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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:octreotide
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Accession:CHEBI:7726 term browser browse the term
Definition:A homodetic cyclic peptide that has formula C49H66N10O10S2.
Synonyms:related_synonym: D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide;   D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide cyclic (2->7)-disulfide;   Formula=C49H66N10O10S2;   Formula=C49H66N10O10S2.2C2H4O2;   InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29-,34-,36+,37+,38-,39?,40+,41+,42+/m1/s1;   InChIKey=DEQANNDTNATYII-FLDZURHUSA-N;   Longastatin;   SMILES=[H][C@]1(NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)NC(CO)[C@@H](C)O)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O;   SMS-201-995;   octreotida;   octreotide acetate;   octreotidum;   sandostatine
 xref: Beilstein:7246145;   CAS:83150-76-9;   DrugBank:DB00104;   Drug_Central:1980;   HMDB:HMDB0014262;   KEGG:C07306;   KEGG:D00442
 xref_mesh: MESH:D015282
 xref: PDB:1SOC;   Patent:EP29579;   Patent:US4395403;   Wikipedia:Octreotide



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octreotide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Octreotide results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Octreotide inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:12890342 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Octreotide results in increased expression of BAX protein
[Bromocriptine co-treated with Octreotide] results in increased expression of BAX protein
CTD PMID:15046398 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO Octreotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO Octreotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Octreotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions ISO Octreotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Casp3 caspase 3 increases activity ISO [Octreotide results in increased activity of SSTR2 protein] which results in increased activity of CASP3 protein; Octreotide results in increased activity of CASP3 protein CTD PMID:16601281 PMID:16954443 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cck cholecystokinin decreases secretion
decreases response to substance
ISO Octreotide results in decreased secretion of CCK protein
Octreotide results in decreased susceptibility to CCK protein
CTD PMID:1631261 PMID:2883060 PMID:8314514 PMID:11148435 PMID:11552916 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide decreases secretion ISO Octreotide results in decreased secretion of CGA protein CTD PMID:1518435 NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP
ISO
Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]
NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]
CTD PMID:23137853 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Octreotide results in increased expression of FAS protein CTD PMID:18642777 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO Octreotide results in increased expression of FASLG protein CTD PMID:18642777 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO
EXP
NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]
Octreotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]; Octreotide inhibits the reaction [FSHB protein results in increased abundance of Estradiol]; Octreotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]; Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]; Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
CTD PMID:23137853 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions ISO [Celecoxib co-treated with Octreotide] results in increased expression of GDF15 mRNA CTD PMID:17959037 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gh1 growth hormone 1 decreases secretion
multiple interactions
affects expression
decreases expression
ISO
EXP
Octreotide results in decreased secretion of GH1 protein
[Octreotide co-treated with Sodium Glutamate] results in decreased expression of and results in decreased secretion of GH1 protein
Octreotide affects the expression of GH1 protein
Octreotide results in decreased expression of GH protein; Octreotide results in decreased expression of GH1 protein
CTD PMID:1516598 PMID:1518433 PMID:1561523 PMID:1682667 PMID:1683947 More... NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Ghrh growth hormone releasing hormone decreases expression
multiple interactions
EXP Octreotide results in decreased expression of GHRH mRNA
[Sodium Glutamate co-treated with Octreotide] results in decreased expression of GHRH mRNA
CTD PMID:9053782 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889
JBrowse link
G Gpt glutamic--pyruvic transaminase affects expression EXP Octreotide affects the expression of GPT protein CTD PMID:25338529 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Grk1 G protein-coupled receptor kinase 1 multiple interactions ISO Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]]; Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA] CTD PMID:18624922 NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792
JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Octreotide affects the expression of HMOX1 mRNA; Octreotide affects the expression of HMOX1 protein CTD PMID:25338529 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]] CTD PMID:23137853 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions EXP Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA] CTD PMID:23137853 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein multiple interactions ISO Octreotide promotes the reaction [BMP2 protein results in increased expression of ID1 mRNA]; Octreotide promotes the reaction [BMP4 protein results in increased expression of ID1 mRNA]; Octreotide promotes the reaction [BMP6 protein results in increased expression of ID1 mRNA]; Octreotide promotes the reaction [BMP7 protein results in increased expression of ID1 mRNA] CTD PMID:23137853 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression
affects expression
ISO Octreotide results in decreased expression of IGF1 protein
Octreotide affects the expression of IGF1 protein
CTD PMID:1516598 PMID:2111918 PMID:2404445 PMID:7711880 PMID:10806600 More... NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ins2 insulin 2 affects secretion
decreases secretion
multiple interactions
decreases expression
ISO
EXP
Octreotide affects the secretion of INS protein
Octreotide results in decreased secretion of INS protein
Octreotide inhibits the reaction [Hydrocortisone results in increased expression of INS protein]
Octreotide results in decreased expression of INS protein
CTD PMID:2111918 PMID:7493436 PMID:7792821 PMID:7917157 PMID:8261660 More... NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Krt18 keratin 18 multiple interactions ISO [Octreotide results in increased activity of SSTR2 protein] which results in increased expression of KRT18 protein modified form CTD PMID:16954443 NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
JBrowse link
G Nog noggin multiple interactions ISO NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Cyclic AMP]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased abundance of Progesterone]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of HSD3B2 mRNA]]; NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]] CTD PMID:23137853 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Prl prolactin decreases expression
affects expression
decreases secretion
multiple interactions
EXP
ISO
Octreotide results in decreased expression of PRL protein
Octreotide affects the expression of PRL protein
Octreotide results in decreased secretion of PRL protein
Colforsin inhibits the reaction [Octreotide results in decreased secretion of PRL protein]; Octreotide inhibits the reaction [Colforsin results in increased expression of PRL protein]; Pertussis Toxin inhibits the reaction [Octreotide results in decreased secretion of PRL protein]
CTD PMID:1322274 PMID:2111918 PMID:15046398 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Rgs1 regulator of G-protein signaling 1 multiple interactions ISO Octreotide inhibits the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of RGS1 mRNA] CTD PMID:18624922 NCBI chr13:56,018,529...56,022,939
Ensembl chr13:56,018,554...56,022,984
JBrowse link
G Smad6 SMAD family member 6 decreases expression EXP Octreotide results in decreased expression of SMAD6 mRNA CTD PMID:23137853 NCBI chr 8:64,450,114...64,519,673
Ensembl chr 8:64,450,114...64,519,763
JBrowse link
G Smad7 SMAD family member 7 decreases expression EXP Octreotide results in decreased expression of SMAD7 mRNA CTD PMID:23137853 NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765
JBrowse link
G Sst somatostatin decreases secretion
decreases expression
ISO
EXP
Octreotide results in decreased secretion of SST protein
Octreotide results in decreased expression of SST mRNA
CTD PMID:9053782 PMID:16601281 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Sstr1 somatostatin receptor 1 multiple interactions ISO Octreotide affects the reaction [SSTR1 protein affects the reaction [[Nitrogen co-treated with Iodoacetic Acid] results in increased expression of GRK1 mRNA]] CTD PMID:18624922 NCBI chr 6:75,832,292...75,836,806
Ensembl chr 6:75,832,530...75,836,802
JBrowse link
G Sstr2 somatostatin receptor 2 increases activity
multiple interactions
affects response to substance
ISO [Octreotide results in increased activity of SSTR2 protein] which results in increased activity of CASP3 protein
[Octreotide results in increased activity of SSTR2 protein] which results in increased expression of KRT18 protein modified form
SSTR2 protein affects the susceptibility to Octreotide
CTD PMID:16954443 PMID:17363388 NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP
ISO
Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
NOG protein inhibits the reaction [Octreotide inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]]
CTD PMID:23137853 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Octreotide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:12890342 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP Octreotide results in decreased expression of TNF mRNA CTD PMID:21692635 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP Octreotide results in increased expression of TNFRSF1A mRNA CTD PMID:21692635 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression EXP Octreotide results in increased expression of TNFRSF1B mRNA; Octreotide results in increased expression of TNFRSF1B protein CTD PMID:21692635 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO Octreotide results in decreased expression of TP53 protein CTD PMID:21764706 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions ISO Octreotide inhibits the reaction [TRH protein affects the activity of TSHB protein] CTD PMID:1518433 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions
decreases secretion
ISO Octreotide inhibits the reaction [TRH protein affects the activity of TSHB protein]
Octreotide results in decreased secretion of TSHB protein
CTD PMID:1518433 PMID:1518435 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Octreotide results in decreased expression of VEGFA protein CTD PMID:19624890 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19823
    role 19773
      biological role 19773
        pharmacological role 18852
          agonist 18262
            hormone agonist 2761
              octreotide 43
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  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        carboacyl group 17490
                                          univalent carboacyl group 17490
                                            carbamoyl group 17304
                                              carboxamide 17304
                                                peptide 9461
                                                  cyclic peptide 8784
                                                    homodetic cyclic peptide 8375
                                                      octreotide 43
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