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ONTOLOGY REPORT - ANNOTATIONS


Term:olanzapine
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Accession:CHEBI:7735 term browser browse the term
Definition:A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Synonyms:exact_synonym: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
 related_synonym: Formula=C17H20N4S;   InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3;   InChIKey=KVWDHTXUZHCGIO-UHFFFAOYSA-N;   SMILES=N1=C(C2=C(NC3=CC=CC=C13)SC(=C2)C)N4CCN(CC4)C;   Zyprexa;   olanzapina;   olanzapinum
 xref: CAS:132539-06-1 "ChemIDplus";   DrugBank:DB00334;   Drug_Central:1982 "DrugCentral";   KEGG:C07322;   KEGG:D00454
 xref_mesh: MESH:C076029
 xref: PMID:18022155 "Europe PMC";   PMID:18504690 "Europe PMC";   PMID:18792627 "Europe PMC";   Patent:EP454436;   Patent:US5229382;   Reaxys:7655141 "Reaxys";   Wikipedia:Olanzapine


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olanzapine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A1bg alpha-1-B glycoprotein JBrowse link 7 102,294,805 102,298,522 RGD:6480464
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:6480464
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Acox1 acyl-CoA oxidase 1 JBrowse link 10 104,724,534 104,748,003 RGD:6480464
G Adcyap1r1 ADCYAP receptor type I JBrowse link 4 85,662,809 85,711,696 RGD:6480464
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:6480464
G Afm afamin JBrowse link 14 19,078,678 19,132,212 RGD:6480464
G Agrp agouti related neuropeptide JBrowse link 19 37,525,941 37,584,875 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:6480464
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6480464
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:6480464
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:6480464
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:6480464
G Apoh apolipoprotein H JBrowse link 10 96,640,013 96,653,939 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Bik BCL2-interacting killer JBrowse link 7 124,390,924 124,410,449 RGD:6480464
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:6480464
G C4a complement C4A JBrowse link 20 2,651,599 2,678,183 RGD:6480464
G C4b complement C4B (Chido blood group) JBrowse link 20 4,302,344 4,316,752 RGD:6480464
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:6480464
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:6480464
G C9 complement C9 JBrowse link 2 55,775,562 55,823,807 RGD:6480464
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:6480464
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:6480464
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464
G Cp ceruloplasmin JBrowse link 2 104,744,249 104,803,034 RGD:6480464
G Cpt2 carnitine palmitoyltransferase 2 JBrowse link 5 127,505,646 127,523,016 RGD:6480464
G Creb1 cAMP responsive element binding protein 1 JBrowse link 9 71,229,753 71,298,994 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Dab1 DAB adaptor protein 1 JBrowse link 5 123,154,360 124,279,170 RGD:6480464
G Dclk1 doublecortin-like kinase 1 JBrowse link 2 144,646,255 144,939,389 RGD:6480464
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:6480464
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:6480464
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fgf2 fibroblast growth factor 2 JBrowse link 2 124,081,072 124,134,133 RGD:6480464
G Fn1 fibronectin 1 JBrowse link 9 78,900,111 78,969,018 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Fosl1 FOS like 1, AP-1 transcription factor subunit JBrowse link 1 220,826,560 220,835,066 RGD:6480464
G Gad1 glutamate decarboxylase 1 JBrowse link 3 56,861,440 56,902,139 RGD:6480464
G Gad2 glutamate decarboxylase 2 JBrowse link 17 89,171,576 89,234,770 RGD:6480464
G Gc GC, vitamin D binding protein JBrowse link 14 20,267,023 20,302,577 RGD:6480464
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:6480464
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 JBrowse link X 127,561,843 127,829,763 RGD:6480464
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:6480464
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:6480464
G Hpx hemopexin JBrowse link 1 170,423,558 170,431,066 RGD:6480464
G Hrg histidine-rich glycoprotein JBrowse link 11 81,621,274 81,639,938 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:6480464
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:6480464
G Htr6 5-hydroxytryptamine receptor 6 JBrowse link 5 157,501,202 157,518,870 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:6480464
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 JBrowse link 17 72,160,734 72,197,248 RGD:6480464
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 JBrowse link 16 6,970,367 6,985,538 RGD:6480464
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:6480464
G Kcna1 potassium voltage-gated channel subfamily A member 1 JBrowse link 4 159,190,781 159,192,526 RGD:6480464
G Kcnab1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 JBrowse link 2 155,555,798 156,011,438 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnip3 potassium voltage-gated channel interacting protein 3 JBrowse link 3 120,023,062 120,087,650 RGD:6480464
G Klc1 kinesin light chain 1 JBrowse link 6 136,330,151 136,373,716 RGD:6480464
G Kng2 kininogen 2 JBrowse link 11 81,509,185 81,516,759 RGD:6480464
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Mal mal, T-cell differentiation protein JBrowse link 3 120,209,647 120,233,655 RGD:6480464
G Maoa monoamine oxidase A JBrowse link X 6,554,698 6,620,722 RGD:6480464
G Maob monoamine oxidase B JBrowse link X 6,430,694 6,533,520 RGD:6480464
G Map2 microtubule-associated protein 2 JBrowse link 9 73,204,753 73,462,965 RGD:6480464
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:6480464
G Ncan neurocan JBrowse link 16 21,050,243 21,076,707 RGD:6480464
G Nedd4 NEDD4 E3 ubiquitin protein ligase JBrowse link 8 79,323,408 79,408,842 RGD:6480464
G Nptn neuroplastin JBrowse link 8 63,379,062 63,445,694 RGD:6480464
G Npy neuropeptide Y JBrowse link 4 79,557,856 79,565,059 RGD:6480464
G Numbl NUMB-like, endocytic adaptor protein JBrowse link 1 84,067,841 84,091,659 RGD:6480464
G Pde1a phosphodiesterase 1A JBrowse link 3 66,803,247 67,263,658 RGD:6480464
G Pde8b phosphodiesterase 8B JBrowse link 2 24,718,548 24,955,533 RGD:6480464
G Plac8 placenta associated 8 JBrowse link 14 10,692,799 10,714,556 RGD:6480464
G Plp1 proteolipid protein 1 JBrowse link X 107,494,326 107,511,355 RGD:6480464
G Pnpla2 patatin-like phospholipase domain containing 2 JBrowse link 1 214,434,638 214,439,720 RGD:6480464
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Prrc2a proline-rich coiled-coil 2A JBrowse link 20 5,139,881 5,155,371 RGD:6480464
G Rapgef4 Rap guanine nucleotide exchange factor 4 JBrowse link 3 58,632,338 58,925,127 RGD:6480464
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:6480464
G Rgs7 regulator of G-protein signaling 7 JBrowse link 13 93,095,659 93,534,452 RGD:6480464
G Rtn4 reticulon 4 JBrowse link 14 114,126,931 114,174,459 RGD:6480464
G S100a9 S100 calcium binding protein A9 JBrowse link 2 190,097,436 190,100,209 RGD:6480464
G Sc5d sterol-C5-desaturase JBrowse link 8 46,525,406 46,537,014 RGD:6480464
G Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M JBrowse link 6 127,808,785 127,816,067 RGD:6480464
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:6480464
G Serpini1 serpin family I member 1 JBrowse link 2 174,013,058 174,111,693 RGD:6480464
G Shbg sex hormone binding globulin JBrowse link 10 56,219,861 56,237,354 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:6480464
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Sypl1 synaptophysin-like 1 JBrowse link 6 52,265,920 52,286,037 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Ttr transthyretin JBrowse link 18 15,532,963 15,542,180 RGD:6480464
G Ucp1 uncoupling protein 1 JBrowse link 19 24,456,976 24,464,808 RGD:6480464
G Vipr2 vasoactive intestinal peptide receptor 2 JBrowse link 6 143,932,960 144,009,476 RGD:6480464
G Vldlr very low density lipoprotein receptor JBrowse link 1 245,236,819 245,273,688 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        pharmacological role 18687
          antagonist 15809
            histamine antagonist 4484
              olanzapine 127
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    main group molecular entity 19539
                      s-block molecular entity 19322
                        hydrogen molecular entity 19312
                          hydrides 18241
                            inorganic hydride 17110
                              pnictogen hydride 17068
                                nitrogen hydride 16889
                                  azane 16565
                                    ammonia 16562
                                      organic amino compound 16561
                                        tertiary amino compound 8525
                                          N-alkylpiperazine 2956
                                            N-methylpiperazine 839
                                              olanzapine 127
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.