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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:olanzapine
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Accession:CHEBI:7735 term browser browse the term
Definition:A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Synonyms:exact_synonym: 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine
 related_synonym: Formula=C17H20N4S;   InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3;   InChIKey=KVWDHTXUZHCGIO-UHFFFAOYSA-N;   SMILES=N1=C(C2=C(NC3=CC=CC=C13)SC(=C2)C)N4CCN(CC4)C;   Zyprexa;   olanzapina;   olanzapinum
 xref: CAS:132539-06-1;   DrugBank:DB00334;   Drug_Central:1982;   KEGG:C07322;   KEGG:D00454
 xref_mesh: MESH:C076029
 xref: PMID:18022155;   PMID:18504690;   PMID:18792627;   Patent:EP454436;   Patent:US5229382;   Reaxys:7655141;   Wikipedia:Olanzapine


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olanzapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1bg alpha-1-B glycoprotein affects phosphorylation ISO olanzapine affects the phosphorylation of A1BG protein CTD PMID:25821032 NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097 		JBrowse link
G A2m alpha-2-macroglobulin affects phosphorylation ISO olanzapine affects the phosphorylation of A2M protein CTD PMID:25821032 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO olanzapine results in decreased activity of ABCB11 protein CTD PMID:22646477 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions		 ISO
EXP		 olanzapine results in decreased activity of ABCB1 protein
[[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which affects the abundance of Olanzapine; [[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which results in increased uptake of Olanzapine; [ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] results in increased abundance of and results in decreased uptake of Olanzapine		 CTD PMID:16810505 PMID:34610281 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions EXP [[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which affects the abundance of Olanzapine; [[ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] affects the susceptibility to Fluoxetine] which results in increased uptake of Olanzapine; [ABCB1A gene mutant form co-treated with ABCB1B gene mutant form] results in increased abundance of and results in decreased uptake of Olanzapine CTD PMID:34610281 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO olanzapine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression
multiple interactions		 ISO Olanzapine results in decreased expression of ACACA mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]		 CTD PMID:32652086 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of ACOX1 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of ACOX1 mRNA CTD PMID:23226405 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I affects expression ISO olanzapine affects the expression of ADCYAP1R1 mRNA CTD PMID:27900577 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
multiple interactions
decreases expression		 ISO olanzapine results in increased expression of ADIPOQ mRNA
capsazepine inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]		 CTD PMID:17651982 PMID:32652086 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Afm afamin affects phosphorylation ISO olanzapine affects the phosphorylation of AFM protein CTD PMID:25821032 NCBI chr14:17,531,022...17,563,868
Ensembl chr14:17,531,024...17,563,870 		JBrowse link
G Agrp agouti related neuropeptide increases expression
multiple interactions		 EXP
ISO		 olanzapine results in increased expression of AGRP protein
Olanzapine results in increased expression of AGRP mRNA
Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA]		 CTD PMID:21695181 PMID:32652086 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression
increases phosphorylation
increases response to substance
multiple interactions
decreases expression		 ISO Olanzapine results in increased expression of AKT1 mRNA; Olanzapine results in increased expression of AKT1 protein
olanzapine results in increased phosphorylation of AKT1 protein
AKT1 gene SNP results in increased susceptibility to olanzapine
capsazepine inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]		 CTD PMID:19440698 PMID:21187413 PMID:32652086 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin affects phosphorylation ISO olanzapine affects the phosphorylation of ALB protein CTD PMID:25821032 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apoa1 apolipoprotein A1 increases phosphorylation ISO olanzapine results in increased phosphorylation of APOA1 protein CTD PMID:25821032 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa4 apolipoprotein A4 affects phosphorylation ISO olanzapine affects the phosphorylation of APOA4 protein CTD PMID:25821032 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apob apolipoprotein B increases phosphorylation ISO olanzapine results in increased phosphorylation of APOB protein CTD PMID:25821032 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoc3 apolipoprotein C3 affects response to substance EXP APOC3 gene polymorphism affects the susceptibility to olanzapine CTD PMID:17726453 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Apoh apolipoprotein H affects phosphorylation ISO olanzapine affects the phosphorylation of APOH protein CTD PMID:25821032 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein]; olanzapine inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15948179 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Aqp4 aquaporin 4 affects response to substance
increases response to substance		 ISO AQP4 gene polymorphism affects the susceptibility to olanzapine
AQP4 protein results in increased susceptibility to olanzapine		 CTD PMID:22544010 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP olanzapine results in increased expression of BAX protein CTD PMID:16462815 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression		 EXP olanzapine inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]
olanzapine results in increased expression of BCL2 mRNA; olanzapine results in increased expression of BCL2 protein		 CTD PMID:15126120 PMID:15276877 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP
ISO		 olanzapine results in increased expression of BDNF mRNA; olanzapine results in increased expression of BDNF protein
Olanzapine results in increased expression of BDNF mRNA; Olanzapine results in increased expression of BDNF protein		 CTD PMID:12478621 PMID:17442489 PMID:29182611 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bik BCL2-interacting killer increases expression ISO olanzapine results in increased expression of BIK mRNA CTD PMID:16160616 NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296 		JBrowse link
G C3 complement C3 affects phosphorylation ISO olanzapine affects the phosphorylation of C3 protein CTD PMID:25821032 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4a complement C4A decreases phosphorylation ISO olanzapine results in decreased phosphorylation of C4A protein CTD PMID:25821032 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080 		JBrowse link
G C4b complement C4B affects phosphorylation ISO olanzapine affects the phosphorylation of C4B protein CTD PMID:25821032 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C5 complement C5 affects phosphorylation ISO olanzapine affects the phosphorylation of C5 protein CTD PMID:25821032 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C6 complement C6 affects phosphorylation ISO olanzapine affects the phosphorylation of C6 protein CTD PMID:25821032 NCBI chr 2:53,846,028...53,921,279
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C9 complement C9 affects phosphorylation ISO olanzapine affects the phosphorylation of C9 protein CTD PMID:25821032 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP olanzapine results in decreased expression of and results in decreased phosphorylation of CAMK2A protein CTD PMID:18061412 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Cat catalase multiple interactions EXP olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein] CTD PMID:15948179 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cfb complement factor B affects phosphorylation ISO olanzapine affects the phosphorylation of CFB protein CTD PMID:25821032 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G Cfh complement factor H decreases phosphorylation ISO olanzapine results in decreased phosphorylation of CFH protein CTD PMID:25821032 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 affects binding ISO olanzapine binds to CHRM1 protein CTD PMID:16983399 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Clu clusterin affects phosphorylation ISO olanzapine affects the phosphorylation of CLU protein CTD PMID:25821032 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases phosphorylation ISO olanzapine results in decreased phosphorylation of COL1A1 protein CTD PMID:25821032 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP olanzapine results in increased expression of COMT mRNA CTD PMID:15964593 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Cp ceruloplasmin affects phosphorylation ISO olanzapine affects the phosphorylation of CP protein CTD PMID:25821032 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of CPT2 mRNA; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased activity of CPT2 protein; [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in increased expression of CPT2 mRNA CTD PMID:23226405 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in decreased phosphorylation of CREB1 protein CTD PMID:14556240 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cs citrate synthase increases activity
multiple interactions		 EXP Olanzapine results in increased activity of CS protein
[Olanzapine co-treated with Fluoxetine] results in increased activity of CS protein		 CTD PMID:20971158 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
increases expression		 ISO olanzapine results in decreased expression of CTNNB1 mRNA
Olanzapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]
Olanzapine results in increased expression of CTNNB1 mRNA		 CTD PMID:18797397 PMID:31563592 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions		 ISO CYP1A2 protein affects the metabolism of olanzapine
Fluvoxamine inhibits the reaction [CYP1A2 protein affects the metabolism of olanzapine]		 CTD PMID:15545309 PMID:15883149 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression EXP olanzapine results in decreased expression of DAB1 protein CTD PMID:19359144 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552 		JBrowse link
G Dclk1 doublecortin-like kinase 1 increases expression ISO olanzapine results in increased expression of DCLK1 mRNA CTD PMID:18797397 NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956 		JBrowse link
G Drd1 dopamine receptor D1 affects binding ISO olanzapine binds to DRD1 protein CTD PMID:24389121 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 increases response to substance
affects activity
affects binding
decreases activity
multiple interactions		 ISO
EXP		 DRD2 gene SNP results in increased susceptibility to olanzapine; DRD2 intron SNP results in increased susceptibility to olanzapine
olanzapine affects the activity of DRD2 protein
olanzapine binds to DRD2 protein
olanzapine results in decreased activity of DRD2 protein
olanzapine promotes the reaction [Dopamine binds to DRD2 protein]		 CTD PMID:10482380 PMID:10831489 PMID:11198054 PMID:15716360 PMID:20361897 More... NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO DRD3 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine] CTD PMID:20021991 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G F2 coagulation factor II, thrombin affects phosphorylation ISO olanzapine affects the phosphorylation of F2 protein CTD PMID:25821032 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Olanzapine results in increased expression of FABP1 mRNA CTD PMID:31437515 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fasn fatty acid synthase increases expression ISO olanzapine results in increased expression of FASN mRNA CTD PMID:17651982 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in increased expression of FGF2 mRNA CTD PMID:15158429 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fn1 fibronectin 1 affects phosphorylation ISO olanzapine affects the phosphorylation of FN1 protein CTD PMID:25821032 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Fluoxetine co-treated with olanzapine] results in decreased expression of FOS protein CTD PMID:14556240 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions EXP olanzapine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of FOSL1 protein] CTD PMID:11425506 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gad1 glutamate decarboxylase 1 decreases expression EXP olanzapine results in decreased expression of GAD1 mRNA; olanzapine results in decreased expression of GAD1 protein CTD PMID:14519413 PMID:19359144 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 decreases expression EXP olanzapine results in decreased expression of GAD2 protein CTD PMID:19359144 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gc GC, vitamin D binding protein affects phosphorylation ISO olanzapine affects the phosphorylation of GC protein CTD PMID:25821032 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Olanzapine results in increased expression of GCLC mRNA CTD PMID:37005277 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621 		JBrowse link
G Ghsr growth hormone secretagogue receptor increases expression
multiple interactions		 ISO Olanzapine results in increased expression of GHSR mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA]		 CTD PMID:32652086 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions
increases expression		 ISO Dietary Fats promotes the reaction [Olanzapine results in increased expression of GPT protein] CTD PMID:37019375 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 increases expression EXP olanzapine results in increased expression of GRIA2 mRNA CTD PMID:11526992 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 increases expression EXP olanzapine results in increased expression of GRIA3 mRNA CTD PMID:11526992 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
decreases expression
multiple interactions		 ISO olanzapine results in increased phosphorylation of GSK3B protein
Olanzapine results in decreased expression of GSK3B mRNA
Olanzapine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]		 CTD PMID:19440698 PMID:31563592 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression
multiple interactions
decreases expression		 ISO
EXP		 olanzapine results in increased expression of HMGCR mRNA
1-(carboxymethylthio)tetradecane promotes the reaction [olanzapine results in decreased expression of HMGCR mRNA]; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of HMGCR mRNA]		 CTD PMID:17052361 PMID:23226405 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO olanzapine results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Olanzapine results in increased expression of HMOX1 mRNA CTD PMID:37005277 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hpx hemopexin affects phosphorylation ISO olanzapine affects the phosphorylation of HPX protein CTD PMID:25821032 NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328 		JBrowse link
G Hrg histidine-rich glycoprotein affects phosphorylation ISO olanzapine affects the phosphorylation of HRG protein CTD PMID:25821032 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389 		JBrowse link
G Hrh1 histamine receptor H 1 affects binding
multiple interactions		 ISO olanzapine binds to HRH1 protein
HRH1 protein results in increased susceptibility to [olanzapine co-treated with Fluoxetine]		 CTD PMID:16983399 PMID:20021991 PMID:24389121 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding
decreases activity		 ISO
EXP		 olanzapine binds to and results in decreased activity of HTR2A protein
olanzapine binds to HTR2A protein
[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein; olanzapine binds to and results in decreased activity of HTR2A protein		 CTD PMID:16983399 PMID:18976543 PMID:19304867 PMID:20521326 PMID:24389121 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C increases response to substance
affects response to substance
affects binding		 ISO HTR2C gene polymorphism results in increased susceptibility to olanzapine
HTR2C gene polymorphism affects the susceptibility to Olanzapine; HTR2C gene SNP affects the susceptibility to Olanzapine; HTR2C protein affects the susceptibility to Olanzapine
olanzapine binds to HTR2C protein		 CTD PMID:15666332 PMID:16983399 PMID:19142110 PMID:19434072 PMID:24389121 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 affects binding ISO olanzapine binds to HTR6 protein CTD PMID:16983399 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912 		JBrowse link
G Il10 interleukin 10 increases expression
multiple interactions
decreases expression		 ISO Olanzapine results in increased expression of IL10 mRNA
Lithium inhibits the reaction [Olanzapine results in decreased expression of IL10 protein]		 CTD PMID:30695037 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL1B protein]
Olanzapine results in increased expression of IL1B mRNA; Olanzapine results in increased expression of IL1B protein		 CTD PMID:30695037 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
Olanzapine results in increased expression of IL6 mRNA; Olanzapine results in increased expression of IL6 protein		 CTD PMID:30695037 PMID:32652086 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 increases secretion
increases expression		 ISO olanzapine results in increased secretion of INS protein
olanzapine results in increased expression of INS protein		 CTD PMID:11769361 PMID:11927762 PMID:16601995 PMID:19512971 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itih2 inter-alpha-trypsin inhibitor heavy chain 2 affects phosphorylation ISO olanzapine affects the phosphorylation of ITIH2 protein CTD PMID:25821032 NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841 		JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 affects phosphorylation ISO olanzapine affects the phosphorylation of ITIH4 protein CTD PMID:25821032 NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions
increases activity		 EXP [[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 mRNA]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in increased expression of RGS7 protein]; [olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein
olanzapine results in increased activity of JAK2 protein		 CTD PMID:18976543 PMID:19304867 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcna1 potassium voltage-gated channel subfamily A member 1 increases expression ISO olanzapine results in increased expression of KCNA1 mRNA CTD PMID:18797397 NCBI chr 4:159,464,223...159,472,905
Ensembl chr 4:159,464,188...159,472,682 		JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 decreases expression ISO olanzapine results in decreased expression of KCNAB1 mRNA CTD PMID:18797397 NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity
multiple interactions		 ISO olanzapine results in decreased activity of KCNH2 protein
olanzapine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]		 CTD PMID:16494862 PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnip3 potassium voltage-gated channel interacting protein 3 decreases expression ISO olanzapine results in decreased expression of KCNIP3 mRNA; olanzapine results in decreased expression of KCNIP3 protein CTD PMID:18797397 NCBI chr 3:114,677,027...114,742,923
Ensembl chr 3:114,677,030...114,743,556 		JBrowse link
G Klc1 kinesin light chain 1 decreases expression ISO olanzapine results in decreased expression of KLC1 mRNA CTD PMID:18797397 NCBI chr 6:130,823,416...130,866,729
Ensembl chr 6:130,823,419...130,867,031 		JBrowse link
G Kng1 kininogen 1 affects phosphorylation ISO Olanzapine affects the phosphorylation of KNG1 protein CTD PMID:25821032 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression
multiple interactions		 ISO olanzapine results in increased expression of LDLR mRNA
olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]		 CTD PMID:17052361 PMID:17651982 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lep leptin increases expression
multiple interactions		 ISO olanzapine results in increased expression of LEP protein
capsazepine inhibits the reaction [Olanzapine results in increased expression of LEP protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of LEP protein]		 CTD PMID:11927762 PMID:19512971 PMID:32652086 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO olanzapine results in decreased expression of MAL mRNA CTD PMID:18797397 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Maoa monoamine oxidase A increases expression EXP olanzapine results in increased expression of MAOA mRNA CTD PMID:15964593 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B increases expression EXP olanzapine results in increased expression of MAOB mRNA CTD PMID:15964593 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP olanzapine results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP Olanzapine results in increased expression of MKI67 protein CTD PMID:38437955 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR gene polymorphism affects the susceptibility to olanzapine; MTHFR protein affects the susceptibility to olanzapine CTD PMID:20547447 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Ncan neurocan decreases expression ISO olanzapine results in decreased expression of NCAN mRNA CTD PMID:18797397 NCBI chr16:19,301,969...19,328,436
Ensembl chr16:19,301,969...19,328,436 		JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase decreases expression ISO olanzapine results in decreased expression of NEDD4 mRNA; olanzapine results in decreased expression of NEDD4 protein CTD PMID:18797397 NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO Olanzapine results in decreased expression of NFE2L2 protein CTD PMID:37019375 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NFKB1 mRNA] CTD PMID:32652086 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nptn neuroplastin increases expression ISO olanzapine results in increased expression of NPTN mRNA CTD PMID:18797397 NCBI chr 8:58,996,873...59,063,402
Ensembl chr 8:58,996,887...59,063,401 		JBrowse link
G Npy neuropeptide Y decreases expression
increases expression
multiple interactions		 EXP
ISO		 olanzapine results in decreased expression of NPY mRNA
olanzapine results in increased expression of NPY protein
capsazepine inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of NPY mRNA]		 CTD PMID:16516965 PMID:21695181 PMID:32652086 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Numbl NUMB-like, endocytic adaptor protein decreases expression ISO olanzapine results in decreased expression of NUMBL mRNA CTD PMID:18797397 NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776 		JBrowse link
G Pde1a phosphodiesterase 1A increases expression EXP olanzapine results in increased expression of PDE1A mRNA CTD PMID:20222156 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde8b phosphodiesterase 8B increases expression EXP olanzapine results in increased expression of PDE8B mRNA CTD PMID:20222156 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions
decreases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] CTD PMID:32652086 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Plac8 placenta associated 8 affects phosphorylation ISO olanzapine affects the phosphorylation of C15 protein CTD PMID:25821032 NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264 		JBrowse link
G Plp1 proteolipid protein 1 decreases expression ISO olanzapine results in decreased expression of PLP1 mRNA CTD PMID:18797397 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 affects expression EXP olanzapine affects the expression of PNPLA2 mRNA CTD PMID:23226405 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions		 EXP
ISO		 olanzapine results in decreased expression of POMC protein
capsazepine inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]; Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA]		 CTD PMID:21695181 PMID:32652086 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO olanzapine results in increased expression of PPARG protein alternative form CTD PMID:17651982 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 EXP olanzapine results in decreased expression of PPARGC1A mRNA
[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of PPARGC1A mRNA; olanzapine promotes the reaction [1-(carboxymethylthio)tetradecane results in decreased expression of PPARGC1A mRNA]		 CTD PMID:23226405 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 increases expression
multiple interactions		 ISO Olanzapine results in increased expression of PRKAG2 mRNA
capsazepine inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]; Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA]		 CTD PMID:32652086 NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Prl prolactin multiple interactions
increases expression
increases secretion		 ISO
EXP		 [olanzapine co-treated with Fluoxetine] results in increased expression of PRL protein
olanzapine results in increased expression of PRL protein
olanzapine results in increased secretion of PRL protein
Bromocriptine inhibits the reaction [Olanzapine results in increased expression of PRL protein]		 CTD PMID:9090331 PMID:9265911 PMID:9376336 PMID:10831029 PMID:11048906 More... NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prlr prolactin receptor increases expression EXP Olanzapine results in increased expression of PRLR mRNA; Olanzapine results in increased expression of PRLR protein CTD PMID:38437955 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718 		JBrowse link
G Prrc2a proline-rich coiled-coil 2A decreases expression ISO olanzapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO olanzapine results in decreased expression of RAPGEF4 mRNA CTD PMID:18797397 NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316 		JBrowse link
G Reln reelin increases expression EXP olanzapine results in increased expression of RELN mRNA; olanzapine results in increased expression of RELN protein CTD PMID:19359144 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Rgs7 regulator of G-protein signaling 7 multiple interactions
increases expression		 EXP [[Olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [Olanzapine results in increased expression of RGS7 mRNA]; [alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [Olanzapine results in increased expression of RGS7 protein]; Olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]; Olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter]
olanzapine results in increased expression of RGS7 mRNA; olanzapine results in increased expression of RGS7 protein		 CTD PMID:18976543 PMID:19304867 NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888 		JBrowse link
G Rtn4 reticulon 4 decreases expression ISO olanzapine results in decreased expression of RTN4 mRNA CTD PMID:18797397 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression ISO olanzapine results in decreased expression of S100A9 mRNA CTD PMID:18797397 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO olanzapine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273 		JBrowse link
G Serpina3n serpin family A member 3N increases phosphorylation ISO Olanzapine results in increased phosphorylation of SERPINA3 protein CTD PMID:25821032 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Serping1 serpin family G member 1 affects phosphorylation ISO olanzapine affects the phosphorylation of SERPING1 protein CTD PMID:25821032 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Serpini1 serpin family I member 1 decreases expression ISO olanzapine results in decreased expression of SERPINI1 mRNA CTD PMID:18797397 NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135 		JBrowse link
G Shbg sex hormone binding globulin decreases expression ISO olanzapine results in decreased expression of SHBG protein CTD PMID:19512971 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO olanzapine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a5 solute carrier family 22 member 5 decreases expression
multiple interactions		 ISO Olanzapine results in decreased expression of SLC22A5 mRNA; Olanzapine results in decreased expression of SLC22A5 protein
Olanzapine inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine analog]		 CTD PMID:31437515 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression ISO Olanzapine results in increased expression of SLC27A2 mRNA CTD PMID:31437515 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208 		JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression ISO Olanzapine results in increased expression of SLC27A5 mRNA CTD PMID:31437515 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO olanzapine results in increased expression of SLC2A4 mRNA CTD PMID:16002093 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Olanzapine results in decreased expression of SLC7A11 mRNA CTD PMID:37005277 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene SNP affects the susceptibility to olanzapine CTD PMID:15823421 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
decreases activity		 EXP
ISO		 olanzapine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; olanzapine inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]; olanzapine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD1 mRNA]
olanzapine results in increased expression of SOD1 mRNA
Dietary Fats promotes the reaction [Olanzapine results in decreased activity of SOD1 protein]		 CTD PMID:12752374 PMID:12868070 PMID:16564057 PMID:37019375 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 ISO olanzapine promotes the reaction [SREBF1 protein results in increased expression of LDLR mRNA]; olanzapine results in increased activity of and results in increased expression of SREBF1 protein
olanzapine results in increased expression of SREBF1 mRNA		 CTD PMID:17651982 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO
EXP		 olanzapine results in increased cleavage of and results in increased activity of SREBF2 protein
[olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of SREBF2 mRNA		 CTD PMID:17052361 PMID:23226405 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP olanzapine promotes the reaction [[STAT3 protein binds to RGS7 promoter] which results in increased expression of RGS7 mRNA]; olanzapine promotes the reaction [STAT3 protein binds to RGS7 promoter] CTD PMID:18976543 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sypl1 synaptophysin-like 1 decreases expression ISO Olanzapine results in decreased expression of SYPL1 mRNA CTD PMID:18797397 NCBI chr 6:49,565,111...49,585,205
Ensembl chr 6:49,565,154...49,585,330 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP olanzapine inhibits the reaction [Methamphetamine results in decreased expression of TH protein] CTD PMID:15276877 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Dietary Fats promotes the reaction [Olanzapine results in increased expression of TNF protein]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF mRNA]; Lithium inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TNF protein]
Olanzapine results in increased expression of TNF mRNA; Olanzapine results in increased expression of TNF protein		 CTD PMID:30695037 PMID:32652086 PMID:37019375 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO olanzapine results in increased expression of TP53 mRNA CTD PMID:16160616 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
increases expression		 ISO capsazepine inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA]; Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV1 mRNA] CTD PMID:32652086 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions
increases expression		 ISO Ruthenium Red inhibits the reaction [Olanzapine results in increased expression of TRPV3 mRNA] CTD PMID:32652086 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Ttr transthyretin increases expression EXP olanzapine results in increased expression of TTR mRNA CTD PMID:15927202 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP [olanzapine co-treated with 1-(carboxymethylthio)tetradecane] results in decreased expression of UCP1 mRNA CTD PMID:23226405 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 affects expression ISO olanzapine affects the expression of VIPR2 mRNA CTD PMID:27900577 NCBI chr 6:136,996,664...137,070,599
Ensembl chr 6:137,001,511...137,070,597 		JBrowse link
G Vldlr very low density lipoprotein receptor increases expression EXP olanzapine results in increased expression of VLDLR protein CTD PMID:19359144 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        pharmacological role 19106
          antagonist 17262
            histamine antagonist 4895
              olanzapine 149
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        tertiary amino compound 10155
                                          N-alkylpiperazine 3404
                                            N-methylpiperazine 1389
                                              olanzapine 149
paths to the root