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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ethylenebis(dithiocarbamate)
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Accession:CHEBI:77308 term browser browse the term
Definition:A member of the class of dithiocarbamate anions resulting from the deprotonation of both of the dithiocarbamic acid moieties of ethylenebis(dithiocarbamic acid). The major species at pH 7.3.
Synonyms:exact_synonym: ethane-1,2-diyldicarbamodithioate
 related_synonym: Formula=C4H6N2S4;   InChI=1S/C4H8N2S4/c7-3(8)5-1-2-6-4(9)10/h1-2H2,(H2,5,7,8)(H2,6,9,10)/p-2;   InChIKey=AWYFNIZYMPNGAI-UHFFFAOYSA-L;   SMILES=[S-]C(=S)NCCNC([S-])=S;   ethylenebis(dithiocarbamic acid)(2-)
 cyclic_relationship: is_conjugate_base_of CHEBI:83986


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mancozeb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects activity
multiple interactions
EXP mancozeb affects the activity of ACHE protein
[carbendazim co-treated with mancozeb] results in increased activity of ACHE protein
CTD PMID:10641187 PMID:33217513 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Actg1 actin, gamma 1 increases expression ISO mancozeb results in increased expression of ACTG1 protein CTD PMID:21375462 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein CTD PMID:19883720 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin decreases expression ISO mancozeb results in decreased expression of ALB protein CTD PMID:21375462 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity EXP mancozeb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases activity EXP mancozeb results in decreased activity of ALDH5A1 protein CTD PMID:17010440 NCBI chr17:42,133,076...42,159,413
Ensembl chr17:42,133,076...42,159,413
JBrowse link
G Anxa2 annexin A2 decreases expression ISO mancozeb results in decreased expression of ANXA2 protein CTD PMID:21375462 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO mancozeb results in increased expression of APAF1 protein CTD PMID:22289270 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor multiple interactions
decreases activity
ISO mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]
mancozeb results in decreased activity of AR protein
CTD PMID:23871939 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO mancozeb results in increased expression of BAX mRNA; mancozeb results in increased expression of BAX protein
lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
CTD PMID:22289270 PMID:27235710 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
mancozeb results in decreased expression of BCL2 mRNA; mancozeb results in decreased expression of BCL2 protein
lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]
CTD PMID:16005924 PMID:22289270 PMID:27235710 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ca3 carbonic anhydrase 3 increases expression ISO mancozeb results in increased expression of CAR3 protein CTD PMID:21375462 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO mancozeb results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]
mancozeb results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:22289270 PMID:22824503 PMID:30037311 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO mancozeb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 increases activity ISO mancozeb results in increased activity of CASP8 protein CTD PMID:22289270 PMID:22824503 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO mancozeb results in increased activity of CASP9 protein
mancozeb results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:22289270 PMID:22824503 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
ISO
EXP
Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
CTD PMID:23024109 PMID:27235710 PMID:29283200 PMID:30037311 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
increases expression
ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
mancozeb results in increased expression of CCND1 protein
CTD PMID:19883720 PMID:21375462 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25c cell division cycle 25C increases phosphorylation ISO mancozeb results in increased phosphorylation of CDC25C protein CTD PMID:21375462 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA] CTD PMID:27235710 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO mancozeb results in increased expression of CYCS protein CTD PMID:27016407 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
decreases expression
EXP
ISO
mancozeb results in decreased activity of CYP1A1 protein
mancozeb results in decreased expression of CYP1A1 protein
CTD PMID:1946188 PMID:31096615 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression ISO mancozeb results in decreased expression of CYP2B6 protein CTD PMID:31096615 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression ISO mancozeb results in decreased expression of CYP2E1 mRNA CTD PMID:31096615 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases expression ISO mancozeb results in decreased expression of CYP3A4 mRNA; mancozeb results in decreased expression of CYP3A4 protein CTD PMID:31096615 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP mancozeb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Elk1 ETS transcription factor ELK1 increases phosphorylation ISO mancozeb results in increased phosphorylation of ELK1 protein CTD PMID:21375462 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO mancozeb results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO mancozeb results in increased expression of FAS protein CTD PMID:22289270 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand increases expression ISO mancozeb results in increased expression of FASLG protein CTD PMID:22289270 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions
increases expression
ISO lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA] CTD PMID:27235710 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 affects activity EXP mancozeb affects the activity of GOT1 protein CTD PMID:10641187 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpt glutamic--pyruvic transaminase affects activity EXP mancozeb affects the activity of GPT protein CTD PMID:10641187 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression
multiple interactions
ISO mancozeb results in decreased expression of GPX1 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]
CTD PMID:30037311 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hdac3 histone deacetylase 3 decreases activity ISO mancozeb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr18:31,073,057...31,094,347
Ensembl chr18:31,073,058...31,094,303
JBrowse link
G Hdac6 histone deacetylase 6 decreases activity ISO mancozeb results in decreased activity of HDAC6 protein CTD PMID:21251949 NCBI chr  X:15,396,185...15,417,486
Ensembl chr  X:15,295,473...15,316,671
Ensembl chr  X:15,295,473...15,316,671
JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression ISO mancozeb results in increased expression of HNRNPM protein CTD PMID:21375462 NCBI chr 7:18,516,253...18,554,536
Ensembl chr 7:18,516,512...18,554,227
JBrowse link
G Ifng interferon gamma multiple interactions ISO mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:15742816 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:16112155 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 affects expression ISO mancozeb affects the expression of IL2 protein CTD PMID:9012323 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Kb15 type II keratin Kb15 decreases expression ISO mancozeb results in decreased expression of KRT6A protein CTD PMID:21375462 NCBI chr 7:143,208,034...143,217,771
Ensembl chr 7:143,208,527...143,217,535
JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 increases activity EXP mancozeb results in increased activity of KCNQ2 protein CTD PMID:23542819 NCBI chr 3:176,585,897...176,645,029
Ensembl chr 3:176,589,906...176,644,951
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor affects expression EXP mancozeb affects the expression of KISS1 mRNA CTD PMID:23660487 NCBI chr13:50,529,506...50,537,603
Ensembl chr13:50,529,510...50,535,389
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein CTD PMID:21375462 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein CTD PMID:21375462 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression
ISO lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression
ISO
EXP
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein
mancozeb results in increased expression of MYC protein
mancozeb results in decreased expression of MYC protein
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]
CTD PMID:16005924 PMID:19883720 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO mancozeb results in increased expression of NOS2 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]
CTD PMID:30037311 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA] CTD PMID:30037311 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity ISO mancozeb results in increased activity of ODC1 protein CTD PMID:1733566 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
decreases expression
ISO lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA] CTD PMID:27235710 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO mancozeb results in increased expression of PRDX2 protein CTD PMID:21375462 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prl prolactin multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of PRL protein CTD PMID:24530807 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptges prostaglandin E synthase increases expression
multiple interactions
ISO mancozeb results in increased expression of PTGES mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]
CTD PMID:27235710 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO mancozeb results in increased expression of PTGS2 protein CTD PMID:21375462 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Pvalb parvalbumin increases expression ISO mancozeb results in increased expression of PVALB protein CTD PMID:21375462 NCBI chr 7:119,428,657...119,443,674
Ensembl chr 7:119,429,019...119,441,487
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation
affects localization
multiple interactions
increases localization
ISO mancozeb results in increased phosphorylation of RELA protein
mancozeb affects the localization of RELA protein
Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
mancozeb results in increased localization of RELA protein
CTD PMID:16112155 PMID:21375462 PMID:22289270 PMID:27235710 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO mancozeb results in increased expression of S100A6 protein CTD PMID:21375462 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO mancozeb results in increased expression of S100A9 protein CTD PMID:21375462 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Sirt1 sirtuin 1 decreases activity ISO mancozeb results in decreased activity of SIRT1 protein CTD PMID:21251949 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt2 sirtuin 2 decreases activity ISO mancozeb results in decreased activity of SIRT2 protein CTD PMID:21251949 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
G Sirt3 sirtuin 3 decreases activity ISO mancozeb results in decreased activity of SIRT3 protein CTD PMID:21251949 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO mancozeb results in decreased expression of SOD1 protein CTD PMID:21375462 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tek TEK receptor tyrosine kinase increases activity ISO mancozeb results in increased activity of TEK protein CTD PMID:21251949 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
CTD PMID:15742816 PMID:15893782 PMID:16112155 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression
increases expression
multiple interactions
ISO mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein
mancozeb results in increased expression of TP53 mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]
CTD PMID:22369882 PMID:27235710 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO mancozeb results in increased expression of TPI1 protein CTD PMID:21375462 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
Ensembl chr 9:157,328,379...157,331,905
JBrowse link
G Tpo thyroid peroxidase decreases activity EXP mancozeb results in decreased activity of TPO protein CTD PMID:9418944 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein CTD PMID:24530807 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases expression
multiple interactions
ISO mancozeb results in decreased expression of XRCC1 mRNA
lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]
CTD PMID:27235710 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
zineb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases expression EXP Zineb results in decreased expression of ACHE protein CTD PMID:3868355 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Zineb inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Casp3 caspase 3 increases activity ISO Zineb results in increased activity of CASP3 protein CTD PMID:17189834 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Zineb results in decreased activity of HSD11B2 protein CTD PMID:22796344 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases activity
ISO [Endosulfan co-treated with Zineb] results in increased activity of NFKB1 protein
Zineb results in increased activity of NFKB1 protein
CTD PMID:17189834 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Zineb inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Zineb inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Zineb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Zineb promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:15256756 PMID:16112155 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpo thyroid peroxidase decreases activity ISO Zineb results in decreased activity of TPO protein CTD PMID:9248629 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    chemical entity 19771
      molecular entity 19770
        ion 15945
          anion 14973
            organic anion 3036
              organic sulfur anion 495
                dithiocarbamate anions 495
                  ethylenebis(dithiocarbamate) 77
                    amobam 0
                    nabam 0
                    zineb + 77
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon group molecular entity 19574
                          organic molecular entity 19564
                            organic ion 8455
                              organic anion 3036
                                organic sulfur anion 495
                                  dithiocarbamate anions 495
                                    ethylenebis(dithiocarbamate) 77
                                      amobam 0
                                      nabam 0
                                      zineb + 77
paths to the root