr18:50,261,268...50,329,336

G

heat shock protein 12A

decreases expression

zoledronic acid results in decreased expression of HSPA12A mRNA

NCBI chr19:58,784,182...58,932,104
Ensembl chr19:58,784,182...58,932,086

G

heat shock protein 2

increases expression

zoledronic acid results in increased expression of HSPA2 protein

NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712

G

heat shock protein 5

increases expression
decreases expression

zoledronic acid results in increased expression of HSPA5 mRNA
Zoledronic Acid results in decreased expression of HSPA5 mRNA; Zoledronic Acid results in decreased expression of HSPA5 protein

PMID:25596134 PMID:35587103

NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559

G

heat shock protein 8

increases expression

zoledronic acid results in increased expression of HSPB8 mRNA

NCBI chr 5:116,546,550...116,560,923
Ensembl chr 5:116,546,550...116,560,923

G

5 hydroxytryptamine (serotonin) receptor 4

increases expression

zoledronic acid results in increased expression of HTR4 mRNA

NCBI chr18:62,456,618...62,636,098
Ensembl chr18:62,457,275...62,629,648

G

HtrA serine peptidase 1

decreases expression

zoledronic acid results in decreased expression of HTRA1 mRNA

NCBI chr 7:130,537,933...130,587,388
Ensembl chr 7:130,537,841...130,587,390

G

integrin binding sialoprotein

multiple interactions
increases expression

[zoledronic acid results in decreased geranoylation of RHOA protein] which results in increased expression of IBSP mRNA; geranylgeraniol inhibits the reaction [zoledronic acid results in increased expression of IBSP mRNA]; zoledronic acid inhibits the reaction [RHOA protein results in decreased expression of IBSP mRNA]; zoledronic acid results in increased expression of and results in decreased degradation of IBSP mRNA
zoledronic acid results in increased expression of IBSP protein

NCBI chr 5:104,447,153...104,459,338
Ensembl chr 5:104,447,037...104,459,335

G

intercellular adhesion molecule 1

increases expression

zoledronic acid results in increased expression of ICAM1 protein

NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113

G

icos ligand

increases expression

zoledronic acid results in increased expression of ICOSLG mRNA

NCBI chr10:77,904,921...77,915,359
Ensembl chr10:77,905,136...77,919,747

G

inhibitor of DNA binding 1, HLH protein

multiple interactions

zoledronic acid promotes the reaction [Gossypol results in decreased expression of ID1 mRNA]

NCBI chr 2:152,578,171...152,579,330
Ensembl chr 2:152,578,171...152,579,330

G

inhibitor of DNA binding 3

increases expression

zoledronic acid results in increased expression of ID3 mRNA

NCBI chr 4:135,871,133...135,872,703
Ensembl chr 4:135,870,808...135,873,066

G

inhibitor of DNA binding 4

increases expression

zoledronic acid results in increased expression of ID4 mRNA

NCBI chr13:48,414,592...48,419,504
Ensembl chr13:48,414,704...48,419,502

G

isocitrate dehydrogenase 2 (NADP+), mitochondrial

decreases expression
increases expression

zoledronic acid results in decreased expression of IDH2 mRNA
zoledronic acid results in increased expression of IDH2 protein

PMID:24714768 PMID:28871336

NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140

G

isopentenyl-diphosphate delta isomerase

increases expression

zoledronic acid results in increased expression of IDI1 mRNA

PMID:18325729 PMID:24714768

NCBI chr13:8,935,642...8,942,432
Ensembl chr13:8,935,537...8,942,487

G

indoleamine 2,3-dioxygenase 1

increases expression

zoledronic acid results in increased expression of IDO1 mRNA; zoledronic acid results in increased expression of INDO mRNA

NCBI chr 8:25,074,148...25,086,987
Ensembl chr 8:25,074,152...25,087,025

G

immediate early response 5

increases expression

zoledronic acid results in increased expression of IER5 mRNA

NCBI chr 1:154,972,113...154,975,382
Ensembl chr 1:154,972,107...154,975,382

G

intermediate filament family orphan 2

increases expression

zoledronic acid results in increased expression of IFFO2 mRNA

NCBI chr 4:139,257,859...139,347,693
Ensembl chr 4:139,257,859...139,347,693

G

interferon, alpha-inducible protein 27

increases expression

zoledronic acid results in increased expression of IFI27 mRNA

NCBI chr12:103,400,448...103,406,504
Ensembl chr12:103,400,470...103,406,498

G

interferon gamma

multiple interactions
increases expression

zoledronic acid promotes the reaction [IL2 protein affects the expression of IFNG protein]
zoledronic acid results in increased expression of IFNG protein

PMID:19400555 PMID:19818098

NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797

G

interferon gamma receptor 1

increases expression

zoledronic acid results in increased expression of IFNGR1 mRNA

NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977

G

intraflagellar transport 81

decreases expression

zoledronic acid results in decreased expression of IFT81 mRNA

NCBI chr 5:122,678,328...122,752,614
Ensembl chr 5:122,688,267...122,752,581

G

insulin-like growth factor 1

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of IGF1 mRNA

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor binding protein 5

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of IGFBP5 mRNA

NCBI chr 1:72,897,224...72,914,024
Ensembl chr 1:72,897,091...72,914,043

G

inhibitor of kappaB kinase epsilon

increases expression

zoledronic acid results in increased expression of IKBKE mRNA

NCBI chr 1:131,182,337...131,207,339
Ensembl chr 1:131,182,080...131,207,344

G

IKAROS family zinc finger 5

decreases expression

zoledronic acid results in decreased expression of IKZF5 mRNA

NCBI chr 7:130,990,378...131,012,243
Ensembl chr 7:130,990,381...131,012,250

G

interleukin 10

decreases expression

zoledronic acid results in decreased expression of IL10 protein

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 10 receptor, alpha

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of IL10RA mRNA

NCBI chr 9:45,165,135...45,180,447
Ensembl chr 9:45,165,135...45,180,447

G

interleukin 13 receptor, alpha 2

increases expression

zoledronic acid results in increased expression of IL13RA2 mRNA

NCBI chr X:146,166,474...146,214,982
Ensembl chr X:146,166,472...146,212,188

G

interleukin 17 receptor B

decreases expression

zoledronic acid results in decreased expression of IL17RB mRNA

PMID:24714768 PMID:25596134

NCBI chr14:29,718,125...29,730,853
Ensembl chr14:29,718,092...29,730,853

G

interleukin 18 receptor 1

increases expression

zoledronic acid results in increased expression of IL18R1 mRNA

NCBI chr 1:40,504,712...40,540,014
Ensembl chr 1:40,504,712...40,540,014

G

interleukin 19

increases expression
increases secretion

zoledronic acid results in increased expression of IL19 mRNA
zoledronic acid results in increased secretion of IL19 protein

NCBI chr 1:130,860,393...130,873,194
Ensembl chr 1:130,860,393...130,867,852

G

interleukin 1 beta

increases expression

zoledronic acid results in increased expression of IL1B mRNA

PMID:24714768 PMID:28871336

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 1 receptor, type I

increases expression

zoledronic acid results in increased expression of IL1R1 mRNA

NCBI chr 1:40,261,651...40,355,361
Ensembl chr 1:40,264,240...40,356,417

G

interleukin 1 receptor, type II

decreases expression

zoledronic acid results in decreased expression of IL1R2 mRNA

NCBI chr 1:40,123,872...40,164,390
Ensembl chr 1:40,113,239...40,164,391

G

interleukin 2

multiple interactions

IL2 protein affects the reaction [zoledronic acid affects the expression of GZMB mRNA]; zoledronic acid promotes the reaction [IL2 protein affects the expression of IFNG protein]

PMID:19400555 PMID:19446661

NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108

G

interleukin 23, alpha subunit p19

increases expression

zoledronic acid results in increased expression of IL23A mRNA

NCBI chr10:128,132,009...128,133,953
Ensembl chr10:128,132,008...128,134,621

G

interleukin 2 receptor, gamma chain

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of IL2RG mRNA

NCBI chr X:100,307,991...100,311,861
Ensembl chr X:100,307,984...100,311,861

G

interleukin 36G

increases expression

Zoledronic Acid results in increased expression of IL36G mRNA

NCBI chr 2:24,076,488...24,083,579
Ensembl chr 2:24,076,488...24,083,580

G

interleukin 4 induced 1

increases expression

zoledronic acid results in increased expression of IL4I1 mRNA

NCBI chr 7:44,485,712...44,490,233
Ensembl chr 7:44,465,811...44,490,233

G

interleukin 6

decreases expression
multiple interactions
increases expression

zoledronic acid results in decreased expression of IL6 mRNA; zoledronic acid results in decreased expression of IL6 protein
SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of IL6 mRNA]
zoledronic acid results in increased expression of IL6 mRNA; zoledronic acid results in increased expression of IL6 protein

PMID:9351880 PMID:18601766 PMID:28871336

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 7

decreases expression

zoledronic acid results in decreased expression of IL7 mRNA

NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820

G

inhibin beta-E

increases expression

zoledronic acid results in increased expression of INHBE mRNA

NCBI chr10:127,185,271...127,187,717
Ensembl chr10:127,184,726...127,190,280

G

insulin induced gene 1

increases expression

zoledronic acid results in increased expression of INSIG1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660

G

IQ motif containing D

increases expression

zoledronic acid results in increased expression of IQCD mRNA

NCBI chr 5:120,724,829...120,745,185
Ensembl chr 5:120,727,081...120,745,183

G

interleukin-1 receptor-associated kinase 2

increases expression

zoledronic acid results in increased expression of IRAK2 mRNA

NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987

G

iron responsive element binding protein 2

increases expression

zoledronic acid results in increased expression of IREB2 mRNA

NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814

G

interferon regulatory factor 2

increases expression

zoledronic acid results in increased expression of IRF2 mRNA

NCBI chr 8:47,192,751...47,300,493
Ensembl chr 8:47,192,767...47,300,493

G

interferon regulatory factor 2 binding protein 1

decreases expression

zoledronic acid results in decreased expression of IRF2BP1 mRNA

NCBI chr 7:18,737,983...18,740,688
Ensembl chr 7:18,737,969...18,740,702

G

interferon regulatory factor 2 binding protein-like

decreases expression

zoledronic acid results in decreased expression of IRF2BPL mRNA

NCBI chr12:86,927,477...86,931,588
Ensembl chr12:86,927,475...86,931,572

G

interferon regulatory factor 8

decreases expression

zoledronic acid results in decreased expression of IRF8 mRNA

NCBI chr 8:121,463,097...121,483,433
Ensembl chr 8:121,463,097...121,483,433

G

Iroquois related homeobox 3

decreases expression

zoledronic acid results in decreased expression of IRX3 mRNA

NCBI chr 8:92,525,139...92,528,282
Ensembl chr 8:92,525,153...92,528,695

G

isthmin 1, angiogenesis inhibitor

increases expression

zoledronic acid results in increased expression of ISM1 mRNA

NCBI chr 2:139,515,169...139,600,500
Ensembl chr 2:139,520,098...139,600,501

G

isthmin 2

decreases expression

zoledronic acid results in decreased expression of ISM2 mRNA

NCBI chr12:87,325,412...87,346,624
Ensembl chr12:87,325,412...87,346,479

G

integrin alpha FG-GAP repeat containing 2

decreases expression

zoledronic acid results in decreased expression of ITFG2 mRNA

NCBI chr 6:128,386,407...128,401,873
Ensembl chr 6:128,386,407...128,401,894

G

integrin alpha 1

increases expression

zoledronic acid results in increased expression of ITGA1 mRNA

NCBI chr13:115,094,615...115,238,500
Ensembl chr13:115,089,632...115,238,500

G

integrin beta 2

increases expression

zoledronic acid results in increased expression of ITGB2 mRNA

NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542

G

integrin beta 5

decreases expression

zoledronic acid results in decreased expression of ITGB5 mRNA

NCBI chr16:33,650,021...33,769,708
Ensembl chr16:33,650,035...33,769,708

G

inter-alpha trypsin inhibitor, heavy chain 3

increases expression

zoledronic acid results in increased expression of ITIH3 protein

NCBI chr14:30,630,529...30,645,748
Ensembl chr14:30,630,529...30,645,717

G

ITPR interacting domain containing 2

decreases expression

zoledronic acid results in decreased expression of ITPRID2 mRNA

NCBI chr 2:79,419,207...79,503,310
Ensembl chr 2:79,465,696...79,503,310

G

influenza virus NS1A binding protein

decreases expression

zoledronic acid results in decreased expression of IVNS1ABP mRNA

NCBI chr 1:151,220,237...151,240,196
Ensembl chr 1:151,220,228...151,240,173

G

iodotyrosine deiodinase

decreases expression

zoledronic acid results in decreased expression of IYD mRNA

NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877

G

IZUMO family member 4

increases expression

zoledronic acid results in increased expression of IZUMO4 mRNA

NCBI chr10:80,537,858...80,541,216
Ensembl chr10:80,538,018...80,541,207

G

Janus kinase 1

increases expression

zoledronic acid results in increased expression of JAK1 mRNA

NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479

G

Janus kinase 2

increases expression

zoledronic acid results in increased expression of JAK2 mRNA

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

Janus kinase 3

increases expression

zoledronic acid results in increased expression of JAK3 mRNA

NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219

G

Josephin domain containing 1

increases expression

zoledronic acid results in increased expression of JOSD1 mRNA

NCBI chr15:79,558,451...79,572,073
Ensembl chr15:79,558,452...79,572,120

G

K(lysine) acetyltransferase 2B

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of KAT2B mRNA

NCBI chr17:53,873,802...53,979,749
Ensembl chr17:53,873,889...53,979,748

G

kelch repeat and BTB (POZ) domain containing 2

increases expression

zoledronic acid results in increased expression of KBTBD2 mRNA

NCBI chr 6:56,754,510...56,774,798
Ensembl chr 6:56,754,509...56,774,798

G

potassium voltage-gated channel, subfamily H (eag-related), member 1

decreases expression

zoledronic acid results in decreased expression of KCNH1 mRNA

NCBI chr 1:191,871,759...192,192,467
Ensembl chr 1:191,873,082...192,192,467

G

potassium voltage-gated channel, subfamily H (eag-related), member 3

decreases expression

zoledronic acid results in decreased expression of KCNH3 mRNA

NCBI chr15:99,122,396...99,140,699
Ensembl chr15:99,122,742...99,140,698

G

Kv channel interacting protein 3, calsenilin

increases expression

zoledronic acid results in increased expression of KCNIP3 mRNA

NCBI chr 2:127,298,418...127,364,014
Ensembl chr 2:127,298,418...127,364,014

G

Kv channel interacting protein 4

decreases expression

zoledronic acid results in decreased expression of KCNIP4 mRNA

NCBI chr 5:48,546,845...49,682,464
Ensembl chr 5:48,546,844...49,682,249

G

potassium inwardly-rectifying channel, subfamily J, member 1

decreases expression

zoledronic acid results in decreased expression of KCNJ1 mRNA

NCBI chr 9:32,283,714...32,310,493
Ensembl chr 9:32,283,789...32,310,493

G

potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3

increases expression

zoledronic acid results in increased expression of KCNS3 mRNA

NCBI chr12:11,140,738...11,201,186
Ensembl chr12:11,140,203...11,201,057

G

potassium channel tetramerisation domain containing 5

increases expression

zoledronic acid results in increased expression of KCTD5 mRNA

NCBI chr17:24,266,694...24,292,459
Ensembl chr17:24,266,708...24,292,459

G

lysine (K)-specific demethylase 3A

increases expression

zoledronic acid results in increased expression of KDM3A mRNA

NCBI chr 6:71,565,954...71,609,963
Ensembl chr 6:71,565,956...71,609,974

G

kinesin family member 13A

decreases expression

zoledronic acid results in decreased expression of KIF13A protein

NCBI chr13:46,902,563...47,083,871
Ensembl chr13:46,902,563...47,083,343

G

kinesin family member 20A

decreases expression

zoledronic acid results in decreased expression of KIF20A mRNA

PMID:20977926 PMID:24714768

NCBI chr18:34,757,677...34,766,330
Ensembl chr18:34,757,666...34,766,330

G

kinesin family member 4

decreases expression

zoledronic acid results in decreased expression of KIF4A mRNA

NCBI chr X:99,669,693...99,770,878
Ensembl chr X:99,669,343...99,770,820

G

kinesin family member C1

decreases expression

Zoledronic Acid results in decreased expression of KIFC1 mRNA

NCBI chr17:34,094,640...34,109,607
Ensembl chr17:34,094,633...34,109,635

G

KIT proto-oncogene receptor tyrosine kinase

increases expression

zoledronic acid results in increased expression of KIT mRNA

NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382

G

kit ligand

decreases expression

zoledronic acid results in decreased expression of KITLG mRNA

NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278

G

Kruppel-like transcription factor 11

increases expression

zoledronic acid results in increased expression of KLF11 mRNA

PMID:20977926 PMID:24714768

NCBI chr12:24,701,370...24,712,781
Ensembl chr12:24,701,273...24,712,788

G

Kruppel-like transcription factor 7 (ubiquitous)

increases expression

zoledronic acid results in increased expression of KLF7 mRNA

NCBI chr 1:64,068,607...64,161,504
Ensembl chr 1:64,068,606...64,161,441

G

kelch-like 13

decreases expression

zoledronic acid results in decreased expression of KLHL13 mRNA

NCBI chr X:23,085,510...23,231,340
Ensembl chr X:23,085,510...23,231,321

G

kallikrein related-peptidase 10

increases expression

zoledronic acid results in increased expression of KLK10 mRNA

NCBI chr 7:43,430,478...43,434,834
Ensembl chr 7:43,430,459...43,434,834

G

kallikrein related-peptidase 6

decreases expression

zoledronic acid results in decreased expression of KLK6 mRNA

NCBI chr 7:43,473,967...43,481,219
Ensembl chr 7:43,473,923...43,481,454

G

killer cell lectin-like receptor subfamily G, member 2

increases expression

zoledronic acid results in increased expression of KLRG2 mRNA

NCBI chr 6:38,593,264...38,615,750
Ensembl chr 6:38,602,628...38,614,177

G

Kirsten rat sarcoma viral oncogene homolog

increases expression

zoledronic acid results in increased expression of KRAS protein

NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965

G

lysine-rich coiled-coil 1

increases expression

zoledronic acid results in increased expression of KRCC1 mRNA

NCBI chr 6:71,248,661...71,263,809
Ensembl chr 6:71,248,661...71,262,303

G

keratin 15

increases expression

zoledronic acid results in increased expression of KRT15 mRNA

NCBI chr11:100,022,585...100,026,775
Ensembl chr11:100,022,584...100,026,754

G

keratin 8

decreases expression

zoledronic acid results in decreased expression of KRT8 mRNA

NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917

G

keratin 80

decreases expression

zoledronic acid results in decreased expression of KRT80 mRNA

NCBI chr15:101,246,196...101,268,043
Ensembl chr15:101,245,325...101,268,043

G

keratin 81

decreases expression

zoledronic acid results in decreased expression of KRT81 mRNA

NCBI chr15:101,356,942...101,361,646
Ensembl chr15:101,356,942...101,361,632

G

kynureninase

increases expression

zoledronic acid results in increased expression of KYNU mRNA

NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734

G

L3MBTL3 histone methyl-lysine binding protein

decreases expression

zoledronic acid results in decreased expression of L3MBTL3 mRNA

NCBI chr10:26,150,361...26,252,426
Ensembl chr10:26,150,366...26,251,967

G

laminin, alpha 1

decreases expression

zoledronic acid results in decreased expression of LAMA1 mRNA

PMID:24714768 PMID:25596134

NCBI chr17:68,004,129...68,129,640
Ensembl chr17:68,004,254...68,129,642

G

laminin, alpha 3

increases expression

zoledronic acid results in increased expression of LAMA3 mRNA

PMID:20977926 PMID:24714768 PMID:25596134

NCBI chr18:12,466,806...12,716,070
Ensembl chr18:12,466,876...12,716,070

G

laminin, alpha 4

decreases expression

zoledronic acid results in decreased expression of LAMA4 mRNA

NCBI chr10:38,841,511...38,986,184
Ensembl chr10:38,841,511...38,986,184

G

laminin, alpha 5

multiple interactions

[zoledronic acid co-treated with Gossypol] results in decreased expression of LAMA5 mRNA

NCBI chr 2:179,818,166...179,867,652
Ensembl chr 2:179,818,166...179,867,652

G

laminin B1

decreases expression

zoledronic acid results in decreased expression of LAMB1 mRNA

NCBI chr12:31,315,230...31,379,643
Ensembl chr12:31,315,233...31,379,643

G

laminin, beta 3

increases expression

zoledronic acid results in increased expression of LAMB3 mRNA

NCBI chr 1:192,976,661...193,026,186
Ensembl chr 1:192,890,007...193,026,186

G

laminin, gamma 2

increases expression

zoledronic acid results in increased expression of LAMC2 mRNA

NCBI chr 1:152,998,502...153,062,193
Ensembl chr 1:152,998,502...153,062,193

G

lysosomal-associated membrane protein 1

decreases expression

zoledronic acid results in decreased expression of LAMP1 protein

NCBI chr 8:13,209,161...13,225,338
Ensembl chr 8:13,209,161...13,225,338

G

limb-bud and heart

increases expression

zoledronic acid results in increased expression of LBH mRNA

NCBI chr17:73,225,300...73,248,941
Ensembl chr17:73,225,300...73,248,942

G

lipocalin 2

increases expression
increases secretion

zoledronic acid results in increased expression of LCN2 mRNA
zoledronic acid results in increased secretion of LCN2 protein

NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264

G

lymphocyte cytosolic protein 1

increases expression

zoledronic acid results in increased expression of LCP1 mRNA

NCBI chr14:75,368,570...75,468,282
Ensembl chr14:75,368,541...75,468,282

G

lipid droplet assembly factor 1

increases expression

Zoledronic Acid results in increased expression of LDAF1 mRNA

NCBI chr 7:119,701,599...119,720,212
Ensembl chr 7:119,701,576...119,720,215

G

LIM domain binding 2

increases expression

zoledronic acid results in increased expression of LDB2 mRNA

NCBI chr 5:44,593,292...44,957,466
Ensembl chr 5:44,629,474...44,957,022

G

low density lipoprotein receptor

increases expression

zoledronic acid results in increased expression of LDLR mRNA

NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215

G

regulator of NFKB signaling

decreases expression

zoledronic acid results in decreased expression of LDOC1 mRNA

NCBI chr X:60,753,217...60,754,556
Ensembl chr X:60,753,103...60,754,561

G

leucine-rich repeat LGI family, member 2

decreases expression

zoledronic acid results in decreased expression of LGI2 mRNA

NCBI chr 5:52,690,859...52,723,689
Ensembl chr 5:52,690,859...52,723,804

G

LHFPL tetraspan subfamily member 6

increases expression

zoledronic acid results in increased expression of LHFPL6 mRNA

NCBI chr 3:52,948,968...53,169,100
Ensembl chr 3:52,948,949...53,169,100

G

LIM homeobox protein 3

increases expression

zoledronic acid results in increased expression of LHX3 mRNA

NCBI chr 2:26,090,224...26,098,261
Ensembl chr 2:26,090,224...26,098,301

G

LIM and calponin homology domains 1

increases expression

zoledronic acid results in increased expression of LIMCH1 mRNA

NCBI chr 5:66,903,232...67,214,502
Ensembl chr 5:66,903,170...67,214,501

G

lin-52 DREAM MuvB core complex component

increases expression

zoledronic acid results in increased expression of LIN52 mRNA

NCBI chr12:84,497,965...84,593,293
Ensembl chr12:84,498,196...84,592,919

G

lines homolog 1

increases expression

zoledronic acid results in increased expression of LINS1 mRNA

NCBI chr 7:66,339,565...66,367,004
Ensembl chr 7:66,339,637...66,367,004

G

lipase, endothelial

increases expression

zoledronic acid results in increased expression of LIPG mRNA

NCBI chr18:75,072,393...75,095,380
Ensembl chr18:75,072,393...75,094,334

G

LPS-induced TN factor

increases expression

zoledronic acid results in increased expression of LITAF mRNA

NCBI chr16:10,777,137...10,810,985
Ensembl chr16:10,777,139...10,884,021

G

limb and CNS expressed 1

decreases expression

zoledronic acid results in decreased expression of LIX1 mRNA

NCBI chr17:17,622,948...17,679,649
Ensembl chr17:17,622,934...17,679,649

G

LLGL2 scribble cell polarity complex component

increases expression

zoledronic acid results in increased expression of LLGL2 mRNA

NCBI chr11:115,714,855...115,746,606
Ensembl chr11:115,714,875...115,746,606

G

lamin A

decreases expression
decreases farnesylation

zoledronic acid results in decreased expression of LMNA mRNA
zoledronic acid results in decreased farnesylation of LMNA protein

PMID:16996129 PMID:24714768

NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263

G

lamin B1

decreases expression
increases expression

zoledronic acid results in decreased expression of LMNB1 mRNA
zoledronic acid results in increased expression of LMNB1 protein

PMID:24714768 PMID:28871336

NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496

G

leucyl/cystinyl aminopeptidase

increases expression

zoledronic acid results in increased expression of LNPEP mRNA

NCBI chr17:17,747,985...17,846,303
Ensembl chr17:17,741,672...17,845,312

G

lysophosphatidic acid receptor 6

increases expression

zoledronic acid results in increased expression of P2RY5 mRNA

NCBI chr14:73,475,331...73,477,798
Ensembl chr14:73,475,335...73,480,734

G

lipin 1

increases expression

zoledronic acid results in increased expression of LPIN1 mRNA

NCBI chr12:16,585,670...16,697,020
Ensembl chr12:16,585,670...16,696,967

G

LRAT domain containing 1

decreases expression

Zoledronic Acid results in decreased expression of LRATD2 mRNA

PMID:24714768 PMID:25596134

NCBI chr15:60,690,845...60,697,954
Ensembl chr15:60,690,843...60,725,627

G

leucine-rich alpha-2-glycoprotein 1

increases expression

zoledronic acid results in increased expression of LRG1 mRNA

NCBI chr17:56,426,678...56,428,946
Ensembl chr17:56,426,678...56,429,001

G

low density lipoprotein receptor-related protein 3

decreases expression

zoledronic acid results in decreased expression of LRP3 mRNA

NCBI chr 7:34,900,303...34,914,770
Ensembl chr 7:34,899,452...34,914,923

G

leucine rich repeat containing 14

increases expression

zoledronic acid results in increased expression of LRRC14 mRNA

NCBI chr15:76,594,820...76,599,297
Ensembl chr15:76,594,823...76,601,899

G

leucine rich repeat containing 19

decreases expression

zoledronic acid results in decreased expression of LRRC19 mRNA

NCBI chr 4:94,523,958...94,538,381
Ensembl chr 4:94,524,890...94,538,381

G

leucine rich repeat containing 26

decreases expression

zoledronic acid results in decreased expression of LRRC26 mRNA

NCBI chr 2:25,179,923...25,181,205
Ensembl chr 2:25,179,927...25,181,192

G

leucine rich repeat containing 75B

decreases expression

zoledronic acid results in decreased expression of LRRC75B mRNA

NCBI chr10:75,385,953...75,396,532
Ensembl chr10:75,385,957...75,396,164

G

leucine-rich repeat kinase 2

decreases expression

zoledronic acid results in decreased expression of LRRK2 mRNA

NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323

G

lanosterol synthase

increases expression

zoledronic acid results in increased expression of LSS mRNA

PMID:18325729 PMID:24714768

NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972

G

lymphotoxin B

increases expression

zoledronic acid results in increased expression of LTB mRNA

NCBI chr17:35,413,483...35,415,281
Ensembl chr17:35,413,415...35,415,296

G

lymphotoxin B receptor

multiple interactions
increases expression

[Tretinoin co-treated with zoledronic acid] results in decreased expression of LTBR mRNA
zoledronic acid results in increased expression of LTBR mRNA

PMID:19036117 PMID:20349282

NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848

G

lactotransferrin

increases expression

zoledronic acid results in increased expression of LTF protein

NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835

G

leucine rich adaptor protein 1-like

decreases expression

zoledronic acid results in decreased expression of LURAP1L mRNA

NCBI chr 4:80,828,923...80,872,538
Ensembl chr 4:80,828,883...80,873,865

G

LYN proto-oncogene, Src family tyrosine kinase

increases expression

zoledronic acid results in increased expression of LYN mRNA

NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122

G

Ly6/Plaur domain containing 1

increases expression

zoledronic acid results in increased expression of LYPD1 mRNA

NCBI chr 1:125,795,359...125,841,134
Ensembl chr 1:125,795,359...125,840,838

G

LY6/PLAUR domain containing 6B

increases expression

zoledronic acid results in increased expression of LYPD6B mRNA

NCBI chr 2:49,677,380...49,838,861
Ensembl chr 2:49,677,700...49,838,861

G

leucine zipper, putative tumor suppressor 1

multiple interactions
decreases expression

[zoledronic acid co-treated with fluvastatin] results in increased expression of LZTS1 mRNA
zoledronic acid results in decreased expression of LZTS1 mRNA

PMID:16996129 PMID:24714768

NCBI chr 8:69,585,311...69,636,901
Ensembl chr 8:69,585,321...69,636,877

G

mannose-6-phosphate receptor, cation dependent

decreases expression

zoledronic acid results in decreased expression of M6PR protein

NCBI chr 6:122,285,679...122,294,639
Ensembl chr 6:122,285,679...122,294,639

G

MAF bZIP transcription factor B

increases expression

zoledronic acid results in increased expression of MAFB mRNA

NCBI chr 2:160,205,597...160,208,985
Ensembl chr 2:160,205,623...160,208,985

G

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)

increases expression

zoledronic acid results in increased expression of MAFF mRNA

NCBI chr15:79,230,813...79,243,278
Ensembl chr15:79,230,821...79,243,276

G

MALT1 paracaspase

increases expression

zoledronic acid results in increased expression of MALT1 mRNA

NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138

G

mannosidase, alpha, class 1C, member 1

decreases expression

zoledronic acid results in decreased expression of MAN1C1 mRNA

NCBI chr 4:134,289,001...134,432,987
Ensembl chr 4:134,289,001...134,431,601

G

microtubule-associated protein 2

decreases expression

zoledronic acid results in decreased expression of MAP2 mRNA

NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742

G

mitogen-activated protein kinase kinase kinase 2

decreases expression

zoledronic acid results in decreased expression of MAP3K2 mRNA

NCBI chr18:32,296,142...32,369,804
Ensembl chr18:32,296,142...32,369,804

G

mitogen-activated protein kinase kinase kinase 8

increases expression

zoledronic acid results in increased expression of MAP3K8 mRNA

PMID:24714768 PMID:25596134

NCBI chr18:4,331,325...4,352,978
Ensembl chr18:4,331,327...4,353,015

G

MAP7 domain containing 3

increases expression

zoledronic acid results in increased expression of MAP7D3 mRNA

NCBI chr X:55,840,193...55,867,866
Ensembl chr X:55,843,218...55,867,686

G

mitogen-activated protein kinase 1

decreases phosphorylation
increases phosphorylation
multiple interactions

zoledronic acid results in decreased phosphorylation of MAPK1 protein
zoledronic acid results in increased phosphorylation of MAPK1 protein
[Zoledronic Acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased phosphorylation of MAPK1 protein; CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Gefitinib promotes the reaction [[Zoledronic Acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased phosphorylation of MAPK1 protein]; Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of MAPK1 protein

PMID:12799645 PMID:16322342 PMID:16996129 PMID:17059425 PMID:19530242

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 10

decreases expression

zoledronic acid results in decreased expression of MAPK10 mRNA

NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation
decreases phosphorylation

[Zoledronic Acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased phosphorylation of MAPK3 protein; CCN1 protein affects the reaction [Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Gefitinib promotes the reaction [[Zoledronic Acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased phosphorylation of MAPK3 protein]; Zoledronic Acid results in decreased phosphorylation of and results in decreased activity of MAPK3 protein
zoledronic acid results in increased phosphorylation of MAPK3 protein
zoledronic acid results in decreased phosphorylation of MAPK3 protein

PMID:12799645 PMID:16322342 PMID:16996129 PMID:17059425 PMID:19530242

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions

zoledronic acid promotes the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

mitogen-activated protein kinase-activated protein kinase 3

decreases expression

zoledronic acid results in decreased expression of MAPKAPK3 mRNA

NCBI chr 9:107,132,125...107,167,082
Ensembl chr 9:107,132,126...107,167,076

G

membrane associated ring-CH-type finger 3

increases expression

Zoledronic Acid results in increased expression of MARCHF3 mRNA

NCBI chr18:56,894,788...57,058,587
Ensembl chr18:56,894,788...57,058,620

G

myristoylated alanine rich protein kinase C substrate

increases expression

zoledronic acid results in increased expression of MARCKS mRNA

NCBI chr10:37,009,239...37,014,922
Ensembl chr10:37,009,371...37,014,916

G

microtubule associated serine/threonine kinase family member 4

increases expression

zoledronic acid results in increased expression of MAST4 mRNA

NCBI chr13:102,868,996...103,471,607
Ensembl chr13:102,868,994...103,471,005

G

matrilin 3

decreases expression

zoledronic acid results in decreased expression of MATN3 mRNA

NCBI chr12:8,997,929...9,022,028
Ensembl chr12:8,997,929...9,022,028

G

Max protein

increases expression

zoledronic acid results in increased expression of MAX mRNA

NCBI chr12:76,984,045...77,009,123
Ensembl chr12:76,984,043...77,008,975

G

Mab-21 domain containing 2

increases expression

zoledronic acid results in increased expression of MB21D2 mRNA

NCBI chr16:28,644,928...28,748,802
Ensembl chr16:28,644,928...28,748,425

G

MAP3K12 binding inhibitory protein 1

increases expression

zoledronic acid results in increased expression of MBIP mRNA

NCBI chr12:56,375,091...56,392,681
Ensembl chr12:56,375,088...56,392,679

G

membrane-bound transcription factor peptidase, site 2

increases expression

zoledronic acid results in increased expression of MBTPS2 mRNA

NCBI chr X:156,330,818...156,381,711
Ensembl chr X:156,318,367...156,381,711

G

myeloid cell leukemia sequence 1

multiple interactions

[Tretinoin co-treated with zoledronic acid] results in decreased expression of MCL1 mRNA

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

minichromosome maintenance 10 replication initiation factor

decreases expression

zoledronic acid results in decreased expression of MCM10 mRNA

NCBI chr 2:4,995,535...5,017,602
Ensembl chr 2:4,994,525...5,017,602

G

minichromosome maintenance complex component 2

multiple interactions
decreases expression

[zoledronic acid co-treated with docetaxel] results in decreased expression of MCM2 protein
zoledronic acid results in decreased expression of MCM2 protein

PMID:17562444 PMID:28871336

NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762

G

minichromosome maintenance complex component 4

increases expression

zoledronic acid results in increased expression of MCM4 mRNA

NCBI chr16:15,441,761...15,455,264
Ensembl chr16:15,441,761...15,455,264

G

minichromosome maintenance complex component 6

decreases expression

zoledronic acid results in decreased expression of MCM6 mRNA

NCBI chr 1:128,259,312...128,287,442
Ensembl chr 1:128,259,327...128,287,401

G

mitochondrial calcium uniporter regulator 1

increases expression

zoledronic acid results in increased expression of MCUR1 mRNA

NCBI chr13:43,691,882...43,714,284
Ensembl chr13:43,691,869...43,713,667

G

midkine

multiple interactions

zoledronic acid promotes the reaction [Gossypol results in decreased expression of MDK mRNA]

NCBI chr 2:91,760,149...91,762,348
Ensembl chr 2:91,760,150...91,762,642

G

transformed mouse 3T3 cell double minute 4

increases expression

zoledronic acid results in increased expression of MDM4 mRNA

NCBI chr 1:132,913,843...132,958,325
Ensembl chr 1:132,887,222...132,958,299

G

malic enzyme 1, NADP(+)-dependent, cytosolic

increases expression

zoledronic acid results in increased expression of ME1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 9:86,463,416...86,577,967
Ensembl chr 9:86,463,424...86,578,006

G

MDS1 and EVI1 complex locus

decreases expression

Zoledronic Acid results in decreased expression of MECOM mRNA

NCBI chr 3:30,005,445...30,563,937
Ensembl chr 3:30,005,445...30,602,157

G

mediator complex subunit 13-like

decreases expression

zoledronic acid results in decreased expression of MED13L mRNA

NCBI chr 5:118,698,363...118,903,503
Ensembl chr 5:118,698,744...118,903,503

G

mediator complex subunit 20

increases expression

zoledronic acid results in increased expression of MED20 mRNA

NCBI chr17:47,922,510...47,935,176
Ensembl chr17:47,922,507...47,935,343

G

mediator complex subunit 23

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of MED23 mRNA

NCBI chr10:24,745,889...24,789,358
Ensembl chr10:24,745,884...24,789,579

G

multiple EGF-like-domains 11

increases expression

zoledronic acid results in increased expression of MEGF11 mRNA

NCBI chr 9:64,291,556...64,618,584
Ensembl chr 9:64,292,908...64,616,487

G

maternal embryonic leucine zipper kinase

decreases expression

zoledronic acid results in decreased expression of MELK mRNA

NCBI chr 4:44,300,876...44,364,301
Ensembl chr 4:44,300,876...44,364,675

G

meteorin, glial cell differentiation regulator-like

decreases expression

zoledronic acid results in decreased expression of METRNL mRNA

NCBI chr11:121,593,253...121,608,215
Ensembl chr11:121,592,370...121,607,132

G

mex3 RNA binding family member C

increases expression

zoledronic acid results in increased expression of MEX3C mRNA

NCBI chr18:73,705,710...73,725,649
Ensembl chr18:73,706,115...73,725,646

G

major facilitator superfamily domain containing 4A

decreases expression

zoledronic acid results in decreased expression of MFSD4A mRNA

NCBI chr 1:131,947,543...131,997,400
Ensembl chr 1:131,950,544...131,995,800

G

mannoside acetylglucosaminyltransferase 3

increases expression

zoledronic acid results in increased expression of MGAT3 mRNA

NCBI chr15:80,057,852...80,099,720
Ensembl chr15:80,057,922...80,099,720

G

microsomal glutathione S-transferase 1

decreases expression

zoledronic acid results in decreased expression of MGST1 mRNA

NCBI chr 6:138,117,525...138,133,753
Ensembl chr 6:138,117,314...138,133,753

G

midline 1

increases expression

zoledronic acid results in increased expression of MID1 mRNA

NCBI chr X:168,468,178...168,773,692
Ensembl chr X:168,468,195...168,773,794

G

misshapen-like kinase 1 (zebrafish)

decreases expression

zoledronic acid results in decreased expression of MINK1 mRNA

NCBI chr11:70,452,272...70,505,309
Ensembl chr11:70,453,707...70,505,309

G

Mir22 host gene (non-protein coding)

decreases expression

zoledronic acid results in decreased expression of MIR22HG mRNA

NCBI chr11:75,352,365...75,357,516
Ensembl chr11:75,352,365...75,357,502

G

microRNA 302c

increases expression

Zoledronic Acid results in increased expression of MIR302C mRNA

NCBI chr 3:127,339,012...127,339,079
Ensembl chr 3:127,339,012...127,339,079

G

antigen identified by monoclonal antibody Ki 67

multiple interactions

[zoledronic acid co-treated with Doxorubicin] results in decreased expression of MKI67 protein

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11

decreases expression

zoledronic acid results in decreased expression of MLLT11 mRNA

NCBI chr 3:95,125,852...95,139,486
Ensembl chr 3:95,126,446...95,139,482

G

membrane metallo-endopeptidase-like 1

increases expression

zoledronic acid results in increased expression of MMEL1 mRNA

NCBI chr 4:154,954,042...154,979,987
Ensembl chr 4:154,954,042...154,979,985

G

matrix metallopeptidase 10

increases expression

zoledronic acid results in increased expression of MMP10 mRNA

NCBI chr 9:7,502,343...7,510,243
Ensembl chr 9:7,502,353...7,510,241

G

matrix metallopeptidase 2

decreases expression

zoledronic acid results in decreased expression of MMP2 protein

NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048

G

matrix metallopeptidase 23

increases expression

zoledronic acid results in increased expression of MMP23B mRNA

NCBI chr 4:155,735,111...155,738,982
Ensembl chr 4:155,735,112...155,737,841

G

matrix metallopeptidase 9

multiple interactions

zoledronic acid results in decreased expression of and results in decreased activity of MMP9 protein

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

molybdenum cofactor synthesis 1

increases expression

zoledronic acid results in increased expression of MOCS1 mRNA

NCBI chr17:49,735,378...49,762,463
Ensembl chr17:49,735,390...49,762,463

G

MON2 homolog, regulator of endosome to Golgi trafficking

increases expression

zoledronic acid results in increased expression of MON2 protein

NCBI chr10:122,827,965...122,913,684
Ensembl chr10:122,827,965...122,912,410

G

monooxygenase, DBH-like 1

increases expression

zoledronic acid results in increased expression of MOXD1 mRNA

NCBI chr10:24,099,415...24,178,681
Ensembl chr10:24,099,415...24,178,688

G

mitochondrial pyruvate carrier 2

decreases expression

zoledronic acid results in decreased expression of MPC2 mRNA

NCBI chr 1:165,288,829...165,308,787
Ensembl chr 1:165,288,206...165,308,783

G

mannose-P-dolichol utilization defect 1

increases expression

zoledronic acid results in increased expression of MPDU1 mRNA

NCBI chr11:69,547,523...69,553,475
Ensembl chr11:69,547,523...69,553,468

G

M-phase phosphoprotein 8

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of MPHOSPH8 mRNA

NCBI chr14:56,905,692...56,934,887
Ensembl chr14:56,905,705...56,934,887

G

myelin protein zero-like 2

increases expression

zoledronic acid results in increased expression of MPZL2 mRNA

NCBI chr 9:44,951,595...44,965,341
Ensembl chr 9:44,951,097...44,965,313

G

melanoregulin

increases expression

zoledronic acid results in increased expression of MREG mRNA

NCBI chr 1:72,198,392...72,251,418
Ensembl chr 1:72,198,601...72,251,466

G

myocardin related transcription factor A

increases expression

zoledronic acid results in increased expression of MRTFA mRNA

NCBI chr15:80,896,482...81,074,937
Ensembl chr15:80,896,482...81,074,958

G

mutS homolog 2

decreases expression
affects localization

zoledronic acid results in decreased expression of MSH2 protein
zoledronic acid affects the localization of MSH2 protein

NCBI chr17:87,979,960...88,031,141
Ensembl chr17:87,979,758...88,031,141

G

mutS homolog 3

increases expression

zoledronic acid results in increased expression of MSH3 mRNA

NCBI chr13:92,348,387...92,491,515
Ensembl chr13:92,348,380...92,491,511

G

methylsterol monoxygenase 1

increases expression

zoledronic acid results in increased expression of MSMO1 mRNA

NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826

G

metallothionein 2

increases expression

zoledronic acid results in increased expression of MT2A mRNA

PMID:24714768 PMID:25596134

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

metastasis associated 1

decreases expression

zoledronic acid results in decreased expression of MTA1 protein

NCBI chr12:113,061,830...113,100,826
Ensembl chr12:113,061,898...113,100,826

G

mitochondrial transcription termination factor 4

increases expression

zoledronic acid results in increased expression of MTERF4 mRNA

NCBI chr 1:93,228,927...93,233,601
Ensembl chr 1:93,226,933...93,233,637

G

mitochondrial poly(A) polymerase

increases expression

zoledronic acid results in increased expression of MTPAP mRNA

NCBI chr18:4,375,573...4,399,888
Ensembl chr18:4,375,592...4,397,330

G

maturin, neural progenitor differentiation regulator homolog (Xenopus)

decreases expression

zoledronic acid results in decreased expression of MTURN mRNA

NCBI chr 6:54,658,609...54,680,840
Ensembl chr 6:54,658,609...54,680,836

G

muscle, skeletal, receptor tyrosine kinase

decreases expression

zoledronic acid results in decreased expression of MUSK mRNA

NCBI chr 4:58,285,742...58,377,848
Ensembl chr 4:58,285,962...58,374,303

G

mevalonate (diphospho) decarboxylase

increases expression

zoledronic acid results in increased expression of MVD mRNA

NCBI chr 8:123,160,335...123,170,161
Ensembl chr 8:123,160,340...123,170,161

G

mevalonate kinase

increases expression

zoledronic acid results in increased expression of MVK mRNA

NCBI chr 5:114,582,324...114,598,652
Ensembl chr 5:114,582,330...114,598,652

G

major vault protein

decreases expression
increases expression

zoledronic acid results in decreased expression of MVP mRNA
zoledronic acid results in increased expression of MVP mRNA

PMID:18225567 PMID:20977926

NCBI chr 7:126,586,036...126,613,729
Ensembl chr 7:126,586,032...126,613,793

G

matrix-remodelling associated 7

increases expression

zoledronic acid results in increased expression of MXRA7 mRNA

NCBI chr11:116,694,226...116,718,953
Ensembl chr11:116,693,888...116,718,872

G

myosin, light polypeptide 3

decreases expression

zoledronic acid results in decreased expression of MYL3 mRNA

NCBI chr 9:110,592,746...110,598,870
Ensembl chr 9:110,570,929...110,598,866

G

NEDD4 binding protein 2-like 1

increases expression

zoledronic acid results in increased expression of N4BP2L1 mRNA

NCBI chr 5:150,495,108...150,518,288
Ensembl chr 5:150,495,109...150,520,653

G

Ngfi-A binding protein 1

increases expression

zoledronic acid results in increased expression of NAB1 mRNA

NCBI chr 1:52,494,146...52,539,553
Ensembl chr 1:52,496,453...52,539,838

G

NLR family, apoptosis inhibitory protein 2

affects expression

zoledronic acid affects the expression of NAIP mRNA

NCBI chr13:100,280,571...100,338,630
Ensembl chr13:100,280,571...100,338,600

G

nicotinamide phosphoribosyltransferase

increases expression

zoledronic acid results in increased expression of NAMPT mRNA

PMID:24714768 PMID:25596134

NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348

G

nanos C2HC-type zinc finger 1

increases expression

zoledronic acid results in increased expression of NANOS1 mRNA

NCBI chr19:60,744,425...60,748,352
Ensembl chr19:60,744,425...60,748,352

G

N-acyl phosphatidylethanolamine phospholipase D

increases expression

zoledronic acid results in increased expression of NAPEPLD mRNA

NCBI chr 5:21,867,899...21,906,620
Ensembl chr 5:21,867,899...21,906,394

G

asparaginyl-tRNA synthetase 1

decreases expression

Zoledronic Acid results in decreased expression of NARS1 mRNA

NCBI chr18:64,632,726...64,649,586
Ensembl chr18:64,632,718...64,649,723

G

N-acetyltransferase 8 (GCN5-related)

decreases expression

zoledronic acid results in decreased expression of NAT8 mRNA

NCBI chr 6:85,807,369...85,813,839
Ensembl chr 6:85,807,370...85,809,064

G

N-acetyltransferase 8B, pseudogene

decreases expression

zoledronic acid results in decreased expression of NAT8B mRNA

NCBI chr 6:85,909,539...85,910,364
Ensembl chr 6:85,909,663...85,910,361

G

neuron navigator 1

decreases expression

zoledronic acid results in decreased expression of NAV1 mRNA

NCBI chr 1:135,362,318...135,616,082
Ensembl chr 1:135,362,318...135,615,843

G

neuron navigator 2

decreases expression

zoledronic acid results in decreased expression of NAV2 mRNA

NCBI chr 7:48,608,796...49,259,838
Ensembl chr 7:48,558,464...49,259,838

G

NBR1, autophagy cargo receptor

increases expression

zoledronic acid results in increased expression of NBR1 mRNA

NCBI chr11:101,442,933...101,472,777
Ensembl chr11:101,442,975...101,472,777

G

non-SMC condensin I complex, subunit G

decreases expression

zoledronic acid results in decreased expression of NCAPG mRNA

NCBI chr 5:45,827,212...45,858,491
Ensembl chr 5:45,827,261...45,857,888

G

non-catalytic region of tyrosine kinase adaptor protein 1

increases expression

zoledronic acid results in increased expression of NCK1 mRNA

NCBI chr 9:100,376,047...100,428,187
Ensembl chr 9:100,374,346...100,428,187

G

NCK-associated protein 5

increases expression

zoledronic acid results in increased expression of NCKAP5 mRNA

NCBI chr 1:125,841,373...126,758,529
Ensembl chr 1:125,841,357...126,758,536

G

nuclear receptor coactivator 7

increases expression

zoledronic acid results in increased expression of NCOA7 mRNA

NCBI chr10:30,521,578...30,683,401
Ensembl chr10:30,504,995...30,679,322

G

NDC80 kinetochore complex component

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of NDC80 mRNA

NCBI chr17:71,803,095...71,833,852
Ensembl chr17:71,803,095...71,833,852

G

nudE neurodevelopment protein 1

increases expression

zoledronic acid results in increased expression of NDE1 mRNA

NCBI chr16:13,981,139...14,010,792
Ensembl chr16:13,981,139...14,010,792

G

N-myc downstream regulated gene 4

increases expression

zoledronic acid results in increased expression of NDRG4 mRNA

NCBI chr 8:96,403,602...96,441,584
Ensembl chr 8:96,403,608...96,441,747

G

neurofilament, light polypeptide

decreases expression

zoledronic acid results in decreased expression of NEFL mRNA

NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544

G

neurofilament, medium polypeptide

decreases expression

zoledronic acid results in decreased expression of NEFM mRNA

NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295

G

NIMA (never in mitosis gene a)-related expressed kinase 2

decreases expression

zoledronic acid results in decreased expression of NEK2 mRNA

NCBI chr 1:191,553,622...191,565,161
Ensembl chr 1:191,553,556...191,565,162

G

nuclear envelope integral membrane protein 1

increases expression

zoledronic acid results in increased expression of NEMP1 mRNA

NCBI chr10:127,512,934...127,536,918
Ensembl chr10:127,502,770...127,536,918

G

neuralized E3 ubiquitin protein ligase 3

increases expression

zoledronic acid results in increased expression of LINCR mRNA

NCBI chr 1:36,303,683...36,313,755
Ensembl chr 1:36,303,678...36,313,760

G

nuclear factor, erythroid derived 2, like 2

increases expression

Zoledronic Acid results in increased expression of NFE2L2 mRNA

PMID:20977926 PMID:35587103

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor, erythroid derived 2, like 3

decreases expression

zoledronic acid results in decreased expression of NFE2L3 mRNA

NCBI chr 6:51,409,649...51,435,752
Ensembl chr 6:51,409,650...51,435,748

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100

increases expression

zoledronic acid results in increased expression of NFKB2 mRNA

NCBI chr19:46,285,478...46,300,839
Ensembl chr19:46,292,759...46,300,824

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

increases expression

zoledronic acid results in increased expression of NFKBIA mRNA

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

increases expression

zoledronic acid results in increased expression of NFKBIZ mRNA

NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262

G

NHS actin remodeling regulator

decreases expression

zoledronic acid results in decreased expression of NHS mRNA

NCBI chr X:160,616,286...160,942,437
Ensembl chr X:160,616,292...160,942,726

G

niban apoptosis regulator 1

increases expression

Zoledronic Acid results in increased expression of NIBAN1 mRNA

NCBI chr 1:151,447,215...151,597,690
Ensembl chr 1:151,446,937...151,597,690

G

NELL2 interacting cell ontogeny regulator 1

decreases expression

Zoledronic Acid results in decreased expression of NICOL1 mRNA

NCBI chr 5:34,140,863...34,142,353
Ensembl chr 5:34,140,777...34,142,357

G

nidogen 2

increases expression

zoledronic acid results in increased expression of NID2 mRNA

NCBI chr14:19,801,325...19,861,855
Ensembl chr14:19,801,333...19,861,855

G

ninjurin 1

decreases expression

zoledronic acid results in decreased expression of NINJ1 mRNA

NCBI chr13:49,341,005...49,349,727
Ensembl chr13:49,340,961...49,349,720

G

ninjurin 2

decreases expression

zoledronic acid results in decreased expression of NINJ2 mRNA

NCBI chr 6:120,070,315...120,177,300
Ensembl chr 6:120,070,311...120,177,300

G

NF-kappaB repressing factor

decreases expression

zoledronic acid results in decreased expression of NKRF mRNA

NCBI chr X:36,149,644...36,167,118
Ensembl chr X:36,151,193...36,167,166

G

nitric oxide synthase 2, inducible

multiple interactions
increases expression

[zoledronic acid results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide
zoledronic acid results in increased expression of NOS2 mRNA

PMID:19818098 PMID:24714768

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

nitric oxide synthase trafficker

decreases expression

zoledronic acid results in decreased expression of NOSTRIN mRNA

NCBI chr 2:68,966,144...69,019,674
Ensembl chr 2:68,966,144...69,019,674

G

notch 3

decreases expression

zoledronic acid results in decreased expression of NOTCH3 mRNA

NCBI chr17:32,339,794...32,385,869
Ensembl chr17:32,339,794...32,385,826

G

NADPH oxidase 4

increases expression

zoledronic acid results in increased expression of NOX4 protein

NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918

G

nuclear protein in the AT region

increases expression

zoledronic acid results in increased expression of NPAT mRNA

NCBI chr 9:53,448,347...53,486,867
Ensembl chr 9:53,448,347...53,485,642

G

NPC1 like intracellular cholesterol transporter 1

increases expression

zoledronic acid results in increased expression of NPC1L1 mRNA

NCBI chr11:6,161,011...6,180,245
Ensembl chr11:6,161,013...6,180,143

G

neuropeptide FF receptor 2

increases expression

zoledronic acid results in increased expression of NPFFR2 mRNA

NCBI chr 5:89,674,805...89,731,473
Ensembl chr 5:89,675,288...89,731,599

G

natriuretic peptide receptor 3

decreases expression

zoledronic acid results in decreased expression of NPR3 mRNA

NCBI chr15:11,839,982...11,907,287
Ensembl chr15:11,839,982...11,907,373

G

NAD(P)H dehydrogenase, quinone 1

decreases expression

zoledronic acid results in decreased expression of NQO1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 1, group H, member 4

decreases expression

zoledronic acid results in decreased expression of NR1H4 mRNA

NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447

G

neuronal cell adhesion molecule

increases expression

zoledronic acid results in increased expression of NRCAM mRNA

NCBI chr12:44,375,568...44,651,977
Ensembl chr12:44,375,668...44,648,747

G

neuronal regeneration related protein

increases expression

zoledronic acid results in increased expression of NREP mRNA

PMID:20977926 PMID:25596134

NCBI chr18:33,570,072...33,597,444
Ensembl chr18:33,570,072...33,597,082

G

neuregulin 1

decreases expression

zoledronic acid results in decreased expression of NRG1 mRNA

NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825

G

nuclear receptor interacting protein 3

increases expression

zoledronic acid results in increased expression of NRIP3 mRNA

NCBI chr 7:109,357,263...109,380,752
Ensembl chr 7:109,357,262...109,381,232

G

NAD(P) dependent steroid dehydrogenase-like

increases expression

zoledronic acid results in increased expression of NSDHL mRNA

NCBI chr X:71,962,127...72,002,134
Ensembl chr X:71,962,163...72,002,120

G

netrin 1

increases expression

zoledronic acid results in increased expression of NTN1 mRNA

NCBI chr11:68,100,190...68,277,652
Ensembl chr11:68,100,190...68,291,649

G

netrin G1

decreases expression

zoledronic acid results in decreased expression of NTNG1 mRNA

NCBI chr 3:109,687,366...110,057,291
Ensembl chr 3:109,687,356...110,051,327

G

nucleoside-triphosphatase, cancer-related

increases expression

zoledronic acid results in increased expression of NTPCR mRNA

NCBI chr 8:126,456,724...126,474,974
Ensembl chr 8:126,456,702...126,474,974

G

neurotrophic tyrosine kinase, receptor, type 2

increases expression

zoledronic acid results in increased expression of NTRK2 mRNA

NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784

G

nucleoporin 93

increases expression

zoledronic acid results in increased expression of NUP93 mRNA

NCBI chr 8:94,941,203...95,043,858
Ensembl chr 8:94,941,192...95,043,855

G

nucleoporin 98

decreases expression

zoledronic acid results in decreased expression of NUP98 mRNA

NCBI chr 7:101,768,607...101,859,359
Ensembl chr 7:101,768,605...101,859,383

G

nucleoredoxin-like 2

decreases expression

zoledronic acid results in decreased expression of NXNL2 mRNA

NCBI chr13:51,324,256...51,329,227
Ensembl chr13:51,325,058...51,329,224

G

nuclear transport factor 2-like export factor 2

increases expression

zoledronic acid results in increased expression of NXT2 mRNA

NCBI chr X:141,009,766...141,022,696
Ensembl chr X:141,009,766...141,022,688

G

oxoglutarate dehydrogenase-like

decreases expression

zoledronic acid results in decreased expression of OGDHL mRNA

NCBI chr14:32,043,941...32,070,108
Ensembl chr14:32,043,976...32,070,108

G

Opa interacting protein 5

decreases expression

zoledronic acid results in decreased expression of OIP5 mRNA

NCBI chr 2:119,440,013...119,448,986
Ensembl chr 2:119,439,993...119,448,950

G

olfactomedin 4

increases expression

zoledronic acid results in increased expression of OLFM4 mRNA

NCBI chr14:80,237,742...80,260,581
Ensembl chr14:80,221,521...80,260,579

G

oxidized low density lipoprotein (lectin-like) receptor 1

increases expression

zoledronic acid results in increased expression of OLR1 protein

NCBI chr 6:129,456,113...129,484,312
Ensembl chr 6:129,462,207...129,484,128

G

optineurin

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of OPTN mRNA

NCBI chr 2:5,023,902...5,069,210
Ensembl chr 2:5,025,453...5,068,862

G

olfactory receptor family 12 subfamily D member 2

increases expression

Zoledronic Acid results in increased expression of OR12D2 mRNA

NCBI chr17:37,624,302...37,625,328
Ensembl chr17:37,622,686...37,627,945

G

olfactory receptor family 2 subfamily H member 1

increases expression

Zoledronic Acid results in increased expression of OR2H1 mRNA

NCBI chr17:37,403,022...37,443,877
Ensembl chr17:37,401,510...37,409,170

G

olfactory receptor family 4 subfamily K member 15

increases expression

zoledronic acid results in increased expression of OR4K15 mRNA

NCBI chr14:50,364,010...50,365,044
Ensembl chr14:50,360,643...50,366,203

G

olfactory receptor family 51 subfamily B member 17

increases expression

zoledronic acid results in increased expression of OR51B2 mRNA

NCBI chr 7:103,542,017...103,543,678
Ensembl chr 7:103,538,692...103,543,692

G

olfactory receptor family 8 subfamily H member 9

increases expression

Zoledronic Acid results in increased expression of OR8H1 mRNA

NCBI chr 2:86,788,862...86,789,800
Ensembl chr 2:86,785,470...86,791,037

G

origin recognition complex, subunit 2

decreases expression

zoledronic acid results in decreased expression of ORC2 protein

NCBI chr 1:58,501,933...58,544,114
Ensembl chr 1:58,501,930...58,544,268

G

O-sialoglycoprotein endopeptidase-like 1

decreases expression

zoledronic acid results in decreased expression of OSGEPL1 mRNA

NCBI chr 1:53,352,070...53,365,502
Ensembl chr 1:53,352,783...53,365,502

G

oxidative stress induced growth inhibitor 1

decreases expression

zoledronic acid results in decreased expression of OSGIN1 mRNA

NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995

G

oviductal glycoprotein 1

increases expression

zoledronic acid results in increased expression of OVGP1 mRNA

NCBI chr 3:105,881,118...105,894,739
Ensembl chr 3:105,881,027...105,894,739

G

purinergic receptor P2X, ligand-gated ion channel 4

increases expression

zoledronic acid results in increased expression of P2RX4 mRNA

NCBI chr 5:122,845,581...122,867,802
Ensembl chr 5:122,845,607...122,867,801

G

prolyl 3-hydroxylase 2

decreases expression

zoledronic acid results in decreased expression of P3H2 mRNA

NCBI chr16:25,778,034...25,924,563
Ensembl chr16:25,778,038...25,924,534

G

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide

increases expression

zoledronic acid results in increased expression of P4HA1 mRNA

NCBI chr10:59,159,019...59,209,126
Ensembl chr10:59,159,118...59,209,126

G

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide

increases expression

zoledronic acid results in increased expression of P4HA2 mRNA

NCBI chr11:53,991,750...54,022,494
Ensembl chr11:53,990,921...54,022,491

G

prolyl 4-hydroxylase, beta polypeptide

increases expression

zoledronic acid results in increased expression of P4HB mRNA

NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079

G

paralemmin

decreases expression

zoledronic acid results in decreased expression of PALM mRNA

NCBI chr10:79,629,406...79,656,749
Ensembl chr10:79,629,406...79,656,730

G

protein associated with LIN7 1, MAGUK family member

multiple interactions

[Zoledronic Acid co-treated with Fluvastatin] results in increased expression of PALS1 mRNA

NCBI chr12:78,795,606...78,887,488
Ensembl chr12:78,795,681...78,887,488

G

pantothenate kinase 1

decreases expression

zoledronic acid results in decreased expression of PANK1 mRNA

PMID:24714768 PMID:25596134

NCBI chr19:34,784,335...34,862,420
Ensembl chr19:34,784,340...34,856,855

G

pregnancy-associated plasma protein A

decreases expression

zoledronic acid results in decreased expression of PAPPA mRNA

NCBI chr 4:65,041,993...65,276,776
Ensembl chr 4:65,042,411...65,275,746

G

pappalysin 2

multiple interactions
decreases expression

[zoledronic acid co-treated with fluvastatin] results in increased expression of PAPPA2 mRNA
zoledronic acid results in decreased expression of PAPPA2 mRNA

PMID:16996129 PMID:24714768

NCBI chr 1:158,539,297...158,788,019
Ensembl chr 1:158,539,297...158,808,060

G

progestin and adipoQ receptor family member V

decreases expression

zoledronic acid results in decreased expression of PAQR5 mRNA

NCBI chr 9:61,861,020...61,934,085
Ensembl chr 9:61,860,763...61,934,138

G

progestin and adipoQ receptor family member VIII

increases expression

zoledronic acid results in increased expression of PAQR8 mRNA

NCBI chr 1:20,960,772...21,009,874
Ensembl chr 1:20,960,830...21,009,874

G

par-6 family cell polarity regulator alpha

decreases expression

zoledronic acid results in decreased expression of PARD6A mRNA

NCBI chr 8:106,427,780...106,430,126
Ensembl chr 8:106,427,780...106,430,128

G

prostate androgen-regulated mucin-like protein 1

increases expression

zoledronic acid results in increased expression of PARM1 mRNA

NCBI chr 5:91,665,559...91,771,870
Ensembl chr 5:91,665,474...91,774,753

G

poly (ADP-ribose) polymerase family, member 1

increases expression
multiple interactions
increases cleavage

zoledronic acid results in increased expression of PARP1 mRNA
arsenic trioxide promotes the reaction [zoledronic acid results in increased cleavage of PARP1 protein]

PMID:10780527 PMID:20977926 PMID:24714768

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

PDZ binding kinase

decreases expression

zoledronic acid results in decreased expression of PBK mRNA

NCBI chr14:66,043,337...66,055,271
Ensembl chr14:66,043,286...66,055,271

G

phenazine biosynthesis-like protein domain containing 1

decreases expression

zoledronic acid results in decreased expression of PBLD mRNA

NCBI chr10:62,896,404...62,913,743
Ensembl chr10:62,895,941...62,913,741

G

protocadherin 17

increases expression

zoledronic acid results in increased expression of PCDH17 mRNA

NCBI chr14:84,680,626...84,775,005
Ensembl chr14:84,681,003...84,776,442

G

protocadherin 20

decreases expression

zoledronic acid results in decreased expression of PCDH20 mRNA

NCBI chr14:88,702,183...88,708,832
Ensembl chr14:88,702,179...88,708,832

G

PC-esterase domain containing 1B

increases expression

zoledronic acid results in increased expression of PCED1B mRNA

NCBI chr15:97,143,563...97,283,574
Ensembl chr15:97,144,988...97,283,561

G

polycomb group ring finger 5

increases expression

zoledronic acid results in increased expression of PCGF5 mRNA

NCBI chr19:36,325,729...36,438,370
Ensembl chr19:36,325,709...36,438,370

G

PCNA clamp associated factor

decreases expression

zoledronic acid results in decreased expression of PCLAF mRNA

NCBI chr 9:65,797,605...65,810,833
Ensembl chr 9:65,797,519...65,810,548

G

procollagen C-endopeptidase enhancer 2

decreases expression

zoledronic acid results in decreased expression of PCOLCE2 mRNA

NCBI chr 9:95,519,681...95,577,604
Ensembl chr 9:95,519,654...95,580,149

G

proprotein convertase subtilisin/kexin type 9

increases expression

zoledronic acid results in increased expression of PCSK9 mRNA

NCBI chr 4:106,299,531...106,321,522
Ensembl chr 4:106,299,526...106,321,526

G

prenylcysteine oxidase 1

increases expression

zoledronic acid results in increased expression of PCYOX1 mRNA

NCBI chr 6:86,362,988...86,374,132
Ensembl chr 6:86,362,988...86,374,136

G

phosphodiesterase 1A, calmodulin-dependent

decreases expression

zoledronic acid results in decreased expression of PDE1A mRNA

NCBI chr 2:79,664,797...80,026,862
Ensembl chr 2:79,664,797...79,959,802

G

phosphodiesterase 4B, cAMP specific

decreases expression

zoledronic acid results in decreased expression of PDE4B mRNA

NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456

G

phosphodiesterase 5A, cGMP-specific

decreases expression

zoledronic acid results in decreased expression of PDE5A mRNA

NCBI chr 3:122,522,822...122,653,023
Ensembl chr 3:122,522,596...122,653,023

G

phosphodiesterase 7B

decreases expression

zoledronic acid results in decreased expression of PDE7B mRNA

NCBI chr10:20,272,798...20,600,824
Ensembl chr10:20,273,750...20,600,824

G

phosphodiesterase 8A

increases expression

zoledronic acid results in increased expression of PDE8A mRNA

NCBI chr 7:80,863,013...80,984,283
Ensembl chr 7:80,863,344...80,984,281

G

platelet derived growth factor, alpha

multiple interactions

[zoledronic acid co-treated with Gossypol] results in decreased expression of PDGFA mRNA

NCBI chr 5:138,961,761...138,986,336
Ensembl chr 5:138,961,769...138,983,125

G

platelet-derived growth factor, C polypeptide

decreases expression

zoledronic acid results in decreased expression of PDGFC mRNA

NCBI chr 3:80,943,723...81,121,347
Ensembl chr 3:80,943,723...81,121,347

G

platelet derived growth factor receptor, alpha polypeptide

increases expression

zoledronic acid results in increased expression of PDGFRA mRNA

NCBI chr 5:75,311,988...75,358,867
Ensembl chr 5:75,312,953...75,358,876

G

platelet-derived growth factor receptor-like

increases expression

zoledronic acid results in increased expression of PDGFRL mRNA

NCBI chr 8:41,379,270...41,443,819
Ensembl chr 8:41,379,249...41,443,822

G

pyruvate dehydrogenase (lipoamide) beta

increases expression

zoledronic acid results in increased expression of PDHB protein

NCBI chr14:14,296,470...14,303,782
Ensembl chr14:14,296,748...14,303,777

G

pyruvate dehydrogenase kinase, isoenzyme 4

decreases expression

zoledronic acid results in decreased expression of PDK4 mRNA

PMID:24714768 PMID:25596134

NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309

G

PDZ and LIM domain 7

increases expression

zoledronic acid results in increased expression of PDLIM7 mRNA

NCBI chr13:55,645,300...55,661,281
Ensembl chr13:55,643,608...55,661,489

G

PDZ domain containing 1

decreases expression

zoledronic acid results in decreased expression of PDZK1 mRNA

NCBI chr 3:96,736,772...96,778,242
Ensembl chr 3:96,736,600...96,778,242

G

PDZK1 interacting protein 1

increases expression

zoledronic acid results in increased expression of PDZK1IP1 mRNA

NCBI chr 4:114,945,905...114,951,091
Ensembl chr 4:114,945,905...114,951,096

G

proliferation and apoptosis adaptor protein 15A

increases expression

zoledronic acid results in increased expression of PEA15 mRNA

NCBI chr 1:172,024,295...172,034,298
Ensembl chr 1:172,024,295...172,034,371

G

platelet/endothelial cell adhesion molecule 1

multiple interactions

zoledronic acid promotes the reaction [[Imatinib Mesylate co-treated with Paclitaxel] results in decreased expression of PECAM1 protein]

NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454

G

pellino 1

increases expression

zoledronic acid results in increased expression of PELI1 mRNA

NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression

zoledronic acid results in increased expression of PFKFB4 mRNA

PMID:24714768 PMID:25596134

NCBI chr 9:108,817,336...108,861,302
Ensembl chr 9:108,820,846...108,861,296

G

peptidoglycan recognition protein 4

increases expression

zoledronic acid results in increased expression of PGLYRP4 mRNA

NCBI chr 3:90,634,008...90,648,824
Ensembl chr 3:90,634,213...90,648,824

G

phosphoglucomutase 5

decreases expression

zoledronic acid results in decreased expression of PGM5 mRNA

NCBI chr19:24,655,625...24,839,206
Ensembl chr19:24,660,380...24,839,219

G

phosphatase and actin regulator 1

increases expression

zoledronic acid results in increased expression of PHACTR1 mRNA

NCBI chr13:42,833,909...43,292,002
Ensembl chr13:42,834,099...43,292,002

G

3-phosphoglycerate dehydrogenase

decreases expression

zoledronic acid results in decreased expression of PHGDH mRNA

PMID:24714768 PMID:25596134

NCBI chr 3:98,220,487...98,247,285
Ensembl chr 3:98,220,486...98,247,306

G

pleckstrin homology like domain, family A, member 3

decreases expression

zoledronic acid results in decreased expression of PHLDA3 mRNA

NCBI chr 1:135,693,823...135,696,872
Ensembl chr 1:135,693,857...135,696,874

G

pleckstrin homology like domain, family B, member 1

decreases expression

zoledronic acid results in decreased expression of PHLDB1 mRNA

NCBI chr 9:44,597,605...44,649,800
Ensembl chr 9:44,597,601...44,646,495

G

phosphohistidine phosphatase 1

increases expression

zoledronic acid results in increased expression of PHPT1 mRNA

NCBI chr 2:25,463,442...25,465,528
Ensembl chr 2:25,463,442...25,465,236

G

polymeric immunoglobulin receptor

increases expression

zoledronic acid results in increased expression of PIGR mRNA

NCBI chr 1:130,754,421...130,779,986
Ensembl chr 1:130,754,421...130,779,986

G

phosphoinositide-3-kinase adaptor protein 1

increases expression

zoledronic acid results in increased expression of PIK3AP1 mRNA

NCBI chr19:41,260,980...41,373,541
Ensembl chr19:41,260,816...41,373,541

G

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

increases expression

zoledronic acid results in increased expression of PIK3C2A mRNA

NCBI chr 7:115,936,500...116,042,693
Ensembl chr 7:115,936,500...116,042,684

G

phosphoinositide-3-kinase regulatory subunit 1

increases expression

zoledronic acid results in increased expression of PIK3R1 mRNA

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

paired immunoglobin-like type 2 receptor alpha

increases expression

zoledronic acid results in increased expression of PILRA mRNA

NCBI chr 5:137,820,214...137,834,540
Ensembl chr 5:137,820,214...137,834,543

G

paired immunoglobin-like type 2 receptor beta 2

increases expression

zoledronic acid results in increased expression of PILRB mRNA

NCBI chr 5:137,864,083...137,870,083
Ensembl chr 5:137,864,089...137,870,077

G

proviral integration site 2

increases expression

zoledronic acid results in increased expression of PIM2 mRNA

NCBI chr X:7,744,545...7,749,671
Ensembl chr X:7,744,501...7,749,671

G

phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2

decreases expression

zoledronic acid results in decreased expression of PIP4P2 mRNA

NCBI chr 4:14,864,219...14,915,501
Ensembl chr 4:14,864,076...14,915,176

G

pirin

increases expression

zoledronic acid results in increased expression of PIR mRNA

NCBI chr X:163,052,427...163,156,009
Ensembl chr X:163,052,367...163,156,007

G

phosphatidylserine decarboxylase

increases expression

zoledronic acid results in increased expression of PISD mRNA

NCBI chr 5:32,893,645...32,943,008
Ensembl chr 5:32,893,645...32,942,990

G

polycystic kidney and hepatic disease 1

decreases expression

zoledronic acid results in decreased expression of PKHD1 mRNA

NCBI chr 1:20,128,003...20,688,306
Ensembl chr 1:20,128,003...20,688,288

G

protein kinase inhibitor, alpha

decreases expression

zoledronic acid results in decreased expression of PKIA mRNA

NCBI chr 3:7,431,695...7,510,426
Ensembl chr 3:7,431,729...7,510,426

G

protein kinase inhibitor beta, cAMP dependent, testis specific

decreases expression

zoledronic acid results in decreased expression of PKIB mRNA

NCBI chr10:57,508,077...57,617,208
Ensembl chr10:57,508,077...57,617,208

G

plakophilin 4

decreases expression

zoledronic acid results in decreased expression of PKP4 mRNA

NCBI chr 2:58,991,123...59,185,549
Ensembl chr 2:58,991,194...59,185,552

G

phospholipase A1 member A

increases expression

zoledronic acid results in increased expression of PLA1A mRNA

NCBI chr16:38,214,245...38,253,553
Ensembl chr16:38,216,479...38,253,507

G

phospholipase A2, group IVC (cytosolic, calcium-independent)

increases expression

zoledronic acid results in increased expression of PLA2G4C mRNA

NCBI chr 7:13,045,432...13,094,597
Ensembl chr 7:13,058,580...13,094,597

G

phospholipase A2, group IVF

decreases expression

zoledronic acid results in decreased expression of PLA2G4F mRNA

NCBI chr 2:120,130,433...120,144,646
Ensembl chr 2:120,130,438...120,144,646

G

plasminogen activator, tissue

increases expression

zoledronic acid results in increased expression of PLAT mRNA

NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860

G

plasminogen activator, urokinase

increases expression

zoledronic acid results in increased expression of PLAU mRNA

NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453

G

phospholipase C, beta 1

decreases expression

zoledronic acid results in decreased expression of PLCB1 mRNA

NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178

G

phospholipase C, delta 4

decreases expression

zoledronic acid results in decreased expression of PLCD4 mRNA

NCBI chr 1:74,581,175...74,605,137
Ensembl chr 1:74,582,047...74,606,953

G

phospholipase C-like 2

increases expression

zoledronic acid results in increased expression of PLCL2 mRNA

NCBI chr17:50,815,893...50,995,522
Ensembl chr17:50,816,431...50,995,512

G

phospholipase D family member 5

increases expression

zoledronic acid results in increased expression of PLD5 mRNA

NCBI chr 1:175,789,867...176,109,078
Ensembl chr 1:175,789,872...176,102,878

G

plectin

decreases expression

zoledronic acid results in decreased expression of PLEC mRNA; zoledronic acid results in decreased expression of PLEC protein

PMID:25596134 PMID:28871336

NCBI chr15:76,055,174...76,115,578
Ensembl chr15:76,055,174...76,116,774

G

pleckstrin

increases expression

zoledronic acid results in increased expression of PLEK mRNA

NCBI chr11:16,921,206...16,958,718
Ensembl chr11:16,921,206...17,002,381

G

pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

decreases expression

zoledronic acid results in decreased expression of PLEKHH2 mRNA

NCBI chr17:84,819,303...84,929,571
Ensembl chr17:84,819,323...84,929,566

G

polo like kinase 1

decreases expression

zoledronic acid results in decreased expression of PLK1 mRNA

NCBI chr 7:121,758,658...121,769,107
Ensembl chr 7:121,758,662...121,769,096

G

procollagen lysine, 2-oxoglutarate 5-dioxygenase 2

increases expression

zoledronic acid results in increased expression of PLOD2 mRNA

NCBI chr 9:92,421,828...92,490,481
Ensembl chr 9:92,424,276...92,490,481

G

phospholipid phosphatase 3

increases expression

zoledronic acid results in increased expression of PLPP3 mRNA

NCBI chr 4:105,014,544...105,089,964
Ensembl chr 4:105,014,544...105,089,961

G

phospholipid scramblase 1

increases expression

zoledronic acid results in increased expression of PLSCR1 mRNA

NCBI chr 9:92,132,265...92,154,034
Ensembl chr 9:92,131,803...92,154,331

G

paroxysmal nonkinesiogenic dyskinesia

increases expression

zoledronic acid results in increased expression of PNKD mRNA

NCBI chr 1:74,323,757...74,392,851
Ensembl chr 1:74,324,089...74,392,853

G

proline-rich nuclear receptor coactivator 2

increases expression

zoledronic acid results in increased expression of PNRC2 mRNA

NCBI chr 4:135,598,229...135,601,157
Ensembl chr 4:135,598,229...135,601,161

G

protein O-glucosyltransferase 2

decreases expression

Zoledronic Acid results in decreased expression of POGLUT2 mRNA

NCBI chr 1:44,143,060...44,158,844
Ensembl chr 1:44,145,706...44,157,968

G

polymerase (RNA) II (DNA directed) polypeptide A

decreases expression

zoledronic acid results in decreased expression of POLR2A mRNA

NCBI chr11:69,624,823...69,649,459
Ensembl chr11:69,624,823...69,649,463

G

polymerase (RNA) II (DNA directed) polypeptide D

increases expression

zoledronic acid results in increased expression of POLR2D mRNA

NCBI chr18:31,922,178...31,929,762
Ensembl chr18:31,922,212...31,929,754

G

protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase

increases expression

zoledronic acid results in increased expression of POMGNT1 mRNA

NCBI chr 4:116,007,700...116,017,041
Ensembl chr 4:115,981,037...116,017,046

G

paraoxonase 1

increases activity
multiple interactions

zoledronic acid results in increased activity of PON1 protein
[zoledronic acid results in increased activity of PON1 protein] which results in increased metabolism of phenyl acetate

NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946

G

paraoxonase 2

multiple interactions

[Tretinoin co-treated with zoledronic acid] results in increased expression of PON2 protein

NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression

Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of PPARA mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of PPARA mRNA]
zoledronic acid results in decreased expression of PPARA mRNA; zoledronic acid results in decreased expression of PPARA protein

NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020

G

peroxisome proliferator activator receptor delta

increases expression

zoledronic acid results in increased expression of PPARD mRNA

NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448

G

peroxisome proliferator activated receptor gamma

affects activity

zoledronic acid affects the activity of PPARG protein

NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360

G

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

decreases expression
multiple interactions

zoledronic acid results in decreased expression of PPARGC1A mRNA; zoledronic acid results in decreased expression of PPARGC1A protein
Fenofibrate inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]

PMID:24714768 PMID:28871336

NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068

G

pro-platelet basic protein

increases expression

zoledronic acid results in increased expression of PPBP mRNA

NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922

G

periplakin

decreases expression

zoledronic acid results in decreased expression of PPL mRNA

NCBI chr16:4,904,155...4,950,345
Ensembl chr16:4,904,155...4,950,285

G

protein phosphatase 1H (PP2C domain containing)

increases expression

zoledronic acid results in increased expression of PPM1H mRNA

NCBI chr10:122,512,720...122,781,700
Ensembl chr10:122,514,667...122,781,700

G

protein phosphatase 1, regulatory subunit 15A

multiple interactions
increases expression

[zoledronic acid co-treated with fluvastatin] results in increased expression of PPP1R15A mRNA
zoledronic acid results in increased expression of PPP1R15A mRNA

PMID:16996129 PMID:20977926

NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692

G

protein phosphatase 1, regulatory inhibitor subunit 1A

decreases expression

zoledronic acid results in decreased expression of PPP1R1A mRNA

NCBI chr15:103,438,706...103,446,465
Ensembl chr15:103,438,706...103,446,430

G

protein phosphatase 1, regulatory inhibitor subunit 1B

decreases expression

zoledronic acid results in decreased expression of PPP1R1B mRNA

NCBI chr11:98,239,232...98,248,622
Ensembl chr11:98,239,230...98,248,622

G

protein phosphatase 2, regulatory subunit B, beta

affects expression

zoledronic acid affects the expression of PPP2R2B mRNA

NCBI chr18:42,777,811...43,192,827
Ensembl chr18:42,770,497...43,216,192

G

protein phosphatase 3, catalytic subunit, alpha isoform

increases expression

zoledronic acid results in increased expression of PPP3CA mRNA

NCBI chr 3:136,375,778...136,643,488
Ensembl chr 3:136,375,885...136,643,488

G

protein regulator of cytokinesis 1

decreases expression

zoledronic acid results in decreased expression of PRC1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 7:79,944,224...79,966,007
Ensembl chr 7:79,944,198...79,966,007

G

PR domain containing 1, with ZNF domain

increases expression

zoledronic acid results in increased expression of PRDM1 mRNA

PMID:24714768 PMID:25596134

NCBI chr10:44,313,170...44,404,579
Ensembl chr10:44,313,173...44,404,497

G

peroxiredoxin 3

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of PRDX3 mRNA

NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

increases expression

zoledronic acid results in increased expression of PREX2 mRNA

NCBI chr 1:11,063,496...11,373,907
Ensembl chr 1:11,063,689...11,373,905

G

protein kinase, AMP-activated, beta 2 non-catalytic subunit

decreases expression

zoledronic acid results in decreased expression of PRKAB2 mRNA

NCBI chr 3:97,565,527...97,581,128
Ensembl chr 3:97,565,509...97,581,128

G

protein kinase, cAMP dependent, catalytic, beta

increases expression

zoledronic acid results in increased expression of PRKACB mRNA

NCBI chr 3:146,435,334...146,518,691
Ensembl chr 3:146,435,329...146,518,745

G

prominin 1

increases expression

zoledronic acid results in increased expression of PROM1 mRNA

NCBI chr 5:44,150,963...44,260,850
Ensembl chr 5:44,150,962...44,259,374

G

proline and serine rich 2

increases expression

zoledronic acid results in increased expression of PROSER2 mRNA

NCBI chr 2:6,103,304...6,135,100
Ensembl chr 2:6,102,418...6,135,022

G

proline and serine rich 3

increases expression

zoledronic acid results in increased expression of PROSER3 mRNA

NCBI chr 7:30,238,553...30,251,802
Ensembl chr 7:30,238,559...30,251,724

G

proline rich 14

increases expression

zoledronic acid results in increased expression of PRR14 mRNA

NCBI chr 7:127,070,189...127,075,932
Ensembl chr 7:127,058,783...127,075,931

G

proline rich 15-like

decreases expression

zoledronic acid results in decreased expression of PRR15L mRNA

NCBI chr11:96,816,987...96,826,474
Ensembl chr11:96,818,930...96,828,656

G

proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

increases expression

zoledronic acid results in increased expression of PRRG4 mRNA

NCBI chr 2:104,657,374...104,680,216
Ensembl chr 2:104,661,086...104,680,221

G

paired related homeobox 2

increases expression

zoledronic acid results in increased expression of PRRX2 mRNA

NCBI chr 2:30,735,076...30,771,263
Ensembl chr 2:30,724,984...30,771,263

G

serine protease 23

decreases expression

zoledronic acid results in decreased expression of PRSS23 mRNA

NCBI chr 7:89,156,988...89,176,399
Ensembl chr 7:89,156,991...89,176,395

G

serine protease 35

increases expression

zoledronic acid results in increased expression of PRSS35 mRNA

NCBI chr 9:86,625,291...86,640,496
Ensembl chr 9:86,625,702...86,640,496

G

prune homolog 2

increases expression

zoledronic acid results in increased expression of PRUNE2 mRNA

NCBI chr19:16,933,033...17,201,322
Ensembl chr19:16,933,482...17,201,296

G

peroxiredoxin like 2B

increases expression

zoledronic acid results in increased expression of PRXL2B mRNA

NCBI chr 4:154,980,884...154,983,522
Ensembl chr 4:154,979,961...154,983,592

G

phosphoserine aminotransferase 1

decreases expression

zoledronic acid results in decreased expression of PSAT1 mRNA

PMID:24714768 PMID:25596134

NCBI chr19:15,882,487...15,902,423
Ensembl chr19:15,882,042...15,924,701

G

proline/serine-rich coiled-coil 1

decreases expression

zoledronic acid results in decreased expression of PSRC1 mRNA

PMID:20977926 PMID:24714768

NCBI chr 3:108,291,120...108,295,547
Ensembl chr 3:108,291,155...108,295,547

G

prostaglandin E receptor 4 (subtype EP4)

increases expression

zoledronic acid results in increased expression of PTGER4 mRNA

NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668

G

prostaglandin-endoperoxide synthase 2

decreases expression
increases expression
multiple interactions

zoledronic acid results in decreased expression of PTGS2 mRNA
zoledronic acid results in increased expression of PTGS2 mRNA
[zoledronic acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of PTGS2 protein; gefitinib promotes the reaction [[zoledronic acid co-treated with 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide] results in decreased expression of PTGS2 protein]

PMID:16322342 PMID:20977926 PMID:24714768

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

parathyroid hormone 1 receptor

decreases expression

zoledronic acid results in decreased expression of PTH1R mRNA

NCBI chr 9:110,551,132...110,576,213
Ensembl chr 9:110,551,153...110,576,213

G

parathyroid hormone-like peptide

affects response to substance
decreases expression

PTHLH protein affects the susceptibility to zoledronic acid
zoledronic acid results in decreased expression of PTHLH mRNA

PMID:16278781 PMID:16475708 PMID:24714768

NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681

G

PTK2 protein tyrosine kinase 2

decreases phosphorylation
increases expression

zoledronic acid results in decreased phosphorylation of PTK2 protein
zoledronic acid results in increased expression of PTK2 mRNA

PMID:12933798 PMID:20977926

NCBI chr15:73,076,951...73,297,192
Ensembl chr15:73,076,951...73,295,129

G

protein tyrosine phosphatase, non-receptor type 13

decreases expression

zoledronic acid results in decreased expression of PTPN13 mRNA

NCBI chr 5:103,573,058...103,746,227
Ensembl chr 5:103,573,058...103,746,169

G

protein tyrosine phosphatase, non-receptor type 20

increases expression

zoledronic acid results in increased expression of PTPN20 mRNA

NCBI chr14:33,311,150...33,362,711
Ensembl chr14:33,311,164...33,362,711

G

protein tyrosine phosphatase receptor type G

increases expression

zoledronic acid results in increased expression of PTPRG mRNA

NCBI chr14:10,227,722...10,916,341
Ensembl chr14:10,227,722...10,916,220

G

liver glycogen phosphorylase

decreases expression

zoledronic acid results in decreased expression of PYGL mRNA

NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262

G

glutaminyl-peptide cyclotransferase (glutaminyl cyclase)

increases expression

zoledronic acid results in increased expression of QPCT mRNA

NCBI chr17:79,359,335...79,397,807
Ensembl chr17:79,359,335...79,397,807

G

RAB10, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB10 protein

NCBI chr12:3,297,428...3,359,969
Ensembl chr12:3,297,428...3,359,969

G

RAB11 family interacting protein 5 (class I)

increases expression

zoledronic acid results in increased expression of RAB11FIP5 protein

NCBI chr 6:85,311,944...85,351,663
Ensembl chr 6:85,311,944...85,351,616

G

RAB23, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB23 mRNA

NCBI chr 1:33,758,991...33,781,642
Ensembl chr 1:33,758,968...33,781,645

G

RAB26, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB26 mRNA

NCBI chr17:24,748,038...24,752,696
Ensembl chr17:24,746,215...24,753,184

G

RAB27B, member RAS oncogene family

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RAB27B mRNA

NCBI chr18:70,112,202...70,274,704
Ensembl chr18:70,112,202...70,274,676

G

RAB2B, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB2B protein

NCBI chr14:52,499,216...52,516,852
Ensembl chr14:52,499,216...52,517,002

G

RAB31, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB31 mRNA

PMID:24714768 PMID:25596134

NCBI chr17:65,958,721...66,079,747
Ensembl chr17:65,958,724...66,079,747

G

RAB32, member RAS oncogene family

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RAB32 mRNA

NCBI chr10:10,420,783...10,433,951
Ensembl chr10:10,420,746...10,434,009

G

RAB35, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB35 protein

NCBI chr 5:115,769,953...115,785,217
Ensembl chr 5:115,769,967...115,785,795

G

RAB5B, member RAS oncogene family

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RAB5B mRNA

NCBI chr10:128,511,980...128,532,160
Ensembl chr10:128,513,044...128,532,133

G

RAB6A, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB6A mRNA

NCBI chr 7:100,256,778...100,290,475
Ensembl chr 7:100,256,617...100,290,475

G

RAB7, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB7A protein

NCBI chr 6:87,976,088...88,022,252
Ensembl chr 6:87,976,088...88,022,252

G

RAB9, member RAS oncogene family

increases expression

zoledronic acid results in increased expression of RAB9A protein

NCBI chr X:165,240,247...165,262,863
Ensembl chr X:165,240,249...165,262,863

G

rabaptin, RAB GTPase binding effector protein 2

decreases expression

zoledronic acid results in decreased expression of RABEP2 protein

NCBI chr 7:126,027,596...126,045,079
Ensembl chr 7:126,027,931...126,048,417

G

RAB GTPase activating protein 1-like

multiple interactions
decreases expression

[zoledronic acid co-treated with fluvastatin] results in increased expression of RABGAP1L mRNA
zoledronic acid results in decreased expression of RABGAP1L protein

PMID:16996129 PMID:28871336

NCBI chr 1:160,046,744...160,621,046
Ensembl chr 1:160,046,744...160,620,781

G

RAB, member RAS oncogene family-like 2

increases expression

zoledronic acid results in increased expression of RABL2B protein

NCBI chr15:89,466,730...89,476,126
Ensembl chr15:89,466,736...89,476,126

G

Rac family small GTPase 1

multiple interactions
increases expression

zoledronic acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein]
zoledronic acid results in increased expression of [RAC1 protein binds to Guanosine Triphosphate]
zoledronic acid results in increased expression of RAC1 protein

PMID:16734383 PMID:28871336

NCBI chr 5:143,491,236...143,513,786
Ensembl chr 5:143,489,389...143,513,791

G

receptor for activated C kinase 1

increases expression

zoledronic acid results in increased expression of RACK1 protein

NCBI chr11:48,691,187...48,697,068
Ensembl chr11:48,691,159...48,697,261

G

RAD17 checkpoint clamp loader component

multiple interactions

[Tretinoin co-treated with zoledronic acid] results in increased expression of RAD17 protein

NCBI chr13:100,753,672...100,787,569
Ensembl chr13:100,753,672...100,787,559

G

RAD51 paralog D

increases expression

zoledronic acid results in increased expression of RAD51D mRNA

NCBI chr11:82,762,786...82,781,571
Ensembl chr11:82,767,260...82,781,440

G

RPA1 related single stranded DNA binding protein, X-linked

decreases expression

zoledronic acid results in decreased expression of RADX mRNA

NCBI chr X:138,381,116...138,455,333
Ensembl chr X:138,381,116...138,455,331

G

v-raf-leukemia viral oncogene 1

decreases expression

zoledronic acid results in decreased expression of RAF1 protein

NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596

G

retinoic acid induced 14

decreases expression

zoledronic acid results in decreased expression of RAI14 mRNA

NCBI chr15:10,569,057...10,719,353
Ensembl chr15:10,569,055...10,714,710

G

retinoic acid induced 2

increases expression

zoledronic acid results in increased expression of RAI2 mRNA

NCBI chr X:160,500,032...160,562,490
Ensembl chr X:160,500,065...160,562,492

G

v-ral simian leukemia viral oncogene A (ras related)

increases expression

zoledronic acid results in increased expression of RALA protein

NCBI chr13:18,055,160...18,118,802
Ensembl chr13:18,055,156...18,118,824

G

RAN binding protein 3-like

decreases expression

zoledronic acid results in decreased expression of RANBP3L mRNA

NCBI chr15:8,997,209...9,071,355
Ensembl chr15:8,997,433...9,067,417

G

RAS-related protein 1a

multiple interactions
decreases expression
increases expression
decreases prenylation
decreases geranoylation

geranylgeraniol inhibits the reaction [zoledronic acid results in decreased geranoylation of RAP1A protein]
Zoledronic Acid results in decreased expression of RAP1A protein modified form
zoledronic acid results in increased expression of RAP1A protein
[zoledronic acid co-treated with Doxorubicin] results in decreased expression of RAP1A protein modified form
zoledronic acid results in decreased prenylation of RAP1A protein

PMID:12406088 PMID:16539721 PMID:16602111 PMID:16675582 PMID:16996129 More...

NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652

G

RAS related protein 1b

increases expression

zoledronic acid results in increased expression of RAP1B mRNA

NCBI chr10:117,650,502...117,681,879
Ensembl chr10:117,649,776...117,681,940

G

Rap1 GTPase-activating protein

decreases expression

zoledronic acid results in decreased expression of RAP1GAP mRNA

NCBI chr 4:137,391,549...137,457,172
Ensembl chr 4:137,392,037...137,457,172

G

retinoic acid receptor, alpha

decreases expression

zoledronic acid results in decreased expression of RARA mRNA

PMID:24714768 PMID:25596134

NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768

G

RAS protein activator like 1 (GAP1 like)

decreases expression

zoledronic acid results in decreased expression of RASAL1 mRNA

NCBI chr 5:120,786,105...120,817,662
Ensembl chr 5:120,786,877...120,817,662

G

RAS guanyl releasing protein 1

increases expression

zoledronic acid results in increased expression of RASGRP1 mRNA

NCBI chr 2:117,110,464...117,173,358
Ensembl chr 2:117,110,474...117,173,482

G

RAS-like, family 11, member B

decreases expression

zoledronic acid results in decreased expression of RASL11B mRNA

NCBI chr 5:74,355,987...74,360,138
Ensembl chr 5:74,355,947...74,360,142

G

Ras association (RalGDS/AF-6) domain family member 5

increases expression

zoledronic acid results in increased expression of RASSF5 mRNA

NCBI chr 1:131,104,147...131,172,915
Ensembl chr 1:131,104,147...131,172,995

G

Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

decreases expression

zoledronic acid results in decreased expression of RASSF7 protein

NCBI chr 7:140,795,338...140,798,571
Ensembl chr 7:140,795,773...140,798,571

G

retinoblastoma binding protein 9, serine hydrolase

increases expression

zoledronic acid results in increased expression of RBBP9 mRNA

NCBI chr 2:144,384,185...144,392,779
Ensembl chr 2:144,384,185...144,392,789

G

RNA binding motif protein 14

increases expression

zoledronic acid results in increased expression of RBM14 mRNA

NCBI chr19:4,850,594...4,861,662
Ensembl chr19:4,850,597...4,861,662

G

RNA binding motif protein 8a

increases expression

zoledronic acid results in increased expression of RBM8A mRNA

NCBI chr 3:96,537,244...96,541,107
Ensembl chr 3:96,537,249...96,541,107

G

RNA binding protein with multiple splicing 2

decreases expression

zoledronic acid results in decreased expression of RBPMS2 mRNA

NCBI chr 9:65,536,638...65,567,818
Ensembl chr 9:65,536,930...65,567,810

G

ring-box 1

decreases expression

zoledronic acid results in decreased expression of RBX1 protein

NCBI chr15:81,350,517...81,360,570
Ensembl chr15:81,350,497...81,360,570

G

regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2

increases expression

zoledronic acid results in increased expression of RCBTB2 mRNA

NCBI chr14:73,376,185...73,421,495
Ensembl chr14:73,360,477...73,445,283

G

reticulocalbin 1

decreases expression

zoledronic acid results in decreased expression of RCN1 protein

NCBI chr 2:105,216,293...105,229,664
Ensembl chr 2:105,216,636...105,229,664

G

reticulocalbin 2

decreases expression

zoledronic acid results in decreased expression of RCN2 protein

NCBI chr 9:55,949,129...55,966,367
Ensembl chr 9:55,949,129...55,969,166

G

retinol dehydrogenase 10 (all-trans)

increases expression

zoledronic acid results in increased expression of RDH10 mRNA

NCBI chr 1:16,176,106...16,202,774
Ensembl chr 1:16,175,998...16,203,958

G

regenerating islet-derived 3 beta

increases expression

zoledronic acid results in increased expression of REG3A mRNA

NCBI chr 6:78,347,868...78,350,449
Ensembl chr 6:78,347,640...78,350,449

G

avian reticuloendotheliosis viral (v-rel) oncogene related B

increases expression

zoledronic acid results in increased expression of RELB mRNA

NCBI chr 7:19,340,142...19,363,352
Ensembl chr 7:19,340,142...19,363,363

G

RALBP1 associated Eps domain containing protein 2

increases expression

zoledronic acid results in increased expression of REPS2 mRNA

NCBI chr X:161,194,949...161,426,701
Ensembl chr X:161,194,950...161,426,645

G

RAS-like, estrogen-regulated, growth-inhibitor

decreases expression

zoledronic acid results in decreased expression of RERG mRNA

NCBI chr 6:137,031,822...137,147,494
Ensembl chr 6:137,031,823...137,147,495

G

reticulophagy regulator 1

increases expression

zoledronic acid results in increased expression of RETREG1 mRNA

NCBI chr15:25,840,795...25,973,782
Ensembl chr15:25,843,266...25,973,773

G

ral guanine nucleotide dissociation stimulator,-like 1

increases expression

zoledronic acid results in increased expression of RGL1 mRNA

NCBI chr 1:152,392,513...152,642,056
Ensembl chr 1:152,392,511...152,642,102

G

regulator of G-protein signaling 11

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RGS11 mRNA

NCBI chr17:26,421,500...26,430,295
Ensembl chr17:26,421,925...26,430,298

G

regulator of G-protein signaling 14

increases expression

zoledronic acid results in increased expression of RGS14 mRNA

NCBI chr13:55,517,269...55,532,504
Ensembl chr13:55,517,545...55,532,500

G

rhomboid domain containing 2

increases expression

zoledronic acid results in increased expression of RHBDD2 mRNA

NCBI chr 5:135,661,508...135,675,230
Ensembl chr 5:135,661,472...135,675,302

G

rhomboid 5 homolog 2

increases expression

zoledronic acid results in increased expression of RHBDF2 mRNA

NCBI chr11:116,488,991...116,517,786
Ensembl chr11:116,488,991...116,517,845

G

ras homolog family member A

multiple interactions
decreases geranoylation

[zoledronic acid results in decreased geranoylation of RHOA protein] which results in increased expression of IBSP mRNA; geranylgeraniol inhibits the reaction [zoledronic acid results in decreased expression of and affects the localization of RHOA protein]; zoledronic acid inhibits the reaction [RHOA protein results in decreased expression of IBSP mRNA]; zoledronic acid results in decreased expression of and affects the localization of RHOA protein; zoledronic acid results in increased expression of [RHOA protein binds to Guanosine Triphosphate]; zoledronic acid results in increased expression of and affects the localization of RHOA protein
zoledronic acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein]

PMID:15324309 PMID:16734383 PMID:28871336

NCBI chr 9:108,183,359...108,215,142
Ensembl chr 9:108,183,328...108,215,133

G

ras homolog family member B

increases expression
multiple interactions

zoledronic acid results in increased expression of RHOB mRNA
[zoledronic acid co-treated with fluvastatin] results in increased expression of RHOB mRNA; zoledronic acid results in increased expression of and affects the localization of RHOB protein

PMID:16996129 PMID:20977926 PMID:28871336

NCBI chr12:8,547,661...8,550,009
Ensembl chr12:8,547,661...8,550,009

G

Rho-related BTB domain containing 1

decreases expression

zoledronic acid results in decreased expression of RHOBTB1 mRNA

NCBI chr10:68,987,106...69,127,621
Ensembl chr10:68,987,264...69,127,621

G

Rho-related BTB domain containing 3

decreases expression

zoledronic acid results in decreased expression of RHOBTB3 mRNA

NCBI chr13:76,017,656...76,092,054
Ensembl chr13:76,017,656...76,092,044

G

ras homolog family member C

affects localization

zoledronic acid affects the localization of RHOC protein

NCBI chr 3:104,696,350...104,701,775
Ensembl chr 3:104,695,691...104,701,775

G

ras homolog family member G

increases expression

zoledronic acid results in increased expression of RHOG protein

NCBI chr 7:101,888,330...101,899,325
Ensembl chr 7:101,888,330...101,905,261

G

ras homolog family member V

increases expression

zoledronic acid results in increased expression of RHOV mRNA

NCBI chr 2:119,099,682...119,108,489
Ensembl chr 2:119,099,682...119,101,753

G

regulating synaptic membrane exocytosis 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RIMS2 mRNA

NCBI chr15:39,061,681...39,547,768
Ensembl chr15:39,061,656...39,547,768

G

regulating synaptic membrane exocytosis 3

decreases expression

zoledronic acid results in decreased expression of RIMS3 mRNA

NCBI chr 4:120,711,976...120,753,777
Ensembl chr 4:120,712,013...120,753,776

G

Ras and Rab interactor 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of RIN2 mRNA

NCBI chr 2:145,613,647...145,729,536
Ensembl chr 2:145,517,135...145,729,536

G

receptor (TNFRSF)-interacting serine-threonine kinase 2

increases expression

zoledronic acid results in increased expression of RIPK2 mRNA

NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647

G

RIPOR family member 3

decreases expression

zoledronic acid results in decreased expression of RIPOR3 mRNA

NCBI chr 2:167,822,081...167,892,809
Ensembl chr 2:167,822,084...167,852,538

G

ripply transcriptional repressor 3

decreases expression

zoledronic acid results in decreased expression of RIPPLY3 mRNA

NCBI chr16:94,129,281...94,137,794
Ensembl chr16:94,129,279...94,137,794

G

Rho family GTPase 1

increases expression

zoledronic acid results in increased expression of RND1 mRNA

PMID:24714768 PMID:25596134

NCBI chr15:98,567,086...98,575,342
Ensembl chr15:98,561,302...98,575,342

G

ring finger protein 114

increases expression

zoledronic acid results in increased expression of RNF114 mRNA

NCBI chr 2:167,334,565...167,358,093
Ensembl chr 2:167,334,565...167,358,093

G

ring finger protein 141

decreases expression

zoledronic acid results in decreased expression of RNF141 mRNA

NCBI chr 7:110,398,676...110,443,659
Ensembl chr 7:110,399,639...110,443,664

G

ring finger protein 144B

increases expression

zoledronic acid results in increased expression of RNF144B mRNA

NCBI chr13:47,276,196...47,401,470
Ensembl chr13:47,276,132...47,401,467

G

ring finger protein 167

increases expression

zoledronic acid results in increased expression of RNF167 mRNA

NCBI chr11:70,538,056...70,542,247
Ensembl chr11:70,538,061...70,542,247

G

ring finger protein, transmembrane 2

decreases expression

zoledronic acid results in decreased expression of RNFT2 mRNA

NCBI chr 5:118,328,799...118,388,518
Ensembl chr 5:118,328,801...118,383,181

G

ribosomal protein L7

increases expression

zoledronic acid results in increased expression of RPL7 mRNA

NCBI chr 1:16,171,519...16,174,657
Ensembl chr 1:16,171,519...16,174,886

G

ribosomal protein S9

decreases expression

zoledronic acid results in decreased expression of RPS9 mRNA

NCBI chr 7:3,707,035...3,709,896
Ensembl chr 7:3,706,992...3,709,896

G

regulatory associated protein of MTOR, complex 1

decreases expression

zoledronic acid results in decreased expression of RPTOR mRNA; zoledronic acid results in decreased expression of RPTOR protein

PMID:20977926 PMID:28871336

NCBI chr11:119,493,731...119,790,417
Ensembl chr11:119,493,731...119,790,402

G

related RAS viral (r-ras) oncogene 2

increases expression

zoledronic acid results in increased expression of RRAS2 protein

NCBI chr 7:113,646,017...113,717,016
Ensembl chr 7:113,646,017...113,717,016

G

ribonucleotide reductase M2

decreases expression

zoledronic acid results in decreased expression of RRM2 mRNA

NCBI chr12:24,758,253...24,764,145
Ensembl chr12:24,758,240...24,764,145

G

radial spoke head 1 homolog (Chlamydomonas)

increases expression

zoledronic acid results in increased expression of RSPH1 mRNA

NCBI chr17:31,473,993...31,496,270
Ensembl chr17:31,473,993...31,496,357

G

arginine/serine-rich coiled-coil 1

decreases expression

zoledronic acid results in decreased expression of RSRC1 mRNA

NCBI chr 3:66,888,694...67,265,736
Ensembl chr 3:66,888,723...67,265,729

G

runt related transcription factor 2

increases expression

zoledronic acid results in increased expression of RUNX2 mRNA

NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684

G

relaxin/insulin-like family peptide receptor 1

increases expression

zoledronic acid results in increased expression of RXFP1 mRNA

NCBI chr 3:79,548,910...79,645,258
Ensembl chr 3:79,548,918...79,645,187

G

S100 calcium binding protein A14

decreases expression

zoledronic acid results in decreased expression of S100A14 mRNA

NCBI chr 3:90,434,156...90,436,144
Ensembl chr 3:90,434,163...90,436,144

G

S100 calcium binding protein A2

decreases expression

zoledronic acid results in decreased expression of S100A2 mRNA

NCBI chr 3:90,497,554...90,498,815
Ensembl chr 3:90,467,670...90,498,838

G

S100 calcium binding protein A3

increases expression

zoledronic acid results in increased expression of S100A3 mRNA

NCBI chr 3:90,467,571...90,510,922
Ensembl chr 3:90,491,966...90,510,009

G

S100 calcium binding protein A6 (calcyclin)

decreases expression

zoledronic acid results in decreased expression of S100A6 protein

NCBI chr 3:90,520,491...90,531,797
Ensembl chr 3:90,520,189...90,531,488

G

S100 calcium binding protein A9 (calgranulin B)

increases expression

zoledronic acid results in increased expression of S100A9 mRNA

NCBI chr 3:90,599,937...90,603,028
Ensembl chr 3:90,599,939...90,603,028

G

serum amyloid A 1

increases expression

zoledronic acid results in increased expression of SAA1 mRNA

NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404

G

serum amyloid A 2

increases expression

zoledronic acid results in increased expression of SAA2 mRNA

NCBI chr 7:46,401,257...46,403,737
Ensembl chr 7:46,401,214...46,403,737

G

serum amyloid A 4

increases expression

zoledronic acid results in increased expression of SAA4 mRNA

NCBI chr 7:46,377,416...46,382,027
Ensembl chr 7:46,377,422...46,382,027

G

spalt like transcription factor 2

decreases expression

zoledronic acid results in decreased expression of SALL2 mRNA

NCBI chr14:52,548,634...52,566,127
Ensembl chr14:52,548,629...52,566,219

G

sterile alpha motif domain containing 11

decreases expression

zoledronic acid results in decreased expression of SAMD11 mRNA

NCBI chr 4:156,331,423...156,342,409
Ensembl chr 4:156,331,423...156,340,717

G

suppressor APC domain containing 2

decreases expression

zoledronic acid results in decreased expression of SAPCD2 mRNA

NCBI chr 2:25,261,974...25,268,225
Ensembl chr 2:25,262,333...25,268,225

G

SAM and SH3 domain containing 1

decreases expression

zoledronic acid results in decreased expression of SASH1 mRNA

NCBI chr10:8,597,981...8,821,290
Ensembl chr10:8,597,983...8,761,814

G

salvador family WW domain containing 1

increases expression

zoledronic acid results in increased expression of SAV1 mRNA

NCBI chr12:70,011,786...70,033,864
Ensembl chr12:70,011,786...70,033,776

G

strawberry notch 2

increases expression

zoledronic acid results in increased expression of SBNO2 protein

NCBI chr10:79,892,826...79,941,942
Ensembl chr10:79,892,826...79,941,405

G

sterol-C5-desaturase

increases expression

zoledronic acid results in increased expression of SC5D mRNA

NCBI chr 9:42,162,888...42,175,607
Ensembl chr 9:42,162,891...42,175,552

G

scavenger receptor class B, member 2

decreases expression

zoledronic acid results in decreased expression of SCARB2 protein

NCBI chr 5:92,589,170...92,653,516
Ensembl chr 5:92,589,173...92,654,692

G

stearoyl-coenzyme A desaturase 3

decreases expression

zoledronic acid results in decreased expression of SCD5 mRNA

NCBI chr19:44,191,727...44,232,455
Ensembl chr19:44,191,708...44,232,455

G

sciellin

decreases expression

zoledronic acid results in decreased expression of SCEL mRNA

NCBI chr14:103,750,499...103,850,782
Ensembl chr14:103,750,778...103,850,233

G

secretogranin V

increases expression

zoledronic acid results in increased expression of SCG5 mRNA

NCBI chr 2:113,606,708...113,659,423
Ensembl chr 2:113,606,707...113,659,466

G

secretoglobin, family 2A, member 2

increases expression

zoledronic acid results in increased expression of SCGB2A1 mRNA

NCBI chr19:9,824,922...9,829,564
Ensembl chr19:9,824,926...9,830,172

G

sodium channel, nonvoltage-gated 1 gamma

increases expression

zoledronic acid results in increased expression of SCNN1G mRNA

NCBI chr 7:121,333,643...121,367,705
Ensembl chr 7:121,333,702...121,367,698

G

short coiled-coil protein

increases expression

zoledronic acid results in increased expression of SCOC mRNA

NCBI chr 8:84,161,121...84,185,055
Ensembl chr 8:84,156,713...84,185,020

G

secretin receptor

decreases expression

zoledronic acid results in decreased expression of SCTR mRNA

NCBI chr 1:119,934,710...119,991,269
Ensembl chr 1:119,934,624...119,991,266

G

syndecan 1

decreases expression

zoledronic acid results in decreased expression of SDC1 mRNA

NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715

G

syndecan 2

decreases expression

zoledronic acid results in decreased expression of SDC2 mRNA

NCBI chr15:32,920,869...33,034,867
Ensembl chr15:32,920,869...33,035,081

G

syndecan 4

increases expression

zoledronic acid results in increased expression of SDC4 mRNA; zoledronic acid results in increased expression of SDC4 protein

PMID:24714768 PMID:28871336

NCBI chr 2:164,266,167...164,285,512
Ensembl chr 2:164,266,167...164,285,807

G

syndecan binding protein (syntenin) 2

increases expression

zoledronic acid results in increased expression of SDCBP2 mRNA

NCBI chr 2:151,414,203...151,431,925
Ensembl chr 2:151,414,542...151,431,925

G

SECIS binding protein 2-like

increases expression

zoledronic acid results in increased expression of SECISBP2L mRNA

NCBI chr 2:125,578,906...125,624,790
Ensembl chr 2:125,578,906...125,624,790

G

selectin, lymphocyte

increases expression

zoledronic acid results in increased expression of SELL mRNA

NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750

G

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B

decreases expression

zoledronic acid results in decreased expression of SEMA5B mRNA

NCBI chr16:35,361,517...35,485,103
Ensembl chr16:35,361,515...35,485,102

G

serine (or cysteine) peptidase inhibitor, clade A, member 3B

increases expression
increases secretion

zoledronic acid results in increased expression of SERPINA3 mRNA
zoledronic acid results in increased secretion of SERPINA3 protein

NCBI chr12:104,094,245...104,105,805
Ensembl chr12:104,094,255...104,105,804

G

serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D

increases expression

zoledronic acid results in increased expression of SERPINB3 mRNA

NCBI chr 1:107,005,893...107,011,210
Ensembl chr 1:107,005,897...107,011,236

G

serine (or cysteine) peptidase inhibitor, clade B, member 7

increases expression

zoledronic acid results in increased expression of SERPINB7 mRNA

NCBI chr 1:107,350,418...107,380,419
Ensembl chr 1:107,327,385...107,380,419

G

serine (or cysteine) peptidase inhibitor, clade F, member 2

decreases expression

zoledronic acid results in decreased expression of SERPINF2 mRNA

NCBI chr11:75,322,562...75,330,327
Ensembl chr11:75,322,558...75,330,417

G

serine (or cysteine) peptidase inhibitor, clade H, member 1

increases expression

zoledronic acid results in increased expression of SERPINH1 mRNA

PMID:20977926 PMID:24714768

NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446

G

SERTA domain containing 1

decreases expression

zoledronic acid results in decreased expression of SERTAD1 mRNA

NCBI chr 7:27,186,378...27,189,741
Ensembl chr 7:27,186,335...27,189,741

G

SERTA domain containing 4

decreases expression

zoledronic acid results in decreased expression of SERTAD4 mRNA

NCBI chr 1:192,526,796...192,538,060
Ensembl chr 1:192,526,796...192,538,064

G

sestrin 1

decreases expression

zoledronic acid results in decreased expression of SESN1 mRNA

NCBI chr10:41,686,570...41,784,432
Ensembl chr10:41,685,931...41,784,420

G

SET binding protein 1

decreases expression

zoledronic acid results in decreased expression of SETBP1 mRNA

NCBI chr18:78,793,593...79,153,659
Ensembl chr18:78,793,595...79,152,606

G

SET domain containing 1A

decreases expression

zoledronic acid results in decreased expression of SETD1A mRNA

NCBI chr 7:127,376,561...127,399,294
Ensembl chr 7:127,375,842...127,399,294

G

sideroflexin 3

decreases expression

zoledronic acid results in decreased expression of SFXN3 mRNA

NCBI chr19:45,036,015...45,044,822
Ensembl chr19:45,035,942...45,044,822

G

sphingomyelin synthase 1

increases expression

zoledronic acid results in increased expression of SGMS1 mRNA

NCBI chr19:32,100,127...32,367,285
Ensembl chr19:32,100,127...32,367,114

G

sphingosine-1-phosphate phosphatase 2

increases expression

zoledronic acid results in increased expression of SGPP2 mRNA

NCBI chr 1:78,286,186...78,396,926
Ensembl chr 1:78,286,982...78,396,926

G

SH2 domain containing 1B2

increases expression

zoledronic acid results in increased expression of SH2D1B mRNA

NCBI chr 1:170,060,440...170,079,156
Ensembl chr 1:170,060,318...170,081,177

G

SH2 domain containing 4A

increases expression

zoledronic acid results in increased expression of SH2D4A mRNA

NCBI chr 8:68,729,180...68,800,356
Ensembl chr 8:68,729,219...68,800,351

G

SHC (Src homology 2 domain containing) family, member 4

decreases expression

zoledronic acid results in decreased expression of SHC4 mRNA

NCBI chr 2:125,469,359...125,566,085
Ensembl chr 2:125,469,367...125,566,068

G

shisa family member 3

decreases expression

zoledronic acid results in decreased expression of SHISA3 mRNA

NCBI chr 5:67,765,226...67,771,330
Ensembl chr 5:67,765,225...67,780,895

G

shroom family member 1

increases expression

zoledronic acid results in increased expression of SHROOM1 mRNA

NCBI chr11:53,347,904...53,358,593
Ensembl chr11:53,348,032...53,358,593

G

signal-regulatory protein beta 1A

increases expression

Zoledronic Acid results in increased expression of SIRPB1 mRNA

NCBI chr 3:15,436,887...15,491,487
Ensembl chr 3:15,436,713...15,491,580

G

S-phase kinase-associated protein 1

decreases expression

zoledronic acid results in decreased expression of SKP1 protein

NCBI chr11:52,121,349...52,137,685
Ensembl chr11:52,122,822...52,137,685

G

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

increases expression

zoledronic acid results in increased expression of SLC11A2 mRNA

NCBI chr15:100,285,779...100,322,090
Ensembl chr15:100,285,779...100,322,953

G

solute carrier family 12, member 1

decreases expression

zoledronic acid results in decreased expression of SLC12A1 mRNA

NCBI chr 2:124,994,430...125,071,922
Ensembl chr 2:124,994,425...125,071,922

G

solute carrier family 14 (urea transporter), member 1

decreases expression

zoledronic acid results in decreased expression of SLC14A1 mRNA

NCBI chr18:78,143,306...78,185,334
Ensembl chr18:78,143,306...78,185,334

G

solute carrier family 15 (oligopeptide transporter), member 1

increases expression

zoledronic acid results in increased expression of SLC15A1 mRNA

NCBI chr14:121,697,033...121,742,666
Ensembl chr14:121,697,033...121,742,664

G

solute carrier family 15 (H+/peptide transporter), member 2

decreases expression

zoledronic acid results in decreased expression of SLC15A2 mRNA

NCBI chr16:36,570,523...36,605,506
Ensembl chr16:36,570,539...36,605,324

G

solute carrier family 16 (monocarboxylic acid transporters), member 1

increases expression

zoledronic acid results in increased expression of SLC16A1 mRNA

NCBI chr 3:104,545,980...104,565,778
Ensembl chr 3:104,545,984...104,565,778

G

solute carrier family 16 (monocarboxylic acid transporters), member 10

increases expression

zoledronic acid results in increased expression of SLC16A10 mRNA

NCBI chr10:39,909,528...40,018,262
Ensembl chr10:39,909,528...40,018,254

G

solute carrier family 16 (monocarboxylic acid transporters), member 14

decreases expression

zoledronic acid results in decreased expression of SLC16A14 mRNA

NCBI chr 1:84,881,344...84,912,927
Ensembl chr 1:84,883,619...84,912,855

G

solute carrier family 16 (monocarboxylic acid transporters), member 4

decreases expression

zoledronic acid results in decreased expression of SLC16A4 mRNA

NCBI chr 3:107,198,543...107,219,437
Ensembl chr 3:107,198,546...107,219,431

G

solute carrier family 1 (glial high affinity glutamate transporter), member 3

increases expression

zoledronic acid results in increased expression of SLC1A3 mRNA

NCBI chr15:8,663,608...8,742,648
Ensembl chr15:8,663,608...8,740,248

G

solute carrier family 1 (neutral amino acid transporter), member 5

decreases expression

zoledronic acid results in decreased expression of SLC1A5 mRNA

NCBI chr 7:16,515,259...16,532,199
Ensembl chr 7:16,515,265...16,532,199

G

solute carrier family 22, member 23

increases expression

zoledronic acid results in increased expression of SLC22A23 mRNA

NCBI chr13:34,363,141...34,530,666
Ensembl chr13:34,363,141...34,529,165

G

solute carrier family 22 (organic cation transporter), member 4

increases expression

zoledronic acid results in increased expression of SLC22A4 mRNA

NCBI chr11:53,873,941...53,920,866
Ensembl chr11:53,873,949...53,918,916

G

solute carrier family 23 (nucleobase transporters), member 2

increases expression

zoledronic acid results in increased expression of SLC23A2 mRNA

NCBI chr 2:131,894,416...131,987,287
Ensembl chr 2:131,894,416...131,987,028

G

solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20

decreases expression

zoledronic acid results in decreased expression of SLC25A20 mRNA

NCBI chr 9:108,539,335...108,561,841
Ensembl chr 9:108,539,287...108,561,840

G

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24

increases expression

zoledronic acid results in increased expression of SLC25A24 mRNA

NCBI chr 3:109,030,465...109,075,725
Ensembl chr 3:109,030,465...109,075,773

G

solute carrier family 25, member 40

increases expression

zoledronic acid results in increased expression of SLC25A40 mRNA

NCBI chr 5:8,472,730...8,504,840
Ensembl chr 5:8,472,850...8,504,797

G

solute carrier family 27 (fatty acid transporter), member 1

increases expression

zoledronic acid results in increased expression of SLC27A1 mRNA

NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946

G

solute carrier family 27 (fatty acid transporter), member 2

decreases expression
multiple interactions
increases expression

zoledronic acid results in decreased expression of SLC27A2 mRNA
SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of ACOX1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of ACOX2 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of CPT1A mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of CPT2 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of PPARA mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in decreased expression of PPARGC1A mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of ACTA2 protein]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL1A1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL3A1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of COL4A1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of FN1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of FN1 protein]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of IL6 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of TIMP1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of TIMP2 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of TNF mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of VIM mRNA]
zoledronic acid results in increased expression of SLC27A2 mRNA; zoledronic acid results in increased expression of SLC27A2 protein

PMID:24714768 PMID:25596134 PMID:28871336

NCBI chr 2:126,394,944...126,430,163
Ensembl chr 2:126,394,327...126,430,163

G

solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

increases expression

zoledronic acid results in increased expression of SLC28A3 mRNA

NCBI chr13:58,701,121...58,758,691
Ensembl chr13:58,693,213...58,758,691

G

solute carrier family 29 (nucleoside transporters), member 4

decreases expression

zoledronic acid results in decreased expression of SLC29A4 mRNA

NCBI chr 5:142,678,226...142,708,245
Ensembl chr 5:142,678,267...142,708,245

G

solute carrier family 34 (sodium phosphate), member 2

increases expression

zoledronic acid results in increased expression of SLC34A2 mRNA

NCBI chr 5:53,206,695...53,229,006
Ensembl chr 5:53,195,423...53,229,006

G

solute carrier family 35, member B3

increases expression

zoledronic acid results in increased expression of SLC35B3 mRNA

NCBI chr13:39,116,112...39,144,855
Ensembl chr13:39,116,112...39,144,851

G

solute carrier family 37 (glycerol-3-phosphate transporter), member 1

increases expression

zoledronic acid results in increased expression of SLC37A1 mRNA

NCBI chr17:31,495,722...31,569,683
Ensembl chr17:31,505,766...31,569,713

G

solute carrier family 37 (glucose-6-phosphate transporter), member 4

increases expression

zoledronic acid results in increased expression of SLC37A4 mRNA

NCBI chr 9:44,308,243...44,314,263
Ensembl chr 9:44,308,149...44,314,265

G

solute carrier family 39 (zinc transporter), member 10

decreases expression

zoledronic acid results in decreased expression of SLC39A10 mRNA

NCBI chr 1:46,846,704...46,964,952
Ensembl chr 1:46,846,704...46,932,012

G

solute carrier family 39 (metal ion transporter), member 8

increases expression

zoledronic acid results in increased expression of SLC39A8 mRNA

NCBI chr 3:135,522,644...135,594,333
Ensembl chr 3:135,531,040...135,594,333

G

solute carrier family 3, member 1

decreases expression

zoledronic acid results in decreased expression of SLC3A1 mRNA

NCBI chr17:85,335,775...85,371,669
Ensembl chr17:85,335,804...85,371,664

G

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

decreases expression

zoledronic acid results in decreased expression of SLC3A2 mRNA

PMID:24714768 PMID:25596134

NCBI chr19:8,684,931...8,700,733
Ensembl chr19:8,684,246...8,700,733

G

solute carrier family 40 (iron-regulated transporter), member 1

increases expression

zoledronic acid results in increased expression of SLC40A1 mRNA

NCBI chr 1:45,947,230...45,965,690
Ensembl chr 1:45,947,228...45,965,683

G

solute carrier family 44, member 2

decreases expression

zoledronic acid results in decreased expression of SLC44A2 mRNA

NCBI chr 9:21,232,015...21,266,324
Ensembl chr 9:21,231,994...21,266,324

G

solute carrier family 45, member 3

decreases expression

zoledronic acid results in decreased expression of SLC45A3 mRNA

NCBI chr 1:131,890,653...131,910,710
Ensembl chr 1:131,890,705...131,910,707

G

solute carrier family 46, member 3

increases expression

zoledronic acid results in increased expression of SLC46A3 mRNA

NCBI chr 5:147,812,707...147,831,670
Ensembl chr 5:147,815,247...147,831,625

G

solute carrier family 47, member 1

decreases expression

zoledronic acid results in decreased expression of SLC47A1 mRNA

NCBI chr11:61,234,226...61,269,668
Ensembl chr11:61,234,227...61,269,171

G

solute carrier family 4 (anion exchanger), member 4

decreases expression

zoledronic acid results in decreased expression of SLC4A4 mRNA

NCBI chr 5:88,941,717...89,387,515
Ensembl chr 5:89,034,345...89,387,512

G

solute carrier family 5 (inositol transporters), member 3

decreases expression

zoledronic acid results in decreased expression of SLC5A3 mRNA

NCBI chr16:91,855,210...91,884,361
Ensembl chr16:91,855,210...91,884,361

G

solute carrier family 6 (neurotransmitter transporter), member 20B

increases expression

zoledronic acid results in increased expression of SLC6A20 mRNA

NCBI chr 9:123,422,888...123,461,603
Ensembl chr 9:123,419,865...123,461,630

G

solute carrier family 6 (neurotransmitter transporter, creatine), member 8

decreases expression

zoledronic acid results in decreased expression of SLC6A8 mRNA

NCBI chr X:72,716,739...72,726,108
Ensembl chr X:72,716,756...72,726,108

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

decreases expression

zoledronic acid results in decreased expression of SLC7A2 mRNA

NCBI chr 8:41,315,404...41,375,107
Ensembl chr 8:41,315,433...41,375,345

G

solute carrier family 7 (cationic amino acid transporter, y+ system), member 5

decreases expression

zoledronic acid results in decreased expression of SLC7A5 mRNA

PMID:24714768 PMID:25596134

NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433

G

solute carrier organic anion transporter family, member 2a1

increases expression

zoledronic acid results in increased expression of SLCO2A1 mRNA

NCBI chr 9:102,885,686...102,973,201
Ensembl chr 9:102,865,911...102,973,201

G

solute carrier organic anion transporter family, member 2b1

increases expression

zoledronic acid results in increased expression of SLCO2B1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 7:99,307,011...99,360,547
Ensembl chr 7:99,307,011...99,360,547

G

solute carrier organic anion transporter family, member 3a1

decreases expression
increases expression

zoledronic acid results in decreased expression of SLCO3A1 mRNA
zoledronic acid results in increased expression of SLCO3A1 mRNA

PMID:20977926 PMID:24714768

NCBI chr 7:73,925,166...74,204,528
Ensembl chr 7:73,925,167...74,204,528

G

solute carrier organic anion transporter family, member 4a1

increases expression

zoledronic acid results in increased expression of SLCO4A1 mRNA

NCBI chr 2:180,098,019...180,116,646
Ensembl chr 2:180,098,038...180,116,660

G

solute carrier organic anion transporter family, member 4C1

decreases expression

zoledronic acid results in decreased expression of SLCO4C1 mRNA

NCBI chr 1:96,744,918...96,800,027
Ensembl chr 1:96,743,995...96,799,896

G

SMC5-SMC6 complex localization factor 2

decreases expression

zoledronic acid results in decreased expression of SLF2 mRNA

NCBI chr19:44,906,948...44,972,225
Ensembl chr19:44,919,558...44,972,225

G

schlafen 5

increases expression

zoledronic acid results in increased expression of SLFN5 mRNA

NCBI chr11:82,842,175...82,855,681
Ensembl chr11:82,842,175...82,855,666

G

SLIT and NTRK-like family, member 4

decreases expression

zoledronic acid results in decreased expression of SLITRK4 mRNA

NCBI chr X:63,308,489...63,320,951
Ensembl chr X:63,308,491...63,320,602

G

sarcolemma associated protein

increases expression

zoledronic acid results in increased expression of SLMAP mRNA

NCBI chr14:26,134,323...26,256,103
Ensembl chr14:26,134,323...26,256,086

G

secretory leukocyte peptidase inhibitor

increases expression

zoledronic acid results in increased expression of SLPI mRNA; zoledronic acid results in increased expression of SLPI protein

PMID:24714768 PMID:28871336

NCBI chr 2:164,195,990...164,231,086
Ensembl chr 2:164,195,990...164,231,015

G

SMAD family member 3

increases expression
increases phosphorylation
multiple interactions

zoledronic acid results in increased expression of SMAD3 mRNA
zoledronic acid results in increased phosphorylation of SMAD3 protein
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [zoledronic acid results in increased phosphorylation of SMAD3 protein]

PMID:24714768 PMID:28871336

NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276

G

single-pass membrane protein with coiled-coil domains 4

decreases expression

zoledronic acid results in decreased expression of SMCO4 mRNA

NCBI chr 9:15,379,736...15,456,556
Ensembl chr 9:15,404,728...15,456,556

G

small integral membrane protein 24

decreases expression

zoledronic acid results in decreased expression of SMIM24 mRNA

NCBI chr10:81,228,898...81,230,913
Ensembl chr10:81,228,885...81,231,226

G

SPARC related modular calcium binding 2

increases expression

zoledronic acid results in increased expression of SMOC2 mRNA

NCBI chr17:14,499,768...14,625,052
Ensembl chr17:14,499,768...14,625,052

G

spermine oxidase

decreases expression

zoledronic acid results in decreased expression of SMOX mRNA

NCBI chr 2:131,333,624...131,367,103
Ensembl chr 2:131,333,416...131,367,842

G

smoothelin

decreases expression

zoledronic acid results in decreased expression of SMTN mRNA

NCBI chr11:3,467,522...3,489,337
Ensembl chr11:3,467,523...3,490,612

G

synaptosomal-associated protein 25

increases expression

zoledronic acid results in increased expression of SNAP25 mRNA

NCBI chr 2:136,555,359...136,624,348
Ensembl chr 2:136,555,373...136,624,348

G

small nucleolar RNA host gene 12

increases expression

Zoledronic Acid results in increased expression of SNHG12 mRNA

NCBI chr 4:132,035,989...132,038,335
Ensembl chr 4:132,035,932...132,038,762

G

syntaphilin

increases expression

zoledronic acid results in increased expression of SNPH mRNA

NCBI chr 2:151,432,469...151,474,527
Ensembl chr 2:151,432,469...151,474,513

G

suppressor of cytokine signaling 1

increases expression

zoledronic acid results in increased expression of SOCS1 mRNA

NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400

G

superoxide dismutase 2, mitochondrial

increases expression

zoledronic acid results in increased expression of SOD2 mRNA

NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950

G

superoxide dismutase 3, extracellular

increases expression

zoledronic acid results in increased expression of SOD3 mRNA

NCBI chr 5:52,521,146...52,527,080
Ensembl chr 5:52,521,133...52,528,760

G

sortilin-related VPS10 domain containing receptor 3

decreases expression

zoledronic acid results in decreased expression of SORCS3 mRNA

NCBI chr19:48,194,464...48,793,944
Ensembl chr19:48,194,464...48,793,944

G

SOS Ras/Rho guanine nucleotide exchange factor 2

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of SOS2 mRNA

NCBI chr12:69,630,535...69,728,626
Ensembl chr12:69,630,536...69,728,626

G

sclerostin domain containing 1

increases expression

zoledronic acid results in increased expression of SOSTDC1 mRNA

NCBI chr12:36,364,168...36,368,451
Ensembl chr12:36,364,138...36,368,451

G

sosondowah ankyrin repeat domain family member C

decreases expression

zoledronic acid results in decreased expression of SOWAHC mRNA

NCBI chr10:59,057,744...59,062,256
Ensembl chr10:59,057,775...59,062,256

G

SRY (sex determining region Y)-box 13

increases expression

zoledronic acid results in increased expression of SOX13 mRNA

NCBI chr 1:133,310,038...133,352,159
Ensembl chr 1:133,310,041...133,352,115

G

SRY (sex determining region Y)-box 17

increases expression

zoledronic acid results in increased expression of SOX17 mRNA

NCBI chr 1:4,561,154...4,567,624
Ensembl chr 1:4,561,154...4,567,577

G

SRY (sex determining region Y)-box 2

increases expression

zoledronic acid results in increased expression of SOX2 mRNA

NCBI chr 3:34,704,144...34,706,610
Ensembl chr 3:34,704,554...34,706,610

G

SRY (sex determining region Y)-box 4

decreases expression

zoledronic acid results in decreased expression of SOX4 mRNA

NCBI chr13:29,132,902...29,137,682
Ensembl chr13:29,132,902...29,137,696

G

SRY (sex determining region Y)-box 9

decreases expression

zoledronic acid results in decreased expression of SOX9 mRNA

NCBI chr11:112,673,036...112,678,583
Ensembl chr11:112,673,050...112,678,586

G

trans-acting transcription factor 1

increases expression

zoledronic acid results in increased expression of SP1 mRNA

NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839

G

spartin

decreases expression

Zoledronic Acid results in decreased expression of SPART protein

NCBI chr 3:55,019,500...55,044,753
Ensembl chr 3:55,019,529...55,044,743

G

spermatogenesis associated 7

increases expression

zoledronic acid results in increased expression of SPATA7 mRNA

NCBI chr12:98,594,169...98,636,078
Ensembl chr12:98,594,416...98,636,074

G

SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)

decreases expression

zoledronic acid results in decreased expression of SPC24 mRNA

NCBI chr 9:21,666,730...21,671,741
Ensembl chr 9:21,666,738...21,671,599

G

spermatogenesis associated glutamate (E)-rich protein 4f2

increases expression

zoledronic acid results in increased expression of C3ORF36 mRNA

NCBI chr 5:17,578,184...17,582,990
Ensembl chr 5:17,578,178...17,583,026

G

spindlin family, member 2C

multiple interactions

[Zoledronic Acid co-treated with Fluvastatin] results in increased expression of SPIN2A mRNA

NCBI chr X:152,615,246...152,617,239
Ensembl chr X:152,615,221...152,617,239

G

serine peptidase inhibitor, Kazal type 1

increases expression

zoledronic acid results in increased expression of SPINK1 mRNA

NCBI chr18:43,861,134...43,870,302
Ensembl chr18:43,861,147...43,870,622

G

sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1

decreases expression

zoledronic acid results in decreased expression of SPOCK1 mRNA

NCBI chr13:57,569,008...58,056,194
Ensembl chr13:57,569,008...58,056,146

G

small proline-rich protein 2F

increases expression

zoledronic acid results in increased expression of SPRR2F mRNA

NCBI chr 3:92,272,494...92,273,754
Ensembl chr 3:92,272,494...92,273,749

G

small proline-rich protein 2H

increases expression

Zoledronic Acid results in increased expression of SPRR2A mRNA

NCBI chr 3:92,292,992...92,294,631
Ensembl chr 3:92,292,992...92,294,631

G

SPRY domain containing 3

decreases expression

zoledronic acid results in decreased expression of SPRYD3 mRNA

NCBI chr15:102,024,961...102,044,678
Ensembl chr15:102,024,963...102,044,669

G

spectrin alpha, non-erythrocytic 1

decreases expression

zoledronic acid results in decreased expression of SPTAN1 protein

NCBI chr 2:29,855,572...29,921,463
Ensembl chr 2:29,855,572...29,921,463

G

serine palmitoyltransferase, long chain base subunit 3

decreases expression

zoledronic acid results in decreased expression of SPTLC3 mRNA

NCBI chr 2:139,335,833...139,478,981
Ensembl chr 2:139,335,833...139,479,594

G

spexin hormone

increases expression

zoledronic acid results in increased expression of SPX mRNA

NCBI chr 6:142,359,114...142,365,466
Ensembl chr 6:142,359,167...142,365,456

G

squalene epoxidase

increases expression

zoledronic acid results in increased expression of SQLE mRNA

PMID:18325729 PMID:20977926 PMID:24714768

NCBI chr15:59,186,941...59,203,042
Ensembl chr15:59,186,926...59,203,041

G

sulfide quinone oxidoreductase

increases expression

zoledronic acid results in increased expression of SQOR mRNA

NCBI chr 2:122,607,249...122,651,473
Ensembl chr 2:122,607,157...122,651,489

G

steroid 5 alpha-reductase 2

increases expression

zoledronic acid results in increased expression of SRD5A2 mRNA

NCBI chr17:74,321,886...74,354,855
Ensembl chr17:74,323,950...74,354,911

G

steroid 5 alpha-reductase 3

increases expression

zoledronic acid results in increased expression of SRD5A3 mRNA

NCBI chr 5:76,285,296...76,303,350
Ensembl chr 5:76,288,118...76,303,351

G

SLIT-ROBO Rho GTPase activating protein 3

increases expression

zoledronic acid results in increased expression of SRGAP3 mRNA

NCBI chr 6:112,694,932...112,924,466
Ensembl chr 6:112,694,932...112,924,227

G

serine and arginine-rich splicing factor 11

decreases expression

zoledronic acid results in decreased expression of SRSF11 mRNA

NCBI chr 3:157,716,552...157,742,304
Ensembl chr 3:157,716,110...157,742,276

G

SS18, subunit of BAF chromatin remodeling complex

increases expression

zoledronic acid results in increased expression of SS18 mRNA

NCBI chr18:14,758,686...14,817,476
Ensembl chr18:14,757,255...14,815,971

G

slingshot protein phosphatase 2

decreases expression

zoledronic acid results in decreased expression of SSH2 mRNA

NCBI chr11:77,107,020...77,351,046
Ensembl chr11:77,107,113...77,351,046

G

somatostatin receptor 1

decreases expression

zoledronic acid results in decreased expression of SSTR1 mRNA

NCBI chr12:58,258,524...58,262,822
Ensembl chr12:58,258,558...58,260,673

G

SSX family member 2 interacting protein

increases expression

zoledronic acid results in increased expression of SSX2IP mRNA

NCBI chr 3:146,110,397...146,145,899
Ensembl chr 3:146,110,397...146,145,899

G

beta galactoside alpha 2,6 sialyltransferase 1

increases expression

zoledronic acid results in increased expression of ST6GAL1 mRNA

NCBI chr16:23,043,478...23,179,100
Ensembl chr16:23,043,490...23,179,100

G

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

increases expression

zoledronic acid results in increased expression of ST6GALNAC1 mRNA

NCBI chr11:116,655,851...116,666,333
Ensembl chr11:116,655,851...116,666,333

G

STAG2 cohesin complex component

decreases expression

zoledronic acid results in decreased expression of STAG2 protein

NCBI chr X:41,238,172...41,366,063
Ensembl chr X:41,238,194...41,366,062

G

StAR related lipid transfer domain containing 13

decreases expression

zoledronic acid results in decreased expression of STARD13 mRNA

NCBI chr 5:150,960,975...151,351,780
Ensembl chr 5:150,960,975...151,157,301

G

StAR related lipid transfer domain containing 8

decreases expression

zoledronic acid results in decreased expression of STARD8 mRNA

NCBI chr X:98,046,539...98,118,334
Ensembl chr X:98,046,854...98,118,334

G

signal transducer and activator of transcription 1

increases expression

zoledronic acid results in increased expression of STAT1 mRNA

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

signal transducer and activator of transcription 3

increases expression

zoledronic acid results in increased expression of STAT3 mRNA

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

signal transducer and activator of transcription 5A

increases expression

zoledronic acid results in increased expression of STAT5A mRNA

NCBI chr11:100,750,177...100,775,995
Ensembl chr11:100,750,177...100,775,995

G

stanniocalcin 1

increases expression

zoledronic acid results in increased expression of STC1 protein

NCBI chr14:69,266,738...69,278,850
Ensembl chr14:69,266,687...69,279,253

G

stanniocalcin 2

increases expression

zoledronic acid results in increased expression of STC2 mRNA

NCBI chr11:31,309,441...31,320,061
Ensembl chr11:31,307,307...31,320,074

G

six transmembrane epithelial antigen of the prostate 1

increases expression

zoledronic acid results in increased expression of STEAP1 mRNA

NCBI chr 5:5,786,322...5,799,317
Ensembl chr 5:5,786,317...5,799,326

G

stimulator of interferon response cGAMP interactor 1

increases expression

Zoledronic Acid results in increased expression of STING1 mRNA

NCBI chr18:35,866,731...35,873,607
Ensembl chr18:35,866,732...35,873,607

G

serine/threonine kinase 32A

decreases expression

zoledronic acid results in decreased expression of STK32A mRNA

NCBI chr18:43,340,762...43,450,546
Ensembl chr18:43,340,648...43,451,747

G

serine/threonine kinase 32B

decreases expression

zoledronic acid results in decreased expression of STK32B mRNA

NCBI chr 5:37,604,169...37,874,503
Ensembl chr 5:37,604,169...37,874,515

G

serine/threonine kinase 40

decreases expression

zoledronic acid results in decreased expression of STK40 mRNA

NCBI chr 4:125,997,738...126,034,822
Ensembl chr 4:125,997,750...126,034,822

G

stathmin 1

decreases expression

zoledronic acid results in decreased expression of STMN1 mRNA

NCBI chr 4:134,195,631...134,201,154
Ensembl chr 4:134,195,631...134,201,154

G

stomatin-like 1

increases expression

zoledronic acid results in increased expression of STOML1 mRNA

NCBI chr 9:58,160,443...58,169,807
Ensembl chr 9:58,160,447...58,169,803

G

syntaxin 16

increases expression

zoledronic acid results in increased expression of STX16 mRNA

NCBI chr 2:173,918,052...173,941,564
Ensembl chr 2:173,918,101...173,941,564

G

syntaxin 17

increases expression

zoledronic acid results in increased expression of STX17 mRNA

NCBI chr 4:48,124,912...48,186,507
Ensembl chr 4:48,124,915...48,186,507

G

syntaxin binding protein 4

decreases expression

zoledronic acid results in decreased expression of STXBP4 mRNA

NCBI chr11:90,367,318...90,528,962
Ensembl chr11:90,367,318...90,528,910

G

succinate receptor 1

decreases expression

zoledronic acid results in decreased expression of SUCNR1 mRNA

NCBI chr 3:59,989,290...59,994,987
Ensembl chr 3:59,989,290...59,994,987

G

succinyl-CoA glutarate-CoA transferase

increases expression

zoledronic acid results in increased expression of SUGCT mRNA

NCBI chr13:17,032,057...17,869,380
Ensembl chr13:17,032,057...17,870,138

G

sulfatase 2

increases expression

zoledronic acid results in increased expression of SULF2 mRNA

NCBI chr 2:165,915,819...165,997,603
Ensembl chr 2:165,915,009...165,997,583

G

supervillin

increases expression

zoledronic acid results in increased expression of SVIL mRNA

NCBI chr18:4,920,497...5,119,290
Ensembl chr18:4,920,540...5,119,299

G

syntabulin (syntaxin-interacting)

decreases expression

Zoledronic Acid results in decreased expression of SYBU mRNA

NCBI chr15:44,535,252...44,651,466
Ensembl chr15:44,535,252...44,651,459

G

synaptojanin 1

increases expression

zoledronic acid results in increased expression of SYNJ1 mRNA

NCBI chr16:90,732,980...90,810,543
Ensembl chr16:90,732,980...90,808,196

G

synaptotagmin XIII

decreases expression

zoledronic acid results in decreased expression of SYT13 mRNA

NCBI chr 2:92,745,446...92,786,403
Ensembl chr 2:92,745,443...92,786,403

G

synaptotagmin-like 2

decreases expression

zoledronic acid results in decreased expression of SYTL2 mRNA

NCBI chr 7:89,951,421...90,059,927
Ensembl chr 7:89,951,460...90,059,927

G

TGF-beta activated kinase 1/MAP3K7 binding protein 2

increases expression

zoledronic acid results in increased expression of TAB2 mRNA

NCBI chr10:7,781,412...7,832,039
Ensembl chr10:7,781,417...7,831,994

G

transforming, acidic coiled-coil containing protein 3

decreases expression

zoledronic acid results in decreased expression of TACC3 mRNA

NCBI chr 5:33,814,808...33,836,331
Ensembl chr 5:33,815,472...33,836,339

G

TATA-box binding protein associated factor 9B

increases expression

zoledronic acid results in increased expression of TAF9B mRNA

NCBI chr X:105,250,480...105,264,764
Ensembl chr X:105,250,489...105,264,764

G

TAP binding protein

increases expression

zoledronic acid results in increased expression of TAPBP mRNA

NCBI chr17:34,138,452...34,148,264
Ensembl chr17:34,134,873...34,148,266

G

TBC1 domain family, member 16

increases expression

zoledronic acid results in increased expression of TBC1D16 mRNA

NCBI chr11:119,033,869...119,119,354
Ensembl chr11:119,033,871...119,119,325

G

TBC1 domain family, member 2B

increases expression

zoledronic acid results in increased expression of TBC1D2B mRNA

NCBI chr 9:90,084,100...90,152,861
Ensembl chr 9:90,084,080...90,152,857

G

TBC1 domain family, member 4

decreases expression

zoledronic acid results in decreased expression of TBC1D4 mRNA

NCBI chr14:101,679,800...101,846,717
Ensembl chr14:101,679,796...101,846,627

G

TBC1 domain family, member 8

increases expression

zoledronic acid results in increased expression of TBC1D8 mRNA

NCBI chr 1:39,410,576...39,517,860
Ensembl chr 1:39,410,573...39,517,836

G

transducin (beta)-like 1X-linked receptor 1

increases expression

zoledronic acid results in increased expression of TBL1XR1 mRNA

NCBI chr 3:22,130,756...22,270,758
Ensembl chr 3:22,130,816...22,270,758

G

T cell activation inhibitor, mitochondrial

increases expression

zoledronic acid results in increased expression of TCAIM mRNA

NCBI chr 9:122,634,586...122,665,397
Ensembl chr 9:122,634,604...122,665,399

G

transcriptional and immune response regulator

increases expression

zoledronic acid results in increased expression of TCIM mRNA

NCBI chr 8:24,927,188...24,928,962
Ensembl chr 8:24,927,196...24,929,000

G

t-complex protein 1

decreases expression

zoledronic acid results in decreased expression of TCP1 mRNA

NCBI chr17:13,135,216...13,143,954
Ensembl chr17:13,134,588...13,143,954

G

TEA domain family member 2

decreases expression

zoledronic acid results in decreased expression of TEAD2 mRNA

NCBI chr 7:44,865,216...44,882,892
Ensembl chr 7:44,865,177...44,883,068

G

teneurin transmembrane protein 4

increases expression

zoledronic acid results in increased expression of TENM4 mRNA

NCBI chr 7:95,550,262...96,560,300
Ensembl chr 7:95,820,453...96,560,300

G

terminal nucleotidyltransferase 5B

decreases expression

zoledronic acid results in decreased expression of TENT5B mRNA

NCBI chr 4:133,207,444...133,215,251
Ensembl chr 4:133,207,443...133,215,249

G

tescalcin

decreases expression

zoledronic acid results in decreased expression of TESC mRNA

NCBI chr 5:118,165,808...118,199,943
Ensembl chr 5:118,165,808...118,199,943

G

thymocyte expressed, positive selection associated 1

decreases expression

zoledronic acid results in decreased expression of TESPA1 mRNA

NCBI chr10:130,158,696...130,199,338
Ensembl chr10:130,158,739...130,199,980

G

transcription factor AP-2 beta

decreases expression

zoledronic acid results in decreased expression of TFAP2B mRNA

NCBI chr 1:19,279,132...19,309,071
Ensembl chr 1:19,279,138...19,308,800

G

transcription factor CP2-like 1

decreases expression

zoledronic acid results in decreased expression of TFCP2L1 mRNA

NCBI chr 1:118,555,646...118,612,898
Ensembl chr 1:118,555,675...118,612,898

G

tuftelin interacting protein 11

decreases expression

zoledronic acid results in decreased expression of TFIP11 mRNA

NCBI chr 5:112,474,235...112,485,939
Ensembl chr 5:112,474,224...112,485,939

G

tissue factor pathway inhibitor

increases expression

zoledronic acid results in increased expression of TFPI mRNA

NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119

G

tissue factor pathway inhibitor 2

increases expression

zoledronic acid results in increased expression of TFPI2 mRNA

NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919

G

transferrin receptor

increases expression

zoledronic acid results in increased expression of TFRC mRNA

NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612

G

transforming growth factor, beta 1

multiple interactions
increases expression

[Alendronate co-treated with zoledronic acid] results in increased expression of TGFB1 protein
zoledronic acid results in increased expression of and results in increased secretion of TGFB1 protein
zoledronic acid results in increased expression of TGFB1 mRNA
zoledronic acid results in increased expression of TGFB1 protein

PMID:18504149 PMID:28871336

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

transforming growth factor beta 1 induced transcript 1

increases expression

zoledronic acid results in increased expression of TGFB1I1 protein

NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871

G

transforming growth factor, beta 2

increases expression

zoledronic acid results in increased expression of TGFB2 mRNA

NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186

G

transforming growth factor, beta receptor associated protein 1

increases expression

zoledronic acid results in increased expression of TGFBRAP1 protein

NCBI chr 1:43,086,360...43,137,788
Ensembl chr 1:43,086,360...43,137,797

G

transglutaminase 2, C polypeptide

increases expression

zoledronic acid results in increased expression of TGM2 mRNA

NCBI chr 2:157,958,325...157,988,312
Ensembl chr 2:157,958,322...157,988,356

G

thrombospondin 1

decreases expression

zoledronic acid results in decreased expression of THBS1 mRNA

NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614

G

TRAF-interacting protein with forkhead-associated domain

increases expression

zoledronic acid results in increased expression of TIFA mRNA

NCBI chr 3:127,582,524...127,592,043
Ensembl chr 3:127,583,454...127,625,813

G

Trp53 induced glycolysis regulatory phosphatase

decreases expression

zoledronic acid results in decreased expression of TIGAR mRNA

NCBI chr 6:127,062,079...127,086,564
Ensembl chr 6:127,062,079...127,086,520

G

tissue inhibitor of metalloproteinase 1

multiple interactions
increases expression

Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of TIMP1 mRNA]
zoledronic acid results in increased expression of TIMP1 mRNA; zoledronic acid results in increased expression of TIMP1 protein

NCBI chr X:20,736,524...20,740,972
Ensembl chr X:20,736,405...20,740,974

G

tissue inhibitor of metalloproteinase 2

increases expression
multiple interactions

zoledronic acid results in increased expression of TIMP2 mRNA; zoledronic acid results in increased expression of TIMP2 protein
Fenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP2 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of TIMP2 mRNA]

NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566

G

tubulointerstitial nephritis antigen

decreases expression

zoledronic acid results in decreased expression of TINAG mRNA

PMID:24714768 PMID:25596134

NCBI chr 9:76,858,980...76,953,084
Ensembl chr 9:76,858,975...76,953,076

G

TCDD-inducible poly(ADP-ribose) polymerase

increases expression

zoledronic acid results in increased expression of TIPARP mRNA

PMID:24714768 PMID:25596134

NCBI chr 3:65,435,868...65,462,939
Ensembl chr 3:65,435,831...65,462,939

G

TLC domain containing 3A

increases expression

Zoledronic Acid results in increased expression of TLCD3A mRNA

NCBI chr11:76,070,497...76,100,243
Ensembl chr11:76,070,497...76,105,653

G

transducin-like enhancer of split 4

increases expression

zoledronic acid results in increased expression of TLE4 mRNA

NCBI chr19:14,425,434...14,575,542
Ensembl chr19:14,425,514...14,575,415

G

toll-like receptor 5

increases expression

zoledronic acid results in increased expression of TLR5 mRNA

NCBI chr 1:182,782,317...182,804,010
Ensembl chr 1:182,782,353...182,804,010

G

transmembrane 4 superfamily member 4

decreases expression

zoledronic acid results in decreased expression of TM4SF4 mRNA

NCBI chr 3:57,332,831...57,349,098
Ensembl chr 3:57,332,735...57,349,098

G

transmembrane 7 superfamily member 2

increases expression

zoledronic acid results in increased expression of TM7SF2 mRNA

NCBI chr19:6,112,851...6,117,880
Ensembl chr19:6,112,851...6,118,403

G

transmembrane channel-like gene family 5

increases expression

zoledronic acid results in increased expression of TMC5 mRNA

NCBI chr 7:118,196,520...118,274,308
Ensembl chr 7:118,196,520...118,274,309

G

transmembrane and coiled coil domains 1

decreases expression

zoledronic acid results in decreased expression of TMCC1 mRNA

NCBI chr 6:115,995,572...116,170,485
Ensembl chr 6:115,995,572...116,170,447

G

transmembrane and coiled-coil domains 3

increases expression

zoledronic acid results in increased expression of TMCO3 mRNA

NCBI chr 8:13,333,214...13,372,924
Ensembl chr 8:13,338,190...13,372,924

G

transmembrane protein 125

decreases expression

zoledronic acid results in decreased expression of TMEM125 mRNA

NCBI chr 4:118,398,138...118,402,110
Ensembl chr 4:118,398,138...118,401,241

G

transmembrane protein 132A

increases expression

zoledronic acid results in increased expression of TMEM132A mRNA

NCBI chr19:10,835,193...10,847,569
Ensembl chr19:10,835,186...10,847,304

G

transmembrane protein 154

decreases expression

zoledronic acid results in decreased expression of TMEM154 mRNA

NCBI chr 3:84,573,499...84,611,882
Ensembl chr 3:84,573,499...84,611,882

G

transmembrane protein 171

increases expression

zoledronic acid results in increased expression of TMEM171 mRNA

NCBI chr13:98,822,744...98,832,142
Ensembl chr13:98,822,743...98,831,342

G

transmembrane protein 213

decreases expression

zoledronic acid results in decreased expression of TMEM213 mRNA

NCBI chr 6:38,086,288...38,092,741
Ensembl chr 6:38,086,190...38,092,744

G

transmembrane protein 259

increases expression

zoledronic acid results in increased expression of TMEM259 mRNA

NCBI chr10:79,812,954...79,820,159
Ensembl chr10:79,810,782...79,820,164

G

transmembrane protein 267

increases expression

zoledronic acid results in increased expression of TMEM267 mRNA

NCBI chr13:119,624,622...120,071,995
Ensembl chr13:119,624,575...120,072,595

G

transmembrane protein 30A

increases expression

zoledronic acid results in increased expression of TMEM30A mRNA

NCBI chr 9:79,676,223...79,700,712
Ensembl chr 9:79,676,225...79,700,789

G

transmembrane protein 37

decreases expression

zoledronic acid results in decreased expression of TMEM37 mRNA

NCBI chr 1:119,995,106...120,001,799
Ensembl chr 1:119,995,107...120,001,804

G

transmembrane protein 52B

decreases expression

zoledronic acid results in decreased expression of TMEM52B mRNA

NCBI chr 6:129,489,512...129,496,190
Ensembl chr 6:129,489,518...129,496,190

G

transmembrane protein 72

decreases expression

zoledronic acid results in decreased expression of TMEM72 mRNA

NCBI chr 6:116,668,500...116,693,943
Ensembl chr 6:116,656,024...116,693,874

G

transmembrane protein 74B

increases expression

zoledronic acid results in increased expression of TMEM74B mRNA

NCBI chr 2:151,543,294...151,558,665
Ensembl chr 2:151,543,928...151,554,077

G

transmembrane protein 86A

decreases expression

zoledronic acid results in decreased expression of TMEM86A mRNA

NCBI chr 7:46,700,388...46,704,524
Ensembl chr 7:46,700,349...46,704,525

G

transmembrane protein 87B

increases expression

zoledronic acid results in increased expression of TMEM87B mRNA

NCBI chr 2:128,659,991...128,696,181
Ensembl chr 2:128,660,038...128,696,181

G

transmembrane protein 97

increases expression

zoledronic acid results in increased expression of TMEM97 mRNA

NCBI chr11:78,432,643...78,441,561
Ensembl chr11:78,432,643...78,441,603

G

tropomodulin 1

increases expression

zoledronic acid results in increased expression of TMOD1 mRNA

NCBI chr 4:46,038,940...46,116,032
Ensembl chr 4:46,038,935...46,116,032

G

transmembrane protease, serine 3

increases expression

zoledronic acid results in increased expression of TMPRSS3 mRNA

NCBI chr17:31,398,237...31,419,478
Ensembl chr17:31,398,239...31,417,951

G

thymosin beta 10

decreases expression

zoledronic acid results in decreased expression of TMSB10 protein

NCBI chr 6:72,934,330...72,935,731
Ensembl chr 6:72,934,330...72,935,731

G

thymosin beta 15a

decreases expression

zoledronic acid results in decreased expression of TMSB15A mRNA

NCBI chr X:134,619,416...134,626,010
Ensembl chr X:134,619,416...134,626,010

G

thymosin, beta 4, X chromosome

decreases expression

zoledronic acid results in decreased expression of TMSB4X protein

NCBI chr X:165,990,089...165,996,475
Ensembl chr X:165,990,089...165,992,311

G

transmembrane and tetratricopeptide repeat containing 2

increases expression

zoledronic acid results in increased expression of TMTC2 mRNA

NCBI chr10:105,023,524...105,410,340
Ensembl chr10:105,023,524...105,410,312

G

tenascin C

increases expression

zoledronic acid results in increased expression of TNC mRNA

NCBI chr 4:63,878,022...63,965,554
Ensembl chr 4:63,878,022...63,965,252

G

tumor necrosis factor

increases expression
multiple interactions

Zoledronic Acid results in increased expression of TNF mRNA; Zoledronic Acid results in increased expression of TNF protein
zoledronic acid results in increased expression of TNF mRNA
SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of TNF mRNA]
zoledronic acid promotes the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]

PMID:9351880 PMID:17059425 PMID:19036117 PMID:24714768 PMID:28871336 More...

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor, alpha-induced protein 2

increases expression

zoledronic acid results in increased expression of TNFAIP2 mRNA

NCBI chr12:111,408,898...111,421,452
Ensembl chr12:111,408,903...111,421,452

G

tumor necrosis factor, alpha-induced protein 3

increases expression

zoledronic acid results in increased expression of TNFAIP3 mRNA

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

G

tumor necrosis factor alpha induced protein 6

increases expression

zoledronic acid results in increased expression of TNFAIP6 mRNA

NCBI chr 2:51,928,125...51,946,693
Ensembl chr 2:51,928,021...51,946,698

G

tumor necrosis factor, alpha-induced protein 8

increases expression

zoledronic acid results in increased expression of TNFAIP8 mRNA

PMID:24714768 PMID:25596134

NCBI chr18:50,112,494...50,226,296
Ensembl chr18:50,112,494...50,240,240

G

tumor necrosis factor receptor superfamily, member 10b

multiple interactions
increases expression

[zoledronic acid co-treated with fluvastatin] results in increased expression of TNFRSF10A mRNA
zoledronic acid results in increased expression of TNFRSF10A mRNA

PMID:16996129 PMID:19036117

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

affects expression
increases expression
multiple interactions
increases secretion

zoledronic acid affects the expression of TNFRSF11B protein
zoledronic acid results in increased expression of TNFRSF11B mRNA; zoledronic acid results in increased expression of TNFRSF11B protein
TNFRSF11B protein affects the reaction [zoledronic acid results in decreased activity of ALPL protein]
zoledronic acid results in increased secretion of TNFRSF11B protein
zoledronic acid inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; zoledronic acid inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]

PMID:11855844 PMID:14753746 PMID:16121404 PMID:17041912 PMID:18496637 More...

NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880

G

tumor necrosis factor receptor superfamily, member 12a

multiple interactions

[Tretinoin co-treated with zoledronic acid] results in increased expression of TNFRSF12A mRNA

NCBI chr17:23,894,419...23,896,423
Ensembl chr17:23,894,419...23,896,442

G

tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

increases expression

zoledronic acid results in increased expression of TNFRSF14 mRNA

NCBI chr 4:155,002,944...155,013,077
Ensembl chr 4:155,006,390...155,013,020

G

tumor necrosis factor receptor superfamily, member 1a

increases expression
multiple interactions

zoledronic acid results in increased expression of TNFRSF1A mRNA
[Tretinoin co-treated with zoledronic acid] results in increased expression of TNFRSF1A mRNA

PMID:19036117 PMID:20349282

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor receptor superfamily, member 1b

increases expression

zoledronic acid results in increased expression of TNFRSF1B mRNA

NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440

G

tumor necrosis factor receptor superfamily, member 21

decreases expression
increases expression

zoledronic acid results in decreased expression of TNFRSF21 mRNA
zoledronic acid results in increased expression of TNFRSF21 mRNA

PMID:19036117 PMID:25596134

NCBI chr17:43,327,446...43,400,079
Ensembl chr17:43,327,446...43,400,080

G

tumor necrosis factor receptor superfamily, member 25

decreases expression

zoledronic acid results in decreased expression of TNFRSF25 mRNA

NCBI chr 4:152,199,985...152,204,568
Ensembl chr 4:152,200,391...152,204,576

G

tumor necrosis factor receptor superfamily, member 9

decreases expression
increases expression

zoledronic acid results in decreased expression of TNFRSF9 mRNA
zoledronic acid results in increased expression of TNFRSF9 mRNA

PMID:19036117 PMID:24714768

NCBI chr 4:151,004,612...151,030,561
Ensembl chr 4:150,999,019...151,030,559

G

tumor necrosis factor (ligand) superfamily, member 11

multiple interactions
decreases expression
affects expression

ADAM17 protein promotes the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]; TAPI-2 inhibits the reaction [zoledronic acid results in decreased expression of TNFSF11 protein]
zoledronic acid affects the expression of TNFSF11 protein

PMID:14753746 PMID:17041912

NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483

G

tumor necrosis factor (ligand) superfamily, member 15

increases expression

zoledronic acid results in increased expression of TNFSF15 mRNA

NCBI chr 4:63,642,837...63,663,296
Ensembl chr 4:63,642,840...63,663,350

G

tumor necrosis factor (ligand) superfamily, member 8

increases expression

zoledronic acid results in increased expression of TNFSF8 mRNA

NCBI chr 4:63,749,439...63,779,745
Ensembl chr 4:63,749,545...63,779,584

G

tumor necrosis factor (ligand) superfamily, member 9

increases expression

zoledronic acid results in increased expression of TNFSF9 mRNA

NCBI chr17:57,412,113...57,414,757
Ensembl chr17:57,412,325...57,414,757

G

TNFAIP3 interacting protein 1

increases expression

zoledronic acid results in increased expression of TNIP1 mRNA

NCBI chr11:54,801,613...54,853,766
Ensembl chr11:54,801,611...54,853,743

G

TNFAIP3 interacting protein 3

increases expression

zoledronic acid results in increased expression of TNIP3 mRNA

NCBI chr 6:65,567,382...65,611,024
Ensembl chr 6:65,502,297...65,611,024

G

tankyrase 1 binding protein 1

increases expression

zoledronic acid results in increased expression of TNKS1BP1 mRNA

NCBI chr 2:84,878,356...84,903,392
Ensembl chr 2:84,878,366...84,903,392

G

transportin 3

decreases expression

zoledronic acid results in decreased expression of TNPO3 mRNA

NCBI chr 6:29,540,826...29,609,918
Ensembl chr 6:29,540,826...29,609,886

G

transducer of ErbB-2.1

increases expression

zoledronic acid results in increased expression of TOB1 mRNA

NCBI chr11:94,100,668...94,106,321
Ensembl chr11:94,102,280...94,106,321

G

toll interacting protein

increases expression

zoledronic acid results in increased expression of TOLLIP mRNA

NCBI chr 7:141,435,317...141,456,198
Ensembl chr 7:141,428,550...141,472,244

G

topoisomerase (DNA) II alpha

decreases expression

zoledronic acid results in decreased expression of TOP2A mRNA

NCBI chr11:98,883,773...98,915,037
Ensembl chr11:98,883,769...98,915,015

G

torsin family 2, member A

decreases expression

zoledronic acid results in decreased expression of TOR2A mRNA

NCBI chr 2:32,647,289...32,652,256
Ensembl chr 2:32,647,246...32,652,256

G

TOX high mobility group box family member 4

increases expression

zoledronic acid results in increased expression of TOX4 mRNA

NCBI chr14:52,516,603...52,532,966
Ensembl chr14:52,516,603...52,533,858

G

two pore channel 1

increases expression

zoledronic acid results in increased expression of TPCN1 mRNA

NCBI chr 5:120,672,222...120,726,731
Ensembl chr 5:120,672,218...120,726,738

G

tumor protein D52-like 1

decreases expression

zoledronic acid results in decreased expression of TPD52L1 mRNA

PMID:24714768 PMID:25596134

NCBI chr10:31,208,369...31,321,989
Ensembl chr10:31,208,372...31,321,954

G

tropomyosin 2, beta

decreases expression

zoledronic acid results in decreased expression of TPM2 protein

NCBI chr 4:43,513,726...43,523,583
Ensembl chr 4:43,514,711...43,523,765

G

transmembrane protein, adipocyte asscociated 1

increases expression

zoledronic acid results in increased expression of TPRA1 mRNA

NCBI chr 6:88,879,238...88,889,216
Ensembl chr 6:88,879,233...88,889,220

G

protein-tyrosine sulfotransferase 2

decreases expression

zoledronic acid results in decreased expression of TPST2 mRNA

NCBI chr 5:112,424,548...112,463,222
Ensembl chr 5:112,424,557...112,463,227

G

tumor protein, translationally-controlled 1

decreases expression

zoledronic acid results in decreased expression of TPT1 protein

NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965

G

TPX2, microtubule-associated

decreases expression

zoledronic acid results in decreased expression of TPX2 mRNA

NCBI chr 2:152,689,859...152,737,241
Ensembl chr 2:152,689,884...152,737,241

G

TNFRSF1A-associated via death domain

increases expression

zoledronic acid results in increased expression of TRADD mRNA

NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241

G

TNF receptor-associated factor 2

increases expression

zoledronic acid results in increased expression of TRAF2 mRNA

NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952

G

TNF receptor-associated factor 3

increases expression

zoledronic acid results in increased expression of TRAF3 mRNA

PMID:19036117 PMID:24714768

NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587

G

TRAF-interacting protein

increases expression

zoledronic acid results in increased expression of TRAIP mRNA

NCBI chr 9:107,828,158...107,849,469
Ensembl chr 9:107,827,335...107,849,469

G

T cell receptor alpha joining 18

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of STK17A mRNA

NCBI chr14:54,438,234...54,438,299
Ensembl chr14:54,438,234...54,438,299

G

transcriptional regulating factor 1

increases expression

zoledronic acid results in increased expression of TRERF1 mRNA

NCBI chr17:47,451,868...47,673,250
Ensembl chr17:47,451,801...47,672,883

G

tribbles pseudokinase 3

increases expression

zoledronic acid results in increased expression of TRIB3 mRNA

NCBI chr 2:152,179,345...152,185,980
Ensembl chr 2:152,179,342...152,185,952

G

tripartite motif-containing 16

increases expression

zoledronic acid results in increased expression of TRIM16 mRNA

NCBI chr11:62,711,034...62,733,774
Ensembl chr11:62,711,057...62,741,634

G

tripartite motif-containing 30A

increases expression

Zoledronic Acid results in increased expression of TRIM22 mRNA

NCBI chr 7:104,058,232...104,114,400
Ensembl chr 7:104,058,232...104,114,400

G

tripartite motif-containing 37

increases expression

zoledronic acid results in increased expression of TRIM37 mRNA

NCBI chr11:87,017,675...87,141,700
Ensembl chr11:87,017,903...87,111,509

G

tripartite motif-containing 55

increases expression

zoledronic acid results in increased expression of TRIM55 mRNA

NCBI chr 3:19,698,591...19,746,748
Ensembl chr 3:19,698,638...19,746,585

G

thyroid hormone receptor interactor 13

decreases expression

zoledronic acid results in decreased expression of TRIP13 mRNA

NCBI chr13:74,060,577...74,085,855
Ensembl chr13:74,059,466...74,085,903

G

triple QxxK/R motif containing

increases expression

zoledronic acid results in increased expression of TRIQK mRNA

NCBI chr 4:12,906,837...12,981,485
Ensembl chr 4:12,906,838...12,983,553

G

TMF1-regulated nuclear protein 1

decreases expression

zoledronic acid results in decreased expression of TRNP1 mRNA

NCBI chr 4:133,218,408...133,226,446
Ensembl chr 4:133,218,411...133,225,861

G

transformation related protein 53

affects activity
increases expression
multiple interactions

zoledronic acid affects the activity of TP53 protein
Zoledronic Acid results in increased expression of TP53 mRNA
[Tretinoin co-treated with zoledronic acid] results in decreased expression of TP53 protein

PMID:20349282 PMID:25596134 PMID:35587103

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

transformation related protein 53 inducible nuclear protein 1

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of TP53INP1 mRNA

NCBI chr 4:11,156,441...11,174,379
Ensembl chr 4:11,156,431...11,174,379

G

transient receptor potential cation channel, subfamily V, member 2

decreases expression

zoledronic acid results in decreased expression of TRPV2 mRNA

NCBI chr11:62,465,312...62,491,131
Ensembl chr11:62,465,312...62,491,341

G

trypsin 4

increases expression

zoledronic acid results in increased expression of PRSS3 mRNA

NCBI chr 6:41,279,206...41,282,467
Ensembl chr 6:41,279,203...41,282,466

G

TSC22 domain family, member 1

increases expression

zoledronic acid results in increased expression of TSC22D1 mRNA

NCBI chr14:76,652,401...76,745,205
Ensembl chr14:76,652,401...76,745,205

G

TSC22 domain family, member 3

increases expression

zoledronic acid results in increased expression of TSC22D3 mRNA

NCBI chr X:139,440,277...139,501,257
Ensembl chr X:139,440,277...139,501,408

G

tetraspanin 15

increases expression

zoledronic acid results in increased expression of TSPAN15 mRNA

NCBI chr10:62,021,175...62,067,055
Ensembl chr10:62,021,175...62,067,030

G

tetraspanin 18

increases expression

zoledronic acid results in increased expression of TSPAN18 mRNA

NCBI chr 2:93,032,105...93,164,898
Ensembl chr 2:93,032,105...93,164,850

G

tetraspanin 7

decreases expression

zoledronic acid results in decreased expression of TSPAN7 mRNA

NCBI chr X:10,351,355...10,462,843
Ensembl chr X:10,351,397...10,462,844

G

tetratricopeptide repeat domain 29

increases expression

zoledronic acid results in increased expression of TTC29 mRNA

NCBI chr 8:78,939,911...79,120,955
Ensembl chr 8:78,939,926...79,120,955

G

tetratricopeptide repeat domain 39C

increases expression

zoledronic acid results in increased expression of TTC39C mRNA

NCBI chr18:12,716,168...12,872,461
Ensembl chr18:12,732,953...12,871,920

G

tetratricopeptide repeat domain 9

increases expression

zoledronic acid results in increased expression of TTC9 mRNA

NCBI chr12:81,678,023...81,714,331
Ensembl chr12:81,678,023...81,714,331

G

Ttk protein kinase

decreases expression

zoledronic acid results in decreased expression of TTK mRNA

NCBI chr 9:83,716,704...83,754,442
Ensembl chr 9:83,716,742...83,754,442

G

tubulin, alpha 1A

decreases expression

zoledronic acid results in decreased expression of TUBA1A mRNA

NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584

G

tubulin, alpha 1B

decreases expression

zoledronic acid results in decreased expression of TUBA1B mRNA

NCBI chr15:98,829,310...98,832,271
Ensembl chr15:98,829,306...98,832,446

G

tubulin, alpha 1C

decreases expression

zoledronic acid results in decreased expression of TUBA1C mRNA

NCBI chr15:98,927,772...98,935,986
Ensembl chr15:98,927,772...98,935,991

G

tubulin, alpha 3B

decreases expression

zoledronic acid results in decreased expression of TUBA3D mRNA

NCBI chr 6:145,561,689...145,567,203
Ensembl chr 6:145,561,483...145,567,205

G

tubulin, alpha 4A

decreases expression

zoledronic acid results in decreased expression of TUBA4A mRNA

NCBI chr 1:75,190,867...75,197,905
Ensembl chr 1:75,190,872...75,196,509

G

tubulin, beta 1 class VI

increases expression

zoledronic acid results in increased expression of TUBB1 protein

NCBI chr 2:174,292,388...174,300,173
Ensembl chr 2:174,292,488...174,299,675

G

tubulin, beta 2B class IIB

decreases expression

zoledronic acid results in decreased expression of TUBB2B mRNA

NCBI chr13:34,310,991...34,314,337
Ensembl chr13:34,310,731...34,314,449

G

tubulin, beta 3 class III

decreases expression

zoledronic acid results in decreased expression of TUBB3 mRNA

NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754

G

tubulin, beta 4A class IVA

decreases expression

zoledronic acid results in decreased expression of TUBB4A mRNA

NCBI chr17:57,387,061...57,394,600
Ensembl chr17:57,387,066...57,394,782

G

tubulin, beta 4B class IVB

decreases expression

zoledronic acid results in decreased expression of TUBB4B mRNA

NCBI chr 2:25,112,170...25,114,714
Ensembl chr 2:25,112,172...25,114,714

G

tubulin, beta 5 class I

decreases expression

zoledronic acid results in decreased expression of TUBB mRNA

NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198

G

thioredoxin interacting protein

increases expression

zoledronic acid results in increased expression of TXNIP mRNA

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

thymidine phosphorylase

increases expression
multiple interactions

zoledronic acid results in increased expression of TYMP mRNA
Gossypol inhibits the reaction [zoledronic acid results in increased expression of TYMP mRNA]

NCBI chr15:89,255,834...89,261,282
Ensembl chr15:89,256,134...89,261,242

G

ubiquitin D

increases expression

zoledronic acid results in increased expression of UBD mRNA

NCBI chr17:37,504,783...37,506,992
Ensembl chr17:37,504,783...37,506,986

G

ubiquitin-conjugating enzyme E2C

decreases expression

zoledronic acid results in decreased expression of UBE2C mRNA

NCBI chr 2:164,611,849...164,614,822
Ensembl chr 2:164,611,818...164,620,742

G

ubiquilin 1

increases expression

zoledronic acid results in increased expression of UBQLN1 protein

NCBI chr13:58,323,970...58,363,467
Ensembl chr13:58,323,970...58,363,467

G

UDP glucuronosyltransferase 1 family, polypeptide A6B

decreases expression

zoledronic acid results in decreased expression of UGT1A6 mRNA

NCBI chr 1:88,030,979...88,146,720
Ensembl chr 1:88,030,974...88,146,725

G

UDP galactosyltransferase 8A

decreases expression

zoledronic acid results in decreased expression of UGT8 mRNA

NCBI chr 3:125,655,071...125,732,301
Ensembl chr 3:125,658,920...125,732,268

G

ubiquitin-like, containing PHD and RING finger domains, 1

decreases expression

zoledronic acid results in decreased expression of UHRF1 mRNA

NCBI chr17:56,610,405...56,630,486
Ensembl chr17:56,610,321...56,630,486

G

unc-51 like kinase 2

increases expression

zoledronic acid results in increased expression of ULK2 mRNA

NCBI chr11:61,666,424...61,750,754
Ensembl chr11:61,666,475...61,745,899

G

unc-13 homolog D

increases expression

zoledronic acid results in increased expression of UNC13D mRNA

NCBI chr11:115,952,921...115,969,321
Ensembl chr11:115,952,921...115,968,787

G

unc-5 netrin receptor A

increases expression

zoledronic acid results in increased expression of UNC5A mRNA

NCBI chr13:55,090,545...55,153,831
Ensembl chr13:55,097,224...55,153,831

G

uridine phosphorylase 1

decreases expression

zoledronic acid results in decreased expression of UPP1 mRNA

NCBI chr11:9,068,008...9,086,170
Ensembl chr11:9,068,103...9,086,170

G

ubiquinol-cytochrome c reductase core protein 1

decreases expression

zoledronic acid results in decreased expression of UQCRC1 protein

NCBI chr 9:108,765,716...108,778,709
Ensembl chr 9:108,765,701...108,778,691

G

ubiquinol-cytochrome c reductase hinge protein

decreases expression

zoledronic acid results in decreased expression of UQCRH protein

NCBI chr 4:115,924,162...115,932,267
Ensembl chr 4:115,924,162...115,932,268

G

ubiquitin specific peptidase 13 (isopeptidase T-3)

decreases expression

zoledronic acid results in decreased expression of USP13 mRNA

NCBI chr 3:32,870,432...32,992,224
Ensembl chr 3:32,871,695...32,992,220

G

ubiquitin specific peptidase 24

decreases expression

zoledronic acid results in decreased expression of USP24 mRNA

NCBI chr 4:106,173,179...106,303,798
Ensembl chr 4:106,173,417...106,298,519

G

ubiquitin specific peptidase 31

increases expression

zoledronic acid results in increased expression of USP31 mRNA

NCBI chr 7:121,241,244...121,306,683
Ensembl chr 7:121,241,244...121,306,476

G

UV radiation resistance associated gene

increases expression

zoledronic acid results in increased expression of UVRAG mRNA

NCBI chr 7:98,535,949...98,790,373
Ensembl chr 7:98,534,228...98,790,348

G

vesicle-associated membrane protein 2

increases expression

zoledronic acid results in increased expression of VAMP2 protein

NCBI chr11:68,979,354...68,983,207
Ensembl chr11:68,979,316...68,983,210

G

vesicle-associated membrane protein 3

increases expression

zoledronic acid results in increased expression of VAMP3 mRNA

NCBI chr 4:151,131,762...151,142,410
Ensembl chr 4:151,131,757...151,142,420

G

VANGL planar cell polarity 1

decreases expression

zoledronic acid results in decreased expression of VANGL1 mRNA

NCBI chr 3:102,060,899...102,112,012
Ensembl chr 3:102,060,899...102,112,009

G

valyl-tRNA synthetase 1

increases expression

Zoledronic Acid results in increased expression of VARS1 mRNA

NCBI chr17:35,219,895...35,235,304
Ensembl chr17:35,219,963...35,235,298

G

vasohibin 1

increases expression

zoledronic acid results in increased expression of VASH1 mRNA

NCBI chr12:86,725,474...86,742,462
Ensembl chr12:86,725,474...86,738,865

G

vascular endothelial growth factor A

increases expression

zoledronic acid results in increased expression of VEGFA mRNA

NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295

G

vimentin

multiple interactions
increases expression

SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of VIM mRNA]

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

vasoactive intestinal peptide receptor 1

increases expression

zoledronic acid results in increased expression of VIPR1 mRNA

NCBI chr 9:121,471,782...121,502,020
Ensembl chr 9:121,471,782...121,502,020

G

vanin 1

increases expression

zoledronic acid results in increased expression of VNN1 mRNA

NCBI chr10:23,770,586...23,781,242
Ensembl chr10:23,770,586...23,781,241

G

vanin 3

increases expression

Zoledronic Acid results in increased expression of VNN3P mRNA

NCBI chr10:23,727,360...23,745,741
Ensembl chr10:23,727,360...23,745,741

G

vacuolar protein sorting 13A

increases expression

zoledronic acid results in increased expression of VPS13A protein

NCBI chr19:16,592,730...16,758,433
Ensembl chr19:16,592,730...16,758,297

G

VPS53 GARP complex subunit

decreases expression

zoledronic acid results in decreased expression of VPS53 protein

NCBI chr11:75,937,052...76,070,464
Ensembl chr11:75,937,052...76,070,473

G

V-set domain containing T cell activation inhibitor 1

increases expression

zoledronic acid results in increased expression of VTCN1 mRNA

PMID:24714768 PMID:25596134

NCBI chr 3:100,732,775...100,805,555
Ensembl chr 3:100,732,775...100,804,238

G

von Willebrand factor A domain containing 3B

increases expression

zoledronic acid results in increased expression of VWA3B mRNA

NCBI chr 1:37,068,372...37,226,689
Ensembl chr 1:37,065,677...37,226,694

G

Von Willebrand factor

increases expression

zoledronic acid results in increased expression of VWF mRNA

NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642

G

WD repeat domain 1

increases expression

zoledronic acid results in increased expression of WDR1 mRNA

NCBI chr 5:38,684,149...38,720,265
Ensembl chr 5:38,684,156...38,720,564

G

WD repeat domain 72

decreases expression

zoledronic acid results in decreased expression of WDR72 mRNA

NCBI chr 9:74,017,608...74,190,485
Ensembl chr 9:74,017,638...74,190,590

G

WD and tetratricopeptide repeats 1

increases expression

zoledronic acid results in increased expression of WDTC1 mRNA

NCBI chr 4:133,019,777...133,080,811
Ensembl chr 4:133,019,770...133,080,792

G

WAP four-disulfide core domain 21

increases expression

zoledronic acid results in increased expression of WFDC21P mRNA

NCBI chr11:83,637,766...83,643,472
Ensembl chr11:83,637,766...83,643,468

G

WAP four-disulfide core domain 5

increases expression

zoledronic acid results in increased expression of WFDC5 mRNA

NCBI chr 2:164,018,245...164,024,662
Ensembl chr 2:164,018,247...164,024,662

G

WAS protein homolog associated with actin, golgi membranes and microtubules

increases expression

zoledronic acid results in increased expression of WHAMM mRNA

NCBI chr 7:81,220,403...81,246,585
Ensembl chr 7:81,221,014...81,246,584

G

wntless WNT ligand secretion mediator

decreases expression

zoledronic acid results in decreased expression of WLS mRNA

NCBI chr 3:159,545,287...159,644,302
Ensembl chr 3:159,545,309...159,644,300

G

WNK lysine deficient protein kinase 1

decreases expression

zoledronic acid results in decreased expression of WNK1 mRNA

NCBI chr 6:119,900,930...120,015,659
Ensembl chr 6:119,900,930...120,015,633

G

wingless-type MMTV integration site family, member 11

multiple interactions

[zoledronic acid co-treated with fluvastatin] results in increased expression of WNT11 mRNA

NCBI chr 7:98,484,293...98,503,954
Ensembl chr 7:98,484,319...98,504,402

G

wingless-type MMTV integration site family, member 5A

increases expression

zoledronic acid results in increased expression of WNT5A mRNA

NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405

G

WSC domain containing 1

decreases expression

zoledronic acid results in decreased expression of WSCD1 mRNA

NCBI chr11:71,640,719...71,680,475
Ensembl chr11:71,640,746...71,680,473

G

WT1 associating protein

increases expression

zoledronic acid results in increased expression of WTAP mRNA

NCBI chr17:13,185,686...13,211,430
Ensembl chr17:13,185,683...13,213,056

G

xanthine dehydrogenase

increases expression

zoledronic acid results in increased expression of XDH mRNA

NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191

G

X-linked inhibitor of apoptosis

decreases expression

zoledronic acid results in decreased expression of XIAP mRNA

NCBI chr X:41,148,483...41,198,541
Ensembl chr X:41,148,556...41,198,533

G

exportin 6

increases expression

zoledronic acid results in increased expression of XPO6 protein

NCBI chr 7:125,700,890...125,799,715
Ensembl chr 7:125,700,887...125,799,673

G

tyrosyl-tRNA synthetase 1

decreases expression

Zoledronic Acid results in decreased expression of YARS1 mRNA

NCBI chr 4:129,083,595...129,113,033
Ensembl chr 4:129,083,553...129,113,400

G

YTH N6-methyladenosine RNA binding protein 3

increases expression

zoledronic acid results in increased expression of YTHDF3 mRNA

NCBI chr 3:16,237,309...16,271,201
Ensembl chr 3:16,237,376...16,271,201

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

decreases expression

zoledronic acid results in decreased expression of YWHAZ protein

NCBI chr15:36,770,505...36,803,228
Ensembl chr15:36,771,014...36,797,173

G

zinc finger and BTB domain containing 4

decreases expression

zoledronic acid results in decreased expression of ZBTB4 mRNA

NCBI chr11:69,656,738...69,674,852
Ensembl chr11:69,656,738...69,674,849

G

zinc finger CCCH type containing 12A

increases expression

zoledronic acid results in increased expression of ZC3H12A mRNA

NCBI chr 4:125,012,207...125,021,674
Ensembl chr 4:125,012,216...125,021,633

G

zinc finger CCCH type containing 12C

increases expression

zoledronic acid results in increased expression of ZC3H12C mRNA

NCBI chr 9:52,020,869...52,080,028
Ensembl chr 9:52,022,644...52,079,872

G

zinc finger CCCH type, antiviral 1

increases expression

zoledronic acid results in increased expression of ZC3HAV1 mRNA

NCBI chr 6:38,282,221...38,332,859
Ensembl chr 6:38,282,221...38,331,538

G

zinc finger protein 146

increases expression

zoledronic acid results in increased expression of ZNF146 mRNA

NCBI chr 7:29,859,912...29,869,225
Ensembl chr 7:29,860,694...29,869,175

G

zinc finger protein 36, C3H type-like 2

increases expression

zoledronic acid results in increased expression of ZFP36L2 mRNA

NCBI chr17:84,491,352...84,495,375
Ensembl chr17:84,491,359...84,495,375

G

zinc finger protein 385B

decreases expression

zoledronic acid results in decreased expression of ZNF385B mRNA

NCBI chr 2:77,240,966...77,648,050
Ensembl chr 2:77,240,978...77,649,983

G

zinc finger protein 46

increases expression

zoledronic acid results in increased expression of ZNF436 mRNA

NCBI chr 4:136,011,479...136,021,163
Ensembl chr 4:136,011,994...136,021,253

G

zinc finger protein 467

increases expression

zoledronic acid results in increased expression of ZNF467 mRNA

NCBI chr 6:48,404,626...48,422,926
Ensembl chr 6:48,404,631...48,422,759

G

zinc finger protein 644

increases expression

zoledronic acid results in increased expression of ZNF644 mRNA

NCBI chr 5:106,764,605...106,844,696
Ensembl chr 5:106,764,605...106,845,153

G

zinc finger protein 775

increases expression

zoledronic acid results in increased expression of ZNF775 mRNA

NCBI chr 6:48,578,937...48,598,482
Ensembl chr 6:48,578,997...48,600,161

G

zinc finger protein 809

decreases expression

Zoledronic Acid results in decreased expression of ZNF684 mRNA

NCBI chr 9:22,136,980...22,165,413
Ensembl chr 9:22,137,010...22,154,650

G

zinc finger protein 827

increases expression

zoledronic acid results in increased expression of ZNF827 mRNA

NCBI chr 8:79,753,754...79,920,397
Ensembl chr 8:79,755,066...79,920,395

G

zinc and ring finger 3

decreases expression

zoledronic acid results in decreased expression of ZNRF3 mRNA

NCBI chr11:5,226,329...5,394,847
Ensembl chr11:5,226,324...5,394,847

G

zona pellucida 3 receptor

increases expression

zoledronic acid results in increased expression of C4BPA mRNA

NCBI chr 1:130,474,847...130,557,371
Ensembl chr 1:130,504,450...130,557,358

G

zinc finger and SCAN domain containing 25

increases expression

zoledronic acid results in increased expression of ZSCAN25 mRNA

NCBI chr 5:145,217,261...145,229,050
Ensembl chr 5:145,217,310...145,228,088

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	22178
chemical entity	22208
atom	22170
nonmetal atom	22055
phosphorus atom	13027
phosphorus molecular entity	13027
phosphorus oxoacids and derivatives	13001
phosphonic acids	5293
1,1-bis(phosphonic acid)	1696
IBANDRONATE	0
Pamidronate disodium	0
Risedronate sodium	14
[1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid	0
alendronic acid	79
butedronic acid	0
clodronic acid	240
etidronic acid	3
hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate	0
incadronic acid	0
medronic acid	0
neridronic acid	0
oxidronic acid	0
zoledronic acid	1503
Path 2
Term	Annotations
CHEBI ontology	22178
subatomic particle	22170
composite particle	22170
hadron	22201
baryon	22170
nucleon	22170
atomic nucleus	22170
atom	22170
main group element atom	22104
p-block element atom	22104
pnictogen	20333
phosphorus atom	13027
phosphorus molecular entity	13027
phosphorus oxoacids and derivatives	13001
phosphonic acids	5293
1,1-bis(phosphonic acid)	1696
IBANDRONATE	0
Pamidronate disodium	0
Risedronate sodium	14
[1-(4-hydroxyphenoxy)-1-phosphonoethyl]phosphonic acid	0
alendronic acid	79
butedronic acid	0
clodronic acid	240
etidronic acid	3
hydroxy-[1-hydroxy-3-[methyl(pentyl)amino]-1-phosphonopropyl]phosphinate	0
incadronic acid	0
medronic acid	0
neridronic acid	0
oxidronic acid	0
zoledronic acid	1503

paths to the root