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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ofloxacin
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Accession:CHEBI:7731 term browser browse the term
Definition:An oxazinoquinolone carrying carboxy, fluoro, methyl and 4-methylpiperazino substituents. A synthetic fluoroquinolone antibacterial agent, it inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Synonyms:exact_synonym: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
 related_synonym: 8-Fluoro-3-methyl-9-(4-methyl-piperazin-1-yl)-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid;   Formula=C18H20FN3O4;   InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25);   InChIKey=GSDSWSVVBLHKDQ-UHFFFAOYSA-N;   OFLX;   SMILES=CC1COc2c(N3CCN(C)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O;   ofloxacine;   ofloxacino;   ofloxacinum
 alt_id: CHEBI:100146
 xref: CAS:82419-36-1;   DrugBank:DB01165;   Drug_Central:1981;   HMDB:HMDB0015296;   KEGG:C07321;   KEGG:D00453;   LINCS:LSM-4370
 xref_mesh: MESH:D015242
 xref: MetaCyc:CPD-12843;   PMID:11710934;   PMID:15008519;   PMID:16669862;   PMID:19646516;   PMID:24497308;   PMID:24550337;   PMID:7884650;   Reaxys:3657947;   VSDB:1898;   Wikipedia:Ofloxacin


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ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Ofloxacin results in decreased activity of ABCB11 protein
Ofloxacin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 affects expression ISO Ofloxacin affects the expression of ARHGAP45 mRNA CTD PMID:25811541 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Ofloxacin results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP1A2 protein results in increased metabolism of Theophylline] CTD PMID:11408986 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Ofloxacin results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA] CTD PMID:16148020 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO Ofloxacin results in decreased expression of ITGB4 protein CTD PMID:14687228 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]
Ofloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression EXP Ofloxacin results in increased expression of MMP3 mRNA CTD PMID:20688128 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Ofloxacin results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Ofloxacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:165,966,128...165,982,327 JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression ISO Ofloxacin results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression EXP Ofloxacin results in increased expression of PLAUR mRNA CTD PMID:20688128 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ofloxacin results in increased expression of PTGS2 mRNA CTD PMID:20688128 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Ofloxacin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO
EXP
Ofloxacin inhibits the reaction [SLC22A5 protein results in increased uptake of Carnitine] CTD PMID:16928358 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects localization
decreases expression
ISO Ofloxacin affects the localization of SLC2A1 mRNA
Ofloxacin results in decreased expression of SLC2A1 mRNA
CTD PMID:19022360 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A increases expression EXP Ofloxacin results in increased expression of TNFRSF12A mRNA CTD PMID:20688128 NCBI chr10:12,995,904...12,997,930
Ensembl chr10:12,995,904...12,997,930
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ofloxacin CTD PMID:15769885 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
levofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd1 abhydrolase domain containing 1 decreases expression EXP Levofloxacin results in decreased expression of ABHD1 mRNA CTD PMID:24136188 NCBI chr 6:26,787,807...26,792,795
Ensembl chr 6:26,784,058...26,792,808
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 decreases expression EXP Levofloxacin results in decreased expression of ACSF2 mRNA CTD PMID:24136188 NCBI chr10:82,284,719...82,326,771
Ensembl chr10:82,284,720...82,326,771
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP Levofloxacin results in decreased expression of ACSL5 mRNA CTD PMID:24136188 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Actg1 actin, gamma 1 decreases expression EXP Levofloxacin results in decreased expression of ACTG1 mRNA CTD PMID:24136188 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Acy1 aminoacylase 1 decreases expression EXP Levofloxacin results in decreased expression of ACY1 mRNA CTD PMID:24136188 NCBI chr 8:115,134,792...115,140,171
Ensembl chr 8:115,134,765...115,140,080
JBrowse link
G Afp alpha-fetoprotein decreases expression EXP Levofloxacin results in decreased expression of AFP mRNA CTD PMID:24136188 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP Levofloxacin results in decreased expression of ALDH1B1 mRNA CTD PMID:24136188 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression EXP Levofloxacin results in increased expression of ANGPTL6 mRNA CTD PMID:24136188 NCBI chr 8:21,895,523...21,902,002
Ensembl chr 8:21,895,524...21,901,829
JBrowse link
G Anxa1 annexin A1 decreases expression EXP Levofloxacin results in decreased expression of ANXA1 mRNA CTD PMID:24136188 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Anxa2 annexin A2 decreases expression EXP Levofloxacin results in decreased expression of ANXA2 mRNA CTD PMID:24136188 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression EXP Levofloxacin results in decreased expression of AP1S1 mRNA CTD PMID:24136188 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Arl4a ADP-ribosylation factor like GTPase 4A increases expression EXP Levofloxacin results in increased expression of ARL4A mRNA CTD PMID:24136188 NCBI chr 6:59,945,926...59,950,586
Ensembl chr 6:59,948,577...59,950,586
JBrowse link
G Aspa aspartoacylase decreases expression EXP Levofloxacin results in decreased expression of ASPA mRNA CTD PMID:24136188 NCBI chr10:59,839,693...59,888,244
Ensembl chr10:59,839,852...59,892,960
JBrowse link
G Atg2b autophagy related 2B increases expression EXP Levofloxacin results in increased expression of ATG2B mRNA CTD PMID:24136188 NCBI chr 6:129,449,451...129,519,599
Ensembl chr 6:129,449,449...129,509,720
JBrowse link
G Atp6v0e2 ATPase, H+ transporting V0 subunit e2 decreases expression EXP Levofloxacin results in decreased expression of ATP6V0E2 mRNA CTD PMID:24136188 NCBI chr 4:78,168,117...78,171,265
Ensembl chr 4:78,168,117...78,171,265
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [Levofloxacin co-treated with TNF protein] results in increased expression of BIRC2 mRNA CTD PMID:32035082 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression EXP Levofloxacin results in decreased expression of BST2 mRNA CTD PMID:24136188 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Btg1 BTG anti-proliferation factor 1 increases expression EXP Levofloxacin results in increased expression of BTG1 mRNA CTD PMID:24136188 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
JBrowse link
G C2cd2 C2 calcium-dependent domain containing 2 decreases expression EXP Levofloxacin results in decreased expression of C2CD2 mRNA CTD PMID:24136188 NCBI chr11:38,354,746...38,420,133
Ensembl chr11:38,357,424...38,420,119
JBrowse link
G C4b complement C4B (Chido blood group) increases expression EXP Levofloxacin results in increased expression of C4B mRNA CTD PMID:24136188 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G C5 complement C5 increases expression EXP Levofloxacin results in increased expression of C5 mRNA CTD PMID:24136188 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Ca14 carbonic anhydrase 14 decreases expression EXP Levofloxacin results in decreased expression of CAR14 mRNA CTD PMID:24136188 NCBI chr 2:198,010,142...198,017,635
Ensembl chr 2:198,010,349...198,016,898
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccdc6 coiled-coil domain containing 6 increases expression EXP Levofloxacin results in increased expression of CCDC6 mRNA CTD PMID:24136188 NCBI chr20:19,729,005...19,825,219
Ensembl chr20:19,732,894...19,825,150
JBrowse link
G Ccdc80 coiled-coil domain containing 80 decreases expression EXP Levofloxacin results in decreased expression of CCDC80 mRNA CTD PMID:24136188 NCBI chr11:60,645,660...60,679,249
Ensembl chr11:60,645,086...60,679,555
JBrowse link
G Cd302 CD302 molecule increases expression EXP Levofloxacin results in increased expression of CD302 mRNA CTD PMID:24136188 NCBI chr 3:46,327,382...46,361,092
Ensembl chr 3:46,327,383...46,361,092
JBrowse link
G Cdc42ep4 CDC42 effector protein 4 increases expression EXP Levofloxacin results in increased expression of CDC42EP4 mRNA CTD PMID:24136188 NCBI chr10:102,244,680...102,269,272
Ensembl chr10:102,244,681...102,269,272
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression EXP Levofloxacin results in decreased expression of CDK1 mRNA CTD PMID:24136188 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP Levofloxacin results in decreased expression of CDKN3 mRNA CTD PMID:24136188 NCBI chr15:23,553,171...23,564,538
Ensembl chr15:23,553,128...23,564,535
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression EXP Levofloxacin results in increased expression of CEBPB mRNA CTD PMID:24136188 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Cfhr1 complement factor H-related 1 increases expression EXP Levofloxacin results in increased expression of CFHR1 mRNA CTD PMID:24136188 NCBI chr13:56,862,666...56,877,650
Ensembl chr13:56,836,994...56,877,650
JBrowse link
G Cgn cingulin decreases expression EXP Levofloxacin results in decreased expression of CGN mRNA CTD PMID:24136188 NCBI chr 2:195,909,691...195,937,130
Ensembl chr 2:195,909,626...195,935,878
JBrowse link
G Chpt1 choline phosphotransferase 1 increases expression EXP Levofloxacin results in increased expression of CHPT1 mRNA CTD PMID:24136188 NCBI chr 7:29,019,518...29,070,928
Ensembl chr 7:29,043,916...29,070,928
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP Levofloxacin results in decreased expression of CKS2 mRNA CTD PMID:24136188 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Clec14a C-type lectin domain containing 14A increases expression EXP Levofloxacin results in increased expression of CLEC14A mRNA CTD PMID:24136188 NCBI chr 6:79,303,301...79,306,443
Ensembl chr 6:79,303,304...79,306,443
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Levofloxacin results in decreased expression of CMBL mRNA CTD PMID:24136188 NCBI chr 2:84,645,084...84,666,836
Ensembl chr 2:84,645,084...84,666,835
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression EXP Levofloxacin results in increased expression of CPT1A mRNA CTD PMID:24136188 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP Levofloxacin results in increased expression of CYP27A1 mRNA CTD PMID:24136188 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression EXP Levofloxacin results in increased expression of CYP4B1 mRNA CTD PMID:24136188 NCBI chr 5:134,508,728...134,526,103
Ensembl chr 5:134,508,730...134,526,089
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP Levofloxacin results in increased expression of CYP51 mRNA CTD PMID:24136188 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Ddc dopa decarboxylase decreases expression EXP Levofloxacin results in decreased expression of DDC mRNA CTD PMID:24136188 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Ddhd1 DDHD domain containing 1 decreases expression EXP Levofloxacin results in decreased expression of DDHD1 mRNA CTD PMID:24136188 NCBI chr15:19,963,639...20,032,263
Ensembl chr15:19,965,187...20,032,191
JBrowse link
G Dhfr dihydrofolate reductase decreases activity ISO Levofloxacin results in decreased activity of DHFR protein CTD PMID:25418905 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 decreases expression EXP Levofloxacin results in decreased expression of DNAJC9 mRNA CTD PMID:24136188 NCBI chr15:4,356,512...4,360,788
Ensembl chr15:4,356,261...4,360,564
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression EXP Levofloxacin results in decreased expression of DNPH1 mRNA CTD PMID:24136188 NCBI chr 9:16,845,764...16,848,514
Ensembl chr 9:16,845,525...16,848,503
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression EXP Levofloxacin results in decreased expression of DTYMK mRNA CTD PMID:24136188 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Dut deoxyuridine triphosphatase decreases expression EXP Levofloxacin results in decreased expression of DUT mRNA CTD PMID:24136188 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression EXP Levofloxacin results in increased expression of EDEM1 mRNA CTD PMID:24136188 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 decreases expression EXP Levofloxacin results in decreased expression of ELOVL5 mRNA CTD PMID:24136188 NCBI chr 8:85,220,941...85,287,449
Ensembl chr 8:85,259,982...85,285,983
JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression EXP Levofloxacin results in increased expression of ENC1 mRNA CTD PMID:24136188 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression EXP Levofloxacin results in decreased expression of EPHX1 mRNA CTD PMID:24136188 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erg28 ergosterol biosynthesis 28 homolog increases expression EXP Levofloxacin results in increased expression of ERG28 mRNA CTD PMID:24136188 NCBI chr 6:109,683,252...109,692,218
Ensembl chr 6:109,683,253...109,692,218
JBrowse link
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 decreases expression EXP Levofloxacin results in decreased expression of ERGIC1 mRNA CTD PMID:24136188 NCBI chr10:16,821,393...16,912,050
Ensembl chr10:16,821,880...16,910,641
JBrowse link
G Fgl1 fibrinogen-like 1 increases expression EXP Levofloxacin results in increased expression of FGL1 mRNA CTD PMID:24136188 NCBI chr16:54,153,086...54,188,120
Ensembl chr16:54,153,054...54,188,181
JBrowse link
G Fkbp4 FKBP prolyl isomerase 4 decreases expression EXP Levofloxacin results in decreased expression of FKBP4 mRNA CTD PMID:24136188 NCBI chr 4:161,748,993...161,757,447
Ensembl chr 4:161,748,993...161,757,447
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Levofloxacin results in increased expression of FKBP5 mRNA CTD PMID:24136188 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Flna filamin A decreases expression EXP Levofloxacin results in decreased expression of FLNA mRNA CTD PMID:24136188 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Fndc3b fibronectin type III domain containing 3B increases expression EXP Levofloxacin results in increased expression of FNDC3B mRNA CTD PMID:24136188 NCBI chr 2:113,109,949...113,415,171
Ensembl chr 2:113,112,902...113,345,577
JBrowse link
G Fzd8 frizzled class receptor 8 increases expression EXP Levofloxacin results in increased expression of FZD8 mRNA CTD PMID:24136188 NCBI chr17:62,259,910...62,267,239
Ensembl chr17:62,262,129...62,265,113
JBrowse link
G Gas6 growth arrest specific 6 increases expression EXP Levofloxacin results in increased expression of GAS6 mRNA CTD PMID:24136188 NCBI chr16:81,213,364...81,243,824
Ensembl chr16:81,213,364...81,243,757
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression EXP Levofloxacin results in decreased expression of GCLC mRNA CTD PMID:24136188 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 decreases expression EXP Levofloxacin results in decreased expression of GPD1 mRNA CTD PMID:24136188 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 decreases expression EXP Levofloxacin results in decreased expression of HACD3 mRNA CTD PMID:24136188 NCBI chr 8:70,471,572...70,509,874
Ensembl chr 8:70,471,572...70,509,874
JBrowse link
G Haus4 HAUS augmin-like complex, subunit 4 decreases expression EXP Levofloxacin results in decreased expression of HAUS4 mRNA CTD PMID:24136188 NCBI chr15:33,182,139...33,193,880
Ensembl chr15:33,182,128...33,193,537
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP Levofloxacin results in increased expression of HERPUD1 mRNA CTD PMID:24136188 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hmgb2 high mobility group box 2 decreases expression EXP Levofloxacin results in decreased expression of HMGB2 mRNA CTD PMID:24136188 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgn2 high mobility group nucleosomal binding domain 2 decreases expression EXP Levofloxacin results in decreased expression of HMGN2 mRNA CTD PMID:24136188 NCBI chr 5:152,195,359...152,198,813
Ensembl chr 5:152,195,361...152,198,813
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression EXP Levofloxacin results in decreased expression of HTATIP2 mRNA CTD PMID:24136188 NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO Levofloxacin results in decreased expression of ICAM1 mRNA
[Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein
CTD PMID:32035082 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Levofloxacin results in increased expression of IDI1 mRNA CTD PMID:24136188 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifng interferon gamma increases expression EXP Levofloxacin results in increased expression of IFNG CTD PMID:24136188 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein CTD PMID:30876886 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6r interleukin 6 receptor increases expression EXP Levofloxacin results in increased expression of IL6R mRNA CTD PMID:24136188 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 increases expression EXP Levofloxacin results in increased expression of IP6K2 mRNA CTD PMID:24136188 NCBI chr 8:117,574,136...117,599,849
Ensembl chr 8:117,574,161...117,599,848
JBrowse link
G Ivns1abp influenza virus NS1A binding protein increases expression EXP Levofloxacin results in increased expression of IVNS1ABP mRNA CTD PMID:24136188 NCBI chr13:68,702,970...68,722,472
Ensembl chr13:68,702,820...68,722,472
JBrowse link
G Klf15 Kruppel-like factor 15 increases expression EXP Levofloxacin results in increased expression of KLF15 mRNA CTD PMID:24136188 NCBI chr 4:122,364,688...122,377,690
Ensembl chr 4:122,365,093...122,377,659
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression EXP Levofloxacin results in increased expression of KLF9 mRNA CTD PMID:24136188 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Kpna2 karyopherin subunit alpha 2 decreases expression EXP Levofloxacin results in decreased expression of KPNA2 mRNA CTD PMID:24136188 NCBI chr10:95,200,029...95,212,111
Ensembl chr10:95,200,030...95,212,111
JBrowse link
G Kpnb1 karyopherin subunit beta 1 decreases expression EXP Levofloxacin results in decreased expression of KPNB1 mRNA CTD PMID:24136188 NCBI chr10:85,096,517...85,124,641
Ensembl chr10:85,093,841...85,124,644
JBrowse link
G Krt18 keratin 18 decreases expression EXP Levofloxacin results in decreased expression of KRT18 mRNA CTD PMID:24136188 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Levofloxacin results in increased expression of LBP mRNA CTD PMID:24136188 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 decreases expression EXP Levofloxacin results in decreased expression of LCMT1 mRNA CTD PMID:24136188 NCBI chr 1:193,335,629...193,391,620
Ensembl chr 1:193,335,645...193,391,638
JBrowse link
G Lmnb1 lamin B1 decreases expression EXP Levofloxacin results in decreased expression of LMNB1 mRNA CTD PMID:24136188 NCBI chr18:51,785,111...51,822,264
Ensembl chr18:51,785,111...51,822,264
JBrowse link
G Lmo7 LIM domain 7 decreases expression EXP Levofloxacin results in decreased expression of LMO7 mRNA CTD PMID:24136188 NCBI chr15:86,242,911...86,458,512
Ensembl chr15:86,243,148...86,457,739
JBrowse link
G Lpin1 lipin 1 increases expression EXP Levofloxacin results in increased expression of LPIN1 mRNA CTD PMID:24136188 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like increases expression EXP Levofloxacin results in increased expression of LURAP1L mRNA CTD PMID:24136188 NCBI chr 5:98,468,039...98,515,126
Ensembl chr 5:98,469,047...98,515,125
JBrowse link
G Manba mannosidase beta decreases expression EXP Levofloxacin results in decreased expression of MANBA mRNA CTD PMID:24136188 NCBI chr 2:240,668,213...240,760,264
Ensembl chr 2:240,668,195...240,760,261
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A increases expression EXP Levofloxacin results in increased expression of MFSD2A mRNA CTD PMID:24136188 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression EXP Levofloxacin results in increased expression of NAMPT mRNA CTD PMID:24136188 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP Levofloxacin results in decreased expression of NEDD9 mRNA CTD PMID:24136188 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression EXP Levofloxacin results in decreased expression of NFE2L2 mRNA CTD PMID:24136188 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression
multiple interactions
EXP
ISO
Levofloxacin results in increased expression of NFKBIA mRNA
[Levofloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA
CTD PMID:24136188, PMID:32035082 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbiz NFKB inhibitor zeta increases expression EXP Levofloxacin results in increased expression of NFKBIZ mRNA CTD PMID:24136188 NCBI chr11:47,243,342...47,271,487
Ensembl chr11:47,243,342...47,271,487
JBrowse link
G Nrbp2 nuclear receptor binding protein 2 increases expression EXP Levofloxacin results in increased expression of NRBP2 mRNA CTD PMID:24136188 NCBI chr 7:117,145,106...117,151,694
Ensembl chr 7:117,145,961...117,151,694
JBrowse link
G Nudt4 nudix hydrolase 4 increases expression EXP Levofloxacin results in increased expression of NUDT4 mRNA CTD PMID:24136188 NCBI chr 7:36,643,916...36,660,334
Ensembl chr 7:36,643,916...36,660,141
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP Levofloxacin results in increased expression of NUPR1 mRNA CTD PMID:24136188 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Omd osteomodulin increases expression EXP Levofloxacin results in increased expression of OMD mRNA CTD PMID:24136188 NCBI chr17:15,476,100...15,484,324
Ensembl chr17:15,475,710...15,484,269
JBrowse link
G Osbpl1a oxysterol binding protein-like 1A decreases expression EXP Levofloxacin results in decreased expression of OSBPL1A mRNA CTD PMID:24136188 NCBI chr18:4,097,011...4,294,136
Ensembl chr18:4,097,012...4,294,136
JBrowse link
G Palmd palmdelphin decreases expression EXP Levofloxacin results in decreased expression of PALMD mRNA CTD PMID:24136188 NCBI chr 2:220,481,292...220,536,004
Ensembl chr 2:220,481,616...220,535,751
JBrowse link
G Pbld1 phenazine biosynthesis-like protein domain containing 1 increases expression EXP Levofloxacin results in increased expression of PBLD1 mRNA CTD PMID:24136188 NCBI chr20:27,103,300...27,118,650
Ensembl chr20:27,103,317...27,117,663
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression EXP Levofloxacin results in increased expression of PID1 mRNA CTD PMID:24136188 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Pigu phosphatidylinositol glycan anchor biosynthesis, class U increases expression EXP Levofloxacin results in increased expression of PIGU mRNA CTD PMID:24136188 NCBI chr 3:150,803,096...150,885,597
Ensembl chr 3:150,803,097...150,885,616
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression EXP Levofloxacin results in increased expression of PLA2G12A mRNA CTD PMID:24136188 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972
JBrowse link
G Plgrkt plasminogen receptor with a C-terminal lysine decreases expression EXP Levofloxacin results in decreased expression of PLGRKT mRNA CTD PMID:24136188 NCBI chr 1:247,502,274...247,514,540
Ensembl chr 1:247,502,280...247,514,540
JBrowse link
G Plin3 perilipin 3 decreases expression EXP Levofloxacin results in decreased expression of PLIN3 mRNA CTD PMID:24136188 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Plp2 proteolipid protein 2 decreases expression EXP Levofloxacin results in decreased expression of PLP2 mRNA CTD PMID:24136188 NCBI chr  X:15,679,254...15,682,653
Ensembl chr  X:15,679,254...15,682,652
JBrowse link
G Polg2 DNA polymerase gamma 2, accessory subunit increases expression EXP Levofloxacin results in increased expression of POLG2 mRNA CTD PMID:24136188 NCBI chr10:94,968,836...94,979,259
Ensembl chr10:94,968,836...94,979,259
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Levofloxacin results in decreased expression of PPARA mRNA CTD PMID:25689681 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppcs phosphopantothenoylcysteine synthetase increases expression EXP Levofloxacin results in increased expression of PPCS mRNA CTD PMID:24136188 NCBI chr 5:138,466,298...138,470,108
Ensembl chr 5:138,466,293...138,470,096
JBrowse link
G Ppif peptidylprolyl isomerase F decreases expression EXP Levofloxacin results in decreased expression of PPIF mRNA CTD PMID:24136188 NCBI chr16:1,979,191...1,985,912
Ensembl chr16:1,979,191...1,985,908
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A decreases expression EXP Levofloxacin results in decreased expression of PPP1R14A mRNA CTD PMID:24136188 NCBI chr 1:87,224,683...87,232,842
Ensembl chr 1:87,224,677...87,232,848
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 decreases expression EXP Levofloxacin results in decreased expression of PRKAG2 mRNA CTD PMID:24136188 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Proser2 proline and serine rich 2 increases expression EXP Levofloxacin results in increased expression of PROSER2 mRNA CTD PMID:24136188 NCBI chr17:76,079,641...76,140,428
Ensembl chr17:76,079,720...76,137,697
JBrowse link
G Prxl2b peroxiredoxin like 2B increases expression EXP Levofloxacin results in increased expression of PRXL2B mRNA CTD PMID:24136188 NCBI chr 5:172,304,799...172,307,402
Ensembl chr 5:172,304,758...172,307,431
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression EXP Levofloxacin results in decreased expression of PTTG1 mRNA CTD PMID:24136188 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 increases expression EXP Levofloxacin results in increased expression of RAPGEF4 mRNA CTD PMID:24136188 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Levofloxacin co-treated with Lipopolysaccharides] affects the localization of RELA protein CTD PMID:32035082 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retreg1 reticulophagy regulator 1 increases expression EXP Levofloxacin results in increased expression of RETREG1 mRNA CTD PMID:24136188 NCBI chr 2:78,391,921...78,401,569
Ensembl chr 2:78,391,921...78,399,987
JBrowse link
G RGD1308742 similar to Complement C5 precursor increases expression EXP Levofloxacin results in increased expression of RGD1308742 mRNA CTD PMID:24136188 NCBI chr 3:14,273,552...14,291,401
Ensembl chr 3:14,276,280...14,291,343
JBrowse link
G RGD1309534 similar to RIKEN cDNA 4931406C07 decreases expression EXP Levofloxacin results in decreased expression of RGD1309534 mRNA CTD PMID:24136188 NCBI chr 8:13,838,549...13,861,120
Ensembl chr 8:13,838,572...13,861,212
JBrowse link
G RGD1311251 similar to RIKEN cDNA 4930550C14 increases expression EXP Levofloxacin results in increased expression of RGD1311251 mRNA CTD PMID:24136188 NCBI chr 8:57,983,168...58,012,474
Ensembl chr 8:57,983,556...58,011,962
JBrowse link
G Rmdn2 regulator of microtubule dynamics 2 decreases expression EXP Levofloxacin results in decreased expression of RMDN2 mRNA CTD PMID:24136188 NCBI chr 6:2,215,062...2,292,288
Ensembl chr 6:2,216,623...2,280,777
JBrowse link
G Rnd2 Rho family GTPase 2 increases expression EXP Levofloxacin results in increased expression of RND2 mRNA CTD PMID:24136188 NCBI chr10:89,376,530...89,380,101
Ensembl chr10:89,376,530...89,380,101
JBrowse link
G Rnf4 ring finger protein 4 decreases expression EXP Levofloxacin results in decreased expression of RNF4 mRNA CTD PMID:24136188 NCBI chr14:81,658,400...81,679,756
Ensembl chr14:81,660,354...81,679,082
JBrowse link
G Rnpepl1 arginyl aminopeptidase like 1 increases expression EXP Levofloxacin results in increased expression of RNPEPL1 mRNA CTD PMID:24136188 NCBI chr 9:100,080,144...100,089,834
Ensembl chr 9:100,080,144...100,089,834
JBrowse link
G Rpa1 replication protein A1 decreases expression EXP Levofloxacin results in decreased expression of RPA1 mRNA CTD PMID:24136188 NCBI chr10:62,140,419...62,191,518
Ensembl chr10:62,140,419...62,191,512
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression EXP Levofloxacin results in decreased expression of RRM2 mRNA CTD PMID:24136188 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rsrp1 arginine and serine rich protein 1 decreases expression EXP Levofloxacin results in decreased expression of RSRP1 mRNA CTD PMID:24136188 NCBI chr 5:153,260,930...153,264,669
Ensembl chr 5:153,260,930...153,264,669
JBrowse link
G Rxra retinoid X receptor alpha increases expression EXP Levofloxacin results in increased expression of RXRA mRNA CTD PMID:24136188 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP Levofloxacin results in increased expression of SC5D mRNA CTD PMID:24136188 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Sdc4 syndecan 4 increases expression EXP Levofloxacin results in increased expression of SDC4 mRNA CTD PMID:24136188 NCBI chr 3:160,872,503...160,891,190
Ensembl chr 3:160,872,503...160,891,190
JBrowse link
G Serpina11 serpin family A member 11 increases expression EXP Levofloxacin results in increased expression of SERPINA11 mRNA CTD PMID:24136188 NCBI chr 6:127,647,180...127,656,603
Ensembl chr 6:127,647,184...127,656,603
JBrowse link
G Serpinh1 serpin family H member 1 decreases expression EXP Levofloxacin results in decreased expression of SERPINH1 mRNA CTD PMID:24136188 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Sesn2 sestrin 2 increases expression EXP Levofloxacin results in increased expression of SESN2 mRNA CTD PMID:24136188 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Sfpq splicing factor proline and glutamine rich decreases expression EXP Levofloxacin results in decreased expression of SFPQ mRNA CTD PMID:24136188 NCBI chr 5:145,079,803...145,088,517
Ensembl chr 5:145,079,803...145,088,498
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 increases expression EXP Levofloxacin results in increased expression of SH3BP5 mRNA CTD PMID:24136188 NCBI chr16:7,473,367...7,559,976
Ensembl chr16:7,473,370...7,538,201
JBrowse link
G Slc13a3 solute carrier family 13 member 3 increases expression EXP Levofloxacin results in increased expression of SLC13A3 mRNA CTD PMID:24136188 NCBI chr 3:162,084,336...162,147,398
Ensembl chr 3:162,084,315...162,147,393
JBrowse link
G Slc17a3 solute carrier family 17 member 3 decreases expression EXP Levofloxacin results in decreased expression of SLC17A3 mRNA CTD PMID:24136188 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185
JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression EXP Levofloxacin results in increased expression of SLC38A2 mRNA CTD PMID:24136188 NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
JBrowse link
G Spa17 sperm autoantigenic protein 17 decreases expression EXP Levofloxacin results in decreased expression of SPA17 mRNA CTD PMID:24136188 NCBI chr 8:40,066,954...40,078,131
Ensembl chr 8:40,067,076...40,078,165
JBrowse link
G Srxn1 sulfiredoxin 1 decreases expression EXP Levofloxacin results in decreased expression of SRXN1 mRNA CTD PMID:24136188 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Ssx2ip SSX family member 2 interacting protein decreases expression EXP Levofloxacin results in decreased expression of SSX2IP mRNA CTD PMID:24136188 NCBI chr 2:252,263,323...252,296,049
Ensembl chr 2:252,263,386...252,296,051
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP Levofloxacin results in increased expression of STAT3 mRNA CTD PMID:24136188 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Steap3 STEAP3 metalloreductase decreases expression EXP Levofloxacin results in decreased expression of STEAP3 mRNA CTD PMID:24136188 NCBI chr13:36,257,220...36,274,144
Ensembl chr13:36,257,112...36,290,531
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP Levofloxacin results in decreased expression of STMN1 mRNA CTD PMID:24136188 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Synrg synergin, gamma increases expression EXP Levofloxacin results in increased expression of SYNRG mRNA CTD PMID:24136188 NCBI chr10:71,278,698...71,357,791 JBrowse link
G Syvn1 synoviolin 1 increases expression EXP Levofloxacin results in increased expression of SYVN1 mRNA CTD PMID:24136188 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 decreases expression EXP Levofloxacin results in decreased expression of TCIRG1 mRNA CTD PMID:24136188 NCBI chr 1:219,126,687...219,139,466
Ensembl chr 1:219,127,602...219,139,464
JBrowse link
G Tef TEF transcription factor, PAR bZIP family member increases expression EXP Levofloxacin results in increased expression of TEF mRNA CTD PMID:24136188 NCBI chr 7:123,033,971...123,058,606
Ensembl chr 7:123,043,503...123,058,604
JBrowse link
G Tjp2 tight junction protein 2 decreases expression EXP Levofloxacin results in decreased expression of TJP2 mRNA CTD PMID:24136188 NCBI chr 1:241,945,816...242,084,044
Ensembl chr 1:241,945,841...242,083,484
JBrowse link
G Tkt transketolase decreases expression EXP Levofloxacin results in decreased expression of TKT mRNA CTD PMID:24136188 NCBI chr16:6,609,670...6,634,608
Ensembl chr16:6,609,668...6,634,595
JBrowse link
G Tmem176b transmembrane protein 176B increases expression EXP Levofloxacin results in increased expression of TMEM176B mRNA CTD PMID:24136188 NCBI chr 4:78,450,724...78,458,600
Ensembl chr 4:78,450,724...78,458,179
JBrowse link
G Tmem38b transmembrane protein 38B increases expression EXP Levofloxacin results in increased expression of TMEM38B mRNA CTD PMID:24136188 NCBI chr 5:70,639,156...70,675,055
Ensembl chr 5:70,639,156...70,675,054
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Levofloxacin co-treated with [TNF protein co-treated with IL6 protein co-treated with IL1B protein]] results in increased activity of CASP3 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA
[Levofloxacin co-treated with TNF protein] results in increased expression of BIRC2 mRNA; [Levofloxacin co-treated with TNF protein] results in increased expression of ICAM1 protein; [Levofloxacin co-treated with TNF protein] results in increased expression of NFKBIA mRNA; [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA
CTD PMID:30876886, PMID:32035082 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO [Levofloxacin co-treated with TNF protein] results in increased expression of TNFAIP3 mRNA CTD PMID:32035082 NCBI chr 1:14,401,103...14,416,369
Ensembl chr 1:14,402,913...14,412,807
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 decreases expression EXP Levofloxacin results in decreased expression of TNFRSF9 mRNA CTD PMID:24136188 NCBI chr 5:168,009,245...168,035,813
Ensembl chr 5:168,009,393...168,035,810
JBrowse link
G Tob2 transducer of ERBB2, 2 increases expression EXP Levofloxacin results in increased expression of TOB2 mRNA CTD PMID:24136188 NCBI chr 7:123,079,520...123,088,240
Ensembl chr 7:123,079,537...123,088,279
JBrowse link
G Tpm3 tropomyosin 3 decreases expression EXP Levofloxacin results in decreased expression of TPM3 mRNA CTD PMID:24136188 NCBI chr 2:189,423,534...189,451,340
Ensembl chr 2:189,423,559...189,451,029
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression EXP Levofloxacin results in increased expression of TSC22D3 mRNA CTD PMID:24136188 NCBI chr  X:111,884,285...111,944,693
Ensembl chr  X:111,884,295...111,887,906
JBrowse link
G Tstd3 thiosulfate sulfurtransferase like domain containing 3 decreases expression EXP Levofloxacin results in decreased expression of TSTD3 mRNA CTD PMID:24136188 NCBI chr 5:35,892,783...35,902,243
Ensembl chr 5:35,892,737...35,902,262
JBrowse link
G Tuba1c tubulin, alpha 1C decreases expression EXP Levofloxacin results in decreased expression of TUBA1C mRNA CTD PMID:24136188 NCBI chr 7:140,716,113...140,723,717
Ensembl chr 7:140,716,113...140,723,714
JBrowse link
G Tubb4b tubulin, beta 4B class IVb decreases expression EXP Levofloxacin results in decreased expression of TUBB4B mRNA CTD PMID:24136188 NCBI chr 3:2,441,585...2,444,369
Ensembl chr 3:2,441,733...2,444,281
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Levofloxacin results in decreased expression of TUBB5 mRNA CTD PMID:24136188 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Tubb6 tubulin, beta 6 class V decreases expression EXP Levofloxacin results in decreased expression of TUBB6 mRNA CTD PMID:24136188 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression EXP Levofloxacin results in increased expression of USP2 mRNA CTD PMID:24136188 NCBI chr 8:48,403,985...48,432,525
Ensembl chr 8:48,406,260...48,430,885
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Levofloxacin results in increased expression of VCAM1 mRNA CTD PMID:24136188 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vim vimentin decreases expression EXP Levofloxacin results in decreased expression of VIM mRNA CTD PMID:24136188 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression EXP Levofloxacin results in increased expression of VMP1 mRNA CTD PMID:24136188 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link
G Wasl WASP like actin nucleation promoting factor increases expression EXP Levofloxacin results in increased expression of WASL mRNA CTD PMID:24136188 NCBI chr 4:51,677,722...51,726,212
Ensembl chr 4:51,677,722...51,726,212
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression EXP Levofloxacin results in increased expression of WIPI1 mRNA CTD PMID:24136188 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
G Xpo1 exportin 1 decreases expression EXP Levofloxacin results in decreased expression of XPO1 mRNA CTD PMID:24136188 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Zfp354a zinc finger protein 354A increases expression EXP Levofloxacin results in increased expression of ZFP354A mRNA CTD PMID:24136188 NCBI chr10:36,586,495...36,600,172
Ensembl chr10:36,589,181...36,600,469
JBrowse link
G Zfp446 zinc finger protein 446 increases expression EXP Levofloxacin results in increased expression of ZFP446 mRNA CTD PMID:24136188 NCBI chr 1:65,595,518...65,608,757 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          quinolone antibiotic 581
            ofloxacin 193
              levofloxacin 174
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          oxo monocarboxylic acid 6261
                                            3-oxo monocarboxylic acid 218
                                              ofloxacin 193
                                                levofloxacin 174
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.