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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oltipraz
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Accession:CHEBI:77319 term browser browse the term
Definition:A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
Synonyms:exact_synonym: 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione
 related_synonym: 4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione;   5-(2-Pyrazinyl)-4-methyl-1,2-dithiole-3-thione;   Formula=C8H6N2S3;   InChI=1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3;   InChIKey=CKNAQFVBEHDJQV-UHFFFAOYSA-N;   RP 35972;   RP-35,972;   SMILES=Cc1c(ssc1=S)-c1cnccn1;   oltiprazum
 xref: Beilstein:978110;   CAS:64224-21-1;   HMDB:HMDB0041967
 xref_mesh: MESH:C026209
 xref: PMID:19833192;   PMID:20095791;   PMID:20655236;   PMID:20664537;   PMID:21161163;   PMID:21492164;   PMID:21757314;   PMID:22223846;   PMID:22820161;   PMID:23590302;   PMID:23592516;   PMID:23978715;   PMID:24176857;   PMID:6482725;   PMID:7105289;   PMID:8412206;   Reaxys:978110;   Wikipedia:Oltipraz

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oltipraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO oltipraz results in decreased expression of ABCB11 mRNA CTD PMID:16837569 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO oltipraz results in increased expression of ABCB1 mRNA CTD PMID:16837569 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC1 protein CTD PMID:18032408 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression		 ISO
EXP		 [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC2 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA
oltipraz results in increased expression of ABCC2 mRNA; oltipraz results in increased expression of ABCC2 protein		 CTD PMID:12920174 PMID:15833929 PMID:16837569 PMID:18032408 PMID:25752797 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions		 ISO
EXP		 oltipraz results in increased expression of ABCC3 mRNA
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of ABCC3 mRNA]
[oltipraz results in increased expression of ABCC3 protein] which affects the export of Acetaminophen metabolite
oltipraz results in increased expression of ABCC3 mRNA; oltipraz results in increased expression of ABCC3 protein		 CTD PMID:12920174 PMID:15833929 PMID:16837569 PMID:22496397 PMID:30114225 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions
increases expression		 ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC4 mRNA]
oltipraz results in increased expression of ABCC4 mRNA; oltipraz results in increased expression of ABCC4 protein
oltipraz promotes the reaction [ABCC4 protein results in increased transport of Arsenic]		 CTD PMID:15833929 PMID:18032408 PMID:20395535 PMID:22496397 PMID:25752797 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
increases expression		 ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC5 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA
oltipraz results in increased expression of ABCC5 mRNA		 CTD PMID:15833929 PMID:18032408 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions
increases expression		 ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA
oltipraz results in increased expression of ABCC6 mRNA		 CTD PMID:15833929 NCBI chr 1:101,954,786...102,013,252
Ensembl chr 1:101,959,540...102,013,243 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
increases expression		 ISO oltipraz promotes the reaction [ABCG2 protein results in increased transport of Benzo(a)pyrene metabolite]
oltipraz results in increased activity of ABCG2 protein
oltipraz results in increased expression of ABCG2 mRNA		 CTD PMID:15917307 PMID:16837569 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions ISO [oltipraz co-treated with NFE2L2 protein mutant form] affects the expression of ABCG5 mRNA CTD PMID:22496397 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity		 ISO [oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA; oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]; resveratrol inhibits the reaction [[oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA]
oltipraz results in increased activity of AHR protein		 CTD PMID:11959854 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases activity EXP oltipraz results in increased activity of AKR7A3 protein CTD PMID:9328168 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Alb albumin decreases expression EXP oltipraz results in decreased expression of ALB mRNA CTD PMID:9395210 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions
increases expression		 ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ALDH1A1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ALDH1A1 mRNA] CTD PMID:17998271 PMID:22496397 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of BAX mRNA CTD PMID:19433268 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of BCL2L1 mRNA CTD PMID:19433268 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP [Dexamethasone co-treated with oltipraz] results in increased activity of CEBPB protein; N-acetylsphingosine inhibits the reaction [oltipraz results in increased localization of CEBPB protein]; oltipraz promotes the reaction [CEBPB protein binds to GSTA2 promoter]; oltipraz results in increased localization of and results in increased activity of CEBPB protein CTD PMID:12509401 PMID:15319326 PMID:15870285 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910 		JBrowse link
G Ces1d carboxylesterase 1D increases expression
multiple interactions		 ISO oltipraz results in increased expression of CES1 mRNA
NFE2L2 protein promotes the reaction [oltipraz results in increased expression of CES1 mRNA]		 CTD PMID:30114225 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Ces2c carboxylesterase 2C increases expression
multiple interactions		 ISO oltipraz results in increased expression of CES2C mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES2C mRNA]		 CTD PMID:22429928 NCBI chr 1:282,640,752...282,648,319
Ensembl chr 1:282,638,017...282,702,424 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
affects metabolic processing
decreases activity
affects activity		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [oltipraz results in increased expression of CYP1A1 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [[oltipraz results in increased abundance of Calcium] which results in increased expression of CYP1A1 mRNA]; [oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA; [oltipraz results in increased abundance of Calcium] which results in increased expression of CYP1A1 mRNA; oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]; oltipraz results in increased expression of and results in increased activity of CYP1A1 protein; resveratrol inhibits the reaction [[oltipraz promotes the reaction [AHR protein binds to CYP1A1 promoter]] which results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [oltipraz results in increased expression of CYP1A1 mRNA]
CYP1A1 protein affects the metabolism of oltipraz
oltipraz results in increased expression of CYP1A1 mRNA; oltipraz results in increased expression of CYP1A1 protein
oltipraz metabolite results in decreased activity of CYP1A1 protein
oltipraz affects the activity of CYP1A1 protein		 CTD PMID:10775323 PMID:11959854 PMID:15831204 PMID:15890477 PMID:15920769 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases expression
multiple interactions
increases activity
affects metabolic processing		 ISO
EXP		 oltipraz metabolite results in decreased activity of CYP1A2 protein; oltipraz results in decreased activity of CYP1A2 protein
oltipraz results in increased expression of CYP1A2 mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of CYP1A2 mRNA]
oltipraz results in increased activity of CYP1A2 protein
oltipraz inhibits the reaction [CYP1A2 results in increased activity of 2-amino-3,4-dimethylimidazo(4,5-f)quinoline]
CYP1A2 protein affects the metabolism of oltipraz		 CTD PMID:8625305 PMID:10775323 PMID:15831204 PMID:15920769 PMID:22496397 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
affects activity
increases expression		 ISO oltipraz metabolite results in decreased activity of CYP1B1 protein
oltipraz affects the activity of CYP1B1 protein
oltipraz results in increased expression of CYP1B1 mRNA		 CTD PMID:10775323 PMID:15890477 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects metabolic processing
increases expression		 EXP
ISO		 CYP2B1 protein affects the metabolism of oltipraz
oltipraz results in increased expression of CYP2B10 mRNA		 CTD PMID:15831204 PMID:15920769 PMID:17627975 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects metabolic processing EXP CYP2B2 protein affects the metabolism of oltipraz CTD PMID:15831204 PMID:15920769 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases activity
increases expression		 ISO oltipraz results in decreased activity of CYP2B6 protein
oltipraz results in increased expression of CYP2B6 mRNA; oltipraz results in increased expression of CYP2B6 protein		 CTD PMID:19833192 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of oltipraz CTD PMID:15831204 PMID:15920769 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 affects metabolic processing EXP CYP2D1 protein affects the metabolism of oltipraz CTD PMID:15831204 PMID:15920769 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects activity ISO oltipraz affects the activity of CYP2E1 protein CTD PMID:10775323 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing EXP CYP3A2 protein affects the metabolism of oltipraz CTD PMID:15831204 PMID:15920769 NCBI chr12:11,641,500...11,677,818
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects metabolic processing EXP CYP3A23-3A1 protein affects the metabolism of oltipraz CTD PMID:15831204 PMID:15920769 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity
affects activity		 ISO oltipraz metabolite results in decreased activity of CYP3A4 protein; oltipraz results in decreased activity of CYP3A4 protein
oltipraz affects the activity of CYP3A4 protein		 CTD PMID:10775323 PMID:19833192 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases expression EXP oltipraz results in increased expression of GSTA3 mRNA; oltipraz results in increased expression of GSTA3 protein CTD PMID:9203627 PMID:9794803 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression
multiple interactions		 EXP
ISO		 oltipraz results in increased expression of GSTA2 mRNA; oltipraz results in increased expression of GSTA2 protein
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA1 mRNA]
oltipraz results in increased expression of GSTA1 mRNA; oltipraz results in increased expression of GSTA1 protein
2-tert-butylhydroquinone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 mRNA]; Dexamethasone inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; N-acetylsphingosine inhibits the reaction [oltipraz results in increased expression of GSTA2 protein]; oltipraz promotes the reaction [CEBPB protein binds to GSTA2 promoter]		 CTD PMID:9203627 PMID:11309284 PMID:12242683 PMID:12509401 PMID:15155840 PMID:15319326 PMID:15870285 PMID:22496397 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO oltipraz results in increased expression of GSTA2 protein CTD PMID:11309284 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases activity
increases expression		 EXP oltipraz results in increased activity of GSTA5 protein
oltipraz results in increased expression of GSTA5 mRNA; oltipraz results in increased expression of GSTA5 protein		 CTD PMID:8051171 PMID:8625305 PMID:9203627 PMID:9328168 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179 		JBrowse link
G Gsta6 glutathione S-transferase alpha 6 increases expression
multiple interactions		 ISO oltipraz results in increased expression of GSTA1 mRNA; oltipraz results in increased expression of GSTA1 protein
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA1 mRNA]		 CTD PMID:11309284 PMID:22496397 NCBI chr 9:27,475,273...27,533,939
Ensembl chr 9:27,475,273...27,511,176 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
increases expression		 ISO
EXP		 [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM1 mRNA] CTD PMID:9203627 PMID:18723825 PMID:22496397 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions
increases expression		 ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM2 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM2 mRNA] CTD PMID:18723825 PMID:22496397 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856 		JBrowse link
G Gstm4 glutathione S-transferase mu 4 multiple interactions
increases expression		 ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM4 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM4 mRNA] CTD PMID:18723825 PMID:22496397 NCBI chr 2:210,834,013...210,839,242
Ensembl chr 2:210,833,884...210,839,295 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions
increases expression		 ISO
EXP		 [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM3 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM3 mRNA]
oltipraz results in increased expression of GSTM3 protein		 CTD PMID:9794803 PMID:18723825 PMID:22496397 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions		 ISO
EXP		 oltipraz results in increased expression of GSTP1 mRNA
oltipraz results in increased expression of GSTP1 protein
oltipraz results in increased expression of and results in increased activity of GSTP1 protein		 CTD PMID:9794803 PMID:15374950 PMID:16950796 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects localization
increases expression		 EXP oltipraz affects the localization of GSTT1 protein
oltipraz results in increased expression of GSTT1 protein		 CTD PMID:9794803 PMID:9855024 PMID:10413528 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526 		JBrowse link
G Ivl involucrin decreases expression ISO oltipraz results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Lithocholic Acid co-treated with oltipraz] results in increased expression of MCL1 mRNA CTD PMID:19433268 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase increases expression
multiple interactions		 ISO oltipraz results in increased expression of MGMT mRNA
oltipraz results in increased expression of and results in increased activity of MGMT protein		 CTD PMID:16950796 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 multiple interactions
increases expression		 ISO [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of MGST3 mRNA
oltipraz results in increased expression of MGST3 mRNA		 CTD PMID:18723825 PMID:22496397 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects activity
increases activity
multiple interactions
affects response to substance		 ISO oltipraz affects the activity of NFE2L2 protein
oltipraz results in increased activity of NFE2L2 protein
[oltipraz co-treated with NFE2L2 protein mutant form] affects the expression of ABCG5 mRNA; [oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B1 mRNA; [oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B35 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ALDH1A1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM1 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM2 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM4 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of MGST3 mRNA; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ABCC4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of ALDH1A1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES1G mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CES2C mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of CYP1A2 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM2 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM3 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM4 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of SULT3A1 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT1A6A mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B34 mRNA]; NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B36 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of CES1 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of NQO1 mRNA]; oltipraz binds to and results in increased activity of NFE2L2 protein
NFE2L2 protein affects the susceptibility to oltipraz		 CTD PMID:11309284 PMID:15833929 PMID:15919853 PMID:19150646 PMID:20086057 PMID:22429928 PMID:22496397 PMID:25752797 PMID:30114225 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
multiple interactions
increases expression		 ISO oltipraz results in increased activity of NQO1 protein
oltipraz promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]
oltipraz metabolite results in increased expression of NQO1 protein; oltipraz results in increased expression of NQO1 mRNA; oltipraz results in increased expression of NQO1 protein
[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [oltipraz results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [oltipraz results in increased expression of NQO1 mRNA]; oltipraz promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NQO1 mRNA]		 CTD PMID:11309284 PMID:12407167 PMID:15919853 PMID:17627975 PMID:18488193 PMID:19144771 PMID:19785463 PMID:22496397 PMID:28959534 PMID:30114225 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO oltipraz inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein] CTD PMID:19433268 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression ISO oltipraz results in decreased expression of SLC10A1 mRNA CTD PMID:16837569 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO oltipraz results in decreased expression of SLC22A7 mRNA CTD PMID:16837569 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 decreases expression ISO oltipraz results in decreased expression of SLCO1B3 mRNA CTD PMID:16837569 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression ISO oltipraz results in increased expression of SLCO2B1 mRNA CTD PMID:15919853 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP oltipraz results in increased expression of SOD2 mRNA CTD PMID:9395210 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO oltipraz results in increased expression of TXNRD1 mRNA CTD PMID:16451816 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400 		JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO oltipraz inhibits the reaction [Doxorubicin results in decreased expression of UCP2 protein] CTD PMID:29061315 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
multiple interactions		 ISO oltipraz results in increased expression of UGT1A1 mRNA
oltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A7 mRNA]		 CTD PMID:15374950 PMID:19144771 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO oltipraz results in increased expression of UGT1A5 mRNA CTD PMID:19144771 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions
increases expression		 ISO oltipraz inhibits the reaction [Butylhydroxybutylnitrosamine results in decreased expression of UGT1A6 mRNA]
oltipraz results in increased expression of UGT1A6 mRNA		 CTD PMID:15374950 PMID:19144771 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression ISO oltipraz results in decreased expression of UGT2A3 mRNA CTD PMID:22496397 NCBI chr14:22,251,507...22,267,899
Ensembl chr14:22,192,970...22,619,968 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression
multiple interactions		 ISO oltipraz results in decreased expression of UGT2B1 mRNA
[oltipraz co-treated with NFE2L2 protein mutant form] results in decreased expression of UGT2B1 mRNA		 CTD PMID:19144771 PMID:22496397 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases expression
multiple interactions		 ISO oltipraz results in increased expression of UGT2B34 mRNA
NFE2L2 protein affects the reaction [oltipraz results in increased expression of UGT2B34 mRNA]		 CTD PMID:22496397 NCBI chr14:22,597,103...22,619,968 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      chemical role 19260
        antioxidant 14254
          oltipraz 62
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  organic heteromonocyclic compound 16987
                                    diazines 12208
                                      pyrazines 1048
                                        oltipraz 62
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