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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:11-hydroxy-Delta(9)-tetrahydrocannabinol
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Accession:CHEBI:77270 term browser browse the term
Definition:A phytocannabinoid that is Delta(9)-tetrahydrocannabinol in which the methyl group at C-11 has been hydroxylated . Major metabolite of Delta(9)-tetrahydrocannabinol.
Synonyms:exact_synonym: (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
 related_synonym: (-)-11-hydroxy-Delta(9)-THC;   (6aR,10aR)-6a,7,8,10a-tetrahydro-1-hydroxy-6,6-dimethyl-3-pentyl-6H-dibenzo[b,d]pyran-9-methanol;   11-Hydroxy-delta(sup 9)tetrahydrocannabinol;   11-Hydroxytetrahydrocannabinol;   11-OH-THC;   Formula=C21H30O3;   InChI=1S/C21H30O3/c1-4-5-6-7-14-11-18(23)20-16-10-15(13-22)8-9-17(16)21(2,3)24-19(20)12-14/h10-12,16-17,22-23H,4-9,13H2,1-3H3/t16-,17-/m1/s1;   InChIKey=YCBKSSAWEUDACY-IAGOWNOFSA-N;   SMILES=CCCCCc1cc(O)c2[C@@H]3C=C(CO)CC[C@H]3C(C)(C)Oc2c1
 xref: Beilstein:4259929;   CAS:36557-05-8;   HMDB:HMDB0060906
 xref_mesh: MESH:C001427
 xref: PMID:20630472;   PMID:21871147;   PMID:24185550;   Reaxys:4697849;   Wikipedia:11-Hydroxy-THC


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11-hydroxy-Delta(9)-tetrahydrocannabinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp1 fatty acid binding protein 1 multiple interactions ISO
EXP		 [FABP1 protein affects the transport of Dronabinol] which affects the abundance of 11-hydroxy-delta(9)-tetrahydrocannabinol
11-hydroxy-delta(9)-tetrahydrocannabinol inhibits the reaction [11-(dansylamino)undecanoic acid binds to FABP1 protein]
11-hydroxy-delta(9)-tetrahydrocannabinol affects the folding of and results in increased stability of FABP1 protein; 11-hydroxy-delta(9)-tetrahydrocannabinol inhibits the reaction [anandamide analog binds to FABP1 protein]		 CTD PMID:30232874 PMID:31110286 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Trpv2 transient receptor potential cation channel, subfamily V, member 2 multiple interactions EXP 11-hydroxy-delta(9)-tetrahydrocannabinol binds to and results in increased activity of TRPV2 protein CTD PMID:18550765 NCBI chr10:47,265,524...47,294,263
Ensembl chr10:47,272,931...47,294,260 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects metabolic processing ISO UGT1A9 gene SNP affects the metabolism of 11-hydroxy-delta(9)-tetrahydrocannabinol CTD PMID:30191314 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        epitope 7028
          Delta(9)-tetrahydrocannabinol 3
            11-hydroxy-Delta(9)-tetrahydrocannabinol 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    main group molecular entity 19759
                      s-block molecular entity 19628
                        hydrogen molecular entity 19614
                          hydrides 19087
                            organic hydride 18656
                              organic fundamental parent 18656
                                hydrocarbon 18396
                                  terpene 14014
                                    terpenoid 13711
                                      diterpenoid 13020
                                        Delta(9)-tetrahydrocannabinol 3
                                          11-hydroxy-Delta(9)-tetrahydrocannabinol 3
paths to the root